Historia general de España

Contiene: Reyes cristianos desde Alfonso VI hasta Alfonso XI en Castilla, Aragon, Navarra y Portugal / por Manuel Colmeiro, 1 v.-- Castilla y Leon durante los reinados de Pedro I, Enrique II, Juan I y Enrique III, Tomo I / por Juan Catalina Garcia. -- 1892. -- Reinado de Carlos III / por Manuel Danvila y Collado, Tomo I. -- 1893. -- Reinado de Carlos IV / por el general Jose Gomez de Arteche, Tomo I. -- 1893PALAU 115612IndicesNota

Multiplicity dependence of light (anti-)nuclei production in p–Pb collisions at sNN=5.02 TeV

The measurement of the deuteron and anti-deuteron production in the rapidity range −1 < y < 0 as a function of transverse momentum and event multiplicity in p–Pb collisions at √sNN = 5.02 TeV is presented. (Anti-)deuterons are identified via their specific energy loss dE/dx and via their time-of- flight. Their production in p–Pb collisions is compared to pp and Pb–Pb collisions and is discussed within the context of thermal and coalescence models. The ratio of integrated yields of deuterons to protons (d/p) shows a significant increase as a function of the charged-particle multiplicity of the event starting from values similar to those observed in pp collisions at low multiplicities and approaching those observed in Pb–Pb collisions at high multiplicities. The mean transverse particle momenta are extracted from the deuteron spectra and the values are similar to those obtained for p and particles. Thus, deuteron spectra do not follow mass ordering. This behaviour is in contrast to the trend observed for non-composite particles in p–Pb collisions. In addition, the production of the rare 3He and 3He nuclei has been studied. The spectrum corresponding to all non-single diffractive p-Pb collisions is obtained in the rapidity window −1 < y < 0 and the pT-integrated yield dN/dy is extracted. It is found that the yields of protons, deuterons, and 3He, normalised by the spin degeneracy factor, follow an exponential decrease with mass number

Genetic landscape of 6089 inherited retinal dystrophies affected cases in Spain and their therapeutic and extended epidemiological implications

Inherited retinal diseases (IRDs), defined by dysfunction or progressive loss of photoreceptors, are disorders characterized by elevated heterogeneity, both at the clinical and genetic levels. Our main goal was to address the genetic landscape of IRD in the largest cohort of Spanish patients reported to date. A retrospective hospital-based cross-sectional study was carried out on 6089 IRD affected individuals (from 4403 unrelated families), referred for genetic testing from all the Spanish autonomous communities. Clinical, demographic and familiar data were collected from each patient, including family pedigree, age of appearance of visual symptoms, presence of any systemic findings and geographical origin. Genetic studies were performed to the 3951 families with available DNA using different molecular techniques. Overall, 53.2% (2100/3951) of the studied families were genetically characterized, and 1549 different likely causative variants in 142 genes were identified. The most common phenotype encountered is retinitis pigmentosa (RP) (55.6% of families, 2447/4403). The most recurrently mutated genes were PRPH2, ABCA4 and RS1 in autosomal dominant (AD), autosomal recessive (AR) and X-linked (XL) NON-RP cases, respectively; RHO, USH2A and RPGR in AD, AR and XL for non-syndromic RP; and USH2A and MYO7A in syndromic IRD. Pathogenic variants c.3386G &gt; T (p.Arg1129Leu) in ABCA4 and c.2276G &gt; T (p.Cys759Phe) in USH2A were the most frequent variants identified. Our study provides the general landscape for IRD in Spain, reporting the largest cohort ever presented. Our results have important implications for genetic diagnosis, counselling and new therapeutic strategies to both the Spanish population and other related populations

Neutral pion and η\eta meson production in p-Pb collisions at sNN=5.02\sqrt{s_\mathrm{NN}} = 5.02 TeV

Neutral pion and $\eta$ meson invariant differential yields were measured in non-single diffractive p–Pb collisions at $\sqrt{s_{\mathrm{NN}}}$  = 5.02 TeV with the ALICE experiment at the CERN LHC. The analysis combines results from three complementary photon measurements, utilizing the PHOS and EMCal calorimeters and the Photon Conversion Method. The invariant differential yields of $\pi ^{0}$ and $\eta$ meson inclusive production are measured near mid-rapidity in a broad transverse momentum range of $0.3 4$\hbox {GeV}/c$at$0.483 \pm 0.015_{\mathrm{stat}} \pm 0.015_{\mathrm{sys}}$. A deviation from$m_{\mathrm{T}}$scaling is observed for$p_{\mathrm{T}}<$2$\hbox {GeV}/c$. The measured$\eta /\pi ^{0}$ratio is consistent with previous measurements from proton-nucleus and pp collisions over the full$p_{\mathrm{T}}$range. The measured$\eta /\pi ^{0}$ratio at high$p_{\mathrm{T}}$also agrees within uncertainties with measurements from nucleus–nucleus collisions. The$\pi ^{0}$and$\eta $yields in p–Pb relative to the scaled pp interpolated reference,$R_{{\mathrm{pPb}}}$, are presented for$0.3 < p_{\mathrm{T}}<$20$\hbox {GeV}/c$and$0.7 < p_{\mathrm{T}}<$20$\hbox {GeV}/c$, respectively. The results are compared with theoretical model calculations. The values of$R_{{\mathrm{pPb}}}$are consistent with unity for transverse momenta above 2$\hbox {GeV}/c$ . These results support the interpretation that the suppressed yield of neutral mesons measured in Pb–Pb collisions at LHC energies is due to parton energy loss in the hot QCD medium

