153 research outputs found
Retinoid Signaling in Pancreatic Cancer, Injury and Regeneration
- Author
- A Molotkov
- AL Means
- Amanda Mawson
- Andrew V. Biankin
- AV Biankin
- AV Biankin
- BA Neuschwander-Tetri
- BA Neuschwander-Tetri
- C Balague
- C Jeronimo
- CA Eads
- Christopher J. Scarlett
- CJ Yeo
- CW Michalski
- D Cvetkovic
- D Segara
- Davendra Segara
- David K. Chang
- DM Berman
- DR Soprano
- EF Farias
- Elizabeth A. Musgrove
- Emily K. Colvin
- FE Froeling
- G Bistulfi
- Hidayatullah G. Munshi
- Ilse Rooman
- J Rossant
- James G. Kench
- JG Herman
- Johana M. Susanto
- JP Neoptolemos
- K Kimura
- M Andrianifahanana
- M Esteller
- M Martin
- M Ostrom
- M Rovira
- M Shutoh
- Mark Pinese
- Minoti V. Apte
- NB Ghyselinck
- NB Prasad
- PW Heiser
- R Lotan
- RH Hruban
- Robert L. Sutherland
- S Maeda
- Sandra A. O'Toole
- SJ Freemantle
- SP Thayer
- SR Hingorani
- SY Sun
- T Crnogorac-Jurcevic
- T Furukawa
- V Fendrich
- Vivienna N. Ong
- Y Miyamoto
- YL Gong
- YS Kuppumbatti
- Publication venue
- Public Library of Science
- Publication date
- 01/01/2011
- Field of study
Background: Activation of embryonic signaling pathways quiescent in the adult pancreas is a feature of pancreatic cancer (PC). These discoveries have led to the development of novel inhibitors of pathways such as Notch and Hedgehog signaling that are currently in early phase clinical trials in the treatment of several cancer types. Retinoid signaling is also essential for pancreatic development, and retinoid therapy is used successfully in other malignancies such as leukemia, but little is known concerning retinoid signaling in PC. Methodology/Principal Findings: We investigated the role of retinoid signaling in vitro and in vivo in normal pancreas, pancreatic injury, regeneration and cancer. Retinoid signaling is active in occasional cells in the adult pancreas but is markedly augmented throughout the parenchyma during injury and regeneration. Both chemically induced and genetically engineered mouse models of PC exhibit a lack of retinoid signaling activity compared to normal pancreas. As a consequence, we investigated Cellular Retinoid Binding Protein 1 (CRBP1), a key regulator of retinoid signaling known to play a role in breast cancer development, as a potential therapeutic target. Loss, or significant downregulation of CRBP1 was present in 70% of human PC, and was evident in the very earliest precursor lesions (PanIN-1A). However, in vitro gain and loss of function studies and CRBP1 knockout mice suggested that loss of CRBP1 expression alone was not sufficient to induce carcinogenesis or to alter PC sensitivity to retinoid based therapies. Conclusions/Significance: In conclusion, retinoid signalling appears to play a role in pancreatic regeneration and carcinogenesis, but unlike breast cancer, it is not mediated directly by CRBP1
Whole genome resequencing of the human parasite Schistosoma mansoni reveals population history and effects of selection
- Author
- A Stamatakis
- AJ Norton
- AK Holloway
- AM Emery
- AS Brooks
- AV Protasio
- AV Protasio
- BL Webster
- C Sturmbauer
- CL Valentim
- CM Gower
- CW Marean
- D Geggus
- DG Colley
- DJ Conway
- DL Halligan
- EC Faust
- EK Karlsson
- H Li
- H Li
- H Mi
- I Gronau
- I McDougall
- IJ Tsai
- IJ Tsai
- J Morgan
- J Schwetz
- J Stothard
- JA Morgan
- JA Morgan
- JD Clark
- JE Tierney
- JE Yellen
- JK Pritchard
- JP Salter
- KF Hoffmann
- KI Bos
- KN Harper
- L Despres
- L Després
- LP Farias
- LR Brunet
- M Berriman
- M Fletcher
- M Lynch
- M Lynch
- M Sironi
- MA DePristo
- MC Campbell
- ML Steinauer
- NA Rosenberg
- OE Cornejo
- PC Sabeti
- PJ Hotez
- R Anderson
- R Leblois
- RC Walter
- RD Finn
- S Brooker
- S Schiffels
- T Crellen
- TD Otto
- WH Gharib
- Y Xue
- Z Yang
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 13/01/2016
- Field of study
This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. The attached file is the published version of the article
Human IgG1 Responses to Surface Localised Schistosoma mansoni Ly6 Family Members Drop following Praziquantel Treatment
- Author
- A Bamezai
- A Davies
- A de Morree
- A Galat
- A Garza-Garcia
- A Hijazi
- A Leaver-Fay
- A Ribeiro de Jesus
- AL Roldan
- AV Protasio
- B Eisenhaber
- B Moussian
- B Su
- BW van Balkom
- C Auriault
- CH King
- Christine Pierrot
- CM Fitzsimmons
- CM Fitzsimmons
- Colin M. Fitzsimmons
- David W. Dunne
- DG Colley
- DL Bodian
- DW Crompton
- E Hansell
