256 research outputs found
Mutations of the ret protooncogene in German multiple endocrine neoplasia families: Relation between genotype and phenotype.
It has been suggested that not only the position but also the nature of the mutations of the ret protooncogene strongly correlate with the clinical manifestation of the multiple endocrine neoplasm type 2 (MEN 2) syndrome. In particular, individuals with a Cys634-Arg substitution should have a greater risk of developing parathyroid disease. We, therefore, analyzed 94 unrelated families from Germany with inherited medullary thyroid carcinoma (MTC) for mutation of the ret protooncogene. In all but 1 of 59 families with MEN 2A, germline mutations in the extracellular domain of the ret protein were found. Some 81% of the MEN 2A mutations affected codon 634. Phenotype-genotype correlations suggested that the prevalence of pheochromocytoma and hyperparathyroidism is significantly higher in families with codon 634 mutations, but there was no correlation with the nature of the mutation. In all but 1 of 27 familial MTC (FMTC) families, mutations were detected in 1 of 4 cysteines in the extracellular domain of the ret protooncogene. Half of the FMTC mutations affected codon 634. Mutations outside of codon 634 occurred more often in FMTC families than in MEN 2A families. In all but 1 of 8 MEN 2B patients, de novo mutations in codon 918 were found. These data confirm the preferential localization of MEN 2-associated mutations and the correlation between disease phenotype and the position of the ret mutation, but there was no correlation between the occurrence of hyperparathyroidism or pheochromocytoma and the nature of the mutation
The PANDA GEM-based TPC Prototype
We report on the development of a GEM-based TPC prototype for the PANDA
experiment. The design and requirements of this device will be illustrated,
with particular emphasis on the properties of the recently tested GEM-detector,
the characterization of the read-out electronics and the development of the
tracking software that allows to evaluate the GEM-TPC data.Comment: submitted to NIMA 4 pages, 6 picture
Bathymetric controls on calving processes at Pine Island Glacier
Pine Island Glacier is the largest current Antarctic contributor to sea level rise. Its ice loss has substantially increased over the last 25 years through thinning, acceleration and grounding line retreat. However, the calving line positions of the stabilizing ice shelf did not show any trend within the observational record (last 70 years) until calving in 2015 led to unprecedented retreat and changed alignment of the calving front. Bathymetric surveying revealed a ridge below the former ice shelf and two shallower highs to the north. Satellite imagery shows that ice contact on the ridge likely was lost in 2006 but was followed by intermittent contact resulting in back stress fluctuations on the ice shelf. Continuing ice shelf flow also led to occasional ice shelf contact with the northern bathymetric highs, which initiated rift formation that led to calving. The observations show that bathymetry is an important factor in initiating calving events
Autonomous clustering using rough set theory
This paper proposes a clustering technique that minimises the need for subjective
human intervention and is based on elements of rough set theory. The proposed algorithm is
unified in its approach to clustering and makes use of both local and global data properties to
obtain clustering solutions. It handles single-type and mixed attribute data sets with ease and
results from three data sets of single and mixed attribute types are used to illustrate the
technique and establish its efficiency
O agir econômico como motor da política de saúde na Alemanha: consequências para a prevenção e promoção da saúde
Measurement of the charged-pion polarisability
The COMPASS collaboration at CERN has investigated pion Compton scattering,
, at centre-of-mass energy below 3.5 pion
masses. The process is embedded in the reaction
, which is initiated by
190\,GeV pions impinging on a nickel target. The exchange of quasi-real photons
is selected by isolating the sharp Coulomb peak observed at smallest momentum
transfers, \,(GeV/). From a sample of 63\,000 events the
pion electric polarisability is determined to be $\alpha_\pi\ =\ (\,2.0\ \pm\
0.6_{\mbox{\scriptsize stat}}\ \pm\ 0.7_{\mbox{\scriptsize syst}}\,) \times
10^{-4}\,\mbox{fm}^3\alpha_\pi=-\beta_\pi$, which
relates the electric and magnetic dipole polarisabilities. It is the most
precise measurement of this fundamental low-energy parameter of strong
interaction, that has been addressed since long by various methods with
conflicting outcomes. While this result is in tension with previous dedicated
measurements, it is found in agreement with the expectation from chiral
perturbation theory. An additional measurement replacing pions by muons, for
which the cross-section behavior is unambigiously known, was performed for an
independent estimate of the systematic uncertainty.Comment: Published version: 9 pages, 3 figures, 1 tabl
Transverse spin effects in hadron-pair production from semi-inclusive deep inelastic scattering
First measurements of azimuthal asymmetries in hadron-pair production in
deep-inelastic scattering of muons on transversely polarised ^6LiD (deuteron)
and NH_3 (proton) targets are presented. The data were taken in the years
2002-2004 and 2007 with the COMPASS spectrometer using a muon beam of 160 GeV/c
at the CERN SPS. The asymmetries provide access to the transversity
distribution functions, without involving the Collins effect as in single
hadron production. The sizeable asymmetries measured on the NH_ target indicate
non-vanishing u-quark transversity and two-hadron interference fragmentation
functions. The small asymmetries measured on the ^6LiD target can be
interpreted as indication for a cancellation of u- and d-quark transversities.Comment: 13 pages, 4 figures, updated to the published versio
Leading order determination of the gluon polarisation from DIS events with high-p_T hadron pairs
We present a determination of the gluon polarisation Delta g/g in the
nucleon, based on the longitudinal double-spin asymmetry of DIS events with a
pair of large transverse-momentum hadrons in the final state. The data were
obtained by the COMPASS experiment at CERN using a 160 GeV/c polarised muon
beam scattering off a polarised ^6LiD target. The gluon polarisation is
evaluated by a Neural Network approach for three intervals of the gluon
momentum fraction x_g covering the range 0.04 < x_g < 0.27. The values obtained
at leading order in QCD do not show any significant dependence on x_g. Their
average is Delta g/g = 0.125 +/- 0.060 (stat.) +/- 0.063 (syst.) at x_g=0.09
and a scale of mu^2 = 3 (GeV/c)^2.Comment: 13 pages, 6 figures and 3 table
First Measurement of Chiral Dynamics in \pi^- \gamma -> \pi^- \pi^- \pi^+
The COMPASS collaboration at CERN has investigated the \pi^- \gamma -> \pi^-
\pi^- \pi^+ reaction at center-of-momentum energy below five pion masses,
sqrt(s) < 5 m(\pi), embedded in the Primakoff reaction of 190 GeV pions
impinging on a lead target. Exchange of quasi-real photons is selected by
isolating the sharp Coulomb peak observed at smallest momentum transfers, t' <
0.001 (GeV/c)^2. Using partial-wave analysis techniques, the scattering
intensity of Coulomb production described in terms of chiral dynamics and its
dependence on the 3\pi-invariant mass m(3\pi) = sqrt(s) were extracted. The
absolute cross section was determined in seven bins of with an
overall precision of 20%. At leading order, the result is found to be in good
agreement with the prediction of chiral perturbation theory over the whole
energy range investigated.Comment: 10 pages, 5 figure
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