Ultra-Low Noise Microwave Extraction from Fiber-Based Optical Frequency Comb

In this letter, we report on all-optical fiber approach to the generation of ultra-low noise microwave signals. We make use of two erbium fiber mode-locked lasers phase locked to a common ultra-stable laser source to generate an 11.55 GHz signal with an unprecedented relative phase noise of -111 dBc/Hz at 1 Hz from the carrier.The residual frequency instability of the microwave signals derived from the two optical frequency combs is below 2.3 10^(-16) at 1s and about 4 10^(-19) at 6.5 10^(4)s (in 5 Hz bandwidth, three days continuous operation).Comment: 12 pages, 3 figure

White-faced Darter distribution is associated with coniferous forests in Great Britain

Abstract 1) Understanding of dragonfly distributions is often geographically comprehensive but less so in ecological terms. 2) White-faced darter (Leucorhinnia dubia) is a lowland peatbog specialist dragonfly which has experienced population declines in Great Britain. White-faced darter are thought to rely on peat-rich pool complexes within woodland but this has not yet been empirically tested. 3) We used dragonfly recording data collected by volunteers of the British Dragonfly Society from 2005 to 2018 to model habitat preference for white-faced darter using species distribution models across Great Britain and, with a more detailed landcover dataset, specifically in the North of Scotland. 4) Across the whole of Great Britain our models used the proportion of coniferous forest within 1km as the most important predictor of habitat suitability but were not able to predict all current populations in England. 5) In the North of Scotland our models were more successful and suggest that habitats characterised by native coniferous forest and areas high potential evapotranspiration represent the most suitable habitat for white-faced darter. 6) We recommend that future white-faced darter monitoring should be expanded to include areas currently poorly surveyed but with high suitability in the North of Scotland. 7) Our results also suggest that white-faced darter management should concentrate on maintaining Sphagnum rich pool complexes and the maintenance and restoration of native forests in which these pool complexes occur

Antikinetoplastid SAR study in 3-nitroimidazopyridine series: identification of a novel non-genotoxic and potent anti-T. b. brucei hit-compound with improved pharmacokinetic properties

To study the antikinetoplastid 3-nitroimidazo[1,2-a]pyridine pharmacophore, a structure-activity relationship study was conducted through the synthesis of 26 original derivatives and their in vitro evaluation on both Leishmania spp and Trypanosoma brucei brucei. This SAR study showed that the antitrypanosomal pharmacophore was less restrictive than the antileishmanial one and highlighted positions 2, 6 and 8 of the imidazopyridine ring as key modulation points. None of the synthesized compounds allowed improvement in antileishmanial activity, compared to previous hit molecules in the series. Nevertheless, compound 8, the best antitrypanosomal molecule in this series (EC50 = 17 nM, SI = 2650 & E° = -0.6 V), was not only more active than all reference drugs and previous hit molecules in the series but also displayed improved aqueous solubility and better in vitro pharmacokinetic characteristics: good microsomal stability (T1/2 > 40 min), moderate albumin binding (77%) and moderate permeability across the blood brain barrier according to a PAMPA assay. Moreover, both micronucleus and comet assays showed that nitroaromatic molecule 8 was not genotoxic in vitro. It was evidenced that bioactivation of molecule 8 was operated by T. b. brucei type 1 nitroreductase, in the same manner as fexinidazole. Finally, a mouse pharmacokinetic study showed that 8 displayed good systemic exposure after both single and repeated oral administrations at 100 mg/kg (NOAEL) and satisfying plasmatic half-life (T1/2 = 7.7 h). Thus, molecule 8 appears as a good candidate for initiating a hit to lead drug discovery program

Catching MPC Cheaters: Identification and Openability

Secure multi-party computation (MPC) protocols do not completely prevent malicious parties from cheating or disrupting the computation. We augment MPC with three new properties to discourage cheating. First is a strengthening of identifiable abort, called completely identifiable abort, where all parties who do not follow the protocol will be identified as cheaters by each honest party. The second is completely identifiable auditability, which means that a third party can determine whether the computation was performed correctly (and who cheated if it was not). The third is openability, which means that a distinguished coalition of parties can recover the MPC inputs. We construct the first (efficient) MPC protocol achieving these properties. Our scheme is built on top of the SPDZ protocol (Damgard et al., Crypto 2012), which leverages an offline (computation-independent) pre-processing phase to speed up the online computation. Our protocol is optimistic, retaining online SPDZ efficiency when no one cheats. If cheating does occur, each honest party performs only local computation to identify cheaters. Our main technical tool is a new locally identifiable secret sharing scheme (as defined by Ishai, Ostrovsky, and Zikas (TCC 2012)) which we call commitment enhanced secret sharing or CESS. The work of Baum, Damgard, and Orlandi (SCN 2014) introduces the concept of auditability, which allows a third party to verify that the computation was executed correctly, but not to identify the cheaters if it was not. We enable the third party to identify the cheaters by augmenting the scheme with CESS. We add openability through the use of verifiable encryption and specialized zero-knowledge proofs

