Late Quaternary palaeohydrology of Lake Huinaymarca (Bolivia)

L'analyse des associations d'ostracodes présents dans les échantillons prélevés dans les sédiments du lac Huinaymarca permet de retracer l'évolution hydrobiologique du lac (variation du niveau lacustre, variation de l'oxygénation par rapport à la position de la thermocline, interconnections avec les différents bassins du lac) au cours des dix derniers millénaire

Growth Route Toward III-V Multispectral Solar Cells on Silicon

To date, high efficiency multijunction solar cells have been developed on Ge or GaAs substrates for space applications, and terrestrial applications are hampered by high fabrication costs. In order to reduce this cost, we propose a breakthrough technique of III-V compound heteroepitaxy on Si substrates without generation of defects critical to PV applications. With this technique we expect to achieve perfect integration of heterogeneous Ga1-xInxAs micro-crystals on Si substrates. In this paper, we show that this is the case for x=0. GaAs crystals were grown by Epitaxial Lateral Overgrowth on Si (100) wafers covered with a thin SiO2 nanostructured layer. The cristallographic structure of these crystals is analysed by MEB and TEM imaging. Micro-Raman and Micro-Photomuminescence spectra of GaAs crystals grown with different conditions are compared with those of a reference GaAs wafer in order to have more insight on eventual local strains and their cristallinity. This work aims at developping building blocks to further develop a GaAs/Si tandem demonstrator with a potential conversion efficiency of 29.6% under AM1.5G spectrum without concentration, as inferred from our realistic modeling. This paper shows that Epitaxial Lateral Overgrowth has a very interesting potential to develop multijunction solar cells on silicon approaching the today 30.3% world record of a GaInP/GaAs tandem cell under the same illumination conditions, but on a costlier substrate than silicon.Comment: Preprint of the 28th EUPVSEC proceedings, September 2013, Paris, France. (5 pages

La dernière transition glaciaire/interglaciaire des Andes tropicales sud (Bolivie) d'après l'étude des variations des niveaux lacustres et des fluctuations glaciaires

Une comparaison entre les variations des niveaux lacustres dans le bassin de Uyuni-Coipasa et les fluctuations glaciaires dans la Cordillère Orientale montre que les lacs et les glaciers ont simultanément enregistré les changements des précipitations. Un intense maximum lacustre (environ 13-12 14C ka BP) a eu lieu aux latitudes tropicales sud de la Bolivie, 4 000 à 6 000 ans avant le maximum lacustre de l'Afrique nord-équatoriale. (Résumé d'auteur

Interaction-Induced Magnetization of the Two-Dimensional Electron Gas

We consider the contribution of electron-electron interactions to the orbital magnetization of a two-dimensional electron gas, focusing on the ballistic limit in the regime of negligible Landau-level spacing. This regime can be described by combining diagrammatic perturbation theory with semiclassical techniques. At sufficiently low temperatures, the interaction-induced magnetization overwhelms the Landau and Pauli contributions. Curiously, the interaction-induced magnetization is third-order in the (renormalized) Coulomb interaction. We give a simple interpretation of this effect in terms of classical paths using a renormalization argument: a polygon must have at least three sides in order to enclose area. To leading order in the renormalized interaction, the renormalization argument gives exactly the same result as the full treatment.Comment: 11 pages including 4 ps figures; uses revtex and epsf.st

Entanglement between Demand and Supply in Markets with Bandwagon Goods

Whenever customers' choices (e.g. to buy or not a given good) depend on others choices (cases coined 'positive externalities' or 'bandwagon effect' in the economic literature), the demand may be multiply valued: for a same posted price, there is either a small number of buyers, or a large one -- in which case one says that the customers coordinate. This leads to a dilemma for the seller: should he sell at a high price, targeting a small number of buyers, or at low price targeting a large number of buyers? In this paper we show that the interaction between demand and supply is even more complex than expected, leading to what we call the curse of coordination: the pricing strategy for the seller which aimed at maximizing his profit corresponds to posting a price which, not only assumes that the customers will coordinate, but also lies very near the critical price value at which such high demand no more exists. This is obtained by the detailed mathematical analysis of a particular model formally related to the Random Field Ising Model and to a model introduced in social sciences by T C Schelling in the 70's.Comment: Updated version, accepted for publication, Journal of Statistical Physics, online Dec 201

Freezing transitions and the density of states of 2D random Dirac Hamiltonians

Using an exact mapping to disordered Coulomb gases, we introduce a novel method to study two dimensional Dirac fermions with quenched disorder in two dimensions which allows to treat non perturbative freezing phenomena. For purely random gauge disorder it is known that the exact zero energy eigenstate exhibits a freezing-like transition at a threshold value of disorder $\sigma=\sigma_{th}=2$. Here we compute the dynamical exponent $z$ which characterizes the critical behaviour of the density of states around zero energy, and find that it also exhibits a phase transition. Specifically, we find that $\rho(E=0 + i \epsilon) \sim \epsilon^{2/z-1}$ (and $\rho(E) \sim E^{2/z-1}$) with $z=1 + \sigma$ for $\sigma < 2$ and $z=\sqrt{8 \sigma} - 1$ for $\sigma > 2$. For a finite system size $L<\epsilon^{-1/z}$ we find large sample to sample fluctuations with a typical $\rho_{\epsilon}(0) \sim L^{z-2}$. Adding a scalar random potential of small variance $\delta$, as in the corresponding quantum Hall system, yields a finite noncritical $\rho(0) \sim \delta^{\alpha}$ whose scaling exponent $\alpha$ exhibits two transitions, one at $\sigma_{th}/4$ and the other at $\sigma_{th}$. These transitions are shown to be related to the one of a directed polymer on a Cayley tree with random signs (or complex) Boltzmann weights. Some observations are made for the strong disorder regime relevant to describe transport in the quantum Hall system

