FACTORES INFLUYENTES EN LA VULNERANCION DEL DERECHO AL PLAZO RAZONABLE EN LA INVESTIGACION PRELIMINAR EN LA FISCALIA PROVINCIAL PENAL DE LAMAS 2018

El presente trabajo de investigación tiene como principal objeto de estudio desvelar cuáles son los factores que influyen en la vulneración del derecho al plazo razonable en la investigación preliminar. La investigación realizada encuentra como punto de partida el nuevo código procesal penal, específicamente en su tercer libro, código que fue promulgado el año 2004 y se implementó por primera vez el año 2006 en el distrito fiscal de Huaura, asimismo, se realizó su implementación en el distrito fiscal de San Martin en el año 2010, cuerpo legal que en un primer momento se caracterizó y emblemátizo como un código garantista, esto a razón de que con este nuevo cuerpo legal se integraba al proceso penal a un juez de investigación preparatoria el cual tiene como uno de sus fines velar por la no vulneración de los derechos de los sujetos procesales, en especial del investigado o imputado, es por ello que muchas veces el juez de investigación preparatoria es conocido como el juez de garantías, por otro lado este cuerpo legal también surgió con la esperanza de que una de sus principales características seria la celeridad procesal, características que a la fecha se duda que se estén plasmando en la realidad. Proveyendo posibles vulneraciones a los derechos de los sujetos procesales este Nuevo Código Procesal Penal implementó como uno de los medios de protección, frente a la vulneración del derecho a un plazo justo de investigación, el control del plazo, la cual se puede aplicar tanto en la investigación preliminar como en la investigación preparatoria, la misma que será parte fundamental de la presente investigación.Tesi

Mejora de los parámetros energéticos e impacto ambiental de la caldera de vapor en Postes del Norte S. A. mediante el cambio de carbón antracita por cáscara de arroz como combustible

RESUMEN El trabajo de investigación está basado en la mejora de los Parámetros Energéticos e Impacto Ambiental de la caldera en la empresa POSTES DEL NORTE S.A. De la evaluación realizada se han observado deficiencias en los parámetros de dicha caldera afectando el rendimiento energético; asimismo, se evidenció que las cenizas emitidas son el principal factor que afecta a los habitantes de la zona aledaña. Por lo descrito anteriormente, se efectuó el análisis y comparación de las emisiones de gases y cenizas emitidas por la caldera, llegando a la conclusión que se puede reducir el impacto ambiental cambiando el combustible inicial (carbón) que tienen gases de 61,52N2, 6.25CO2, 0.07S, a uno de Biomasa (cáscara de arroz) que se obtendría 27,92N2, 3.12CO2 y 0.00S2 reduciendo de esta manera la emisión de cenizas.ABSTRACT The research is based on the Improved Energy and Environmental Impact Parameters Boiler EMPRESA POSTES DEL NORTE S.A.. From assessment deficiencies have been observed in the parameters of the boiler affecting energy performance also showed that the ashes are issued are the main factor affecting inhabitants of the surrounding sector. By the above, and analysis was performed comparing the gas and ash emissions emitted by the boiler, leading to the conclusion that can reduce environmental impact changing the initial fuel (coal) to one of Biomass (rice husk) reducing ash emissions

Scientometric study of treatment technologies of soil pollution: present and future challenges

There are few bibliometric studies showing current technologies and their combinations for the remediation of contaminated soils. For this reason, a scientometric study was carried out in order to know the trends in soil contamination treatment technologies. The study considered original articles and reviews published in the Scopus and Web of Science databases between January 2010 and June 2021, evaluating: (a) characteristics of the publications, (b) main research sources, (c) citations and production by journals, (d) keywords used, (e) countries, institutions and authors active in research production, (f) most cited articles and (g) trends in soil treatment and remediation techniques. The results showed: (a) continuous growth of publications on soil remediation in the “Environmental Science” subject area and a limited contribution of the “Soil Science” and “Agriculture and Biological Science” subject areas, (b) leadership of countries such as China, USA, India, Italy and Spain in research production, (c) phytoremediation, bioremediation and biodegradation were the most studied treatment technologies in the last decade and (d) recent research (from 2020) studied pesticides and herbicides, including Chlorimuron-ethyl and also microplastics and other emerging pollutants. It is also noted that the current trend of combinations of techniques for the treatment of soil contamination is attractive for future research.Campus San Juan de Luriganch

