Non-Pharmacological Approach to Irritable Bowel Syndrome

Irritable bowel syndrome (IBS) is a commonly diagnosed gastrointestinal condition. It represents a significant healthcare burden and still remains a real challenge. Over the years, IBS has been described as a strict illness of the gastrointestinal tract (medical model) or as a more complex multi-symptomatic disorder of the brain-gut axis (biopsychosocial or psychosomatic model). The reason why IBS has been such a challenge and is so difficult to handle might be related to different approaches. These differences in the view of the syndrome have affected the assessment, treatment and handling of the IBS patient. Patients with IBS, where the symptoms from the gastrointestinal tract are one part of a multi-symptom palette sometimes hidden in the body or mind, need a more holistic outlook. The key to an effective treatment approach is a gastroenterological examination to exclude other diseases along with an assessment of the whole body and its awareness by a body-mind therapist. This chapter discusses the view of the patient together with patient evaluations and body-mind treatment from a practical point of view

Limits of ultra-high-precision optical astrometry: Stellar surface structures

We investigate the astrometric effects of stellar surface structures as a practical limitation to ultra-high-precision astrometry, e.g. in the context of exoplanet searches, and to quantify the expected effects in different regions of the HR-diagram. Stellar surface structures are likely to produce fluctuations in the integrated flux and radial velocity of the star, as well as a variation of the observed photocentre, i.e. astrometric jitter, and closure phase. We use theoretical considerations supported by Monte Carlo simulations to derive statistical relations between the corresponding astrometric, photometric, and radial-velocity effects. For most stellar types the astrometric jitter due to stellar surface structures is expected to be of order 10 micro-AU or greater. This is more than the astrometric displacement typically caused by an Earth-size exoplanet in the habitable zone, which is about 1-4 micro-AU for long-lived main-sequence stars. Only for stars with extremely low photometric variability (<0.5 mmag) and low magnetic activity, comparable to that of the Sun, will the astrometric jitter be of order 1 micro-AU, suffcient to allow the astrometric detection of an Earth-sized planet in the habitable zone. While stellar surface structure may thus seriously impair the astrometric detection of small exoplanets, it has in general negligible impact on the detection of large (Jupiter-size) planets and on the determination of stellar parallax and proper motion. From the starspot model we also conclude that the commonly used spot filling factor is not the most relevant parameter for quantifying the spottiness in terms of the resulting astrometric, photometric and radial-velocity variations.Comment: 12 pages, 4 figures, submitted to A&

Optically controlling the competition between spin flips and intersite spin transfer in a Heusler half-metal on sub-100 fs timescales

The direct manipulation of spins via light may provide a path toward ultrafast energy-efficient devices. However, distinguishing the microscopic processes that can occur during ultrafast laser excitation in magnetic alloys is challenging. Here, we study the Heusler compound Co2MnGa, a material that exhibits very strong light-induced spin transfers across the entire M-edge. By combining the element-specificity of extreme ultraviolet high harmonic probes with time-dependent density functional theory, we disentangle the competition between three ultrafast light-induced processes that occur in Co2MnGa: same-site Co-Co spin transfer, intersite Co-Mn spin transfer, and ultrafast spin-flips mediated by spin-orbit coupling. By measuring the dynamic magnetic asymmetry across the entire M-edges of the two magnetic sublattices involved, we uncover the relative dominance of these processes at different probe energy regions and times during the laser pulse. Our combined approach enables a comprehensive microscopic interpretation of laser-induced magnetization dynamics on timescales shorter than 100 fs.Comment: 31 pages, 12 figure

Critical review of immediate implant loading

Background : Implant dentistry has become successful with the discovery of the biological properties of titanium. In the original protocol, studies have advocated a 2-stage surgical protocol for load-free and submerged healing to ensure predictable osseointegration. However, the discomfort, inconvenience, and anxiety associated with waiting period remains a challenge to both patients and clinicians. Hence, loading implant right after placement was attempted and has gained popularity among clinicians. Issues/questions related to this approach remain unanswered. Therefore, it is the purpose of this review article to (1) review and analyze critically the current available literature in the field of immediate implant loading and (2) discuss, based on scientific evidence, factors that may influence this treatment modality. Material and Methods : Literature published over the past 20 years was selected and reviewed. Findings from these studies were discussed and summarized in the tables. The advantages and disadvantages associated with immediate implant loading were analyzed. Factors that may influence the success of immediate implant loading, including patient selection, type of bone quality, required implant length, micro- and macrostructure of the implant, surgical skill, need for achieving primary stability/control of occlusal force, and prosthesis guidelines, were thoroughly reviewed and discussed. Results and Conclusion : Various studies have demonstrated the feasibility and predictability of this technique. However, most of these articles are based on retrospective data or uncontrolled cases. Randomized, prospective, parallel-armed longitudinal human trials are primarily based on short-term results and long-term follow-ups are still scarce in this field. Nonetheless, from available literature, it may be concluded that anatomic locations, implant designs, and restricted prosthetic guidelines are key to ensure successful outcomes. Future studies, preferably randomized, prospective longitudinal studies, are certainly needed before this approach can be widely used. To cite this article: Gapski R, Wang H-L, Mascarenhas P, Lang NP. Critical review of immediate implant loading. Clin. Oral Impl. Res , 14 , 2003; 515–527Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/73058/1/j.1600-0501.2003.00950.x.pd