Prompt and non-prompt J/ψ\hbox {J}/\psi production and nuclear modification at mid-rapidity in p–Pb collisions at sNN=5.02\mathbf{\sqrt{{ s}_{\text {NN}}}= 5.02} TeV

A measurement of beauty hadron production at mid-rapidity in proton-lead collisions at a nucleon–nucleon centre-of-mass energy $\sqrt{s_\text {NN}}=5.02$ TeV is presented. The semi-inclusive decay channel of beauty hadrons into $\hbox {J}/\psi$ is considered, where the $\hbox {J}/\psi$ mesons are reconstructed in the dielectron decay channel at mid-rapidity down to transverse momenta of 1.3 GeV/c. The $\hbox {b}\bar{\hbox {b}}$ production cross section at mid-rapidity, $\hbox {d}\sigma _{\hbox {b}\bar{\hbox {b}}}/\hbox {d}y$ , and the total cross section extrapolated over full phase space, $\sigma _{\text {b}\bar{\text {b}}}$ , are obtained. This measurement is combined with results on inclusive $\hbox {J}/\psi$ production to determine the prompt $\hbox {J}/\psi$ cross sections. The results in p–Pb collisions are then scaled to expectations from pp collisions at the same centre-of-mass energy to derive the nuclear modification factor $R_{\text {pPb}}$ , and compared to models to study possible nuclear modifications of the production induced by cold nuclear matter effects. $R_{\text {pPb}}$ is found to be smaller than unity at low $p_{\mathrm{T}}$ for both $\hbox {J}/\psi$ coming from beauty hadron decays and prompt $\hbox {J}/\psi$

Global polarization of ΛΛˉ\Lambda \bar \Lambda hyperons in Pb-Pb collisions at sNN\sqrt {s_{NN}} = 2.76 and 5.02 TeV

International audienceThe global polarization of the $\Lambda$ and $\overline\Lambda$ hyperons is measured for Pb-Pb collisions at $\sqrt{s_{\rm{NN}}}$ = 2.76 and 5.02 TeV recorded with the ALICE at the LHC. The results are reported differentially as a function of collision centrality and hyperon's transverse momentum ($p_{\rm{T}}$) for the range of centrality 5-50%, $0.5 < p_{\rm{T}} <5$ GeV/$c$, and rapidity $|y|<0.5$. The hyperon global polarization averaged for Pb-Pb collisions at $\sqrt{s_{\rm{NN}}}$ = 2.76 and 5.02 TeV is found to be consistent with zero, $\langle P_{\rm{H}}\rangle$ (%) $\approx$ 0.01 $\pm$ 0.06 (stat.) $\pm$ 0.03 (syst.) in the collision centrality range 15-50%, where the largest signal is expected. The results are compatible with expectations based on an extrapolation from measurements at lower collision energies at RHIC, hydrodynamical model calculations, and empirical estimates based on collision energy dependence of directed flow, all of which predict the global polarization values at LHC energies of the order of 0.01%

Measurement of prompt D0^{0}, D+^{+}, D∗+^{*+}, and DS+ {\mathrm{D}}_{\mathrm{S}}^{+} production in p–Pb collisions at sNN \sqrt{{\mathrm{s}}_{\mathrm{NN}}} = 5.02 TeV

