OBJETOS DE APRENDIZAGEM E SCORM

Apresentar os conceitos relacionados ao projeto, desenvolvimento e empacotamento de objetos de aprendizagem em conformidade com o padrão SCORM (Sharable Content Object Reference Model) e ferramentas para criação e empacotamento de objetos nesse padrão

CESTA - coletânea de entidades de suporte ao uso de tecnologia na aprendizagem

A tecnologia de informática e comunicação atualmente permite criar material didático usando multimídia com interatividade que tornam mais efetivos os ambientes de ensino-aprendizagem apoiados nas TICs. Todavia o projeto e desenvolvimento deste tipo de material de apoio demanda muito esforço, mesmo considerando- o uso de linguagens de autoração. Isto ensejou o desenvolvimento da estratégia de orientar sua construção na metodologia orientada a objetos. Os recursos educacionais construídos segundo esta estrágeia foram denominados objetos educacionais (learning objects) e organismos de padronização como o IEEE ( 1484.12.1-2002 IEEE Standard for Learning Object Metadata ) e ISO (SC 36 WG 2 - Information Technology for Learning, Education, and Training) tem grupos trabalhando na elaboração de propostas para sua estruturação e categorização (metadados) de modo a alcançar acessibilidade, interoperabilidade durabilidade e reusabilidade dos recursos educacionais construídos. Este trabalho pretende apresentar os resultados alcançados numa fase preliminar de criação de um repositórios de objetos educacionais reusáveis, a estrutura de metadados criada para sua categorização e o ambiente de implementação do sistema de cadastramento dos objetos educacionais, o qual usa um servidor de diretório baseado no padrão LDAP (Lightweight Directory Access Protocol).Eje: III - Workshop de tecnología informática aplicada en educaciónRed de Universidades con Carreras en Informática (RedUNCI

CESTA - coletânea de entidades de suporte ao uso de tecnologia na aprendizagem

A tecnologia de informática e comunicação atualmente permite criar material didático usando multimídia com interatividade que tornam mais efetivos os ambientes de ensino-aprendizagem apoiados nas TICs. Todavia o projeto e desenvolvimento deste tipo de material de apoio demanda muito esforço, mesmo considerando- o uso de linguagens de autoração. Isto ensejou o desenvolvimento da estratégia de orientar sua construção na metodologia orientada a objetos. Os recursos educacionais construídos segundo esta estrágeia foram denominados objetos educacionais (learning objects) e organismos de padronização como o IEEE ( 1484.12.1-2002 IEEE Standard for Learning Object Metadata ) e ISO (SC 36 WG 2 - Information Technology for Learning, Education, and Training) tem grupos trabalhando na elaboração de propostas para sua estruturação e categorização (metadados) de modo a alcançar acessibilidade, interoperabilidade durabilidade e reusabilidade dos recursos educacionais construídos. Este trabalho pretende apresentar os resultados alcançados numa fase preliminar de criação de um repositórios de objetos educacionais reusáveis, a estrutura de metadados criada para sua categorização e o ambiente de implementação do sistema de cadastramento dos objetos educacionais, o qual usa um servidor de diretório baseado no padrão LDAP (Lightweight Directory Access Protocol).Eje: III - Workshop de tecnología informática aplicada en educaciónRed de Universidades con Carreras en Informática (RedUNCI

Concerns about the widespread use of rodent models for human risk assessments of endocrine disruptors.

International audienceFetal testis is a major target of endocrine disruptors (EDs). During the last 20 years, we have developed an organotypic culture system that maintains the function of the different fetal testis cell types and have used this approach as a toxicological test to evaluate the effects of various compounds on gametogenesis and steroidogenesis in rat, mouse and human testes. We named this test rat, mouse and human fetal testis assay. With this approach, we compared the effects of six potential EDs ((mono-(2-ethylhexyl) phthalate (MEHP), cadmium, depleted uranium, diethylstilboestrol (DES), bisphenol A (BPA) and metformin) and one signalling molecule (retinoic acid (RA)) on the function of rat, mouse and human fetal testis at a comparable developmental stage. We found that the response is similar in humans and rodents for only one third of our analyses. For instance, RA and MEHP have similar negative effects on gametogenesis in the three species. For another third of our analyses, the threshold efficient concentrations that disturb gametogenesis and/or steroidogenesis differ as a function of the species. For instance, BPA and metformin have similar negative effects on steroidogenesis in human and rodents, but at different threshold doses. For the last third of our analyses, the qualitative response is species specific. For instance, MEHP and DES affect steroidogenesis in rodents, but not in human fetal testis. These species differences raise concerns about the extrapolation of data obtained in rodents to human health risk assessment and highlight the need of rigorous comparisons of the effects in human and rodent models, when assessing ED risk

Efficacy of the Janus kinase 1/2 inhibitor ruxolitinib in the treatment of vasculopathy associated with TMEM173-activating mutations in 3 children

International audienc

Profiling the landscape of transcription, chromatin accessibility and chromosome conformation of cattle, pig, chicken and goat genomes [FAANG pilot project]

