Oops I Did It Again: Preventing Medication Errors Using BCMA

This is literature review of current studies to answer the question “What effect does the use of electronic scanners have on medication administration errors in hospitalized patients as compared to manual MAR methods?” Current evidence shows that errors in the medication administration step pose to be the most problematic of the entire medication process in hospital settings. It is also known that less than 2% of medication errors are intercepted and corrected at the bedside. Traditional medication administration records (MAR) using pen and paper have dominated the hospital setting for the past several decades but could be largely responsible for the majority of medication errors. With the increasing use of technology, a bar code medication administration (BCMA) system has been implemented to overcome this common problem. Seven research studies were examined to determine whether an implemented BCMA system into hospital settings continuously proves to lower medication administration errors. Not only has BCMA shown to lower medication administration errors, but it has also shown to decrease turn-around time to process medication doses in the pharmacy as well as increase accuracy of patient identification, inventory, and staffing of nurses and pharmacists. Abandonment of traditional MAR systems and implementation of BCMA systems in hospital settings increases patient safety and saves money. Keywords: medication administration, bar code scanning, technology, prevention, and erro

NASA/Goddard Thermal Technology Overview 2014

This presentation summarizes the current plans and efforts at NASA Goddard to develop new thermal control technology for anticipated future missions. It will also address some of the programmatic developments currently underway at NASA, especially with respect to the Technology Development Program at NASA. While funding for basic technology development is still scarce, significant efforts are being made in direct support of flight programs. New technology development continues to be driven by the needs of future missions, and applications of these technologies to current Goddard programs will be addressed. Many of these technologies also have broad applicability to DOD, DOE, and commercial programs. Partnerships have been developed with the Air Force, Navy, and various universities to promote technology development. In addition, technology development activities supported by internal research and development (IRAD) program, the Small Business Innovative Research (SBIR) program, and the NASA Engineering and Safety Center (NESC), are reviewed in this presentation. Specific technologies addressed include; two-phase systems applications and issues on NASA missions, latest developments of electro-hydrodynamically pumped systems, development of high electrical conductivity coatings, and various other research activities. New Technology program underway at NASA, although funding is limited center dot NASA/GSFC's primary mission of science satellite development is healthy and vibrant, although new missions are scarce - now have people on overhead working new missions and proposals center dot Future mission applications promise to be thermally challenging center dot Direct technology funding is still very restricted - Projects are the best source for direct application of technology - SBIR thermal subtopic resurrected in FY 14 - Limited Technology development underway via IRAD, NESC, other sources - Administrator pushing to revive technology and educational programs at NASA - new HQ directorate establishe

The High-Mass End of the Red Sequence at z~0.55 from SDSS-III/BOSS: completeness, bimodality and luminosity function

We have developed an analytical method based on forward-modeling techniques to characterize the high-mass end of the red sequence (RS) galaxy population at redshift $z\sim0.55$, from the DR10 BOSS CMASS spectroscopic sample, which comprises $\sim600,000$ galaxies. The method, which follows an unbinned maximum likelihood approach, allows the deconvolution of the intrinsic CMASS colour-colour-magnitude distributions from photometric errors and selection effects. This procedure requires modeling the covariance matrix for the i-band magnitude, g-r colour and r-i colour using Stripe 82 multi-epoch data. Our results indicate that the error-deconvolved intrinsic RS distribution is consistent, within the photometric uncertainties, with a single point ($<0.05~{\rm{mag}}$) in the colour-colour plane at fixed magnitude, for a narrow redshift slice. We have computed the high-mass end ($^{0.55}M_i \lesssim -22$) of the $^{0.55}i$-band RS Luminosity Function (RS LF) in several redshift slices within the redshift range $0.52<z<0.63$. In this narrow redshift range, the evolution of the RS LF is consistent, within the uncertainties in the modeling, with a passively-evolving model with $\Phi_* = (7.248 \pm 0.204) \times10^{-4}$ Mpc$^{-3}$ mag$^{-1}$, fading at a rate of $1.5\pm0.4$ mag per unit redshift. We report RS completeness as a function of magnitude and redshift in the CMASS sample, which will facilitate a variety of galaxy-evolution and clustering studies using BOSS. Our forward-modeling method lays the foundations for future studies using other dark-energy surveys like eBOSS or DESI, which are affected by the same type of photometric blurring/selection effects.Comment: 27 pages, 20 figures, accepted for publication in MNRA