- Edridah M. Tukahebwa
- EJ Farnell
- F Liu
- FA Lewis
- FC Cardoso
- FC Cardoso
- Frances M. Jones
- H Gardsvoll
- H Tallima
- Iain W. Chalmers
- IW Chalmers
- J Greenwald
- J Mulvenna
- Jakub M. Wawrzyniak
- Jamal Khalife
- JD Bendtsen
- Jeffrey Michael Bethony
- JH Chou
- JM Fitzpatrick
- K Ginalski
- Karl F. Hoffmann
- KaS W. Hofmann
- KD Pruitt
- KJ Leath
- LA de Oliveira Fraga
- LP Farias
- LP Farias
- M Berriman
- M Ismail
- M Mallya
- M Punta
- Martha Brown
- MH Meevissen
- MH Tran
- N Reimers
- Narcis Fernandez-Fuentes
- ND Young
- NR Bergquist
- R El Ridi
- RA Wilson
- RA Wilson
- RC Edgar
- S Braschi
- S Raman
- SF Altschul
- TA Wynn
- TR Hawn
- W Castro-Borges
- Publication venue
- Publication date
- 01/01/2015
- Field of study
The heptalaminate-covered, syncytial tegument is an important anatomical adaptation that enables schistosome parasites to maintain long-term, intravascular residence in definitive hosts. Investigation of the proteins present in this surface layer and the immune responses elicited by them during infection is crucial to our understanding of host/parasite interactions. Recent studies have revealed a number of novel tegumental surface proteins including three (SmCD59a, SmCD59b and Sm29) containing uPAR/Ly6 domains (renamed SmLy6A SmLy6B and SmLy6D in this study). While vaccination with SmLy6A (SmCD59a) and SmLy6D (Sm29) induces protective immunity in experimental models, human immunoglobulin responses to representative SmLy6 family members have yet to be thoroughly explored.Using a PSI-BLAST-based search, we present a comprehensive reanalysis of the Schistosoma mansoni Ly6 family (SmLy6A-K). Our examination extends the number of members to eleven (including three novel proteins) and provides strong evidence that the previously identified vaccine candidate Sm29 (renamed SmLy6D) is a unique double uPAR/Ly6 domain-containing representative. Presence of canonical cysteine residues, signal peptides and GPI-anchor sites strongly suggest that all SmLy6 proteins are cell surface-bound. To provide evidence that SmLy6 members are immunogenic in human populations, we report IgG1 (as well as IgG4 and IgE) responses against two surface-bound representatives (SmLy6A and SmLy6B) within a cohort of S. mansoni-infected Ugandan males before and after praziquantel treatment. While pre-treatment IgG1 prevalence for SmLy6A and SmLy6B differs amongst the studied population (7.4% and 25.3% of the cohort, respectively), these values are both higher than IgG1 prevalence (2.7%) for a sub-surface tegumental antigen, SmTAL1. Further, post-treatment IgG1 levels against surface-associated SmLy6A and SmLy6B significantly drop (p = 0.020 and p < 0.001, respectively) when compared to rising IgG1 levels against sub-surface SmTAL1.Collectively, these results expand the number of SmLy6 proteins found within S. mansoni and specifically demonstrate that surface-associated SmLy6A and SmLy6B elicit immunological responses during infection in endemic communities
Moringa oleifera: bioactive compounds and nutritional potential
- Author
- Abdulkarim SM
- Abdulla M
- Amaya DR
- Ana de FĂĄtima Urano Carvalho
- Berger MR
- Bharali R
- CĂĄrceres A
- Davi Felipe Farias
- Delaveau P
- Dhar B
- Donli PO
- Eilert U
- Farias DF
- Ferrao AMBC
- Ferreira PMP
- Fish BC
- Foidl N
- Gerdes G
- Ghebremichael KA
- Gilani AH
- Grabow WOK
- Gupta M
- Hodge HC
- Jahn SAA
- Jang M
- José Tadeu de Abreu Oliveira
- Kawada N
- Kummar V
- Machado DIS
- Madsen M
- Makkar HPS
- Mehta LK
- Morton JF
- Ndabigengesere A
- Nordberg J
- Odee D
- Okuda T
- Oliveira JTA
- Pal SK
- Paulo Michel Pinheiro Ferreira
- Ramachandran C
- Rangaswani S
- Rao AV
- Santos AFS
- Siddhuraju P
- Siguel EM
- Silva AR
- Singh U
- Soliva CR
- Stephensen CB
- Thompson LU
- Tsaknis J
- Vasconcelos IM
- Verma SC
- Publication venue
- 'FapUNIFESP (SciELO)'
- Publication date
- Field of study
Lessons for livestock genomics from genome and transcriptome sequencing in cattle and other mammals
- Author
- A Gouin
- AC Darby
- AC Ward
- AH Freedman
- AV Zimin
- BJ Haas
- BJ Williams
- C Camacho
- C Trapnell
- CD Marsden
- CJ Hanthorn
- D Gilliam
- D Gilliam
- D Sims
- DG MacArthur
- DJ Garrick
- DM Bickhart
- DM Bickhart
- FH Farias
- FH Farias
- G Gorjanc
- G Marçais
- H Tae
- HA Noyes
- HD Daetwyler
- J Guo
- J Guo
- JaeWoo Kim
- Jared E. Decker
- JE Decker
- JE Decker
- Jeremy F. Taylor
- Jesse L. Hoff
- KM Draheim
- KT Lee
- L Andersson
