The Socialization of Human Rights as an Inroad to Protect Sacred Space

Serious problems exist for cultural heritage protection, and these problems are even more serious when accounting for the protection of sacred space and holy places. The lack of effectiveness of the majority of existing international norms and institutions will be reviewed in this paper, which shall then turn to potential sources for entrenching protection of scared space within states. The paper shall rely on the human right to freedom of religion or belief as the basis for upholding sacred space given an emerging broader understanding of the right within the human rights framework. The paper shall principally focus on the means by which the human right to freedom of religion or belief can be better entrenched within a social landscape by accounting for what has been termed the socialization of human rights. The notion is that as a human right like the freedom of religion or belief becomes enmeshed within society, the grounds for protection can improve, leading to a more effective manner of protection for sacred space

The quality of medical advice in low-income countries

This paper provides an overview of recent work on quality measurement of medical care and its correlates in four low and middle-income countries-India, Indonesia, Tanzania, and Paraguay. The authors describe two methods-testing doctors and watching doctors-that are relatively easy to implement and yield important insights about the nature of medical care in these countries. The paper discusses the properties of these measures, their correlates, and how they may be used to evaluate policy changes. Finally, the authors outline an agenda for further research and measurement.Health Monitoring&Evaluation,Health Systems Development&Reform,Gender and Health,Health Economics&Finance,Disease Control&Prevention

Reconsidering The Israeli Courts\u27 Application Of Customary International Law In The Human Rights Context

Discussions regarding the problem of identifying customary international law have essentially focused on two principal issues

The International Human Right to Freedom of Conscience: An Approach to Its Application and Development.

This thesis considers the scope and application of the human right to freedom of conscience. It traces the development of the right to conscience in international law, analyses the principal human rights treaties which codify the right, and considers various interpretations of the right to conscience in select national courts. The thesis argues that in judicial and scholarly interpretation, the human right to freedom of conscience has been linked too closely to religious belief, thus obscuring the non-religious dimensions of the right. The thesis aims to develop a jurisprudential framework to facilitate a broader practical application of the right to conscience. Developing an analysis of the scope of the right to conscience, the thesis considers two distinct aspects: first, the forum internum, relating to the right to harbour a conscientious belief internally, and second, the forum externum, relating to the right to externally manifest a conscientious belief. Building upon this scheme, the argument turns to three practical applications of the right to conscience: conscientious objection to military service, objection to certain types of state taxation on conscientious grounds, and objection to the performance of a termination of pregnancy. For each example, the international and national aspects are considered. The thesis concludes that a more generous scope be accorded to the right to conscience and more rigorous analysis be utilised when considering the application of the right

Three-Dimensional Simulations of Mixing Instabilities in Supernova Explosions

We present the first three-dimensional (3D) simulations of the large-scale mixing that takes place in the shock-heated stellar layers ejected in the explosion of a 15.5 solar-mass blue supergiant star. The outgoing supernova shock is followed from its launch by neutrino heating until it breaks out from the stellar surface more than two hours after the core collapse. Violent convective overturn in the post-shock layer causes the explosion to start with significant asphericity, which triggers the growth of Rayleigh-Taylor (RT) instabilities at the composition interfaces of the exploding star. Deep inward mixing of hydrogen (H) is found as well as fast-moving, metal-rich clumps penetrating with high velocities far into the H-envelope of the star as observed, e.g., in the case of SN 1987A. Also individual clumps containing a sizeable fraction of the ejected iron-group elements (up to several 0.001 solar masses) are obtained in some models. The metal core of the progenitor is partially turned over with Ni-dominated fingers overtaking oxygen-rich bullets and both Ni and O moving well ahead of the material from the carbon layer. Comparing with corresponding 2D (axially symmetric) calculations, we determine the growth of the RT fingers to be faster, the deceleration of the dense metal-carrying clumps in the He and H layers to be reduced, the asymptotic clump velocities in the H-shell to be higher (up to ~4500 km/s for the considered progenitor and an explosion energy of 10^{51} ergs, instead of <2000 km/s in 2D), and the outward radial mixing of heavy elements and inward mixing of hydrogen to be more efficient in 3D than in 2D. We present a simple argument that explains these results as a consequence of the different action of drag forces on moving objects in the two geometries. (abridged)Comment: 15 pages, 8 figures, 30 eps files; significantly extended and more figures added after referee comments; accepted by The Astrophysical Journa

Detection of Wolf-Rayet stars in host galaxies of Gamma-Ray Bursts (GRBs): are GRBs produced by runaway massive stars ejected from high stellar density regions ?

We have obtained deep spectroscopic observations of several nearby gamma-ray burst (GRB) host galaxies revealing for the first time the presence of Wolf-Rayet (WR) stars and numerous O stars located in rich and compact clusters or star forming regions. Surprisingly, high spatial resolution imaging shows that the GRBs and the associated supernovae did not occur in these regions, but several hundreds of parsec away. Considering various scenarios for GRB progenitors, we do not find any simple explanation of why they should be preferentially born in regions with low stellar densities. All the examined GRBs and associated SNe have occurred 400 to 800 pc from very high density stellar environments including large numbers of WR stars. Such distances can be travelled through at velocities of 100 km/s or larger, assuming the travel time to be the typical life time of WR stars. It leads us to suggest that GRB progenitors may be runaway massive stars ejected from compact massive star clusters. The ejection from such super star clusters may lead to a spin-up of these stars, producing the loss of the hydrogen and/or helium envelopes leading to the origin of the type Ibc supernovae associated with GRBs. If this scenario applies tocd text/Sc all GRBs, it provides a natural explanation of the very small fraction of massive stars that emit a GRB at the end of their life. An alternative to this scenario could be a binary origin for GRBs, but this still requires an explanation of why it would preferentially occur in low stellar density regions.Comment: (1) GEPI, Observatoire de Paris-Meudon, France, (2) Observatoire de Geneve, Switzerland, (3) Laboratoire d'Astrophysique Toulouse-Tarbes, France,(4) Steward Observatory, University of Arizona, US

