Interfaceamento GPS/CAD em tempo real : estudo de caso

Orientador: Milton de Azevedo CamposDissertação (mestrado) -Universidade Federal do ParanaResumo: Este trabalho foi desenvolvido para testar a possibilidade do interfaceamento entre o sistema de posicionamento GPS (Global Positioning System) e um software do tipo CAD (Computer Assisted Design), em tempo real, para o monitoramento do deslocamento de veículos ferroviários. Como teste para o interfaceamento, foi utilizado o trecho ferroviário Curitiba - Rio Branco do Sul, de propriedade da Rede Ferroviária Federal S. A. (R.F.F.S.A). No teste, empregou-se um receptor de navegação instalado em um veiculo ferroviário, que coletava informações quanto a sua posição, ou seja, latitude e longitude. Essas informações foram retransmitidas via radio para uma base de controle. Esta base estava localizada na região central da cidade de Curitiba. As coordenadas coletadas pelo receptor sofreram transformações geométricas para que pudessem ser interpretadas pelo software AutoCAD para posterior plotagem em monitor de vídeo, sobre uma base cartográfica do trecho ferroviário utilizado no presente trabalho. O interfaceamento foi desenvolvido, na linguagem de programação C/C++, a partir da simulação de uma mesa digitalizadora utilizado pelo software AutoCAD. No presente trabalho, a simulação da mesa digitalizadora foi direcionada para o modelo de mesa Calcomp 9100. Este interfaceamento foi executado com sucesso, possibilitando assim a utilização do software AutoCAD para auxiliar o controle de trafego de veículos ferroviários, a partir de dados coletados por receptores GPS de navegação em tempo real.Abstract: The research described in this Dissertation was developed to test the connection between the Global Positioning System (GPS) and a sotfware of the type "Computer Assisted Design" (CAD), in real time in order to monitor the motion of railroad vehicles. For the purpose of their test, a survey was cossied out in fo in the railroad between Curitiba - Rio Branco do Sul, which belongs the Rede Ferroviaria Federal S.A. (RFFSA). A navigation GPS receiver on board the railroad vehicle, collected data which was transmitted via radio link to a base located in the central region of Curitiba. The coordinates transmitted from the receiver went through geometric transformations, allowing its use by the AutoCAD software. It was plotters in a video monitor, on the cartographic base describing the railroad previously surveyed. The interfacement was developed, in the language C/C++, simulating a Calcomp 9100 digitalizer table used by the AutoCAD software. The interfacement was sucessfully accomplished, showing the suitability of the application of the AutoCAD software to assist the control of railroad traffic in real time

The Open Spaces Systems in the Brazilian Urban from Constitution: Production and Apropriation (QUAPÁSEL II)

Esta proposta é continuação do projeto temático de pesquisa “Os Sistemas de Espaços Livres e a Constituição da Esfera Pública Contemporânea no Brasil”, desenvolvido nos anos de 2006-2011 no Laboratório QUAPÁ da FAUUSP em conjunto com o Grupo de Pesquisa “Requalificação Urbana” do CEATEC/ PUC-Campinas, processo FAPESP n. 2006/56623-2 com o envolvimento da Rede Nacional de Pesquisa QUAPÁ-SEL. Trata-se de novo Projeto Temático que visa investigar as relações entre os sistemas de espaços livres e a produção da forma urbana das cidades brasileiras na atualidade. O objeto é complexo (MORIN, 2008): não são os espaços livres nem a forma urbana em si, mas as relações que se estabelecem entre ambos que constituem o foco desta pesquisa. Tais relações constituem sistema, apresentam estrutura e organização que contêm em seu interior, dialeticamente, as relações que a estabelecem e que a desestabilizam. Impõe-se abordagem crítica para apreender o processo socioespacial de constituição das formas, e o que é comum à produção do espaço a nível nacional e para cada local investigado. Aprofunda-se o entendimento do papel dos principais agentes da produção do objeto investigado – do espaço concebido ao espaço vivido(LEFÈBVRE, 1974) – e estabelecer critérios de qualidade que considerem as especificidades locais – do clima às manifestações culturais – e as possibilidades de arranjo dos espaços livres e edificados integrantes do sistema espacial quanto às suas formas, funções e apropriações. Não se trata de criar manual da boa forma urbana, mas de estabelecer princípios teóricos e consolidar métodos de avaliação contribuindo para as diversas escalas de planejamento e de projeto do espaço urbano, com ênfase na vida pública.This proposal continues the thematic research project “The Open Spaces Systems and the Constitution of the Contemporary Public Sphere in Brazil”, developed by the QUAPÁ Laboratory at FAUUSP together with the Urban Renewal Research Group at CEATEC-PUC-Campinas, FAPESP process nº 2006/56623-2 in the years 2006-2011. It is a new thematic research project that aims to investigate the relationship between the open spaces systems and the urban form production in the Brazilian cities today. The object is a complex one (MORIN, 2008): it is not the open spaces, neither the urban form itself, but the relationship established between them that are the focus of this research. This relationship constitutes a system, presents a structure, and an organization which contains, dialectically, the relationship that establishes and destabilizes it. A critical approach is mandatory in order to comprehend the social and spatial process that constitutes the urban forms, and what it is common in national basis and for each investigated area. Continuing the national research network QUAPÁ-SEL, the objective is to understand the main stakeholders’ role that produces the investigated object – the conceived space and the living space (LEFÈBVRE, 1974) – and to establish quality criteria that considered the local specificities – from weather to cultural manifestations – and the open spaces and buildings arrangements possibilities that integrated the spatial system related to forms, functions and appropriations. It is not a goal to develop another good urban form guide, but to establish theoretical principles and consolidate evaluation methods to contribute to urban planning, with emphasis in public life