- LJ Gershwin
- LK Matukumalli
- LK Whitacre
- Lynsey K. Whitacre
- M Saatchi
- M Saatchi
- M Sargolzaei
- MG Grabherr
- P Stothard
- PC Tizioto
- Polyana C. Tizioto
- R Binsbergen van
- R Zeng
- RA Gibbs
- RF BrĂžndum
- RH Chapple
- Robert D. Schnabel
- RT Loftus
- S MacEachern
- SM Dabo
- SR Browning
- T Mhlanga-Mutangadura
- U Mudunuri
- X Peng
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Sequencing technologies and genome sequencing
- Author
- A Bashamboo
- A Edwards
- AA Shah
- AB Singleton
- AJ Amaral
- AL Archibald
- AM Maxam
- AM Ramos
- AR Jex
- AS Laere Van
- AV Zimin
- B Grisart
- B Shapiro
- BJ McComish
- BM Henn
- C DrögemĂŒller
- C Lind
- C Popp
- CA Maher
- CB Kingsley
- CF Wright
- CG Elsik
- CJ Bell
- CJ Edwards
- CM Wade
- CP Tassell Van
- D Hong
- D Pushkarev
- DA Wheeler
- DE MacHugh
- DJ Burgess
- DJ McBride
- DJ Turner
- DS Tawfik
- E Farias-Hesson
- EE Schadt
- ER Mardis
- ER Mardis
- ER Mardis
- ER Mardis
- ER Mardis
- ES Lander
- F Bhaijee
- F Erhard
- F Ozsolak
- F Ozsolak
- F Ozsolak
- F Sanger
- F Sanger
- F Sanger
- FL Raymond
- FS Collins
- G Bormann
- G KuhlenbÀumer
- G Ramsingh
- G Robertson
- G Yamey
- GE Liu
- GM Euskirchen
- GP Pfeifer
- HP Buermans
- HY Zoghbi
- I Braslavsky
- I Hajirasouliha
- I Leifer
- J Eid
- J Shendure
- J Wang
- J Womack
- JC Venter
- JH Yang
- JI Kim
- JR Lupski
- JU Pontius
- K Lindblad-Toh
- KJ McKernan
- KV Voelkerding
- L Andersson
- L Ding
- L Kedes
- LA Bright
- LM Smith
- LW Hillier
- LW Lee
- M Georges
- M Hackenberg
- M Margulies
- M Meyerson
- M PĂ©rez-Enciso
- M Ronaghi
- M Ronaghi
- M Soroka
- MJ Levene
- ML Metzker
- MS Hestand
- N Nagarajan
- N Rusk
- N Whiteford
- Nyren
- P Nyren
- P Senapathy
- PR Selvin
- R Li
- R Li
- R Wernersson
- R Xi
- RA Dalloul
- RD Green
- RD Mitra
- RD Morin
- RJ Leary
- RM Durbin
- RT Wiedmann
- S Dames
- S Jiao
- S Marguerat
- S Marklund
- S Vermeer
- SC Isom
- SC Schuster
- SD Fouse
- SH Eck
- SJ Bowne
- SJ Coleman
- SM Ahn
- T Neff
- T Walsh
- T Werner
- TD Harris
- U Amstutz
- U Nagalakshmi
- V Bansal
- V Costa
- V Costa
- VN Michelizzi
- VN Michelizzi
- W Ansorge
- W Ansorge
- WC Wang
- WJ Greenleaf
- X Fang
- Y Astier
- Y Liu
- Publication venue
- Springer-Verlag
- Publication date
- 01/01/2011
- Field of study
The high-throughput - next generation sequencing (HT-NGS) technologies are currently the hottest topic in the field of human and animals genomics researches, which can produce over 100 times more data compared to the most sophisticated capillary sequencers based on the Sanger method. With the ongoing developments of high throughput sequencing machines and advancement of modern bioinformatics tools at unprecedented pace, the target goal of sequencing individual genomes of living organism at a cost of $1,000 each is seemed to be realistically feasible in the near future. In the relatively short time frame since 2005, the HT-NGS technologies are revolutionizing the human and animal genome researches by analysis of chromatin immunoprecipitation coupled to DNA microarray (ChIP-chip) or sequencing (ChIP-seq), RNA sequencing (RNA-seq), whole genome genotyping, genome wide structural variation, de novo assembling and re-assembling of genome, mutation detection and carrier screening, detection of inherited disorders and complex human diseases, DNA library preparation, paired ends and genomic captures, sequencing of mitochondrial genome and personal genomics. In this review, we addressed the important features of HT-NGS like, first generation DNA sequencers, birth of HT-NGS, second generation HT-NGS platforms, third generation HT-NGS platforms: including single molecule Heliscopeâą, SMRTâą and RNAP sequencers, Nanopore, Archon Genomics X PRIZE foundation, comparison of second and third HT-NGS platforms, applications, advances and future perspectives of sequencing technologies on human and animal genome research
Particular characteristics of allergic symptoms in tropical environments: follow up to 24 months in the FRAAT birth cohort study
- Author
- A Host
- AA Camara
- AA Litonjua
- AD Mohangoo
- Adriana Bornacelly
- AL Kozyrskyj
- AL Wright
- AM Rosa
- AP Matson
- AV Fedulov
- BD Spycher
- C Almqvist
- C Mata Fernandez
- C Ober
- C Rodriguez Martinez
- C Vergara
- Carlos QuirĂłz
- D Caudri
- D Gustafsson
- D Nicolae
- D Simon
- D Sole
- D Sole
- Dalgys MartĂnez
- Dilia Mercado
- DJ Purvis
- E Fernandez-Caldas
- E Fernandez-Caldas
- E Garcia
- E Melen
- E von Mutius
