31 research outputs found

    Studies of beauty baryon decays to D0ph− and Λ+ch− final states

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    A study of CP violation in B-+/- -> DK +/- and B-+/- -> D pi(+/-) decays with D -> (KSK +/-)-K-0 pi(-/+) final states

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    A first study of CP violation in the decay modes B±[KS0K±π]Dh±B^\pm\to [K^0_{\rm S} K^\pm \pi^\mp]_D h^\pm and B±[KS0Kπ±]Dh±B^\pm\to [K^0_{\rm S} K^\mp \pi^\pm]_D h^\pm, where hh labels a KK or π\pi meson and DD labels a D0D^0 or D0\overline{D}^0 meson, is performed. The analysis uses the LHCb data set collected in pppp collisions, corresponding to an integrated luminosity of 3 fb1^{-1}. The analysis is sensitive to the CP-violating CKM phase γ\gamma through seven observables: one charge asymmetry in each of the four modes and three ratios of the charge-integrated yields. The results are consistent with measurements of γ\gamma using other decay modes

    Measurement of Upsilon production in collisions at root s=2.76 TeV

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    The production of Υ(1S)\Upsilon(1S), Υ(2S)\Upsilon(2S) and Υ(3S)\Upsilon(3S) mesons decaying into the dimuon final state is studied with the LHCb detector using a data sample corresponding to an integrated luminosity of 3.3 pb1pb^{-1} collected in proton-proton collisions at a centre-of-mass energy of s=2.76\sqrt{s}=2.76 TeV. The differential production cross-sections times dimuon branching fractions are measured as functions of the Υ\Upsilon transverse momentum and rapidity, over the ranges $p_{\rm T} Upsilon(1S) X) x B(Upsilon(1S) -> mu+mu-) = 1.111 +/- 0.043 +/- 0.044 nb, sigma(pp -> Upsilon(2S) X) x B(Upsilon(2S) -> mu+mu-) = 0.264 +/- 0.023 +/- 0.011 nb, sigma(pp -> Upsilon(3S) X) x B(Upsilon(3S) -> mu+mu-) = 0.159 +/- 0.020 +/- 0.007 nb, where the first uncertainty is statistical and the second systematic

    Study of forward Z + jet production in pp collisions at √s=7 TeV

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    A measurement of the Z(μ+μ)Z(\rightarrow\mu^+\mu^-)+jet production cross-section in pppp collisions at a centre-of-mass energy s=7\sqrt{s} = 7 TeV is presented. The analysis is based on an integrated luminosity of 1.0fb11.0\,\text{fb}^{-1} recorded by the LHCb experiment. Results are shown with two jet transverse momentum thresholds, 10 and 20 GeV, for both the overall cross-section within the fiducial volume, and for six differential cross-section measurements. The fiducial volume requires that both the jet and the muons from the Z boson decay are produced in the forward direction (2.0<η<4.52.0<\eta<4.5). The results show good agreement with theoretical predictions at the second-order expansion in the coupling of the strong interaction.A measurement of the Z(μ+μ)Z(\rightarrow\mu^+\mu^-)+jet production cross-section in pppp collisions at a centre-of-mass energy s=7\sqrt{s} = 7 TeV is presented. The analysis is based on an integrated luminosity of 1.0fb11.0\,\text{fb}^{-1} recorded by the LHCb experiment. Results are shown with two jet transverse momentum thresholds, 10 and 20 GeV, for both the overall cross-section within the fiducial volume, and for six differential cross-section measurements. The fiducial volume requires that both the jet and the muons from the Z boson decay are produced in the forward direction (2.0<η<4.52.0<\eta<4.5). The results show good agreement with theoretical predictions at the second-order expansion in the coupling of the strong interaction

    Inpatient coronary angiography and revascularisation following non-ST-elevation acute coronary syndrome in patients with renal impairment: a cohort study using the Myocardial Ischaemia National Audit Project.

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    BACKGROUND: International guidelines support an early invasive management strategy (including early coronary angiography and revascularisation) for non-ST-elevation acute coronary syndrome (NSTE-ACS) in patients with renal impairment. However, evidence from outside the UK suggests that this approach is underutilised. We aimed to describe practice within the NHS, and to determine whether the severity of renal dysfunction influenced the provision of angiography and modified the association between early revascularisation and survival. METHODS: We performed a cohort study, using multivariable logistic regression and propensity score analyses, of data from the Myocardial Ischaemia National Audit Project for patients presenting with NSTE-ACS to English or Welsh hospitals between 2008 and 2010. FINDINGS: Of 35 881 patients diagnosed with NSTE-ACS, eGFR of 90 ml/minute/1.73 m(2), patients with an eGFR between 45-59 ml/minute/1.73 m(2) were 33% less likely to undergo angiography (adjusted OR 0.67, 95% CI 0.55-0.81); those with an eGFR<30/minute/1.73 m(2) had a 64% reduction in odds of undergoing angiography (adjusted OR 0.36, 95%CI 0.29-0.43). Of 16 646 patients who had inpatient coronary angiography, 58.5% underwent inpatient revascularisation. After adjusting for co-variables, inpatient revascularisation was associated with approximately a 30% reduction in death within 1 year compared with those managed medically after coronary angiography (adjusted OR 0.66, 95%CI 0.57-0.77), with no evidence of modification by renal function (p(interaction) = 0.744). INTERPRETATION: Early revascularisation may offer a similar survival benefit in patients with and without renal dysfunction, yet renal impairment is an important determinant of the provision of coronary angiography following NSTE-ACS. A randomised controlled trial is needed to evaluate the efficacy of an early invasive approach in patients with severe renal dysfunction to ensure that all patients who may benefit are offered this treatment option

