Meta-analysis of epigenome-wide association studies in neonates reveals widespread differential DNA methylation associated with birthweight

Birthweight is associated with health outcomes across the life course, DNA methylation may be an underlying mechanism. In this meta-analysis of epigenome-wide association studies of 8,825 neonates from 24 birth cohorts in the Pregnancy And Childhood Epigenetics Consortium, we find that DNA methylation in neonatal blood is associated with birthweight at 914 sites, with a difference in birthweight ranging from -183 to 178 grams per 10% increase in methylation (P-Bonferroni <1.06 x 10(-7)). In additional analyses in 7,278 participants,Peer reviewe

Geophysical tomography as a tool to estimate the geometry of soil layers: relevance for the reliability assessment of dikes

The geometric variability of soil layers is a large source of uncertainty in the reliability assessment of dikes. Because direct samples of the subsurface soils are often insufficient to capture the complexity of the subsurface, geophysical methods provide a powerful source of complementary information. A combined approach to estimate the geometry of soil layers is presented. The approach combines local point data, i.e. data obtained from a CPT or a borehole log, and geophysical tomography in a universal cokriging framework. The approach uses the contact points between soil layers obtained from local point data and the orientations of the layers derived from geophysical tomography. To reduce subjectivity in the interpretation of tomographic images, an automated edge detection technique was used. The combined approach was applied to characterise two test sites where the presence of paleochannels locally change the geometry of soil layers. The results show that a combined approach enables the reduction of sampling efforts with an improved estimation of geometric variability.Geo-engineeringGeoscience and Engineerin