- EL Simpson
- G Halmerbauer
- H Bisgaard
- H Johnke
- HC Williams
- HC Williams
- J Hallberg
- J Heinrich
- J Ker
- J Mallol
- J Mallol
- J Mallol
- JA Castro-Rodriguez
- JA Lima
- JE Gern
- JH Park
- JL Peters
- JM Spergel
- Jorge SĂĄnchez
- Josefina Zakzuk
- K Hamada
- Ketty Mendoza
- KM Maslowski
- L Caraballo
- L Caraballo
- L Caraballo
- L Puerta
- L Puerta
- LO Lubchenco
- Luis Caraballo
- M Roman
- M Wang
- Marta Puello
- ME Penny
- ML Barreto
- MN Chatkin
- MR Becklake
- MR de Farias
- MW Weber
- N Acevedo
- N Acevedo
- N Ait-Khaled
- N Lopez
- N Novak
- N Pearce
- N Sigurs
- Nathalie Acevedo
- NC Nicolaou
- PJ Cooper
- PJ Cooper
- PM Pitrez
- R Dennis
- R Kapoor
- RA Wood
- RH Lim
- RH Lim
- Rueda FA EA
- S Illi
- Silvia Jiménez
- ST Weiss
- T Bieber
- T Jartti
- T Keil
- T Zheng
- U Gehring
- VE Rullo
- WD Dupont
- WHO
- Y Belyhun
- YK Lee
- YM Abdulrazzaq
- Ălvaro Alvarez
- Publication venue
- BioMed Central
- Publication date
- 01/01/2012
- Field of study
Antiinflammatory Therapy with Canakinumab for Atherosclerotic Disease
- Author
- A Abbate
- A Abhyankar
- A Adams
- A Agafina
- A Akyea-Djamson
- A Alan
- A Alfieri
- A Alfrey
- A Alvarisqueta
- A Amos
- A Anadiotis
- A Anneveldt
- A Antolick
- A Arthur
- A Aslam
- Abaci F
- Abdullakutty J
- Abhaichand R
- Abib E Jr
- Aboufakher R
- Abrantes J
- Abreu M
- Abulencia K
- Acampora D
- Acampora M
- Accini Mendoza Jl
- Aceto L
- Acevedo B
- Acevedo L
- Acheatel R
- Actis Mv
- Adams M
- Adjic Nc
- Affaki Gs
- Agarwal Dk
- Aggarwal Rk
- Agosta Gf
- Aguilar M
- Aguilar M
- Ahire N
- Ahmad I
- Ahmed Sh
- Ahn Y
- Aish B
- Aiub F
- Aiub J
- Ajax K
- Ajioka M
- Akai Y
- Akatova E
- Akrap B
- Al Joundi T
- Al-Khalili F
- Albisu J
- Alcalde Jm
- Alcide P
- Alfonso T
- Allen J
- Alllison Dc
- Almaliky T
- Amerena J
- Andersen K
- Andor M
- Angelova I
- Angiolillo D
- Anita S
- Anker Sd
- Antalik L
- Antonicelli R
- Aparicio Cv
- Apel T
- Apostolovic S
- Ara M
- Aragorn L
- Arango Jl
- Araujo Fonseca M
- Ardissino D
- Arenas Leon Jl
- Arevalo S
- Argiolas G
- Arif I
- Armas E
- Aron G
- Arora S
- Asafu-Adjaye N
- Ashcom T
- Ashford M
- Ashino K
- Asim Oktay Ao
- Assarsson E
- Ata B
- Ather N
- Atieh M
- Aull L
- Avalos V
- Avdonina N
- Awasthi Ak
- Axthelm C
- Ayala M
- Ayasse D
- Ayasse M
- Azizad M
- Azize Gm
- B Becker
- Baar M
- Babu R
- Backer T
- Badea C
- Baden M
- Baehl S
- Baek C
- Baeumer A
- Bagi Es
- Bai A
- Bailey K
- Bailey S
- Bair S
- Baker A
- Baker C
- Bakhai A
- Bakker H
- Baksi A
- Baldin Mg
- Bali Hk
- Ballantyne C
- Ballmajo M
- Balode A
- Balukova E
- Bang Sa
- Banker D
- Banker K
- Baquero A
- Barbarash Ol
- Barbato E
- Barbosa E
- Barnett S
- Baron S
- Barreto M
- Barroso A
- Barroso W
- Bartkowiak A
- Bartosh L
- Bartuseviciene S
- Bashir K
- Baszak J
- Bata Ir
- Bayram E
- Beall K
- Beaudry M
- Beauregard La
- Beckett L
- Belejchak P
- Belle Isle J
- Belohlavek J
- Bendelow T
- Bender D
- Benedetti G
- Benjamin S
- Benton J
- Berdoff R
- Berger V
- Bergeron P
- Bergholtz T
- Bergler-Klein J
- Berk M
- Berli Ma
- Bernstein M
- Berra Fc
- Berti S
- Berulfsen A
- Bevilacqua Mt
- Bhadade S
- Bilazarian S
- Bilodeau N
- Binder A
- Binns Y
- Birdane A
- Bisne V
- Bitzer V
- Blagdon M
- Blahey M
- Blankenberg S
- Blazsek Z
- Bloch S
- Blom Kb
- Bluemel J
- Blumberg C
- Blumenthal R
- Bocanera M
- Bodanese L
- Boffetti P
- Bohra P
- Bohula E
- Boivin Mc
- Bolduc H
- Boley K
- Bolognesi Mg
- Bolsmann C
- Boman K
- Bonner J
- Borrayo Na
- Boström PÄ
- Botelho R
- Botta C
- Boudreaux R
- Boulanger K
- Bourgeois S
- Bouvy C
- Bowen L
- Boyarkin M
- Bradley A
- Brady L
- Bramlet D
- Brath H
- Braun P
- Bredlau C
- Brickman T
- Briggs S
- Briké C
- Brodmann M
- Brons S
- Brousalis L
- Brouwer M
- Brown C
- Brown N
- Brown S
- Buchannan C
- Budaj A
- Budassi N
- Budkova J
- Bugan V
- Buhlman S
- Bulashova O
- Bunschoten P
- Burke W
- Burley T
- Burova N
- Burris H
- Burton C
- Burton J
- Burton M
- Burtt D
- Busak L
- Busic N
- Byars W
- BĂžen Rh
- C Clavier-Firmin
- C Conradie
- C Contzen
- C Cotes
- C Covert
- C Cuneo
- Caballero-Valiente B
- Cabau Jr
- Calabrese A
- Campanale Eg
- Candusso R
- Cantor W
- CANTOS Trial Group. Krum H
- Capova L
- Carabajal T
- Carr K
- Carrillo J
- Caruso G
- Casala J
- Caso P
- Casoinic F
- Castillo J
- Castillo T
- Cech V
- Cei L
- Cendali G
- Cepinskiene L
- Cerda L
- Cermak O
- Chachalis G
- Chaggar S
- Chambers J
- Chamblee T
- Chang K
- Chang Kc
- Chang Wh
- Charlier F