Large Late-time Asphericities in Three Type IIP Supernovae

Type II-plateau supernovae (SNe IIP) are the results of the explosions of red supergiants and are the most common subclass of core-collapse supernovae. Past observations have shown that the outer layers of the ejecta of SNe IIP are largely spherical, but the degree of asphericity increases toward the core. We present evidence for high degrees of asphericity in the inner cores of three recent SNe IIP (SNe 2006my, 2006ov, and 2007aa), as revealed by late-time optical spectropolarimetry. The three objects were all selected to have very low interstellar polarization (ISP), which minimizes the uncertainties in ISP removal and allows us to use the continuum polarization as a tracer of asphericity. The three objects have intrinsic continuum polarizations in the range of 0.83-1.56% in observations taken after the end of the photometric plateau, with the polarization dropping to almost zero at the wavelengths of strong emission lines. Our observations of SN 2007aa at earlier times, taken on the photometric plateau, show contrastingly smaller continuum polarizations (~0.1%). The late-time H-alpha and [O I] line profiles of SN 2006ov provide further evidence for asphericities in the inner ejecta. Such high core polarizations in very ordinary core-collapse supernovae provide further evidence that essentially all core-collapse supernova explosions are highly aspherical, even if the outer parts of the ejecta show only small deviations from spherical symmetry.Comment: 15 pages, 13 figures, minor revisions to match published version (2010, ApJ, 713, 1363

Non-spherical core collapse supernovae III. Evolution towards homology and dependence on the numerical resolution

(abridged) We study the hydrodynamic evolution of a non-spherical core-collapse supernova in two spatial dimensions. We find that our model displays a strong tendency to expand toward the pole. We demonstrate that this expansion is a physical property of the low-mode, SASI instability. The SASI leaves behind a large lateral velocity gradient in the post shock layer which affects the evolution for minutes and hours later. This results in a prolate deformation of the ejecta and a fast advection of Ni-rich material from moderate latitudes to the polar regions. This effect might actually be responsible for the global asymmetry of the nickel lines in SN 1987A. The simulations demonstrate that significant radial and lateral motions in the post-shock region, produced by convective overturn and the SASI during the early explosion phase, contribute to the evolution for minutes and hours after shock revival. They lead to both later clump formation, and a significant prolate deformation of the ejecta which are observed even as late as one week after the explosion. As pointed out recently by Kjaer et al., such an ejecta morphology is in good agreement with the observational data of SN 1987A. Systematic future studies are needed to investigate how the SASI-induced late-time lateral expansion depends on the dominant mode of the SASI, and to which extent it is affected by the dimensionality of the simulations. The impact on and importance of the SASI for the distribution of iron group nuclei and the morphology of the young SNR argues for future three-dimensional explosion and post-explosion studies on singularity-free grids that cover the entire sphere. Given the results of our 2D resolution study, present 3D simulations must be regarded as underresolved, and their conclusions must be verified by a proper numerical convergence analysis in three dimensions.Comment: 16 pages, 20 figures, accepted for publication in Astronomy & Astrophysic

A Peptide-binding Motif for I-Ag7, the Class II Major Histocompatibility Complex (MHC) Molecule of NOD and Biozzi AB/H Mice

The class II major histocompatibility complex molecule I-Ag7 is strongly linked to the development of spontaneous insulin-dependent diabetes mellitus (IDDM) in non obese diabetic mice and to the induction of experimental allergic encephalomyelitis in Biozzi AB/H mice. Structurally, it resembles the HLA-DQ molecules associated with human IDDM, in having a non-Asp residue at position 57 in its β chain. To identify the requirements for peptide binding to I-Ag7 and thereby potentially pathogenic T cell epitopes, we analyzed a known I-Ag7-restricted T cell epitope, hen egg white lysozyme (HEL) amino acids 9–27. NH2- and COOH-terminal truncations demonstrated that the minimal epitope for activation of the T cell hybridoma 2D12.1 was M12-R21 and the minimum sequence for direct binding to purified I-Ag7 M12-Y20/ K13-R21. Alanine (A) scanning revealed two primary anchors for binding at relative positions (p) 6 (L) and 9 (Y) in the HEL epitope. The critical role of both anchors was demonstrated by incorporating L and Y in poly(A) backbones at the same relative positions as in the HEL epitope. Well-tolerated, weakly tolerated, and nontolerated residues were identified by analyzing the binding of peptides containing multiple substitutions at individual positions. Optimally, p6 was a large, hydrophobic residue (L, I, V, M), whereas p9 was aromatic and hydrophobic (Y or F) or positively charged (K, R). Specific residues were not tolerated at these and some other positions. A motif for binding to I-Ag7 deduced from analysis of the model HEL epitope was present in 27/30 (90%) of peptides reported to be I-Ag7–restricted T cell epitopes or eluted from I-Ag7. Scanning a set of overlapping peptides encompassing human proinsulin revealed the motif in 6/6 good binders (sensitivity = 100%) and 4/13 weak or non-binders (specificity = 70%). This motif should facilitate identification of autoantigenic epitopes relevant to the pathogenesis and immunotherapy of IDDM