Mengintegrasikan Nilai-nilai Anti Korupsi Dalam Pembelajaran Pendidikan Agama Islam Di Sekolah Menengah Atas

This paper discusses the anti-corruption values which are supposed to provide a solution to the problems of crime of corruption that are befalling the nation. The research aimed to describe and integrate anticorruption values into subjects of Islamic Education in High School. This is done because the subjects of Islamic Education in High School has a strategic role in achieving the goals of national education which is then internalized into the psyche of learners. The approach used is qualitatively using literature study. From the results of this study found a draft of lesson plan, contained in them values such as honesty, caring, self-reliance, discipline, responsibilities, hard work, temperance, courage and justice

Ascorbic acid effects on in vitro maturation of mouse oocyte with or without cumulus cell

Ascorbic acid has long been associated with fertility. This study was designed to determine the effects of ascorbic acid on in vitro maturation of mouse oocyte with or without cumulus cells. In this study, 508denuded oocytes (DOs) and 527 cumulus–oocyte complexes (COCs) from mice stimulated with pregnant mare’s serum gonadotrophin (PMSG) were incubated for 24 h in medium containing 0, 80, 250 and 750 &#956 M/ml of ascorbic acid prior to in vitro maturation. Maturation rate was compared. A significant decrease in the maturation rate was observed only when the DOs and COCs were exposed to 750 &#956 M/ml of ascorbic acid (P < 0.05). The maturation rate in COCs was significantly higher than DOs in all groups (P < 0.05). These results indicate that exposure ascorbic acid promotes the development of mouse DOs and COCs from germinal vesicle breakdown (GVBD) to metaphase II (MII) and prevents cumulus celldegeneration at certain levels, especially 250 &#956 M/ml of ascorbic acid (P < 0.05). However, further studies on the potential effects of different concentrations of ascorbic acid on oocyte maturation are needed

BASE DEFICIT IN IMMEDIATE POSTOPERATIVE PERIOD OF OPEN HEART SURGERY AND OUTCOME OF PATIENTS

Abstract- Base deficit is a non-respiratory indicator of acid base status. Aim of this study is to assess relationship between the base deficit value in immediate post operative period of CABG and valvular heart disease with cardiopulmonary and in hospital outcome of patient. A total of 136 consecutive with CABG and valvular heart disease scheduled in study. 20 variables were determined during the pre-intraand postoperative period. Statistical univariate analysis was performed differentiating patients whose initial base deficit after weaning from cardiopulmonary bypass was -8 meq and these whose base deficit was equal or more than -8 meq. Secondly a logistic regression model was performed on the variables shown to have a statistically significant difference in univariate analysis with determination of the odd ratio. 3 variables had a statistically significant difference in univariate analysis and 2 of them high lighted by the linear logistic model. The value of base deficit measured during the immediate postoperative open-heart surgery is correlated with volume of fresh frozen plasma and blood transfusion after open heart surgery and using of intra aortic balloon pump after surgery

An estimation of sonic velocities in shale using clay and silt fractions from the elemental capture spectroscopy log

Anisotropic differential effective medium approach is used to simulate elastic properties of shales from elastic properties and volume fractions of clay and silt constituents. Anisotropic elastic coefficients of the wet clay pack are assumed to be independent of mineralogy and to be linearly dependent on clay packing density (CPD), a fraction of clay in an individual wet clay pack. Simulated compressional and shear velocities normal to the bedding plane and are shown to be in a good agreement with measured sonic velocities. Further, elastic coefficients of shales, and, calculated from the log sonic velocities, calibrated porosity and clay fraction obtained from the mineralogy tool are used to invert for elastic constants of clays, C33 and C44. The obtained elastic coefficients of clays show lower scatter than the original elastic coefficients of shales. The noticeable increase of the clay elastic coefficients with the depth increase is shown to result from the positive trend of the CPD with depth. Being interpolated to the same CPD = 0.8, elastic coefficients of clays show no depth dependency. Our findings show that the CPD and silt fraction are the key parameters that can be used for successful modelling of elastic properties of shales

Evaluation of individual and environmental sound pressure level and drawing noise-isosonic maps using Surfer V.14 and Noise at Work V.5.0