Diretriz sobre Diagnóstico e Tratamento da Cardiomiopatia Hipertrófica – 2024

Hypertrophic cardiomyopathy (HCM) is a form of genetically caused heart muscle disease, characterized by the thickening of the ventricular walls. Diagnosis requires detection through imaging methods (Echocardiogram or Cardiac Magnetic Resonance) showing any segment of the left ventricular wall with a thickness > 15 mm, without any other probable cause. Genetic analysis allows the identification of mutations in genes encoding different structures of the sarcomere responsible for the development of HCM in about 60% of cases, enabling screening of family members and genetic counseling, as an important part of patient and family management. Several concepts about HCM have recently been reviewed, including its prevalence of 1 in 250 individuals, hence not a rare but rather underdiagnosed disease. The vast majority of patients are asymptomatic. In symptomatic cases, obstruction of the left ventricular outflow tract (LVOT) is the primary disorder responsible for symptoms, and its presence should be investigated in all cases. In those where resting echocardiogram or Valsalva maneuver does not detect significant intraventricular gradient (> 30 mmHg), they should undergo stress echocardiography to detect LVOT obstruction. Patients with limiting symptoms and severe LVOT obstruction, refractory to beta-blockers and verapamil, should receive septal reduction therapies or use new drugs inhibiting cardiac myosin. Finally, appropriately identified patients at increased risk of sudden death may receive prophylactic measure with implantable cardioverter-defibrillator (ICD) implantation.La miocardiopatía hipertrófica (MCH) es una forma de enfermedad cardíaca de origen genético, caracterizada por el engrosamiento de las paredes ventriculares. El diagnóstico requiere la detección mediante métodos de imagen (Ecocardiograma o Resonancia Magnética Cardíaca) que muestren algún segmento de la pared ventricular izquierda con un grosor > 15 mm, sin otra causa probable. El análisis genético permite identificar mutaciones en genes que codifican diferentes estructuras del sarcómero responsables del desarrollo de la MCH en aproximadamente el 60% de los casos, lo que permite el tamizaje de familiares y el asesoramiento genético, como parte importante del manejo de pacientes y familiares. Varios conceptos sobre la MCH han sido revisados recientemente, incluida su prevalencia de 1 entre 250 individuos, por lo tanto, no es una enfermedad rara, sino subdiagnosticada. La gran mayoría de los pacientes son asintomáticos. En los casos sintomáticos, la obstrucción del tracto de salida ventricular izquierdo (TSVI) es el trastorno principal responsable de los síntomas, y su presencia debe investigarse en todos los casos. En aquellos en los que el ecocardiograma en reposo o la maniobra de Valsalva no detecta un gradiente intraventricular significativo (> 30 mmHg), deben someterse a ecocardiografía de esfuerzo para detectar la obstrucción del TSVI. Los pacientes con síntomas limitantes y obstrucción grave del TSVI, refractarios al uso de betabloqueantes y verapamilo, deben recibir terapias de reducción septal o usar nuevos medicamentos inhibidores de la miosina cardíaca. Finalmente, los pacientes adecuadamente identificados con un riesgo aumentado de muerte súbita pueden recibir medidas profilácticas con el implante de un cardioversor-desfibrilador implantable (CDI).A cardiomiopatia hipertrófica (CMH) é uma forma de doença do músculo cardíaco de causa genética, caracterizada pela hipertrofia das paredes ventriculares. O diagnóstico requer detecção por métodos de imagem (Ecocardiograma ou Ressonância Magnética Cardíaca) de qualquer segmento da parede do ventrículo esquerdo com espessura > 15 mm, sem outra causa provável. A análise genética permite identificar mutações de genes codificantes de diferentes estruturas do sarcômero responsáveis pelo desenvolvimento da CMH em cerca de 60% dos casos, permitindo o rastreio de familiares e aconselhamento genético, como parte importante do manejo dos pacientes e familiares. Vários conceitos sobre a CMH foram recentemente revistos, incluindo sua prevalência de 1 em 250 indivíduos, não sendo, portanto, uma doença rara, mas subdiagnosticada. A vasta maioria dos pacientes é assintomática. Naqueles sintomáticos, a obstrução do trato de saída do ventrículo esquerdo (OTSVE) é o principal distúrbio responsável pelos sintomas, devendo-se investigar a sua presença em todos os casos. Naqueles em que o ecocardiograma em repouso ou com Manobra de Valsalva não detecta gradiente intraventricular significativo (> 30 mmHg), devem ser submetidos à ecocardiografia com esforço físico para detecção da OTSVE.   Pacientes com sintomas limitantes e grave OTSVE, refratários ao uso de betabloqueadores e verapamil, devem receber terapias de redução septal ou uso de novas drogas inibidoras da miosina cardíaca. Por fim, os pacientes adequadamente identificados com risco aumentado de morta súbita podem receber medida profilática com implante de cardiodesfibrilador implantável (CDI)