- Charmarthi B
- Chattin W
- Chauhan D
- Chauhan H
- Chaussé I
- Chavada J
- Chaverra I
- Chaware G
- Chee L
- Chella S
- Chen Cp
- Chen J
- Chen Mh
- Chen Y
- Chen Yc
- Chen Zc
- Cheng Jj
- Cheng S
- Cheng Sm
- Cherlin R
- Cheung D
- Chhabra A
- Chintala P
- Chiodi L
- Choi Aj
- Chou S
- Chouinard G
- Christensen L
- Christenson S
- Chung A
- Churina S
- Cifkova R
- Ciglenecki N
- Cioffi A
- Cislowski D
- Cleveland T
- Clocotan M
- Cmrecnjak J
- Colfer H
- Colhoun H
- Collier D
- Collins R
- Coloma G
- Colquhoun D
- Colvin T
- Coman S
- Commerford P
- Commerford P
- Conrado Y
- Cools F
- Cornel Jh
- Corona V
- Coronel J
- Cosgrove N
- Cosgrove S
- Cosmi F
- Costa Amorim R
- Coufalova Z
- Covell W
- Cox B
- Cox R
- Craig W
- Crandall L
- Crawford G
- Crea F
- Crepps K
- Crocamo A
- Cromer M
- Cruz H
- Cruz H
- Cruz M
- Csala L
- Cucher F
- Cuentas I
- Cuervo A
- Curiac D
- Cymerman K
- Cyprian R
- Czerski T
- D'Amours Dg
- D Dash
- D Dattani
- D Denham
- D Desai
- D Desalle
- D Digangi
- D Dunn
- Da Costa F
- Da Silva A
- Da Silva D Jr
- Da Silva O Jr
- Dahlen G
- Dalseg Am
- Damron M
- Danik J
- Davalos C
- Dave B
- Dave K
- Davidsson K
- Davies M
- Davies N
- Davis B
- Davis M
- Dawkins-Hughes S
- Dawood Sy
- Dayer M
- De Boer P
- De Caterina R
- De Jong C
- De Knijf K
- De Krumbach L
- De Los Milagros Had M
- De Los Rios M
- De Rosa S
- De Vos A
- De Wolf L
- Dean J
- Debnam S
- Decsi K
- Decsi Kl
- Dedek V
- Dedkova S
- Defosse C
- Degennaro N
- Dehning M
- Dela Llana A
- Delfonso F
- Delforge M
- Delgadillo T
- Dellasa M
- Dellborg M
- Dellorso M
- Demidova M
- Den Hartog F
- Denecke C
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- Zielinski M
- Zieve F
- Zineldine A.
- Zirlik A
- Zucchetti C
- Publication venue
- 'Massachusetts Medical Society'
- Publication date
- 01/01/2017
- Field of study
Background: Experimental and clinical data suggest that reducing inflammation without affecting lipid levels may reduce the risk of cardiovascular disease. Yet, the inflammatory hypothesis of atherothrombosis has remained unproved. Methods: We conducted a randomized, double-blind trial of canakinumab, a therapeutic monoclonal antibody targeting interleukin-1ÎČ, involving 10,061 patients with previous myocardial infarction and a high-sensitivity C-reactive protein level of 2 mg or more per liter. The trial compared three doses of canakinumab (50 mg, 150 mg, and 300 mg, administered subcutaneously every 3 months) with placebo. The primary efficacy end point was nonfatal myocardial infarction, nonfatal stroke, or cardiovascular death. RESULTS: At 48 months, the median reduction from baseline in the high-sensitivity C-reactive protein level was 26 percentage points greater in the group that received the 50-mg dose of canakinumab, 37 percentage points greater in the 150-mg group, and 41 percentage points greater in the 300-mg group than in the placebo group. Canakinumab did not reduce lipid levels from baseline. At a median follow-up of 3.7 years, the incidence rate for the primary end point was 4.50 events per 100 person-years in the placebo group, 4.11 events per 100 person-years in the 50-mg group, 3.86 events per 100 person-years in the 150-mg group, and 3.90 events per 100 person-years in the 300-mg group. The hazard ratios as compared with placebo were as follows: in the 50-mg group, 0.93 (95% confidence interval [CI], 0.80 to 1.07; P = 0.30); in the 150-mg group, 0.85 (95% CI, 0.74 to 0.98; P = 0.021); and in the 300-mg group, 0.86 (95% CI, 0.75 to 0.99; P = 0.031). The 150-mg dose, but not the other doses, met the prespecified multiplicity-adjusted threshold for statistical significance for the primary end point and the secondary end point that additionally included hospitalization for unstable angina that led to urgent revascularization (hazard ratio vs. placebo, 0.83; 95% CI, 0.73 to 0.95; P = 0.005). Canakinumab was associated with a higher incidence of fatal infection than was placebo. There was no significant difference in all-cause mortality (hazard ratio for all canakinumab doses vs. placebo, 0.94; 95% CI, 0.83 to 1.06; P = 0.31). Conclusions: Antiinflammatory therapy targeting the interleukin-1ÎČ innate immunity pathway with canakinumab at a dose of 150 mg every 3 months led to a significantly lower rate of recurrent cardiovascular events than placebo, independent of lipid-level lowering. (Funded by Novartis; CANTOS ClinicalTrials.gov number, NCT01327846.