Statistical modeling approach for PM10 prediction before and during confinement by COVID-19 in South Lima, Perú

A total of 188,859 meteorological-PM10 data validated before (2019) and during the COVID-19 pandemic (2020) were used. In order to predict PM10 in two districts of South Lima in Peru, hourly, daily, monthly and seasonal variations of the data were analyzed. Principal Component Analysis (PCA) and linear/nonlinear modeling were applied. The results showed the highest annual average PM10 for San Juan de Mirafores (SJM) (PM10-SJM: 78.7 µg/m3) and the lowest in Santiago de Surco (SS) (PM10 -SS: 40.2 µg/m3). The PCA showed the infuence of relative humidity (RH)-atmospheric pressure (AP)temperature (T)/dew point (DP)-wind speed (WS)-wind direction (WD) combinations. Cool months with higher humidity and atmospheric instability decreased PM10 values in SJM and warm months increased it, favored by thermal inversion (TI). Dust resuspension, vehicular transport and stationary sources contributed more PM10 at peak times in the morning and evening. The Multiple linear regression (MLR) showed the best correlation (r = 0.6166), followed by the three-dimensional model LogAP-LogWD-LogPM10 (r = 0.5753); the RMSE-MLR (12.92) exceeded that found in the 3D models (RMSE < 0.3) and the NSE-MLR criterion (0.3804) was acceptable. PM10 prediction was modeled using the algorithmic approach in any scenario to optimize urban management decisions in times of pandemic.Campus San Juan de Luriganch

Transcriptional recapitulation and subversion of embryonic colon development by mouse colon tumor models and human colon cancer

Colon tumors from four independent mouse models and 100 human colorectal cancers all exhibited striking recapitulation of embryonic colon gene expression from embryonic days 13.5-18.5

Transcriptional recapitulation and subversion of embryonic colon development by mouse colon tumor models and human colon cancer

Abstract Background The expression of carcino-embryonic antigen by colorectal cancer is an example of oncogenic activation of embryonic gene expression. Hypothesizing that oncogenesis-recapitulating-ontogenesis may represent a broad programmatic commitment, we compared gene expression patterns of human colorectal cancers (CRCs) and mouse colon tumor models to those of mouse colon development embryonic days 13.5-18.5. Results We report here that 39 colon tumors from four independent mouse models and 100 human CRCs encompassing all clinical stages shared a striking recapitulation of embryonic colon gene expression. Compared to normal adult colon, all mouse and human tumors over-expressed a large cluster of genes highly enriched for functional association to the control of cell cycle progression, proliferation, and migration, including those encoding MYC, AKT2, PLK1 and SPARC. Mouse tumors positive for nuclear β-catenin shifted the shared embryonic pattern to that of early development. Human and mouse tumors differed from normal embryonic colon by their loss of expression modules enriched for tumor suppressors (EDNRB, HSPE, KIT and LSP1). Human CRC adenocarcinomas lost an additional suppressor module (IGFBP4, MAP4K1, PDGFRA, STAB1 and WNT4). Many human tumor samples also gained expression of a coordinately regulated module associated with advanced malignancy (ABCC1, FOXO3A, LIF, PIK3R1, PRNP, TNC, TIMP3 and VEGF). Conclusion Cross-species, developmental, and multi-model gene expression patterning comparisons provide an integrated and versatile framework for definition of transcriptional programs associated with oncogenesis. This approach also provides a general method for identifying pattern-specific biomarkers and therapeutic targets. This delineation and categorization of developmental and non-developmental activator and suppressor gene modules can thus facilitate the formulation of sophisticated hypotheses to evaluate potential synergistic effects of targeting within- and between-modules for next-generation combinatorial therapeutics and improved mouse models

