10,655 research outputs found
Mid-IR period-magnitude relations for AGB stars
Asymptotic Giant Branch variables are found to obey period-luminosity
relations in the mid-IR similar to those seen at K_S (2.14 microns), even at 24
microns where emission from circumstellar dust is expected to be dominant.
Their loci in the M, logP diagrams are essentially the same for the LMC and for
NGC6522 in spite of different ages and metallicities. There is no systematic
trend of slope with wavelength. The offsets of the apparent magnitude vs. logP
relations imply a difference between the two fields of 3.8 in distance modulus.
The colours of the variables confirm that a principal period with log P > 1.75
is a necessary condition for detectable mass-loss. At the longest observed
wavelength, 24 microns, many semi-regular variables have dust shells comparable
in luminosity to those around Miras. There is a clear bifurcation in LMC
colour-magnitude diagrams involving 24 micron magnitudes.Comment: 5 pages, 4 figure
Entrainment and chaos in a pulse-driven Hodgkin-Huxley oscillator
The Hodgkin-Huxley model describes action potential generation in certain
types of neurons and is a standard model for conductance-based, excitable
cells. Following the early work of Winfree and Best, this paper explores the
response of a spontaneously spiking Hodgkin-Huxley neuron model to a periodic
pulsatile drive. The response as a function of drive period and amplitude is
systematically characterized. A wide range of qualitatively distinct responses
are found, including entrainment to the input pulse train and persistent chaos.
These observations are consistent with a theory of kicked oscillators developed
by Qiudong Wang and Lai-Sang Young. In addition to general features predicted
by Wang-Young theory, it is found that most combinations of drive period and
amplitude lead to entrainment instead of chaos. This preference for entrainment
over chaos is explained by the structure of the Hodgkin-Huxley phase resetting
curve.Comment: Minor revisions; modified Fig. 3; added reference
Evaluation of a Phosphate Management Protocol to Achieve Optimum Serum Phosphate Levels in Hemodialysis Patients
Original article can be found at: http://www.sciencedirect.com/science/journal/10512276 Copyright National Kidney Foundation, Inc. DOI: 10.1053/j.jrn.2008.05.003To evaluate the effectiveness of a protocol designed to optimize serum phosphate levels in patients undergoing regular hemodialysis (HD).Peer reviewe
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Managing knowledge in the context of sustainable construction
The 21st century has been a growing awareness of the importance of the sustainability agenda. Moreover for construction, it has become increasingly important as clients are pushing for a more sustainable product to complement their organisations’ own strategic plans. Sustainable development can be defined as development that meets the needs of the present without compromising the ability of future generations to meet their needs. Sustainable construction is therefore seen as the application of sustainable practices to the activities of the construction sector. One of the key factors in making construction projects more sustainable is overcoming the obstacles of capturing and managing the knowledge required by project teams to effect such change. Managing this knowledge is key to the construction industry because of the unique characteristics of its projects, i.e. multi-disciplinary teams, dynamic participation of team members, heavy reliance on previous experiences/heuristics, the one-off nature of the projects, tight schedules, limited budget, etc. Initiatives within the industry and academic research are developing mechanisms and tools for managing knowledge in construction firms and projects. Such work has so far addressed the issues of capturing, storing, and transferring knowledge
Ultralow noise performance of an 8.4-GHz maser-feedhorn system
A total system noise temperature of 6.6 K was demonstrated with an 8.4-GHz traveling wave maser and feedhorn operating in a cryogenic environment. Both the maser and feedhorn were inserted in the helium cryostat, with the maser operating in the 1.6-K liquid bath and the feedhorn cooled in the helium gas, with a temperature gradient along the horn ranging from the liquid bath temperature at its lower end to room temperature at its top. The ruby maser exhibited 43 dB of gain with a bandwidth of 76 MHz(-3 dB) centered at 8400 MHz. Discussions of the maser, cooled feedhorn, and cryostat designs are presented along with a discussion of the noise temperature measurements
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Validation of machine learning models to detect amyloid pathologies across institutions.