    NA62 Technical Design

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    NA62 technical design repor

    The vast complexity of primary open angle glaucoma:Disease genes, risks, molecular mechanisms and pathobiology

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    <p>Primary open angle glaucoma (POAG) is a complex progressive optic nerve neuropathy triggered by both environmental and genetic risk factors. Several ocular tissues, including the ciliary body, trabecular meshwork and optic nerve head, and perhaps even brain tissues, are involved in a chain of pathological events leading to POAG.</p><p>Genetic risk evidence for POAG came from family linkage-studies implicating a small number of disease genes (MYOC, OPEN, WDR36). Recent Genome Wide Association Studies (GWAS) identified a large number of new POAG loci and disease genes, such as CAV1, CDKN2B and GAS7. In the current study, we reviewed over 120 family and GWA studies. We selected in total 65 (candidate) POAG disease genes and proceeded to assess their function, mRNA expression in POAG relevant eye tissues and possible changes in disease state. We found that the proteins corresponding to these 65 (candidate) POAG disease genes take part in as few as four common functional molecular networks. Functions attributed to these 4 networks were developmental (dys)function, lipid metabolism, and inflammatory processes. For the 65 POAG disease genes, we reviewed the available (transgenic) mouse models of POAG, which may be useful for future functional studies. Finally, we showed that the 65 (candidate) POAG genes substantially increased the specificity and sensitivity of a discriminative POAG risk test. This suggests that personal risk assessment and personalized medicine for POAG are on the horizon. Taken together, the data presented are essential to comprehend the role of genetic variation in POAG, and may provide leads to understand the pathophysiology of POAG as well as other neurodegenerative disorders, such as Alzheimer's disease. (C) 2013 Elsevier Ltd. All rights reserved.</p>

    Study of beauty hadron decays into pairs of charm hadrons

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    First observations of the decays Λb0Λc+D(s)\Lambda_b^0 \to \Lambda_c^+ D_{(s)}^- are reported using data corresponding to an integrated luminosity of 3fb13\,{\rm fb}^{-1} collected at 7 and 8 TeV center-of-mass energy in proton-proton collisions with the LHCb detector. In addition, the most precise measurement of the branching fraction B(Bs0D+Ds){\mathcal{B}(B_s^0 \to D^+D_s^-)} is made and a search is performed for the decays B(s)0Λc+ΛcB^0_{(s)} \to \Lambda_c^+ \Lambda_c^-. The results obtained are \begin{eqnarray*} \mathcal{B}(\Lambda_b^0 \to \Lambda_c^+ D^-)/\mathcal{B}(\Lambda_b^0 \to \Lambda_c^+ D_{s}^-) &=& 0.042 \pm 0.003({\rm stat}) \pm 0.003({\rm syst}),\\ \left[\frac{\mathcal{B}(\Lambda_b^0 \to \Lambda_c^+ D_{s}^-)}{\mathcal{B}({\kern 0.2em}\overline{\kern -0.2em B}_d^0 \to D^+D_s^-)}\right]\big/\left[\frac{\mathcal{B}(\Lambda_b^0 \to \Lambda_c^+\pi^-)}{\mathcal{B}({\kern 0.2em}\overline{\kern -0.2em B}_d^0 \to D^+\pi^-)}\right] &=& 0.96 \pm 0.02({\rm stat}) \pm 0.06({\rm syst}),\\ \mathcal{B}(B_s^0 \to D^+D_s^-)/\mathcal{B}({\kern 0.2em}\overline{\kern -0.2em B}_d^0 \to D^+D_s^-) &=& 0.038\pm0.004({\rm stat})\pm0.003({\rm syst}),\\ \mathcal{B}({\kern 0.2em}\overline{\kern -0.2em B}^0 \to \Lambda_c^+ \Lambda_c^-)/\mathcal{B}({\kern 0.2em}\overline{\kern -0.2em B}_d^0 \to D^+D_s^-) & < & 0.0022\; [95\% \; {\rm C.L.}],\\ \mathcal{B}(B^0_{s} \to \Lambda_c^+ \Lambda_c^-)/\mathcal{B}(B_s^0 \to D^+D_s^-) & < & 0.30\; [95\% \; {\rm C.L.}]. \end{eqnarray*} Measurement of the mass of the Λb0\Lambda_b^0 baryon relative to the B0B^0 meson gives M(Λb0)M(B0)=339.72±0.24(stat)±0.18(syst){M(\Lambda_b^0) -M(B^0) = 339.72\pm 0.24({\rm stat}) \pm 0.18({\rm syst})} MeV/c2/c^2. This result provides the most precise measurement of the mass of the Λb0\Lambda_b^0 baryon to date
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