Effects of alirocumab on types of myocardial infarction: insights from the ODYSSEY OUTCOMES trial

Aims  The third Universal Definition of Myocardial Infarction (MI) Task Force classified MIs into five types: Type 1, spontaneous; Type 2, related to oxygen supply/demand imbalance; Type 3, fatal without ascertainment of cardiac biomarkers; Type 4, related to percutaneous coronary intervention; and Type 5, related to coronary artery bypass surgery. Low-density lipoprotein cholesterol (LDL-C) reduction with statins and proprotein convertase subtilisin–kexin Type 9 (PCSK9) inhibitors reduces risk of MI, but less is known about effects on types of MI. ODYSSEY OUTCOMES compared the PCSK9 inhibitor alirocumab with placebo in 18 924 patients with recent acute coronary syndrome (ACS) and elevated LDL-C (≥1.8 mmol/L) despite intensive statin therapy. In a pre-specified analysis, we assessed the effects of alirocumab on types of MI. Methods and results  Median follow-up was 2.8 years. Myocardial infarction types were prospectively adjudicated and classified. Of 1860 total MIs, 1223 (65.8%) were adjudicated as Type 1, 386 (20.8%) as Type 2, and 244 (13.1%) as Type 4. Few events were Type 3 (n = 2) or Type 5 (n = 5). Alirocumab reduced first MIs [hazard ratio (HR) 0.85, 95% confidence interval (CI) 0.77–0.95; P = 0.003], with reductions in both Type 1 (HR 0.87, 95% CI 0.77–0.99; P = 0.032) and Type 2 (0.77, 0.61–0.97; P = 0.025), but not Type 4 MI. Conclusion  After ACS, alirocumab added to intensive statin therapy favourably impacted on Type 1 and 2 MIs. The data indicate for the first time that a lipid-lowering therapy can attenuate the risk of Type 2 MI. Low-density lipoprotein cholesterol reduction below levels achievable with statins is an effective preventive strategy for both MI types.For complete list of authors see http://dx.doi.org/10.1093/eurheartj/ehz299</p

Influencia de la Hidroclorotiazida sobre el metabolismo de los Hidratos de Carbono

Se estudió el efecto de la hidroclorotiazida sobre la curva de tolerancia de la glucosa, para cuyo efecto se administró diariamente 200 mq, de hidroclorotiazida durante 7 días a 53 sujetos: 10 presuntos normales, 20 con hipertensión esenciaL 7 con nefropatías difusas e insuficiencia renal, 6 nefrópatas sin insuficiencia renal y 10 con diabetes mellitus de moderada intensidad. No se produjo elevación de la glucosa sanguínea basal, en cambio sí hubo un incremento en las curvas de glicemia en todos los grupos a excepción de los nefrópatas. En los pacientes renales sin insuficiencia no se halló una variación importante, pero en los que acusaron retención nitrogenada la curva descendió. Los sujetos normales mostraron una elevación estadísticamente significativa a los 60 y 90 minutos, pero que no llegó a sobrepasar los límites normales. En los pacientes con hipertensión se observó la aparición de un mayor número de curvas anormales después de la hidroclorotiazida. Los diabéticos no mostraron un incremento importante de sus curvas de glicemia. Se hace una breve revisión de los posibles mecanismos de acción de los tiazidas sobre el metabolismo hidrocarbonado, señalándose, a mérito de las investigaciones practicadas, que la hidroclorotiazida ocasiona una elevación de las curvas de glicemia en sujetos con tolerancia a los hidratos de carbono previamente normal o disminuida, posiblemente por una alteración en la relación sodio/potasio intracelular, sin descartarse la concurrencia de otros mecanismos

Inventario de germosplasma de gramineas y leguminosas de ICA (Colombia) e INIAP (Ecuador)

24 páginasSe presenta un listado de los materiales existentes en gramineas y leguminosas; según su nombre común, seguido del científico