Composition portfolio

EThOS - Electronic Theses Online ServiceGBUnited Kingdo

Sh

Sh is a work for solo guitar that lasts around three minutes

BE GOOD.

Work for solo horn, dedicated to Elliott Carter on the occasion of his 100th birthday. First performed by Fergus Kerr on 28th September 2008

EMG

Work for solo piano requested and first performed by Nicholas Ashton.This work samples vertical chord structures from an earlier piece for piano (EVEN MORE GEESE), which itself was derived from an ensemble piece (More Geese).These samples are presented embedded in a durational structure as if preserved in amber, separated by silences.The work employs all three pedals in various combinations to heighten the harmonic content

BE GOOD.

Work for solo horn, dedicated to Elliott Carter on the occasion of his 100th birthday. First performed by Fergus Kerr on 28th September 2008

DUO1

DUO1 is a work for two bass clarinets.It was requested and first performed by Sarah Watts and Heather Roche.This work forms part of a series of works exploring different ways of notating (and thereby making) chamber music.Initial research for the work was carried out with Heather Roche to discover a series of multiphonic dyads and eighth tone fingerings in a limited range

Pied Beauty.

Composition for soprano and two scordatura violas (alternatively, for soprano and stereo fixed media playback

International genome-wide meta-analysis identifies new primary biliary cirrhosis risk loci and targetable pathogenic pathways.

Primary biliary cirrhosis (PBC) is a classical autoimmune liver disease for which effective immunomodulatory therapy is lacking. Here we perform meta-analyses of discovery data sets from genome-wide association studies of European subjects (n=2,764 cases and 10,475 controls) followed by validation genotyping in an independent cohort (n=3,716 cases and 4,261 controls). We discover and validate six previously unknown risk loci for PBC (Pcombined<5 × 10(-8)) and used pathway analysis to identify JAK-STAT/IL12/IL27 signalling and cytokine-cytokine pathways, for which relevant therapies exist

Scoping potential routes to UK civil unrest via the food system: Results of a structured expert elicitation

We report the results of a structured expert elicitation to identify the most likely typesof potential food system disruption scenarios for the UK, focusing on routes to civil unrest. Wetake a backcasting approach by defining as an end-point a societal event in which 1 in 2000 peoplehave been injured in the UK, which 40% of experts rated as “Possible (20–50%)”, “More likely thannot (50–80%)” or “Very likely (>80%)” over the coming decade. Over a timeframe of 50 years, thisincreased to 80% of experts. The experts considered two food system scenarios and ranked theirplausibility of contributing to the given societal scenario. For a timescale of 10 years, the majorityidentified a food distribution problem as the most likely. Over a timescale of 50 years, the expertswere more evenly split between the two scenarios, but over half thought the most likely route tocivil unrest would be a lack of total food in the UK. However, the experts stressed that the variouscauses of food system disruption are interconnected and can create cascading risks, highlighting theimportance of a systems approach. We encourage food system stakeholders to use these results intheir risk planning and recommend future work to support prevention, preparedness, response andrecovery planning