Noise pollution is one of the common physical harmful factors in many work environments. The current study aimed to assess personal and environmental sound pressure level and project the sound-Isosonic map in one of the Razavi Khorasan Paste manufacture using Surfer V.14 and Noise at work V.5.0. This cross-sectional, descriptive study is analytical that was conducted in 2018 in the Paste factory that contains Canister, production and Brewing unit. Following ISO 9612:2009, Casella Cel-320 was used to measure personal sound pressure level, while CEL-450 sound level meter (manufactured by Casella-Cel, the UK) was employed to assess environmental sound pressure level. Statistical analyzes was done using SPSS V.18 and Linear Regression test. The sound-isosonic maps were projected using Surfer V. 14 and Noise at work V.5.0. The results of assessing personal sound pressure level indicated that the highest received dose (172.21%) and personal equivalent sound level (87.36 dBA) were recorded for workers in the Canister unit. According to results of measuring of the environmental sound pressure level, out of 16 measurement stations in this unit, overall 87.5% were regarded as danger and caution areas. The lowest and highest sound pressure levels in this units were 61 dBA and 92 dBA that belong to Brewing and Canister units respectively. Results indicate Over 75% of the Canister and production units had a sound pressure level greater than 85 dBA and these two units were regarded as the most dangerous area in terms of noise pollution. It is therefore necessary to implement noise control measures, apply hearing protection program and auditory tests among workers in these units

Urinary biomarkers for lupus nephritis: a systems biology approach

Systemic lupus erythematosus (SLE) is the prototypical systemic autoimmune disorder. Kidney involvement, termed lupus nephritis (LN), is seen in 40–60% of patients with systemic lupus erythematosus (SLE). After the diagnosis, serial measurement of proteinuria is the most common method of monitoring treatment response and progression. However, present treatments for LN—corticosteroids and immunosuppressants—target inflammation, not proteinuria. Furthermore, subclinical renal inflammation can persist despite improving proteinuria. Serial kidney biopsies—the gold standard for disease monitoring—are also not feasible due to their inherent risk of complications. Biomarkers that reflect the underlying renal inflammatory process and better predict LN progression and treatment response are urgently needed. Urinary biomarkers are particularly relevant as they can be measured non-invasively and may better reflect the compartmentalized renal response in LN, unlike serum studies that are non-specific to the kidney. The past decade has overseen a boom in applying cutting-edge technologies to dissect the pathogenesis of diseases at the molecular and cellular levels. Using these technologies in LN is beginning to reveal novel disease biomarkers and therapeutic targets for LN, potentially improving patient outcomes if successfully translated to clinical practice

Noise levels of a Massey Fergusson 285 tractor during movement on dirt and paved roads

This study aimed to determine the noise levels of a Massey Fergusson 285 tractor during movement on dirt and paved roads. The Massey Fergusson 285, 75 hp tractor accompanied by a trailer with one-ton load travelled on dirt and paved roads. The test field had 20 m length and 3 m width as defined according to international standards. The sound levels were measured with different gears and for engine speeds of 1000 and 2000 rpm at bystander position and right ear of operator. The difference between A-weighted sound levels for bystanders and right ear of operator, in engine speed of 1000 for dirt and paved roads, was 13.7–15.9 and 10.9–14.7 dB and, in engine speed of 2000, was 12.7–16.1 and 9.8–13.8 dB, respectively. In the bystander position, the sound levels for both engine speeds were lower on the dirt road compared to the paved road. The sound level at the right ear of the operator at engine speed of 1000 rpm was lower than ACGIH standards (85 dB whereas it was higher in engine speed of 2000 rpm for both roads, except in first low and first high gears on the dirt road. Based on similar distance for measurement points on both roads, the lower acoustic impedance of dirt compared with pavement surface provides less noise reflection which leads to lower noise levels in bystander position. The farmers who work near dirt roads are exposed to lower sound levels than those working near paved roads. © 2016 Institute of Noise Control Engineering

