341 research outputs found
Suppression of forward dilepton production from an anisotropic quark-gluon plasma
We calculate the rapidity dependence of leading-order medium dilepton yields
resulting from a quark-gluon plasma which has a local time-dependent anisotropy
in momentum space. We present a phenomenological model which includes temporal
evolution of the plasma anisotropy parameter, xi, and the hard momentum scale,
p_hard. Our model interpolates between 1+1 dimensional collisionally-broadened
expansion at early times and 1+1 dimensional ideal hydrodynamic expansion at
late times. Using our model, we find that at LHC energies, forward high-energy
medium dilepton production would be suppressed by up to a factor of 3 if one
assumes an isotropization/thermalization time of 2 fm/c. Therefore, it may be
possible to use forward dilepton yields to experimentally determine the time of
onset of locally isotropic hydrodynamic expansion of the quark-gluon plasma as
produced in ultrarelativistic heavy-ion collisions.Comment: 12 pages, 5 figure
Highly-anisotropic and strongly-dissipative hydrodynamics with transverse expansion
A recently formulated framework of highly-anisotropic and
strongly-dissipative hydrodynamics (ADHYDRO) is used to describe the evolution
of matter created in ultra-relativistic heavy-ion collisions. New developments
of the model contain: the inclusion of asymmetric transverse expansion
(combined with the longitudinal boost-invariant flow) and comparisons of the
model results with the RHIC data, which have become possible after coupling of
ADHYDRO with THERMINATOR. Various soft-hadronic observables (the
transverse-momentum spectra, the elliptic flow coefficient v_2, and the HBT
radii) are calculated for different initial conditions characterized by the
value of the initial pressure asymmetry. We find that as long as the initial
energy density profile is unchanged the calculated observables remain
practically the same. This result indicates the insensitivity of the analyzed
observables to the initial anisotropy of pressure and suggests that the
complete thermalization of the system may be delayed to easily acceptable times
of about 1 fm/c
Modelling viral encephalitis caused by herpes simplex virus 1 infection in cerebral organoids
Herpes simplex encephalitis is a life-threatening disease of the central nervous system caused by herpes simplex viruses (HSVs). Following standard of care with antiviral acyclovir treatment, most patients still experience various neurological sequelae. Here we characterize HSV-1 infection of human brain organoids by combining single-cell RNA sequencing, electrophysiology and immunostaining. We observed strong perturbations of tissue integrity, neuronal function and cellular transcriptomes. Under acyclovir treatment viral replication was stopped, but did not prevent HSV-1-driven defects such as damage of neuronal processes and neuroepithelium. Unbiased analysis of pathways deregulated upon infection revealed tumour necrosis factor activation as a potential causal factor. Combination of anti-inflammatory drugs such as necrostatin-1 or bardoxolone methyl with antiviral treatment prevented the damages caused by infection, indicating that tuning the inflammatory response in acute infection may improve current therapeutic strategies
Anisotropy studies around the galactic centre at EeV energies with the Auger Observatory
Data from the Pierre Auger Observatory are analyzed to search for
anisotropies near the direction of the Galactic Centre at EeV energies. The
exposure of the surface array in this part of the sky is already significantly
larger than that of the fore-runner experiments. Our results do not support
previous findings of localized excesses in the AGASA and SUGAR data. We set an
upper bound on a point-like flux of cosmic rays arriving from the Galactic
Centre which excludes several scenarios predicting sources of EeV neutrons from
Sagittarius . Also the events detected simultaneously by the surface and
fluorescence detectors (the `hybrid' data set), which have better pointing
accuracy but are less numerous than those of the surface array alone, do not
show any significant localized excess from this direction.Comment: Matches published versio
SELNET clinical practice guidelines for bone sarcoma
Bone sarcoma are infrequent diseases, representing < 0.2% of all adult neoplasms. A multidisciplinary management within reference centers for sarcoma, with discussion of the diagnostic and therapeutic strategies within an expert multidisciplinary tumour board, is essential for these patients, given its heterogeneity and low frequency. This approach leads to an improvement in patient's outcome, as demonstrated in several studies. The Sarcoma European Latin-American Network (SELNET), aims to improve clinical outcome in sarcoma care, with a special focus in Latin-American countries. These Clinical Practice Guidelines (CPG) have been developed and agreed by a multidisciplinary expert group (including medical and radiation oncologist, surgical oncologist, orthopaedic surgeons, radiologist, pathologist, molecular biologist and representatives of patients advocacy groups) of the SELNET consortium, and are conceived to provide the standard approach to diagnosis, treatment and follow-up of bone sarcoma patients in the Latin-American context
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