Combinations of Griffithsin with Other Carbohydrate-Binding Agents Demonstrate Superior Activity Against HIV Type 1, HIV Type 2, and Selected Carbohydrate-Binding Agent-Resistant HIV Type 1 Strains

Abstract Carbohydrate-binding agents (CBAs) are potential HIV microbicidal agents with a high genetic barrier to resistance. We wanted to evaluate whether two mannose-specific CBAs, recognizing multiple and often distinct glycan structures on the HIV envelope gp120, can interact synergistically against HIV-1, HIV-2, and HIV-1 strains that were selected for resistance against particular CBAs [i.e., 2G12 mAb and microvirin (MVN)]. Paired CBA/CBA combinations mainly showed synergistic activity against both wild-type HIV-1 and HIV-2 but also 2G12 mAb- and MVN-resistant HIV-1 strains as based on the median effect principle with combination indices (CIs) ranging between 0.29 and 0.97. Upon combination, an increase in antiviral potency of griffithsin (GRFT) up to ?12-fold (against HIV-1), ?8-fold (against HIV-2), and ?6-fold (against CBA-resistant HIV-1) was observed. In contrast, HHA/GNA combinations showed additive activity against wild-type HIV-1 and HIV-2 strains, but remarkable synergy with HHA and GNA was observed against 2G12 mAb- and MVN-resistant HIV-1 strains (CI, 0.64 and 0.49, respectively). Overall, combinations of GRFT and other CBAs showed synergistic activity against HIV-1, HIV-2, and even against certain CBA-resistant HIV-1 strains. The CBAs tested appear to have distinct binding patterns on the gp120 envelope and therefore do not necessarily compete with each other's glycan binding sites on gp120. As a result, there might be no steric hindrance between two different CBAs in their competition for glycan binding (except for the HHA/GNA combination). These data are encouraging for the use of paired CBA combinations in topical microbicide applications (e.g., creams, gels, or intravaginal rings) to prevent HIV transmission.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/98459/1/aid%2E2012%2E0026.pd

Stratigraphy and geochronology of the Tambien Group, Ethiopia: evidence for globally synchronous carbon isotope change in the Neoproterozoic

The Neoproterozoic Era was an interval characterized by profound environmental and biological transitions. Existing age models for Neoproterozoic nonglacial intervals largely have been based on correlation of carbonate carbon isotope values, but there are few tests of the assumed synchroneity of these records between basins. In contrast to the ash-poor successions typically targeted for Neoproterozoic chemostratigraphy, the Tonian to Cryogenian Tambien Group (Tigray region, Ethiopia) was deposited in an arc-proximal basin where volcanic tuffs suitable for U-Pb geochronology are preserved within the mixed carbonate-siliciclastic sedimentary succession. The Tambien Group culminates in a diamictite interpreted to correlate to the ca. 717–662 Ma Sturtian snowball Earth glaciation. New physical stratigraphic data and high-precision U-Pb dates from intercalated tuffs lead to a new stratigraphic framework for the Tambien Group that confirms identification of negative δ13C values from Assem Formation limestones with the ca. 800 Ma Bitter Springs carbon isotope stage. Integration with data from the Fifteenmile Group of northwestern Canada constitutes a positive test for the global synchroneity of the Bitter Spring Stage and constrains the stage to have started after 811.51 ± 0.25 Ma and to have ended before 788.72 ± 0.24 Ma. These new temporal constraints strengthen the case for interpreting Neoproterozoic carbon isotope variation as a record of large-scale changes to the carbon cycle and provide a framework for age models of paleogeographic change, geochemical cycling, and environmental evolution during the radiation of early eukaryotes