Pervasive gaps in Amazonian ecological research

Biodiversity loss is one of the main challenges of our time,1,2 and attempts to address it require a clear un derstanding of how ecological communities respond to environmental change across time and space.3,4 While the increasing availability of global databases on ecological communities has advanced our knowledge of biodiversity sensitivity to environmental changes,5–7 vast areas of the tropics remain understudied.8–11 In the American tropics, Amazonia stands out as the world’s most diverse rainforest and the primary source of Neotropical biodiversity,12 but it remains among the least known forests in America and is often underrepre sented in biodiversity databases.13–15 To worsen this situation, human-induced modifications16,17 may elim inate pieces of the Amazon’s biodiversity puzzle before we can use them to understand how ecological com munities are responding. To increase generalization and applicability of biodiversity knowledge,18,19 it is thus crucial to reduce biases in ecological research, particularly in regions projected to face the most pronounced environmental changes. We integrate ecological community metadata of 7,694 sampling sites for multiple or ganism groups in a machine learning model framework to map the research probability across the Brazilian Amazonia, while identifying the region’s vulnerability to environmental change. 15%–18% of the most ne glected areas in ecological research are expected to experience severe climate or land use changes by 2050. This means that unless we take immediate action, we will not be able to establish their current status, much less monitor how it is changing and what is being lostinfo:eu-repo/semantics/publishedVersio

Pervasive gaps in Amazonian ecological research

Biodiversity loss is one of the main challenges of our time,1,2 and attempts to address it require a clear understanding of how ecological communities respond to environmental change across time and space.3,4 While the increasing availability of global databases on ecological communities has advanced our knowledge of biodiversity sensitivity to environmental changes,5,6,7 vast areas of the tropics remain understudied.8,9,10,11 In the American tropics, Amazonia stands out as the world's most diverse rainforest and the primary source of Neotropical biodiversity,12 but it remains among the least known forests in America and is often underrepresented in biodiversity databases.13,14,15 To worsen this situation, human-induced modifications16,17 may eliminate pieces of the Amazon's biodiversity puzzle before we can use them to understand how ecological communities are responding. To increase generalization and applicability of biodiversity knowledge,18,19 it is thus crucial to reduce biases in ecological research, particularly in regions projected to face the most pronounced environmental changes. We integrate ecological community metadata of 7,694 sampling sites for multiple organism groups in a machine learning model framework to map the research probability across the Brazilian Amazonia, while identifying the region's vulnerability to environmental change. 15%–18% of the most neglected areas in ecological research are expected to experience severe climate or land use changes by 2050. This means that unless we take immediate action, we will not be able to establish their current status, much less monitor how it is changing and what is being lost

Pervasive gaps in Amazonian ecological research

Biodiversity loss is one of the main challenges of our time,1,2 and attempts to address it require a clear understanding of how ecological communities respond to environmental change across time and space.3,4 While the increasing availability of global databases on ecological communities has advanced our knowledge of biodiversity sensitivity to environmental changes,5,6,7 vast areas of the tropics remain understudied.8,9,10,11 In the American tropics, Amazonia stands out as the world's most diverse rainforest and the primary source of Neotropical biodiversity,12 but it remains among the least known forests in America and is often underrepresented in biodiversity databases.13,14,15 To worsen this situation, human-induced modifications16,17 may eliminate pieces of the Amazon's biodiversity puzzle before we can use them to understand how ecological communities are responding. To increase generalization and applicability of biodiversity knowledge,18,19 it is thus crucial to reduce biases in ecological research, particularly in regions projected to face the most pronounced environmental changes. We integrate ecological community metadata of 7,694 sampling sites for multiple organism groups in a machine learning model framework to map the research probability across the Brazilian Amazonia, while identifying the region's vulnerability to environmental change. 15%–18% of the most neglected areas in ecological research are expected to experience severe climate or land use changes by 2050. This means that unless we take immediate action, we will not be able to establish their current status, much less monitor how it is changing and what is being lost

Monitoring training loads in judo athletes: different time courses of physiological, neuromuscular, and perceptual responses.

