Functional materials for Design

The main problematic of the research is to connect the stimuli-responsive behaviour of functional material to the end-user experience. To make this connection, the research was divided in layers, from the most technical at the bottom, to the most designerly at the top. The objective is to propose a set of chained tools that will eventually allow a seamless journey through all the layers and provide support for designers to use functional material in their projects

Selection Framework for the Implementation of Functional Materials in Product Design

Concept Functional materials, also called “smart materials”, are materials that can “sense environment events, process that sensory information and then act on the environment” [1]. These materials are able to transform a given stimulus into a response. We use the general term “transition phenomenon” to describe this process. These transitions can be as diverse as, e.g.: mechanoluminescence, which is a light emission produced by the application of a strain [2], or thermoelectricity, the convertion of a temperature difference into an electric potential [3]. We designed a specific database and selection process for functional materials. The data structure is organized around their main functionality: the transition phenomenon. This database is implemented in the Cambridge Engineering Selector software, using the “constructor” functionality. Motivations and Objectives The standard selection framework proposed by Ashby [4] relies on 4 successive stages : translation, limits, objectives, documentation. It is not entirely suited to the selection of functional materials, which has to account for the relation between stimuli and responses. Results and Discussion In our database prototype, we introduce a table of transition phenomena, which is organized by families and sub-families of outputs (Fig 1). The relationship between materials and transition phenomena is made by linking the tables together and providing specific attributes that describe the stimuli-responsive properties of the materials. Future developments include tables of existing products and processes used to implement functional materials or functionalize existing ones. In this work, as the entry point to the information system is the stimuli responsive behaviour of functional materials, rather than their structure and properties. The emphasis is thus put on user experience and interaction with materials and products. References [1] M. Addington, D. Schodek, Smart Materials and technologies for the architecture and design professions, Elsevier, 2005 [2] S. M. Jeong, S. Song, K.-I. Joo, J. Kim, S.-H. Hwang, J. Jeong, H. Kim, Bright, wind-driven white mechanoluminescence from zinc sulphide microparticles embedded in a polydimethylsiloxane elastomer [3] A. da Rosa, Thermoelectricity, Fundamentals of Renewable Energy Processes, Elsevier, 2013, 149–212 [4] M. Ashby, Materials Selection in Mechanical Design, Elsevier, 1992-2005(Third edition

Stimuli-responsive materials: Definition, classification and descriptions

Stimuli-responsive materials: definition, classification and descriptions Stimuli-responsive materials have the particularity to change one or more of their properties under a defined stimulus: through a transition phenomenon, they will turn an input, or stimulus, into an output, or response. To make a selection of these materials, a designer will consider first of all the main functionality of these materials, which is their transition phenomenon, as it gives them a capacity to process information. To get a perspective on stimuli-responsive materials and the possibilities they offer, the first step has been to class them according to their transition phenomenon. This has been done in the form of a graph where transition phenomena are represented as a link between their associated input and output. A second representation has been made starting from the first graph, but adding a link to the user of a product which use a stimuli-responsive material. To do so, the inputs of the materials has been differentiated by the fact that they can be activated by the user, the environment or by an intermediary system; the outputs has been linked to the achievable behaviors of a product and with the sensory modality the user will engage to notice these behaviors. After having proposed this classification of stimuli-responsive materials, the next step of the work is to get more detailed information about their behavior, and to organize and represent this information in a coherent and efficient way. To do so, we proposed a description for each type of transition phenomenon, which shows its most important characteristics in a visual way. This information is now being summed up in a database, which is organized with different tables and tree-structures that will describe stimuli-responsive materials, transition phenomena and the link between them. A first prototype of the database will be proposed

Cetaceans have complex brains for complex cognition

MEDLINE® is the source for the citation and abstract of this record.Peer reviewedPublisher PD

Chemoradiation for advanced hypopharyngeal carcinoma: a retrospective study on efficacy, morbidity and quality of life