A922 Sequential measurement of 1 hour creatinine clearance (1-CRCL) in critically ill patients at risk of acute kidney injury (AKI)
- Author
- Abbott TE
- Abdallah RI
- Abdel-Aal IR
- Abdelmonem SA
- Abdo WF
- Abellan AN
- AbellĂĄn AN
- AbellĂĄn AN
- AbellĂĄn AN
- Abrams ST
- Ackerley C
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- Adhikari NK
- Adriano G
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- Affatato R
- Afonso-Rivero D
- Agarossi A
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- Ahn MY
- Aitken LM
- Akalaev R
- Akbarzadeh A
- Akcan-Arikan A
- Akhlagh SH
- Akhtar N
- AKI Research Group
- Akiduki N
- Akin S
- Akizuki N
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- Ala-Kokko T
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- El Sayed E
- El Sayed F
- El Sayed I
- El-Hamamsy M
- El-Keraie A
- Eladawy S
- Elbers PW
- Elgendy M
- Eliet J
- Emmanuel J
- Emmerich M
- Encina B
- Endacott R
- Endacott R
- Engelberts D
- ENVIN-HELICS Study Group
- Erb J
- Erdogan M
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- EscĂłrcio S
- Eslami S
- Espinasse F
- Espinel E
- Estagnasie P
- Esteban A
- Estella A
- Estenssoro E
- Evelein-Brugman S
- Facchin F
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- Fang M
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- Faulds MC
- Fave G
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- Feliot E
- Ferez MA
- Fernandes MJ
- Fernandes N
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- Fernandez R
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- Ferraz AB
- Ferrero-Calleja J
- Ferri F
- Ferry A
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- Fiks T
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- FilekoviÄ S
- Filho CA
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- FINNRESUSCI Study Group
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- Fleischmann E
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- Garnacho-Montero J
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- Garrouste M
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- Gasparovic V
- Gattinoni L
- Gaudard P
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- Japan Septic Disseminated Intravascular Coagulation (JSEPTIC DIC) study group
- Jardim JJ
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- JSEPTIC (Japanese Society of Education for Physicians and Trainees in Intensive Care) Clinical Trial Group
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- Karbing DS
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- Kasdan H
- Kashiya S
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- Katabami K
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- Katira BH
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- Kawano S
- Kay FU
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- Kayambu G
- Kazutoshi F
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- Khaliq W
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- Kirwan CJ
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- Kleinpell R
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- Komuro T
- Kondili E
- Kongpolprom N
- Kooner G
- Kostalas M
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- Kou PS
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- Kwon HM
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- Lissonde F
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- Llorente B
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- Lortat-Jacob B
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- Lukaszewicz AC
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- Macfarlane B
- MacKay A
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- Mackey G
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- Maekawa K
- Maekawa K
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- Maertens B
- Maggiorini M
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- Maistry N
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- Mezidi M
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- Okayama Research Investigation Organizing Network (ORION)investigators
- Olaechea P
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- Oto J
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- Wijayatilake DS
- Wildenberg L
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- Wilson ME
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- WIND study group
- Winder-Rhodes S
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- Yamazaki A
