301 research outputs found

    Higgs self coupling measurement in e+e- collisions at center-of-mass energy of 500 GeV

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    Feasibility of the measurement of the trilinear self-couplings of the Higgs boson is studied. Such a measurement would experimentally determine the structure of the Higgs potential. Full hadronic and semi-leptonic final states of the double-Higgs strahlung have been investigated.Comment: 10 pages, 5 tables, 8 figure

    Beyond sensation seeking: affect regulation as a framework for predicting risk-taking behaviors in high-risk sport.

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    Sensation seeking has been widely studied when investigating individual differences in the propensity for taking risks. However, risk taking can serve many different goals beyond the simple management of physiological arousal. The present study is an investigation of affect self-regulation as a predictor of risk-taking behaviors in high-risk sport. Risk-taking behaviors, negative affectivity, escape self-awareness strategy, and sensation seeking data were obtained from 265 high-risk sportsmen. Moderated hierarchical regression analysis revealed significant main and interaction effects of negative affectivity and escape self-awareness strategy in predicting risk-taking behaviors: high-risk sportsmen�s negative affectivity leads them to adopt risk-taking behaviors only if they also use escape self-awareness strategy. Furthermore, the affective model remained significant when controlling for sensation seeking. The present study contributes to an in-depth understanding of risk taking in high-risk sport

    Who takes risks at high-risks sports? A typological personality approach.

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    International audienceWe investigated the risk-taking behaviors of 302 men involved in high-risk sports (downhill skiing mountaineering rock climbing, paragliding, or skydiving). The sportsmen were classified using a typological approach to personality based on eight personality types, which were constructed from combinations of neuroticism, extraversion, and conscientiousness. Results showed that personality types with a configuration of low conscientiousness combined with high extraversion and/or high neuroticism (impulsive, hedonistic, insecure) were greater risk-takers. Conversely, personality types with a configuration of high conscientiousness combined with low extraversion and/or high extraversion (skeptic, brooder, entrepreneur) were lower risk-takers. Results are discussed in the context of typology and other approaches to understanding who takes risks in high-risk domains

    Reduced-Order Model Construction Procedure for Robust Mistuning Identification of Blisks

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    Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/76089/1/AIAA-2008-2332-822.pd

    Reduced-Order Model Construction Procedure for Robust Mistuning Identification of Blisks

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    Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/77287/1/AIAA-37314-162.pd

    Mistuning Identification of Blisks at Higher Frequencies

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    Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/83571/1/AIAA-2010-2558-725.pd

    Risks management and cobots. Identifying critical variables

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    Trabajo presentado en: 29th European Safety and Reliability Conference (ESREL), 22–26 September 2019, HannoverA collaborative robot or a "Cobot" is the name of a robot that can share a workspace with operators in the absence of a protective fence or with only partial protection. They represent a new and expanding sector of industrial robotics. This investigation draws from the latest international rules and safety parameters related to work with collaborative robots. Its detailed research is motivated by the design of a collaborative industrial robot system, hazard elimination, risk reduction, and different collaborative operations, such as power and force limiting, collaborative operation design, and end-effector safety requirements, among others. The purpose of our study is to analyze the most important variables that must be controlled in accordance with the desired use of the Cobot, according to ISO / TS 15066, ISO / TR 20218-1and some other generic safety regulations on machines and industrial robots. A series of observations and appreciations on the use of the Cobot will also be presented

    The pestivirus N terminal protease N(pro) redistributes to mitochondria and peroxisomes suggesting new sites for regulation of IRF3 by N(pro.)

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    The N-terminal protease of pestiviruses, N(pro) is a unique viral protein, both because it is a distinct autoprotease that cleaves itself from the following polyprotein chain, and also because it binds and inactivates IRF3, a central regulator of interferon production. An important question remains the role of N(pro) in the inhibition of apoptosis. In this study, apoptotic signals induced by staurosporine, interferon, double stranded RNA, sodium arsenate and hydrogen peroxide were inhibited by expression of wild type N(pro), but not by mutant protein N(pro) C112R, which we show is less efficient at promoting degradation of IRF3, and led to the conclusion that N(pro) inhibits the stress-induced intrinsic mitochondrial pathway through inhibition of IRF3-dependent Bax activation. Both expression of N(pro) and infection with Bovine Viral Diarrhea Virus (BVDV) prevented Bax redistribution and mitochondrial fragmentation. Given the role played by signaling platforms during IRF3 activation, we have studied the subcellular distribution of N(pro) and we show that, in common with many other viral proteins, N(pro) targets mitochondria to inhibit apoptosis in response to cell stress. N(pro) itself not only relocated to mitochondria but in addition, both N(pro) and IRF3 associated with peroxisomes, with over 85% of N(pro) puncta co-distributing with PMP70, a marker for peroxisomes. In addition, peroxisomes containing N(pro) and IRF3 associated with ubiquitin. IRF3 was degraded, whereas N(pro) accumulated in response to cell stress. These results implicate mitochondria and peroxisomes as new sites for IRF3 regulation by N(pro), and highlight the role of these organelles in the anti-viral pathway
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