Noise sensitive persons are more likely to have sleep problems

OBJECTIVES: Many insomnia patients complain about a disturbance by even minimal sounds from the environment. However, the concept of noise sensitivity is still poorly understood. Noise sensitive people are more affected by a noisy environment, but they do not seem to have an increased auditory sensitivity. Nevertheless noise sensitivity can have a large impact on daily life and in general they seem to have more sleep problems and more psychological problems. In this study noise sensitivity is studied in relation to individual sleep patterns, sleep quality and symptoms of sleep problems. In addition the association between noise sensitivity with personality traits is studied. METHODS: A group of 450 first year students in completed a noise sensitivity questionnaire (NoiSeQ) and a questionnaire for general sensitivity to environmental stimuli. In addition individual sleep patterns were measured with a general sleep questionnaire and subjective sleep quality was assessed with the Dutch Sleep Quality Scale. The Sleep50 scale was used to measure presence of symptoms of sleep problems. Two personality tests were administered: the 5 PVT (neuroticism and extraversion) and the ZBV to measure the tendency for anxiety. A group of low noise sensitive persons (LO) and a group of high sensitive persons (HI) were selected from NoiSeQ scores for the sleep subscale. RESULTS: More than a third of this student sample (36.5%) judged their chronotype as ‘extreme evening types’. This can be explained by the fact that these young students were still adolescents. 14.1% of the subjects had subjective symptoms of insomnia, 12.8% had symptoms of apnea, whereas 9.4% claimed to have parasomnias like sleepwalking or nightmares. The HI group had a longer sleep latency (p<.05) and more symptoms of insomnia (p<.000), PLMD (p<.01) and biological clock disorders (p<.05). In addition subjects with higher noise sensitivity had a higher score on neuroticism (p<.000) and were more inclined to feel anxious (p<.000). Although noise sensitivity was significantly correlated with general sensitivity for environmental stimuli, general sensitivity was not correlated with any of the sleep parameters. CONCLUSION: Noise sensitive persons have more sleep problems and are more anxious than persons who are not noise sensitive. This cannot be explained by a general sensitivity to environmental stimuli

Age at first birth in women is genetically associated with increased risk of schizophrenia

Prof. Paunio on PGC:n jäsenPrevious studies have shown an increased risk for mental health problems in children born to both younger and older parents compared to children of average-aged parents. We previously used a novel design to reveal a latent mechanism of genetic association between schizophrenia and age at first birth in women (AFB). Here, we use independent data from the UK Biobank (N = 38,892) to replicate the finding of an association between predicted genetic risk of schizophrenia and AFB in women, and to estimate the genetic correlation between schizophrenia and AFB in women stratified into younger and older groups. We find evidence for an association between predicted genetic risk of schizophrenia and AFB in women (P-value = 1.12E-05), and we show genetic heterogeneity between younger and older AFB groups (P-value = 3.45E-03). The genetic correlation between schizophrenia and AFB in the younger AFB group is -0.16 (SE = 0.04) while that between schizophrenia and AFB in the older AFB group is 0.14 (SE = 0.08). Our results suggest that early, and perhaps also late, age at first birth in women is associated with increased genetic risk for schizophrenia in the UK Biobank sample. These findings contribute new insights into factors contributing to the complex bio-social risk architecture underpinning the association between parental age and offspring mental health.Peer reviewe