Insight into the dehydration behaviour of scandium-substituted barium titanate perovskites via simultaneous in situ neutron powder thermodiffractometry and thermogravimetric analysis

Hydration-dehydration cycles are critical to the mechanical performance of ceramic proton conductors. The development of in situ methods is desirable in order to study their structural response under conditions that mimic the operating ones. Neutron powder diffraction studies combined with simultaneous thermogravimetric analysis were performed on the hydrated forms of two members of the oxygen deficient perovskite BaTi1−xScxO3−δseries, with x = 0.5 and x = 0.7. Rietveld analyses agreed with in situ gravimetric data, allowing correlation of occupancy factors of the oxygen site to hydration levels and other structural data. Dehydration is an activated process that impacts on structural parameters and the level of Sc substitution was found to control the structural response during in situ dehydration, with higher Sc content leading to significantly greater volume contraction. This was rationalised by the chemical expansion due to hydration of oxygen vacancies within the x = 0.5 sample being anomalously small. Furthermore, the behaviour of the x = 0.5 system revealed an unexpected cell expansion during the early stages of dehydration, suggesting the hydration level may influence the thermal expansion coefficient (TEC)

Eight common genetic variants associated with serum dheas levels suggest a key role in ageing mechanisms

Dehydroepiandrosterone sulphate (DHEAS) is the most abundant circulating steroid secreted by adrenal glands-yet its function is unknown. Its serum concentration declines significantly with increasing age, which has led to speculation that a relative DHEAS deficiency may contribute to the development of common age-related diseases or diminished longevity. We conducted a meta-analysis of genome-wide association data with 14,846 individuals and identified eight independent common SNPs associated with serum DHEAS concentrations. Genes at or near the identified loci include ZKSCAN5 (rs11761528; p = 3.15×10-36), SULT2A1 (rs2637125; p = 2.61×10-19), ARPC1A (rs740160; p = 1.56×10-16), TRIM4 (rs17277546; p = 4.50×10-11), BMF (rs7181230; p = 5.44×10-11), HHEX (rs2497306; p = 4.64×10-9), BCL2L11 (rs6738028; p = 1.72×10-8), and CYP2C9 (rs2185570; p = 2.29×10-8). These genes are associated with type 2 diabetes, lymphoma, actin filament assembly, drug and xenobiotic metabolism, and zinc finger proteins. Several SNPs were associated with changes in gene expression levels, and the related genes are connected to biological pathways linking DHEAS with ageing. This study provides much needed insight into the function of DHEAS

HVDC links between North Africa and Europe: Impacts and benefits on the dynamic performance of the European system

This document is the Accepted Manuscript version of the following article: Mokhtar Benasla, Tayeb Allaoui, Mostefa Brahami, Mouloud Denai, and Vijay K. Sood, ‘HVDC links between North Africa and Europe: Impacts and benefits on the dynamic performance of the European system’, Renewable and Sustainable Energy Reviews, November 2017. Under embargo. Embargo end date: 20 November 2018. The published version is available online at doi: DOI: https://doi.org/10.1016/j.rser.2017.10.075. Published by Elsevier Ltd. This manuscript version is distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/ ), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way.In the last decade, there have been several initiatives for the deployment of cross-Mediterranean HVDC (High Voltage Direct Current) links to enable the transmission of electrical power from renewable energy sources between North Africa and Europe. These initiatives were mainly driven by the potential economic, environmental and technical benefits of these HVDC interconnections. In previous studies on these projects, some technical aspects of critical importance have not been addressed or studied in sufficient detail. One of these key aspects relates to the impact and possible benefit of these HVDC links on the dynamic performance of the European system which is the major focus of this paper. Several issues relating to the dynamic performance of the system are addressed here. Based on the experience gained from existing AC/DC projects around the world, this paper shows that the HVDC links between North Africa and Europe can greatly improve the dynamic performance of the European system especially in the southern regions. In addition, some challenges on the operation and control of these HVDC links are highlighted and solutions to overcome these challenges are proposed. This review paper, therefore, serves as a preliminary study for further detailed investigation of specific impacts or benefits of these interconnections on the overall performance of the European system.Peer reviewe