The ABCs of EBP: opportunities and challenges for evidence-based practice education in developing countries

The importance of embedding evidence-based practice as part curricula and practice is now well recognised in health disciplines. However, despite this recognition there continues to be ongoing challenges. Nowhere are these challenges more evident than in developing countries where a tsunami of challenges confronts health care stakeholders. This commentary sheds some light on opportunities and challenges for evidence-based practice education in developing counties

Clinical implications of Squat Jump and Countermovement Jump among young females of United Arab Emirates : Comparative Biomechanical Analysis

Background: The countermovement jump (CMJ) and the squat jump (SJ) are two vertical jump (VJ) tests widely used to evaluate lower limb muscle strength and power, respectively. Biomechanical analysis of SJ and CMJ could help to predict the strength associated musculoskeletal clinical disorder which is most commonly seen among females such as patellofemoral pain syndrome, osteoarthritis etc. Therefore, the purpose of the study was to conduct and compare the biomechanical analysis of squat and countermovement jump using advanced motion analysis system and compare the changes among sedentary and active young females of the United Arab Emirates. Methodology: The experimental study was conducted at the Thumbay Physical Therapy and Rehabilitation Hospital, Gulf Medical University, Ajman, UAE. A total of 60 sedentary females, and 60 active females within age group 18-30 years were recruited under the convenience sampling method. The participants were randomly divided into two subgroups of 30 each for SJ and CMJ jump analysis respectively for sedentary and active group. Results: There was a statistically significant difference between the CMJ and SJ among the young females in UAE population (p < 0.05). The outcome variables such as jump height, and lower limb joint force were significantly reduced for SJ and CMJ in the sedentary group compared to active group. Majority of the variables showed moderate to severe effect size. Conclusion: Based on the study findings, it could be suggested that the “Sedentary Group” in the present study had poor muscle strength and ability to sustain the stress on the lower limb joints as also shown with lower mean total work. Since we have conducted the study on healthy non-athletes’ young females, the data could be used for further clinical correlation and comparison for lower limb muscle strength and power

Critical review of the book The integrated medical curriculum by Raja Bandaranayake and strategies to implement integrated medical curriculum

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New structural classes of antituberculosis agents

Tuberculosis (TB), one of the deadliest diseases is shattering the health and socioeconomic status of the society. The emergence of multidrug resistant (MDR) and extremely drug resistant (XDR) strains has provided unprecedented lethal character to TB. The development of MDR and XDR strains of TB results in more deaths, longer duration of therapy, and appearance of the disease in the immunocompromised patients. Because of the development of rapid resistance by Mycobacterium tuberculosis, researchers are confronted with serious challenges in combating TB. For instance, the need for potency and specificity in therapeutic agents approaching clinics, and the increasing demand of low toxicity due to long duration of treatment. Recently, it is proposed that such challenges could be addressed by a shift from contemporary or known classes of drugs to new scaffold‐containing or entirely new structural classes of drugs that possibly act on the previously unknown targets, resulting in possibly less instances of resistance development. The exploitation of advances made in the biology of TB in the last and present decades have created opportunities to discover a large number of new structural classes that specifically targets TB by molecular mechanism of action(s) unknown earlier. We have earlier reviewed new structural classes of anti‐TB agents up to year 2005. This review covers literature reports of the subsequent 10 years on the discovery of new structural classes of synthetic anti‐TB agents. Due to the availability of large number of research reports, we have divided new compounds in 38 structural classes, 368 structures, and 307 references