Functional annotation of livestock genomes is a critical and obvious next step to derive maximum benefit for agriculture, animal science, animal welfare and human health. The aim of the Fr-AgENCODE project is to generate multi-species functional genome annotations by applying high-throughput molecular assays on three target tissues/cells relevant to the study of immune and metabolic traits. An extensive collection of stored samples from other tissues is available for further use (FAANG Biosamples ‘FR-AGENCODE’). From each of two males and two females per species (pig, cattle, goat, chicken), strand-oriented RNA-seq and chromatin accessibility ATAC-seq assays were performed on liver tissue and on two T-cell types (CD3+CD4+&CD3+CD8+) sorted from blood (mammals) or spleen (chicken). Chromosome Conformation Capture (in situ Hi-C) was also carried out on liver. Sequencing reads from the 3 assays were processed using standard processing pipelines. While most (50–70%) RNA-seq reads mapped to annotated exons, thousands of novel transcripts and genes were found, including extensions of annotated protein-coding genes and new lncRNAs (see abstract #69857). Consistency of ATAC-seq results was confirmed by the significant proportion of called peaks in promoter regions (36–66%) and by the specific accumulation pattern of peaks around gene starts (TSS) v. gene ends (TTS). Principal Component Analyses for RNA-seq (based on quantified gene expression) and ATAC-seq (based on quantified chromatin accessibility) highlighted clusters characterised by cell type and sex in all species. From Hi-C data, we generated 40kb-resolution interaction maps, profiled a genome-wide Directionality Index and identified from 4,100 (chicken) to 12,100 (pig) topologically-associating do- mains (TADs). Correlations were reported between RNA-seq and ATAC-seq results (see abstract #71581). In summary, we present here an overview of the first multi-species and -tissue annotations of chromatin accessibility and genome architecture related to gene expression for farm animals

Développer la médiation documentaire numérique

Depuis quelques années, les bibliothèques investissent fortement l'Internet : catalogues en ligne, sites Web devenant peu à peu des portails de services, blogs et réseaux sociaux. Si l'objectif est bien d'être présent dans l'univers numérique des usagers existants ou potentiels, les bibliothèques, aussi bien universitaires que de lecture publique, doivent garder leur spécificité sous peine d'être noyées dans le flot général. L'un des axes de travail pour ce faire est de transposer en ligne la médiation documentaire, c'est-à-dire repenser pour l'Internet tous les moyens à mettre en œuvre pour favoriser la rencontre d'un lecteur avec les documents susceptibles de l'intéresser ou de lui ouvrir de nouveaux horizons. L'ouvrage traite de ce nouvel enjeu en proposant d'une part, un cadre général sur la médiation documentaire numérique (quelle politique documentaire favoriser ? Comment scénariser son catalogue, médiatiser un fonds patrimonial ou de jeux vidéo ? Comment définir son projet et accompagner les équipes ?) et d'autre part, des exemples concrets destinés à servir d'inspiration pour améliorer ou se lancer dans ce continent en pleine construction (quels contenus produire ? Quels outils utiliser ? Comment rédiger un billet de blog, un article de magazine en ligne, des coups de cœurs 2.0 ?). Coordonné par Xavier Galaup, directeur-adjoint de la médiathèque départementale du Haut-Rhin, ce volume collectif, qui réunit des auteurs d'horizons divers (universitaire, bibliothécaire et libraire), s'adresse à tous les acteurs des domaines de la culture et de l'éducation

Hepatic Stem-like Phenotype and Interplay of Wnt/β-Catenin and Myc Signaling in Aggressive Childhood Liver Cancer

SummaryHepatoblastoma, the most common pediatric liver cancer, is tightly linked to excessive Wnt/β-catenin signaling. Here, we used microarray analysis to identify two tumor subclasses resembling distinct phases of liver development and a discriminating 16-gene signature. β-catenin activated different transcriptional programs in the two tumor types, with distinctive expression of hepatic stem/progenitor markers in immature tumors. This highly proliferating subclass was typified by gains of chromosomes 8q and 2p and upregulated Myc signaling. Myc-induced hepatoblastoma-like tumors in mice strikingly resembled the human immature subtype, and Myc downregulation in hepatoblastoma cells impaired tumorigenesis in vivo. Remarkably, the 16-gene signature discriminated invasive and metastatic hepatoblastomas and predicted prognosis with high accuracy

COVID-19 symptoms at hospital admission vary with age and sex: results from the ISARIC prospective multinational observational study

Background: The ISARIC prospective multinational observational study is the largest cohort of hospitalized patients with COVID-19. We present relationships of age, sex, and nationality to presenting symptoms. Methods: International, prospective observational study of 60 109 hospitalized symptomatic patients with laboratory-confirmed COVID-19 recruited from 43 countries between 30 January and 3 August 2020. Logistic regression was performed to evaluate relationships of age and sex to published COVID-19 case definitions and the most commonly reported symptoms. Results: ‘Typical’ symptoms of fever (69%), cough (68%) and shortness of breath (66%) were the most commonly reported. 92% of patients experienced at least one of these. Prevalence of typical symptoms was greatest in 30- to 60-year-olds (respectively 80, 79, 69%; at least one 95%). They were reported less frequently in children (≤ 18 years: 69, 48, 23; 85%), older adults (≥ 70 years: 61, 62, 65; 90%), and women (66, 66, 64; 90%; vs. men 71, 70, 67; 93%, each P < 0.001). The most common atypical presentations under 60 years of age were nausea and vomiting and abdominal pain, and over 60 years was confusion. Regression models showed significant differences in symptoms with sex, age and country. Interpretation: This international collaboration has allowed us to report reliable symptom data from the largest cohort of patients admitted to hospital with COVID-19. Adults over 60 and children admitted to hospital with COVID-19 are less likely to present with typical symptoms. Nausea and vomiting are common atypical presentations under 30 years. Confusion is a frequent atypical presentation of COVID-19 in adults over 60 years. Women are less likely to experience typical symptoms than men

Pour une reproduction durable

Communiqué de presse Les artifices de la reproductionabsen