A Study of Sadaq in Daniel 8:14, Its Relation to the "Cleanse" Semantic Field, and its Importance for Seventh-Day Adventism's Concept of Investigative Judgement

While the Hebrew word root p1~ has a broad semantic range, examination of usage in this work shows that it relates mostly to justice and judgment, often describing the just manner of judicial proceedings. A number of these usages depict contexts that Seventh-day Adventism terms 'investigative judgments'; that is, the preliminary judicial phase in which evidence is examined. The relevant usages of verbal p1~ span narrative, legal, historical, poetic (particularly the individual laments), prophetic and wisdom genres. It frequently relates directly to the general biblical 'good-vs-evil' metannarative. The complex wisdom of Job is very illuminating as here verbal p1~ is utilised a disproportionately high number of times, and in connection with themes developed in Daniel, particularly the notions of test, conflict among professing God-followers, judicial investigation, theodicy, and anthropodicy. Further, there is a manifest connection with the "cleanse" semantic realm in the book of Job, in parallelism and linguistic interchange or substitution. This p1~-"cleanse" linguistic interrelation, also seen in other places in the Hebrew scriptures, is important for the cultic context of Dan 8. It suggests a strong connection between the righting of the sanctuary in Dan 8 (p1~) and the righting or cleansing of the sanctuary in the Day of Atonement service of Lev 16 (1;-m and 1~J pi.). The visual imagery of Dan 8, such as the sanctuary and the ram and goat, combined with the intertextual cultic-judicial usage of p1~ and metaphorical meaning of cultic words like 1;-m, ;i:,r, and 1~J, further gives reason to connect the two passages. Therefore it is legitimate to make the interpretive movement from the apocalyptic Dan 8:14 to the cultic and typological Lev 16, with the common referent of an investigative judgment. To deny a linguistic (and thematic) connection is often due to the restrictive semantic methodology of determinacy. A modified indeterminacy both engages prior usage of p1~, particularly in contexts reflecting Danielic themes, and utilises the present Dan 8 sanctuary context as the final determinant of meaning. Consequently, the translation " ... then shall the sanctuary be cleansed (P1~J)" (Dan 8:14), reflected in the Septuagint, Theodotion, Syriac, Coptic, and Vulgate, is an appropriate rendering as it engages the metaphorical "cleanse" nuance significantly associated with p1~, as seen in Dan 11/12, and particularly germane to the sanctuary and related themes of Dan 8

A novel Alzheimer disease locus located near the gene encoding tau protein

This is the author accepted manuscript. The final version is available from the publisher via the DOI in this recordAPOE ε4, the most significant genetic risk factor for Alzheimer disease (AD), may mask effects of other loci. We re-analyzed genome-wide association study (GWAS) data from the International Genomics of Alzheimer's Project (IGAP) Consortium in APOE ε4+ (10 352 cases and 9207 controls) and APOE ε4- (7184 cases and 26 968 controls) subgroups as well as in the total sample testing for interaction between a single-nucleotide polymorphism (SNP) and APOE ε4 status. Suggestive associations (P<1 × 10-4) in stage 1 were evaluated in an independent sample (stage 2) containing 4203 subjects (APOE ε4+: 1250 cases and 536 controls; APOE ε4-: 718 cases and 1699 controls). Among APOE ε4- subjects, novel genome-wide significant (GWS) association was observed with 17 SNPs (all between KANSL1 and LRRC37A on chromosome 17 near MAPT) in a meta-analysis of the stage 1 and stage 2 data sets (best SNP, rs2732703, P=5·8 × 10-9). Conditional analysis revealed that rs2732703 accounted for association signals in the entire 100-kilobase region that includes MAPT. Except for previously identified AD loci showing stronger association in APOE ε4+ subjects (CR1 and CLU) or APOE ε4- subjects (MS4A6A/MS4A4A/MS4A6E), no other SNPs were significantly associated with AD in a specific APOE genotype subgroup. In addition, the finding in the stage 1 sample that AD risk is significantly influenced by the interaction of APOE with rs1595014 in TMEM106B (P=1·6 × 10-7) is noteworthy, because TMEM106B variants have previously been associated with risk of frontotemporal dementia. Expression quantitative trait locus analysis revealed that rs113986870, one of the GWS SNPs near rs2732703, is significantly associated with four KANSL1 probes that target transcription of the first translated exon and an untranslated exon in hippocampus (P≤1.3 × 10-8), frontal cortex (P≤1.3 × 10-9) and temporal cortex (P≤1.2 × 10-11). Rs113986870 is also strongly associated with a MAPT probe that targets transcription of alternatively spliced exon 3 in frontal cortex (P=9.2 × 10-6) and temporal cortex (P=2.6 × 10-6). Our APOE-stratified GWAS is the first to show GWS association for AD with SNPs in the chromosome 17q21.31 region. Replication of this finding in independent samples is needed to verify that SNPs in this region have significantly stronger effects on AD risk in persons lacking APOE ε4 compared with persons carrying this allele, and if this is found to hold, further examination of this region and studies aimed at deciphering the mechanism(s) are warranted

Formula Electric SAE MQP for 2022-2023

The philosophy for this year's project focused on turning a functioning race car into a competitive one. We strove to redesign and optimize key systems to produce a refined race car capable of excelling at all aspects of the Formula SAE Hybrid competition. The interdisciplinary nature of the electro-mechanical subsystems required to achieve that goal necessitated a team of 20 students spread across the ME, ECE, RBE, and CS departments. Primary challenges were driven by competition rules compliance, finances, and time needed to develop and manufacture almost all new components in-house. The team was able to successfully design and manufacture many new and improved subsystems for the racecar and we are confident that we will perform well at the Formula Hybrid competition in May

The genome of the sea urchin Strongylocentrotus purpuratus.

International audienceWe report the sequence and analysis of the 814-megabase genome of the sea urchin Strongylocentrotus purpuratus, a model for developmental and systems biology. The sequencing strategy combined whole-genome shotgun and bacterial artificial chromosome (BAC) sequences. This use of BAC clones, aided by a pooling strategy, overcame difficulties associated with high heterozygosity of the genome. The genome encodes about 23,300 genes, including many previously thought to be vertebrate innovations or known only outside the deuterostomes. This echinoderm genome provides an evolutionary outgroup for the chordates and yields insights into the evolution of deuterostomes

Author Correction: Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing (Nature Genetics, (2019), 51, 3, (414-430), 10.1038/s41588-019-0358-2)

An amendment to this paper has been published and can be accessed via a link at the top of the paper