Chemoradiation (CRT) is a valuable treatment option for advanced hypopharyngeal squamous cell cancer (HSCC). However, long-term toxicity and quality of life (QOL) is scarcely reported. Therefore, efficacy, acute and long-term toxic effects, and long-term QOL of CRT for advanced HSCC were evaluated,using retrospective study and post-treatment quality of life questionnaires. in a tertiary hospital setting. Analysis was performed of 73 patients that had been treated with CRT. Toxicity was rated using the CTCAE score list. QOL questionnaires EORTC QLQ-C30, QLQ-H&N35, and VHI were analyzed. The most common acute toxic effects were dysphagia and mucositis. Dysphagia and xerostomia remained problematic during long-term follow-up. After 3 years, the disease-specific survival was 41%, local disease control was 71%, and regional disease control was 97%. The results indicated that CRT for advanced HSCC is associated with high locoregional control and disease-specific survival. However, significant acute and long-term toxic effects occur, and organ preservation appears not necessarily equivalent to preservation of function and better QOL

Inhibition of the β-lactamase BlaMab by avibactam improves the in vitro and in vivo efficacy of imipenem against mycobacterium abscessus

Mycobacterium abscessus pulmonary infections are treated with a macrolide (clarithromycin or azithromycin), an aminoglycoside (amikacin), and a β-lactam (cefoxitin or imipenem). The triple combination is used without any β-lactamase inhibitor, even though M. abscessus produces the broad-spectrum β-lactamase BlaMab. We determine whether inhibition of BlaMab by avibactam improves the activity of imipenem against M. abscessus. The bactericidal activity of drug combinations was assayed in broth and in human macrophages. The in vivo efficacy of the drugs was tested by monitoring the survival of infected zebrafish embryos. The level of BlaMab production in broth and in macrophages was compared by quantitative reverse transcription-PCR and Western blotting. The triple combination of imipenem (8 or 32 μg/ml), amikacin (32 μg/ml), and avibactam (4 μg/ml) was bactericidal in broth (<0.1% survival), with 3.2- and 4.3-log10 reductions in the number of CFU being achieved at 72 h when imipenem was used at 8 and 32 μg/ml, respectively. The triple combination achieved significant intracellular killing, with the bacterial survival rates being 54% and 7% with the low (8 μg/ml) and high (32 μg/ml) dosages of imipenem, respectively. In vivo inhibition of BlaMab by avibactam improved the survival of zebrafish embryos treated with imipenem. Expression of the gene encoding BlaMab was induced (20-fold) in the infected macrophages. Inhibition of BlaMab by avibactam improved the efficacy of imipenem against M. abscessus in vitro, in macrophages, and in zebrafish embryos, indicating that this β-lactamase inhibitor should be clinically evaluated. The in vitro evaluation of imipenem may underestimate the impact of BlaMab, since the production of the β-lactamase is inducible in macrophages

Cryopreservation Effect on Proliferative and Chondrogenic Potential of Human Chondrocytes Isolated from Superficial and Deep Cartilage

[Abstract] Objectives: To compare the proliferative and chondrogenic potential of fresh and frozen chondrocytes isolated from superficial and deep articular cartilage biopsies. Materials and Methodology: The study included 12 samples of fresh and frozen healthy human knee articular cartilage. Cell proliferation was tested at 3, 6 and 9 days. Studies of mRNA quantification, protein expression and immunofluorescence for proliferation and chondrogenic markers were performed. Results: Stimulation of fresh and frozen chondrocytes from both superficial and deep cartilage with fetal bovine serum produced an increase in the proliferative capacity compared to the non-stimulated control group. In the stimulated fresh cells group, the proliferative capacity of cells from the deep biopsy was greater than that from cells from the superficial biopsy (0.046 vs 0.028, respectively, p<0.05). There was also a significant difference between the proliferative capacity of superficial zone fresh (0.028) and frozen (0.051) chondrocytes (p<0.05). CCND1 mRNA and protein expression levels, and immunopositivity for Ki67 revealed a higher proliferative capacity for fresh articular chondrocytes from deep cartilage. Regarding the chondrogenic potential, stimulated fresh cells showed higher SOX9 and Col II expression in chondrocytes from deep than from superficial zone (p<0.05, T student test). Conclusions: The highest rate of cell proliferation and chondrogenic potential of fresh chondrocytes was found in cells obtained from deep cartilage biopsies, whereas there were no statistically significant differences in proliferative and chondrogenic capacity between biopsy origins with frozen chondrocytes. These results indicate that both origin and cryopreservation affect the proliferative and chondrogenic potential of chondrocytes.Servizo Galego de Saúde; PS07/84Instituto de Salud Carlos III; CIBER BBN CB06-01-0040Ministerio Ciencia e Innovacion; PLE2009-0144Ministerio Ciencia e Innovación; PI 08/202