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- Yan WW
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- Yang YL
- Yasuda H
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- Yebenes JC
- Yeh YC
- Yemets H
- Yergaliyeva A
- Yılmaz G
- Yilmazer F
- Yodice P
- Yokoyama M
- Yonis H
- Yonis H
- Yonis H
- Yoon SZ
- Yoruk F
- Yoshida K
- Yoshida T
- Yoshida T
- Yoshida T
- Yoshida T
- Yoshihiro S
- Yoshitake E
- You KM
- Youn AM
- Young A
- Yu KM
- Yumoto T
- Yuzawa J
- Yuzawa J
- Zabaletta WJ
- Zabini D
- Zahorec M
- Zaien I
- Zakynthinos S
- Zanello M
- Zani D
- Zarantonello F
- Zayas B
- Zepeda EM
- Zeroual N
- Zerva L
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- Zhou JC
- Zhou JX
- Zhovnir V
- Zibandah N
- Zijlstra F
- Zimmerman J
- Zogheib E
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- Zogheib E
- Zullino V
- Zwaag J
- ZĂœkovĂĄ I
- Ălvarez JT
- Ălvarez-Lerma F
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2016
- Field of study
Meeting abstrac
Combination of searches for heavy spin-1 resonances using 139 fbâ1 of proton-proton collision data at s = 13 TeV with the ATLAS detector
- Author
- Aad G
- Aakvaag E
- Abbott B
- Abeling K
- Abicht NJ
- Abidi SH
- Aboelela M
- Aboulhorma A
- Abramowicz H
- Abreu H
- Abulaiti Y
- Acharya BS
- Ackermann A
- Adam Bourdarios C
- Adamczyk L
- Addepalli SV
- Addison MJ
- Adelman J
- Adiguzel A
- Adye T
- Affolder AA
- Afik Y
- Agaras MN
- Agarwala J
- Aggarwal A
- Agheorghiesei C
- Ahmad A
- Ahmadov F
- Ahmed WS
- Ahuja S
- Ai X
- Aielli G
- Aikot A
- Ait Tamlihat M
- Aitbenchikh B
- Aizenberg I
- Akbiyik M
- Akimov AV
- Akiyama D
- Akolkar NN
- Aktas S
- Al Khoury K
- Alberghi GL
- Albert J
- Albicocco P
- Albouy GL
- Alderweireldt S
- Alegria ZL
- Aleksa M
- Aleksandrov IN
- Alexa C
- Alexopoulos T
- Alfonsi F
- Algren M
- Alhroob M
- Ali B
- Ali HMJ
- Ali S
- Alibocus SW
- Aliev M
- Alimonti G
- Alkakhi W
- Allaire C
- Allbrooke BMM
- Allen JF
- Allendes Flores CA
- Allport PP
- Aloisio A
- Alonso F
- Alpigiani C
- Alvarez Estevez M
- Alvarez Fernandez A
- Alves Cardoso M
- Alviggi MG
- Aly M
- Amaral Coutinho Y
- Ambler A
- Amelung C
- Amerl M
- Ames CG
- Amidei D
- Amirie KJ
- Amor Dos Santos SP
- Amos KR
- An S
- Ananiev V
- Anastopoulos C
- Andeen T
- Anders JK
- Andrean SY
- Andreazza A
- Angelidakis S
- Angerami A
- Anisenkov AV
- Annovi A
- Antel C
- Anthony MT
- Antipov E
- Antonelli M
- Anulli F
- Aoki M
- Aoki T
- Aparisi Pozo JA
- Aparo MA
- Aperio Bella L
- Appelt C
- Apyan A
- Arbiol Val SJ
- Arcangeletti C
- Arce ATH
- Arena E
- Arguin J-F
- Argyropoulos S
- Arling J-H
- Arnaez O
- Arnold H
- Artoni G
- Asada H
- Asai K
- Asai S
- Asbah NA
- Assamagan K
- Astalos R
- Astrand KSV
- Atashi S
- Atkin RJ
- Atkinson M
- Atmani H
- Atmasiddha PA
- Augsten K
- Auricchio S
- Auriol AD
- Austrup VA
- Avolio G
- Axiotis K
- Azuelos G
- Babal D
- Bachacou H
- Bachas K
- Bachiu A
- Backman F
- Badea A
- Baer TM
- Bagnaia P
- Bahmani M
- Bahner D
- Bai K
- Bailey AJ
- Baines JT
- Baines L
- Baker OK
- Bakos E
- Bakshi Gupta D
- Balakrishnan V
- Balasubramanian R
- Baldin EM
- Balek P
- Ballabene E
- Balli F
- Baltes LM
- Balunas WK
- Balz J
- Banas E
- Bandieramonte M
- Bandyopadhyay A
- Bansal S
- Barak L
- Barakat M
- Barberio EL
- Barberis D
- Barbero M
- Barel MZ
- Barends KN
- Barillari T
- Barisits M-S
- Barklow T
- Baron Moreno DA
- Baron P
- Baroncelli A
- Barone G
- Barr AJ
- Barr JD
- Barreiro GuimarĂŁes da Costa J
- Barreiro F
- Barron U
- Barros Teixeira MG
- Barsov S
- Bartels F
- Bartoldus R
- Barton AE
- Bartos P
- Basan A
- Baselga M
- Bassalat A
- Basso MJ
- Bates RL
- Batlamous S
- Batool B
- Battaglia M
- Battulga D
- Bauce M
- Bauer M
- Bauer P
- Bazzano Hurrell LT
- Beacham JB
- Beau T
- Beaucamp JY
- Beauchemin PH
- Bechtle P
- Beck HP
- Becker K
- Beddall AJ
- Bednyakov VA
- Bee CP
- Beemster LJ
- Beermann TA
- Begalli M
- Begel M
- Behera A
- Behr JK
- Beirer JF
- Beisiegel F
- Belfkir M
- Bella G
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- Benchekroun D
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- Benhammou Y
- Benkendorfer KC
- Beresford L
- Beretta M
- Bergeaas Kuutmann E
- Berger N
- Bergmann B
- Beringer J
- Bernardi G
- Bernius C
- Bernlochner FU
- Bernon F
- Berrocal Guardia A
- Berry T
- Berta P
- Berthold A
- Bethke S
- Betti A
- Bevan AJ
- Bhalla NK
- Bhamjee M
- Bhatta S
- Bhattacharya DS
- Bhattarai P
- Bhide KD
- Bhopatkar VS
- Bianchi RM
- Bianco G
- Biebel O
- Bielski R
- Biglietti M
- Billingsley CS
- Bindi M
- Bingul A
