An Appreciative Approach to Diversity Training

One way to combat "diversity fatigue" is to take an appreciative approach to diversity training. This article highlights the six phases of Appreciative Education and how diversity trainers can use specific activities for each phase to deliver effective diversity training

Design development and implementation of an irradiation station at the neutron time-of-flight facility at CERN

A new parasitic, mixed-field, neutron-dominated irradiation station has been recently commissioned at the European Laboratory for Particle Physics (CERN). The station is installed within the neutron time-of-flight (n_TOF) facility, taking advantage of the secondary radiation produced by the neutron spallation target, with neutrons ranging from 0.025 eV to several hundreds of MeV. The new station allows radiation damage studies to be performed in irradiation conditions that are closer to the ones encountered during the operation of particle accelerators; the irradiation tests carried out in the station will be complementary to the standard tests on materials, usually performed with gamma sources. Samples will be exposed to neutron-dominated doses in the MGy range per year, with minimal impact on the n_TOF facility operation. The station has 24 irradiation positions, each hosting up to 100 cm3 of sample material. In view of its proximity to the n_TOF target, inside protective shielding, the irradiation station and its operating procedures have been carefully developed taking into account the safety of personnel and to avoid any unwanted impact on the operation of the n_TOF facility and experiments. Due to the residual radioactivity of the whole area around the n_TOF target and of the irradiated samples, access to the irradiation station is forbidden to human operators even when the n_TOF facility is not in operation. Robots are used for the remote installation and retrieval of the samples, and other optimizations of the handling procedures were developed in compliance with radiation protection regulations and the aim of minimizing doses to personnel. The sample containers were designed to be radiation tolerant, compatible with remote handling, and subject to detailed risk analysis and testing during their development. The whole life cycle of the irradiated materials, including their post-irradiation examinations and final disposal, was considered and optimized

Conceptualizing diversity: Undergraduate student involvement in multicultural student organizations and their perceptions of diversity

In an increasingly globalized world, students graduating from college are expected to be able to communicate and work with people who are different from themselves. The skills needed to compete in this global workforce are not easily learned in a class or seminar, but obtained through experience and interactions with diversity. Involvement in multicultural student organizations or identity-based groups affords students the opportunity to explore their identity and gain experience in understanding diversity. With the growing demand for multiculturally competent graduates increasing, this study seeks to understand students' experiences in multicultural student organizations at the University of South Carolina. The participants of this study consisted of eight members of the undergraduate university community who belonged to a student organization housed under the Office of Multicultural Student Affairs. The Office of Multicultural Student Affairs provides support and leadership for diversity initiatives across campus. Through a series of one time interviews with the eight participants the research sought to understand how the participants defined diversity, what value they assigned to their experience, and the effects students felt their involvement had on their understanding of themselves. Findings from this study demonstrated that students' defined diversity in three increasingly complex ways. First, their appreciation for their involvement in an identity-based organization was grounded in feelings of safety and increased confidence as a result of membership which allowed for more openness to the cognitive dissonance that comes with experiences with diversity. Their perceived understanding of themselves showed that participants' developed both intellectually and ethically

A conserved NR5A1-responsive enhancer regulates SRY in testis-determination

International audienceThe Y-linked SRY gene initiates mammalian testis-determination. However, how the expression of SRY is regulated remains elusive. Here, we demonstrate that a conserved steroidogenic factor-1 (SF-1)/NR5A1 binding enhancer is required for appropriate SRY expression to initiate testis-determination in humans. Comparative sequence analysis of SRY 5’ regions in mammals identified an evolutionary conserved SF-1/NR5A1-binding motif within a 250 bp region of open chromatin located 5 kilobases upstream of the SRY transcription start site. Genomic analysis of 46,XY individuals with disrupted testis-determination, including a large multigenerational family, identified unique single-base substitutions of highly conserved residues within the SF-1/NR5A1-binding element. In silico modelling and in vitro assays demonstrate the enhancer properties of the NR5A1 motif. Deletion of this hemizygous element by genome-editing, in a novel in vitro cellular model recapitulating human Sertoli cell formation, resulted in a significant reduction in expression of SRY . Therefore, human NR5A1 acts as a regulatory switch between testis and ovary development by upregulating SRY expression, a role that may predate the eutherian radiation. We show that disruption of an enhancer can phenocopy variants in the coding regions of SRY that cause human testis dysgenesis. Since disease causing variants in enhancers are currently rare, the regulation of gene expression in testis-determination offers a paradigm to define enhancer activity in a key developmental process