What More Do Bodies Know? Moving with the Gendered Affects of Place

This article focuses on what bodies know yet which cannot be expressed verbally. It starts with a problem encountered during conventional interviewing in an ex-mining community in south Wales when some teen girls struggled to speak. This led us to focus on the body, corporeality and movement in improvisational dance workshops. By slowing down and speeding up video footage from the workshops, we notice movement patterns and speculate about how traces of gendered body-movement practices developed within mining communities over time become actualised in girls’ habitual movement repertoires. Inspired by the works of Gilles Deleuze, Felix Guattari and Erin Manning, a series of cameos (room dancing; the hold; the wiggle; the leap and dance of the not-yet) are presented. We speculate about relations between the actual movements we could see, the in-act infused with the history of place and the virtual potential of what movement

Relevance of gastrointestinal manifestations in a large Spanish cohort of patients with systemic lupus erythematosus: what do we know?

SLE can affect any part of the gastrointestinal (GI) tract. GI symptoms are reported to occur in >50% of SLE patients. To describe the GI manifestations of SLE in the RELESSER (Registry of SLE Patients of the Spanish Society of Rheumatology) cohort and to determine whether these are associated with a more severe disease, damage accrual and a worse prognosis. METHODS: We conducted a nationwide, retrospective, multicentre, cross-sectional cohort study of 3658 SLE patients who fulfil =4 ACR-97 criteria. Data on demographics, disease characteristics, activity (SLEDAI-2K or BILAG), damage (SLICC/ACR/DI) and therapies were collected. Demographic and clinical characteristics were compared between lupus patients with and without GI damage to establish whether GI damage is associated with a more severe disease. RESULTS: From 3654 lupus patients, 3.7% developed GI damage. Patients in this group (group 1) were older, they had longer disease duration, and were more likely to have vasculitis, renal disease and serositis than patients without GI damage (group 2). Hospitalizations and mortality were significantly higher in group 1. Patients in group 1 had higher modified SDI (SLICC Damage Index). The presence of oral ulcers reduced the risk of developing damage in 33% of patients. CONCLUSION: Having GI damage is associated with a worse prognosis. Patients on a high dose of glucocorticoids are at higher risk of developing GI damage which reinforces the strategy of minimizing glucocorticoids. Oral ulcers appear to decrease the risk of GI damage. © The Author(s) 2021. Published by Oxford University Press on behalf of the British Society for Rheumatology

Complement component C4 structural variation and quantitative traits contribute to sex-biased vulnerability in systemic sclerosis

Altres ajuts: Fondo Europeo de Desarrollo Regional (FEDER), "A way of making Europe".Copy number (CN) polymorphisms of complement C4 play distinct roles in many conditions, including immune-mediated diseases. We investigated the association of C4 CN with systemic sclerosis (SSc) risk. Imputed total C4, C4A, C4B, and HERV-K CN were analyzed in 26,633 individuals and validated in an independent cohort. Our results showed that higher C4 CN confers protection to SSc, and deviations from CN parity of C4A and C4B augmented risk. The protection contributed per copy of C4A and C4B differed by sex. Stronger protection was afforded by C4A in men and by C4B in women. C4 CN correlated well with its gene expression and serum protein levels, and less C4 was detected for both in SSc patients. Conditioned analysis suggests that C4 genetics strongly contributes to the SSc association within the major histocompatibility complex locus and highlights classical alleles and amino acid variants of HLA-DRB1 and HLA-DPB1 as C4-independent signals