Calcium Dependent CAMTA1 in Adult Stem Cell Commitment to a Myocardial Lineage

The phenotype of somatic cells has recently been found to be reversible. Direct reprogramming of one cell type into another has been achieved with transduction and over expression of exogenous defined transcription factors emphasizing their role in specifying cell fate. To discover early and novel endogenous transcription factors that may have a role in adult-derived stem cell acquisition of a cardiomyocyte phenotype, mesenchymal stem cells from human and mouse bone marrow and rat liver were co-cultured with neonatal cardiomyocytes as an in vitro cardiogenic microenvironment. Cell-cell communications develop between the two cell types as early as 24 hrs in co-culture and are required for elaboration of a myocardial phenotype in the stem cells 8-16 days later. These intercellular communications are associated with novel Ca(2+) oscillations in the stem cells that are synchronous with the Ca(2+) transients in adjacent cardiomyocytes and are detected in the stem cells as early as 24-48 hrs in co-culture. Early and significant up-regulation of Ca(2+)-dependent effectors, CAMTA1 and RCAN1 ensues before a myocardial program is activated. CAMTA1 loss-of-function minimizes the activation of the cardiac gene program in the stem cells. While the expression of RCAN1 suggests involvement of the well-characterized calcineurin-NFAT pathway as a response to a Ca(2+) signal, the CAMTA1 up-regulated expression as a response to such a signal in the stem cells was unknown. Cell-cell communications between the stem cells and adjacent cardiomyocytes induce Ca(2+) signals that activate a myocardial gene program in the stem cells via a novel and early Ca(2+)-dependent intermediate, up-regulation of CAMTA1

Isolation and Characterization of Novel Murine Epiphysis Derived Mesenchymal Stem Cells

BACKGROUND: While bone marrow (BM) is a rich source of mesenchymal stem cells (MSCs), previous studies have shown that MSCs derived from mouse BM (BMMSCs) were difficult to manipulate as compared to MSCs derived from other species. The objective of this study was to find an alternative murine MSCs source that could provide sufficient MSCs. METHODOLOGY/PRINCIPAL FINDINGS: In this study, we described a novel type of MSCs that migrates directly from the mouse epiphysis in culture. Epiphysis-derived MSCs (EMSCs) could be extensively expanded in plastic adherent culture, and they had a greater ability for clonogenic formation and cell proliferation than BMMSCs. Under specific induction conditions, EMSCs demonstrated multipotency through their ability to differentiate into adipocytes, osteocytes and chondrocytes. Immunophenotypic analysis demonstrated that EMSCs were positive for CD29, CD44, CD73, CD105, CD166, Sca-1 and SSEA-4, while negative for CD11b, CD31, CD34 and CD45. Notably, EMSCs did not express major histocompatibility complex class I (MHC I) or MHC II under our culture system. EMSCs also successfully suppressed the proliferation of splenocytes triggered by concanavalin A (Con A) or allogeneic splenocytes, and decreased the expression of IL-1, IL-6 and TNF-α in Con A-stimulated splenocytes suggesting their anti-inflammatory properties. Moreover, EMSCs enhanced fracture repair, ameliorated necrosis in ischemic skin flap, and improved blood perfusion in hindlimb ischemia in the in vivo experiments. CONCLUSIONS/SIGNIFICANCES: These results indicate that EMSCs, a new type of MSCs established by our simple isolation method, are a preferable alternative for mice MSCs due to their better growth and differentiation potentialities

Characterization of behavioral, signaling and cytokine alterations in a rat neurodevelopmental model for schizophrenia, and their reversal by the 5-HT₆ receptor antagonist SB-399885

Post-weaning social isolation of rats produces neuroanatomical, neurochemical and behavioral alterations resembling some core features of schizophrenia. This study examined the ability of the 5-HT₆ receptor antagonist SB-399885 to reverse isolation-induced cognitive deficits, then investigated alterations in hippocampal cell proliferation and hippocampal and frontal cortical expression of selected intracellular signaling molecules and cytokines. Male Lister-hooded rats (weaned on post-natal day 21-24 and housed individually or in groups of 3-4) received six i.p. injections of vehicle (1% Tween 80, 1 mL/kg) or SB-399885 (5 or 10 mg/kg) over a two week period starting 40 days post-weaning, on the days that locomotor activity, novel object discrimination (NOD), pre-pulse inhibition of acoustic startle and acquisition, retention and extinction of a conditioned freezing response (CFR) were assessed. Tissue was collected 24 h after the final injection for immunohistochemistry, reverse-phase protein microarray and western blotting. Isolation rearing impaired NOD and cue-mediated CFR, decreased cell proliferation within the dentate gyrus, and elevated hippocampal TNFα levels and Cdc42 expression. SB-399885 reversed the NOD deficit and partially normalized CFR and cell proliferation. These effects were accompanied by altered expression of several members of the c-Jun N-terminal Kinase (JNK) and p38 MAPK signaling pathways (including TAK1, MKK4 and STAT3). Although JNK and p38 themselves were unaltered at this time point hippocampal TAK1 expression and phosphorylation correlated with visual recognition memory in the NOD task. Continued use of this neurodevelopmental model could further elucidate the neurobiology of schizophrenia and aid assessment of novel therapies for drug-resistant cognitive symptoms