- Bini C
- Biondini A
- Birch-sykes CJ
- Bird GA
- Birman M
- Biros M
- Biryukov S
- Bisanz T
- Bisceglie E
- Biswal JP
- Biswas D
- BjĂžrke K
- Bloch I
- Blue A
- Blumenschein U
- Blumenthal J
- Bobrovnikov VS
- Boehler M
- Boehm B
- Bogavac D
- Bogdanchikov AG
- Bohm C
- Boisvert V
- Bokan P
- Bold T
- Bomben M
- Bona M
- Boonekamp M
- Booth CD
- Borbély AG
- Bordulev IS
- Borecka-Bielska HM
- Borissov G
- Bortoletto D
- Boscherini D
- Bosman M
- Bossio Sola JD
- Bouaouda K
- Bouchhar N
- Boudreau J
- Bouhova-Thacker EV
- Boumediene D
- Bouquet R
- Boveia A
- Boyd J
- Boye D
- Boyko IR
- Bracinik J
- Brahimi N
- Brandt G
- Brandt O
- Braren F
- Brau B
- Brau JE
- Brener R
- Brenner L
- Brenner R
- Bressler S
- Britton D
- Britzger D
- Brock I
- Brooijmans G
- Brost E
- Brown LM
- Bruce LE
- Bruckler TL
- Bruckman de Renstrom PA
- Bruni A
- Bruni G
- Bruschi M
- Bruscino N
- BrĂŒers B
- Buanes T
- Buat Q
- Buchin D
- Buckley AG
- Bulekov O
- Bullard BA
- Burdin S
- Burgard CD
- Burger AM
- Burghgrave B
- Burlayenko O
- Burr JTP
- Burton CD
- Burzynski JC
- Busch EL
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- Wilson BJ
- Windischhofer PJ
- Winkel FI
- Winklmeier F
- Winter BT
- Winter JK
- Wittgen M
- Wobisch M
- Wolffs Z
- Wollrath J
- Wolter MW
- Wolters H
- Wong MC
- Woodward EL
- Worm SD
- Wosiek BK
- Wozniewski S
- WoĆșniak KW
- Wraight K
- Wu C
- Wu M
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- Wu SL
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- Wuerzinger J
- Wyatt TR
- Wynne BM
- Xella S
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- Xiang J
- Xie M
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- Xiong A
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- Xu D
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- Yabsley B
- Yacoob S
- Yamaguchi Y
- Yamashita E
- Yamauchi H
- Yamazaki T
- Yamazaki Y
- Yan J
- Yan S
- Yan Z
- Yang HJ
- Yang HT
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- Yang X
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- Yang Y
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- Yang Z
- Yao W-M
- Ye H
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- Ye J
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- Yeh Y
- Yeletskikh I
- Yeo BK
- Yexley MR
- Yin P
- Yorita K
- Younas S
- Young C
- Young CJS
- Yu C
- Yu Y
- Yuan M
- Yuan R
- Yue L
- Zaazoua M
- Zabinski B
- Zaid E
- Zak ZK
- Zakareishvili T
- Zakharchuk N
- Zambito S
- Zamora Saa JA
- Zang J
- Zanzi D
- Zaplatilek O
- Zeitnitz C
- Zeng H
- Zeng JC
- Zenger DT
- Zenin O
- Zenz S
- Zerradi S
- Zerwas D
- Zhai M
- Zhang DF
- Zhang J
- Zhang J
- Zhang K
- Zhang L
- Zhang L
- Zhang P
- Zhang R
- Zhang S
- Zhang S
- Zhang T
- Zhang X
- Zhang X
- Zhang Y
- Zhang Y
- Zhang Y
- Zhang Z
- Zhang Z
- Zhao H
- Zhao T
- Zhao Y
- Zhao Z
- Zhao Z
- Zhemchugov A
- Zheng J
- Zheng K
- Zheng X
- Zheng Z
- Zhong D
- Zhou B
- Zhou H
- Zhou N
- Zhou Y
- Zhou Y
- Zhu CG
- Zhu J
- Zhu Y
- Zhu Y
- Zhuang X
- Zhukov K
- Zimine NI
- Zinsser J
- Ziolkowski M
- Zoccoli A
- Zoch K
- Zorbas TG
- Zormpa O
- Zou W
- Zwalinski L
- Ă kesson TPA
- Ăncel ĂO
- ĆœeniĆĄ T
- ĆœivkoviÄ L
- Publication venue
- Springer Nature
- Publication date
- 19/04/2024
- Field of study
A combination of searches for new heavy spin-1 resonances decaying into different pairings of W, Z, or Higgs bosons, as well as directly into leptons or quarks, is presented. The data sample used corresponds to 139 fbâ1 of proton-proton collisions at
= 13 TeV collected during 2015â2018 with the ATLAS detector at the CERN Large Hadron Collider. Analyses selecting quark pairs (qq, bb,
, and tb) or third-generation leptons (ÏÎœ and ÏÏ) are included in this kind of combination for the first time. A simplified model predicting a spin-1 heavy vector-boson triplet is used. Cross-section limits are set at the 95% confidence level and are compared with predictions for the benchmark model. These limits are also expressed in terms of constraints on couplings of the heavy vector-boson triplet to quarks, leptons, and the Higgs boson. The complementarity of the various analyses increases the sensitivity to new physics, and the resulting constraints are stronger than those from any individual analysis considered. The data exclude a heavy vector-boson triplet with mass below 5.8 TeV in a weakly coupled scenario, below 4.4 TeV in a strongly coupled scenario, and up to 1.5 TeV in the case of production via vector-boson fusion
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