International audienceThe measurement of the production of prompt D$^{0}$, D$^{+}$, D$^{*+}$, and ${\mathrm{D}}_{\mathrm{S}}^{+}$ mesons in proton–lead (p–Pb) collisions at the centre-of-mass energy per nucleon pair of $\sqrt{s_{\mathrm{NN}}}$ = 5.02 TeV, with an integrated luminosity of 292 ± 11 μb$^{−1}$, are reported. Differential production cross sections are measured at mid-rapidity (−0.96 < y$_{cms}$< 0.04) as a function of transverse momentum (p$_{T}$) in the intervals 0 < p$_{T}$< 36 GeV/c for D$^{0}$, 1 < p$_{T}$< 36 GeV/c for D$^{+}$ and D$^{*+}$, and 2 < p$_{T}$< 24 GeV/c for D$^{+}$ mesons. For each species, the nuclear modification factor R$_{pPb}$ is calculated as a function of p$_{T}$ using a proton-proton (pp) ref- erence measured at the same collision energy. The results are compatible with unity in the whole p$_{T}$ range. The average of the non-strange D mesons R$_{pPb}$ is compared with theoretical model predictions that include initial-state effects and parton transport model predictions. The p$_{T}$ dependence of the D$^{0}$, D$^{+}$, and D$^{*+}$ nuclear modification factors is also reported in the interval 1 < p$_{T}$< 36 GeV/c as a function of the collision centrality, and the central-to-peripheral ratios are computed from the D-meson yields measured in different centrality classes. The results are further compared with charged-particle measurements and a similar trend is observed in all the centrality classes. The ratios of the p$_{T}$-differential cross sections of D$^{0}$, D$^{+}$, D$^{*+}$, and ${\mathrm{D}}_{\mathrm{S}}^{+}$ mesons are also reported. The ${\mathrm{D}}_{\mathrm{S}}^{+}$ and D$^{+}$ yields are compared as a function of the charged-particle multiplicity for several p$_{T}$ intervals. No modification in the relative abundances of the four species is observed with respect to pp collisions within the statistical and systematic uncertainties

Λ3H^3_\Lambda\mathrm{H} and Λˉ3H‾^3_{\bar{\Lambda}}\mathrm{\overline{H}} lifetime measurement in Pb-Pb collisions at sNN=\sqrt{s_{\mathrm{NN}}} = 5.02 TeV via two-body decay

International audienceAn improved value for the lifetime of the (anti-)hypertriton has been obtained using the data sample of Pb–Pb collisions at sNN=5.02 TeV collected by the ALICE experiment at the LHC. The (anti-)hypertriton has been reconstructed via its charged two-body mesonic decay channel and the lifetime has been determined from an exponential fit to the d N /d( ct ) spectrum. The measured value, τ=242−38+34 (stat.) ± 17 (syst.) ps, is compatible with representative theoretical predictions, thus contributing to the solution of the longstanding hypertriton lifetime puzzle

ϕ\phi meson production at forward rapidity in Pb-Pb collisions at sNN=2.76\sqrt{s_\mathrm{NN}}=2.76 TeV

$\phi$ meson measurements provide insight into strangeness production, which is one of the key observables for the hot medium formed in high-energy heavy-ion collisions. ALICE measured $\phi$ production through its decay in muon pairs in Pb–Pb collisions at $\sqrt{s_\mathrm {NN}} = 2.76$ TeV in the intermediate transverse momentum range $2< p_\mathrm {T}< 5$  GeV/c and in the rapidity interval $2.5<y<4$ . The $\phi$ yield was measured as a function of the transverse momentum and collision centrality. The nuclear modification factor was obtained as a function of the average number of participating nucleons. Results were compared with the ones obtained via the kaon decay channel in the same $p_\mathrm {T}$ range at midrapidity. The values of the nuclear modification factor in the two rapidity regions are in agreement within uncertainties

Production of charged pions, kaons, and (anti-)protons in Pb-Pb and inelastic pppp collisions at sNN\sqrt {s_{NN}} = 5.02 TeV

International audienceMid-rapidity production of $\pi^{\pm}$, $\rm{K}^{\pm}$ and ($\bar{\rm{p}}$)p measured by the ALICE experiment at the LHC, in Pb-Pb and inelastic pp collisions at $\sqrt{s_{\rm{NN}}}$ = 5.02 TeV, is presented. The invariant yields are measured over a wide transverse momentum ($p_{\rm{T}}$) range from hundreds of MeV/$c$ up to 20 GeV/$c$. The results in Pb-Pb collisions are presented as a function of the collision centrality, in the range 0$-$90%. The comparison of the $p_{\rm{T}}$-integrated particle ratios, i.e. proton-to-pion (p/$\pi$) and kaon-to-pion (K/$\pi$) ratios, with similar measurements in Pb-Pb collisions at $\sqrt{s_{\rm{NN}}}$ = 2.76 TeV show no significant energy dependence. Blast-wave fits of the $p_{\rm{T}}$ spectra indicate that in the most central collisions radial flow is slightly larger at 5.02 TeV with respect to 2.76 TeV. Particle ratios (p/$\pi$, K/$\pi$) as a function of $p_{\rm{T}}$ show pronounced maxima at $p_{\rm{T}}$ $\approx$ 3 GeV/$c$ in central Pb-Pb collisions. At high $p_{\rm{T}}$, particle ratios at 5.02 TeV are similar to those measured in pp collisions at the same energy and in Pb-Pb collisions at $\sqrt{s_{\rm{NN}}}$ = 2.76 TeV. Using the pp reference spectra measured at the same collision energy of 5.02 TeV, the nuclear modification factors for the different particle species are derived. Within uncertainties, the nuclear modification factor is particle species independent for high $p_{\rm{T}}$ and compatible with measurements at $\sqrt{s_{\rm{NN}}}$ = 2.76 TeV. The results are compared to state-of-the-art model calculations, which are found to describe the observed trends satisfactorily