Loss of Potential Aquatic-Terrestrial Subsidies Along the Missouri River Floodplain

The floodplains of large rivers have been heavily modified due to riparian development and channel modifications, both of which can eliminate shallow off-channel habitats. The importance of these habitats for aquatic organisms like fishes is well studied. However, loss of off-channel habitat also eliminates habitats for the production of emerging aquatic insects, which subsidize riparian consumers in terrestrial food webs. We used field collections of insect emergence, historical mapping, and statistical modeling to estimate the loss of insect emergence due to channel modifications along eight segments of the Missouri River (USA), encompassing 1566 river km, between 1890 and 2012. We estimate annual production of emerging aquatic insects declined by a median of 36,000 kgC (95% CrI: 3000 to 450,000) between 1890 and 2012 (a 34% loss), due to the loss of surface area in backwaters and related off-channel habitats. Under a conservative assumption that riparian birds obtain 24% of their annual energy budget from adult aquatic insects, this amount of insect loss would be enough to subsidize approximately 790,000 riparan woodland birds during the breeding and nesting period (May to August; 95% CrI: 57,000 to 10,000,000). Most of the loss is concentrated in the lower reaches of the Missouri River, which historically had a wide floodplain, a meandering channel, and a high density of off-channel habitats, but which were substantially reduced due to channelization and bank stabilization. Our results indicate that the loss of off-channel habitats in large river floodplains has the potential to substantially affect energy availability for riparian insectivores, further demonstrating the importance of maintaining and restoring these habitats for linked aquatic-terrestrial ecosystems

Relayed nuclear Overhauser enhancement sensitivity to membrane Cho phospholipids

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/155956/1/mrm28258_am.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/155956/2/mrm28258.pd

Portuguese Native Language Identification

This study presents the first Native Language Identification (NLI) study for L2 Portuguese.We used a sub-set of the NLI-PT dataset, containing texts written by speakers of five different native languages: Chinese, English, German, Italian, and Spanish.We explore the linguistic annotations available in NLI-PT to extract a range of (morpho-)syntactic features and apply NLI classification methods to predict the native language of the authors. The best results were obtained using an ensemble combination of the features, achieving 54:1% accuracy.info:eu-repo/semantics/publishedVersio

Patient-Specific Metrics of Invasiveness Reveal Significant Prognostic Benefit of Resection in a Predictable Subset of Gliomas

Object Malignant gliomas are incurable, primary brain neoplasms noted for their potential to extensively invade brain parenchyma. Current methods of clinical imaging do not elucidate the full extent of brain invasion, making it difficult to predict which, if any, patients are likely to benefit from gross total resection. Our goal was to apply a mathematical modeling approach to estimate the overall tumor invasiveness on a patient-by-patient basis and determine whether gross total resection would improve survival in patients with relatively less invasive gliomas. Methods In 243 patients presenting with contrast-enhancing gliomas, estimates of the relative invasiveness of each patient's tumor, in terms of the ratio of net proliferation rate of the glioma cells to their net dispersal rate, were derived by applying a patient-specific mathematical model to routine pretreatment MR imaging. The effect of varying degrees of extent of resection on overall survival was assessed for cohorts of patients grouped by tumor invasiveness. Results We demonstrate that patients with more diffuse tumors showed no survival benefit (P = 0.532) from gross total resection over subtotal/biopsy, while those with nodular (less diffuse) tumors showed a significant benefit (P = 0.00142) with a striking median survival benefit of over eight months compared to sub-totally resected tumors in the same cohort (an 80% improvement in survival time for GTR only seen for nodular tumors). Conclusions These results suggest that our patient-specific, model-based estimates of tumor invasiveness have clinical utility in surgical decision making. Quantification of relative invasiveness assessed from routinely obtained pre-operative imaging provides a practical predictor of the benefit of gross total resection