682 research outputs found

    Developmental Resting State Functional Connectivity for Clinicians

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    Resting state functional magnetic imaging (fMRI) is a novel means to examine functional brain networks. It allows investigators to identify functional networks defined by distinct, spontaneous signal fluctuations. Resting state functional connectivity (RSFC) studies examining child and adolescent psychiatric disorders are being published with increasing frequency, despite concerns about the impact of motion on findings. Here we review important RSFC findings on typical brain development and recent publications of child and adolescent psychiatric disorders. We close with a summary of the major findings and current strengths and limitations of RSFC studies

    Speech perception from monaural and binaural information

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    Two experiments explored the concept of the binaural spectrogram [Culling and Colburn, J. Acoust. Soc. Am. 107, 517-527 (2000)] and its relationship to monaurally derived information. In each experiment, speech was added to noise at an adverse signal-to-noise ratio in the NoS pi binaural configuration. The resulting monaural and binaural cues were analyzed within an array of spectro-temporal bins and then these cues were resynthesized by modulating the intensity and/or interaural correlation of freshly generated noise. Experiment 1 measured the intelligibility of the resynthesized stimuli and compared them with the original NoSo and NoS pi stimuli at a fixed signal-to-noise ratio. While NoS pi stimuli were approximately equal to 50% intelligible, each cue in isolation produced similar (very low) intelligibility to the NoSo condition. The resynthesized combination produced approximately equal to 25% intelligibility. Modulation of interaural correlation below 1.2 kHz and of amplitude above 1.2 kHz was not as effective as their combination across all frequencies. Experiment 2 measured three-point psychometric functions in which the signal-to-noise ratio of the original NoS pi stimulus was increased in 3-dB steps from the level used in experiment 1. Modulation of interaural correlation alone proved to have a flat psychometric function. The functions for NoS pi and for combined monaural and binaural cues appeared similar in slope, but shifted horizontally. The results indicate that for sentence materials, neither fluctuations in interaural correlation nor in monaural intensity are sufficient to support speech recognition at signal-to-noise ratios where 50% intelligibility is achieved in the NoS pi configuration; listeners appear to synergistically combine monaural and binaural information in this task, to some extent within the same frequency region

    Occupational Exposure to Polycyclic Aromatic Hydrocarbons and Elevated Cancer Incidence in Firefighters

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    Cancer incidence appears to be higher amongst firefighters compared to the general population. Given that many cancers have an environmental component, their occupational exposure to products of carbon combustion such as polycyclic aromatic hydrocarbons (PAHs) is of concern. This is the first UK study identifying firefighters exposure to PAH carcinogens. Wipe samples were collected from skin (jaw, neck, hands), personal protective equipment of firefighters, and work environment (offices, fire stations and engines) in two UK Fire and Rescue Service Stations. Levels of 16 US Environmental Protection Agency (EPA) PAHs were quantified together with more potent carcinogens: 7,12-dimethylbenzo[a]anthracene, and 3-methylcholanthrene (3-MCA) (12 months post-initial testing). Cancer slope factors, used to estimate cancer risk, indicate a markedly elevated risk. PAH carcinogens including benzo[a]pyrene (B[a]P), 3-MCA, and 7,12-dimethylbenz[a]anthracene PAHs were determined on body surfaces (e.g., hands, throat), on PPE including helmets and clothing, and on work surfaces. The main exposure route would appear to be via skin absorption. These results suggest an urgent need to monitor exposures to firefighters in their occupational setting and conduct long-term follow-up regarding their health status

    Automatic Redshift Determination by use of Principal Component Analysis --- I: Fundamentals

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    With the advent of very large redshift surveys of tens to hundreds of thousands of galaxies reliable techniques for automatically determining galaxy redshifts are becoming increasingly important. The most common technique currently in common use is the cross-correlation of a galactic spectrum with a set of templates. This series of papers presents a new method based on Principal Component Analysis. The method generalizes the cross-correlation approach by replacing the individual templates by a simultaneous linear combination of orthogonal templates. This effectively eliminates the mismatch between templates and data and provides for the possibility of better error estimates. In this paper, the first of a series, the basic mathematics are presented along with a simple demonstration of the application.Comment: 23 pages, 9 Figures, minor revisions, accepted for publication in Astrophysical Journa

    Penerapan Metode Pembelajaran Numbered Heads Together (Nht) Untuk Meningkatkan Motivasi Dan Hasil Belajar Kelarutan Dan Hasil Kali Kelarutan Kelas XI IPA 4 Sman 8 Surakarta Tahun Pelajaran 2012/2013

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    Tujuan penelitian ini adalah untuk meningkatkan (1) motivasi belajar kelarutan dan hasil kali kelarutan dan (2) hasil belajar kelarutan dan hasil kali kelarutan melalui penerapan metode pembelajaran Numbered Heads Together (NHT). Penelitian ini merupakan penelitian tindakan kelas (Classroom Action Research) yang dilaksanakan dalam dua siklus dimana setiap siklusnya terdiri atas empat tahapan, yaitu perencanaan, pelaksanaan, pengamatan, dan refleksi. Subjek penelitian adalah siswa kelas XI IPA 4 SMAN 8 Surakarta Tahun Pelajaran 2012/2013. Pengumpulan data dilakukan melalui pengamatan, wawancara, kajian dokumen, angket, dan tes. Data yang diperoleh divalidasi menggunakan teknik triangulasi sumber dan dianalisis menggunakan analisis deskriptif kualitatif yang mengacu pada Miles dan Huberman. Hasil penelitian menunjukkan capaian motivasi belajar pada siklus I dan siklus II masing-masing mencapai 58,33% dan 79,17%. Hasil belajar yang diukur pada aspek kognitif dan afektif menunjukkan pada siklus I mencapai 29,17% dan 62,5% serta pada siklus II mencapai 70,83% dan 83,33%. Simpulan penelitian ini adalah penerapan metode pembelajaran Numbered Heads Together (NHT) mampu meningkatkan (1) motivasi belajar kelarutan dan hasil kali kelarutan dan (2) hasil belajar kelarutan dan hasil kali kelarutan kelas XI IPA 4 SMAN 8 Surakarta

    S100A12 in Digestive Diseases and Health: A Scoping Review

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    Calgranulin proteins are an important class of molecules involved in innate immunity. These members of the S100 class of the EF-hand family of calcium-binding proteins have numerous cellular and antimicrobial functions. One protein in particular, S100A12 (also called EN-RAGE or calgranulin C), is highly abundant in neutrophils during acute inflammation and has been implicated in immune regulation. Structure-function analyses reveal that S100A12 has the capacity to bind calcium, zinc, and copper, processes that contribute to nutritional immunity against invading microbial pathogens. S100A12 is a ligand for the receptor for advanced glycation end products (RAGE), toll-like receptor 4 (TLR4), and CD36, which promote cellular and immunological pathways to alter inflammation. We conducted a scoping review of the existing literature to define what is known about the association of S100A12 with digestive disease and health. Results suggest that S100A12 is implicated in gastroenteritis, necrotizing enterocolitis, gastritis, gastric cancer, Crohn’s disease, irritable bowel syndrome, inflammatory bowel disease, and digestive tract cancers. Together, these results reveal S100A12 is an important molecule broadly associated with the pathogenesis of digestive diseases
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