International Journal of Exercise Science 16(6): 638-653, 2023. This study aims to elucidate the internal load, performance, physiological, and perceptual recovery responses during four weeks of traditional judo training. Ten cadet and junior judo athletes were evaluated daily for four weeks, in which their perception of recovery, heart rate variability, handgrip strength, and countermovement jump performance were assessed. A one-way repeated-measures ANOVA was performed to analyze the variables across the weeks. A significant time effect in internal load (F = 6.51; p = 0.001) has been observed. Handgrip test performance showed significantly higher values in the 3rd and 4th weeks (p \u3c0.001), while countermovement jump performance was significantly higher in the 4th week (p =0.0007). The heart rate variability`s coefficient of variation was lower in both the 3rd and 4th weeks (p =0.02). Regarding perceptual aspects, the Hooper Index showed a significant time effect (p =0.04), but pairwise comparison did not reveal differences between weeks. The present study indicates that neuromuscular, physiological, and perceptual responses to training load alterations present different time courses. This must be considered for the adequate monitoring of training programs

Os Sistemas de Espaços Livres na Constituição da Forma Urbana Contemporânea no Brasil: Produção e Apropriação (QUAPÁSEL II)

Esta proposta é continuação do projeto temático de pesquisa “Os Sistemas de Espaços Livres e a Constituição da Esfera Pública Contemporânea no Brasil”, desenvolvido nos anos de 2006-2011 no Laboratório QUAPÁ da FAUUSP em conjunto com o Grupo de Pesquisa “Requalificação Urbana” do CEATEC/ PUC-Campinas, processo FAPESP n. 2006/56623-2 com o envolvimento da Rede Nacional de Pesquisa QUAPÁ-SEL. Trata-se de novo Projeto Temático que visa investigar as relações entre os sistemas de espaços livres e a produção da forma urbana das cidades brasileiras na atualidade. O objeto é complexo (MORIN, 2008): não são os espaços livres nem a forma urbana em si, mas as relações que se estabelecem entre ambos que constituem o foco desta pesquisa. Tais relações constituem sistema, apresentam estrutura e organização que contêm em seu interior, dialeticamente, as relações que a estabelecem e que a desestabilizam. Impõe-se abordagem crítica para apreender o processo socioespacial de constituição das formas, e o que é comum à produção do espaço a nível nacional e para cada local investigado. Aprofunda-se o entendimento do papel dos principais agentes da produção do objeto investigado – do espaço concebido ao espaço vivido(LEFÈBVRE, 1974) – e estabelecer critérios de qualidade que considerem as especificidades locais – do clima às manifestações culturais – e as possibilidades de arranjo dos espaços livres e edificados integrantes do sistema espacial quanto às suas formas, funções e apropriações. Não se trata de criar manual da boa forma urbana, mas de estabelecer princípios teóricos e consolidar métodos de avaliação contribuindo para as diversas escalas de planejamento e de projeto do espaço urbano, com ênfase na vida pública

Combining discovery and targeted proteomics reveals a prognostic signature in oral cancer

Different regions of oral squamous cell carcinoma (OSCC) have particular histopathological and molecular characteristics limiting the standard tumor-node-metastasis prognosis classification. Therefore, defining biological signatures that allow assessing the prognostic outcomes for OSCC patients would be of great clinical significance. Using histopathology-guided discovery proteomics, we analyze neoplastic islands and stroma from the invasive tumor front (ITF) and inner tumor to identify differentially expressed proteins. Potential signature proteins are prioritized and further investigated by immunohistochemistry (IHC) and targeted proteomics. IHC indicates low expression of cystatin-B in neoplastic islands from the ITF as an independent marker for local recurrence. Targeted proteomics analysis of the prioritized proteins in saliva, combined with machine-learning methods, highlights a peptide-based signature as the most powerful predictor to distinguish patients with and without lymph node metastasis. In summary, we identify a robust signature, which may enhance prognostic decisions in OSCC and better guide treatment to reduce tumor recurrence or lymph node metastasis.Peer reviewe