Efficacy and safety of single-dose ivermectin in mild-to-moderate COVID-19: the double-blind, randomized, placebo-controlled CORVETTE-01 trial

BackgroundTo investigate whether ivermectin inhibits SARS-CoV-2 proliferation in patients with mild-to-moderate COVID-19 using time to a negative COVID-19 reverse transcription-polymerase chain reaction (RT-PCR) test.MethodsCORVETTE-01 was a double-blind, randomized, placebo-controlled study (August 2020–October 2021) conducted in Japan. Overall, 248 patients diagnosed with COVID-19 using RT-PCR were assessed for eligibility. A single oral dose of ivermectin (200  μg/kg) or placebo was administered under fasting. The primary outcome was time to a negative COVID-19 RT-PCR test result for SARS-CoV-2 nucleic acid, assessed using stratified log-rank test and Cox regression models.ResultsOverall, 112 and 109 patients were randomized to ivermectin and placebo, respectively; 106 patients from each group were included in the full analysis set (male [%], mean age: 68.9%, 47.9 years [ivermectin]; 62.3%, 47.5 years [placebo]). No significant difference was observed in the occurrence of negative RT-PCR tests between the groups (hazard ratio, 0.96; 95% confidence interval [CI] 0.70–1.32; p = 0.785). Median (95% CI) time to a negative RT-PCR test was 14.0 (13.0–16.0) and 14.0 (12.0–16.0) days for ivermectin and placebo, respectively; 82.1% and 84% of patients achieved negative RT-PCR tests, respectively.ConclusionIn patients with COVID-19, single-dose ivermectin was ineffective in decreasing the time to a negative RT-PCR test.Clinical Trial RegistrationClinicalTrials.gov, NCT04703205

"Poiēsis" in quanto "praxis": uno studio comparato delle teorie dell’arte di Kitarō Nishida e Luigi Pareyson

This paper aims to compare the aesthetic concepts presented by Kitarō Nishida and Luigi Pareyson. The dissertator analyses them on the moral effect of  practicing the creative (formative in Pareyson’s terminology) acts: how the per- sonality of the creator/former comes in the form through these types of acts. Two  philosophers – one grew up in the East and one in the West – formed their per- sonalities in completely different way which were constructed in different kinds  of circumstances based on different religious concepts, and they were educated as a philosopher by a different method. Despite such different circumstances, they had a common vision: the personality of a subject of creative acts comes to form through the practice of creating (forming) acts. In this thesis, the dissertator tries to declare how they, Nishida using the phenomenological method and Pareyson with the hermeneutic one, arrived at the common conclusion that the practice of creative (forming) acts is the best way for forming one’s personality