Sequential versus combination chemotherapy for the treatment of advanced colorectal cancer (FFCD 2000-05): an open-label, randomised, phase 3 trial

BACKGROUND: The optimum use of cytotoxic drugs for advanced colorectal cancer has not been defined. Our aim was to investigate whether combination treatment is better than the sequential administration of the same drugs in patients with advanced colorectal cancer. METHODS: In this open-label, randomised, phase 3 trial, we randomly assigned patients (1:1 ratio) with advanced, measurable, non-resectable colorectal cancer and WHO performance status 0-2 to receive either first-line treatment with bolus (400 mg/m(2)) and infusional (2400 mg/m(2)) fluorouracil plus leucovorin (400 mg/m(2)) (simplified LV5FU2 regimen), second-line LV5FU2 plus oxaliplatin (100 mg/m(2)) (FOLFOX6), and third-line LV5FU2 plus irinotecan (180 mg/m(2)) (FOLFIRI) or first-line FOLFOX6 and second-line FOLFIRI. Chemotherapy was administered every 2 weeks. Randomisation was done centrally using minimisation (minimisation factors were WHO performance status, previous adjuvant chemotherapy, number of disease sites, and centre). The primary endpoint was progression-free survival after two lines of treatment. Analyses were by intention-to-treat. This trial is registered at ClinicalTrials.gov, NCT00126256. FINDINGS: 205 patients were randomly assigned to the sequential group and 205 to the combination group. 161 (79%) patients in the sequential group and 161 (79%) in the combination group died during the study. Median progression-free survival after two lines was 10·5 months (95% CI 9·6-11·5) in the sequential group and 10·3 months (9·0-11·9) in the combination group (hazard ratio 0·95, 95% CI 0·77-1·16; p=0·61). All six deaths caused by toxic effects of treatment occurred in the combination group. During first-line chemotherapy, significantly fewer severe (grade 3-4) haematological adverse events (12 events in 203 patients in sequential group vs 83 events in 203 patients in combination group; p&lt;0·0001) and non-haematological adverse events (26 events vs 186 events; p&lt;0·0001) occurred in the sequential group than in the combination group. INTERPRETATION: Upfront combination chemotherapy is more toxic and is not more effective than the sequential use of the same cytotoxic drugs in patients with advanced, non-resectable colorectal cancer. FUNDING: Sanofi-Aventis France

European Organization for Research and Treatment of Cancer (EORTC) open label phase II study on glufosfamide administered as a 60-minute infusion every 3 weeks in recurrent glioblastoma multiforme

BACKGROUND: Glufosfamide is a new alkylating agent in which the active metabolite of isophosphoramide mustard is covalently linked to beta-D-glucose to target the glucose transporter system and increase intracellular uptake in tumor cells. We investigated this drug in a multicenter prospective phase II trial in recurrent glioblastoma multiforme (GBM). PATIENTS AND METHODS: Eligible patients had recurrent GBM following surgery, radiotherapy and no more than one prior line of chemotherapy. Patients were treated with glufosfamide 5000 mg/m(2) administered as a 1-h intravenous infusion. Treatment success was defined as patients with either an objective response according to Macdonald's criteria or 6 months progression-free survival. Toxicity was assessed with the Common Toxicity Criteria (CTC) version 2.0. RESULTS: Thirty-one eligible patients were included. Toxicity was modest, the main clinically relevant toxicities being leukopenia (CTC grade >3 in five patients) and hepatotoxicity (in three patients). No responses were observed; one patient (3%; 95% confidence interval 0 to 17%) was free from progression at 6 months. Pharmacokinetic analysis showed a 15% decrease in area under the curve and glufosfamide clearance in patients treated with enzyme-inducing antiepileptic drugs, but no effect of these drugs on maximum concentration and plasma half-life. CONCLUSION: Glufosfamide did not show significant clinical antitumor activity in patients with recurrent GBM

Global Search for New Physics with 2.0/fb at CDF

Data collected in Run II of the Fermilab Tevatron are searched for indications of new electroweak-scale physics. Rather than focusing on particular new physics scenarios, CDF data are analyzed for discrepancies with the standard model prediction. A model-independent approach (Vista) considers gross features of the data, and is sensitive to new large cross-section physics. Further sensitivity to new physics is provided by two additional algorithms: a Bump Hunter searches invariant mass distributions for "bumps" that could indicate resonant production of new particles; and the Sleuth procedure scans for data excesses at large summed transverse momentum. This combined global search for new physics in 2.0/fb of ppbar collisions at sqrt(s)=1.96 TeV reveals no indication of physics beyond the standard model.Comment: 8 pages, 7 figures. Final version which appeared in Physical Review D Rapid Communication