Semi-quantitative scoring schemes like the Consortium to Establish a Registry for Alzheimer's Disease (CERAD) are the most commonly used method in Alzheimer's disease (AD) neuropathology practice. Computational approaches based on machine learning have recently generated quantitative scores for whole slide images (WSIs) that are highly correlated with human derived semi-quantitative scores, such as those of CERAD, for Alzheimer's disease pathology. However, the robustness of such models have yet to be tested in different cohorts. To validate previously published machine learning algorithms using convolutional neural networks (CNNs) and determine if pathological heterogeneity may alter algorithm derived measures, 40 cases from the Goizueta Emory Alzheimer's Disease Center brain bank displaying an array of pathological diagnoses (including AD with and without Lewy body disease (LBD), and / or TDP-43-positive inclusions) and levels of Aβ pathologies were evaluated. Furthermore, to provide deeper phenotyping, amyloid burden in gray matter vs whole tissue were compared, and quantitative CNN scores for both correlated significantly to CERAD-like scores. Quantitative scores also show clear stratification based on AD pathologies with or without additional diagnoses (including LBD and TDP-43 inclusions) vs cases with no significant neurodegeneration (control cases) as well as NIA Reagan scoring criteria. Specifically, the concomitant diagnosis group of AD + TDP-43 showed significantly greater CNN-score for cored plaques than the AD group. Finally, we report that whole tissue computational scores correlate better with CERAD-like categories than focusing on computational scores from a field of view with densest pathology, which is the standard of practice in neuropathological assessment per CERAD guidelines. Together these findings validate and expand CNN models to be robust to cohort variations and provide additional proof-of-concept for future studies to incorporate machine learning algorithms into neuropathological practice
The Aggregation Kinetics of a Simulated Telechelic Polymer
We investigate the aggregation kinetics of a simulated telechelic polymer
gel. In the hybrid Molecular Dynamics (MD) / Monte Carlo (MC) algorithm,
aggregates of associating end groups form and break according to MC rules,
while the position of the polymers in space is dictated by MD. As a result, the
aggregate sizes change every time step. In order to describe this aggregation
process, we employ master equations. They define changes in the number of
aggregates of a certain size in terms of reaction rates. These reaction rates
indicate the likelihood that two aggregates combine to form a large one, or
that a large aggregate splits into two smaller parts. The reaction rates are
obtained from the simulations for a range of temperatures.
Our results indicate that the rates are not only temperature dependent, but
also a function of the sizes of the aggregates involved in the reaction. Using
the measured rates, solutions to the master equations are shown to be stable
and in agreement with the aggregate size distribution, as obtained directly
from simulation data. Furthermore, we show how temperature induced variations
in these rates give rise to the observed changes in the aggregate distribution
that characterizes the sol-gel transition.Comment: 9 pages, 10 figure
A core genetic module : the Mixed Feedback Loop
The so-called Mixed Feedback Loop (MFL) is a small two-gene network where
protein A regulates the transcription of protein B and the two proteins form a
heterodimer. It has been found to be statistically over-represented in
statistical analyses of gene and protein interaction databases and to lie at
the core of several computer-generated genetic networks. Here, we propose and
mathematically study a model of the MFL and show that, by itself, it can serve
both as a bistable switch and as a clock (an oscillator) depending on kinetic
parameters. The MFL phase diagram as well as a detailed description of the
nonlinear oscillation regime are presented and some biological examples are
discussed. The results emphasize the role of protein interactions in the
function of genetic modules and the usefulness of modelling RNA dynamics
explicitly.Comment: To be published in Physical Review
Diverse routes to oscillation death in a coupled-oscillator system.
We study oscillation death (OD) in a well-known coupled-oscillator system that has been used to model cardiovascular phenomena. We derive exact analytic conditions that allow the prediction of OD through the two known bifurcation routes, in the same model, and for different numbers of coupled oscillators. Our exact analytic results enable us to generalize OD as a multiparameter-sensitive phenomenon. It can be induced, not only by changes in couplings, but also by changes in the oscillator frequencies or amplitudes. We observe synchronization transitions as a function of coupling and confirm the robustness of the phenomena in the presence of noise. Numerical and analogue simulations are in good agreement with the theory
ISOGAL Survey of Baade's Windows in the Mid-infrared
The ISOGAL mid-infrared survey of areas close to the Galactic Plane aims to
determine their stellar content and its possible bearing on the history of the
Galaxy. The NGC6522 and Sgr I Baade's Windows of low obscuration towards the
inner parts of the Bulge represent ideal places in which to calibrate and
understand the ISOGAL colour-magnitude diagrams.
The survey observations were made with the ISOCAM instrument of the ISO
satellite. The filter bands chosen were LW2(~7 microns) and LW3(~15 microns).
The results presented here show that most of the detected objects are late
M-type giants on the AGB, with a cut-off for those earlier than M3-M4. The most
luminous members of these two Bulge fields at 7 microns are the Mira variables.
However, it is evident that they represent the end of a sequence of increasing
15 micron dust emission which commences with M giants of earlier sub-type.
In observations of late-type giants the ISOCAM 15 micron band is mainly
sensitive to the cool silicate or aluminate dust shells which overwhelm the
photospheric emission. However, in ordinary M-giant stars, the 7 micron band is
not strongly affected by dust emission and may be influenced instead by
absorption. The nu2 band of water at 6.25 microns and the SiO fundamental at
7.9 microns are likely contribitors to this effect.
A group of late M stars has been found which vary little or not at all but
have infrared colours typical of well-developed dust shells. Their luminosities
are similar to those of 200-300 day Miras but they have slightly redder
[7]-[15] colours which form an extension of the ordinary M giant sequence.
The Mira dust shells show a mid-infrared [7]-[15] colour-period relation. ca
700 days.Comment: 13 pages 15 figure
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