SWiM: Secure Wildcard Pattern Matching From OT Extension

Suppose a server holds a long text string and a receiver holds a short pattern string. Secure pattern matching allows the receiver to learn the locations in the long text where the pattern appears, while leaking nothing else to either party besides the length of their inputs. In this work we consider secure wildcard pattern matching WPM, where the receiver\u27s pattern is allowed to contain wildcards that match to any character. We present SWiM, a simple and fast protocol for WPM that is heavily based on oblivious transfer (OT) extension. As such, the protocol requires only a small constant number of public-key operations and otherwise uses only very fast symmetric-key primitives. SWiM is secure against semi-honest adversaries. We implemented a prototype of our protocol to demonstrate its practicality. We can perform WPM on a DNA text (4-character alphabet) of length $10^5$ and pattern of length $10^3$ in just over 2 seconds, which is over two orders of magnitude faster than the state-of-the-art scheme of Baron et al. (SCN 2012)

Evaluation of Functional Erythropoietin Receptor Status in Skeletal Muscle In Vivo: Acute and Prolonged Studies in Healthy Human Subjects

BACKGROUND: Erythropoietin receptors have been identified in human skeletal muscle tissue, but downstream signal transduction has not been investigated. We therefore studied in vivo effects of systemic erythropoietin exposure in human skeletal muscle. METHODOLOGY/PRINCIPAL FINDINGS: The protocols involved 1) acute effects of a single bolus injection of erythropoietin followed by consecutive muscle biopsies for 1-10 hours, and 2) a separate study with prolonged administration for 16 days with biopsies obtained before and after. The presence of erythropoietin receptors in muscle tissue as well as activation of Epo signalling pathways (STAT5, MAPK, Akt, IKK) were analysed by western blotting. Changes in muscle protein profiles after prolonged erythropoietin treatment were evaluated by 2D gel-electrophoresis and mass spectrometry. The presence of the erythropoietin receptor in skeletal muscle was confirmed, by the M20 but not the C20 antibody. However, no significant changes in phosphorylation of the Epo-R, STAT5, MAPK, Akt, Lyn, IKK, and p70S6K after erythropoietin administration were detected. The level of 8 protein spots were significantly altered after 16 days of rHuEpo treatment; one isoform of myosin light chain 3 and one of desmin/actin were decreased, while three isoforms of creatine kinase and two of glyceraldehyd-3-phosphate dehydrogenase were increased. CONCLUSIONS/SIGNIFICANCE: Acute exposure to recombinant human erythropoietin is not associated by detectable activation of the Epo-R or downstream signalling targets in human skeletal muscle in the resting situation, whereas more prolonged exposure induces significant changes in the skeletal muscle proteome. The absence of functional Epo receptor activity in human skeletal muscle indicates that the long-term effects are indirect and probably related to an increased oxidative capacity in this tissue

Two-Sided Malicious Security for Private Intersection-Sum with Cardinality

Private intersection-sum with cardinality allows two parties, where each party holds a private set and one of the parties additionally holds a private integer value associated with each element in her set, to jointly compute the cardinality of the intersection of the two sets as well as the sum of the associated integer values for all the elements in the intersection, and nothing beyond that. We present a new construction for private intersection sum with cardinality that provides malicious security with abort and guarantees that both parties receive the output upon successful completion of the protocol. A central building block for our constructions is a primitive called shuffled distributed oblivious PRF (DOPRF), which is a PRF that offers oblivious evaluation using a secret key shared between two parties, and in addition to this allows obliviously permuting the PRF outputs of several parallel oblivious evaluations. We present the first construction for shuffled DOPRF with malicious security. We further present several new sigma proof protocols for relations across Pedersen commitments, ElGamal encryptions, and Camenisch-Shoup encryptions that we use in our main construction, for which we develop new batching techniques to reduce communication. We implement and evaluate the efficiency of our protocol and show that we can achieve communication cost that is only 4-5 times greater than the most efficient semi-honest protocol. When measuring monetary cost of executing the protocol in the cloud, our protocol is 25 times more expensive than the semi-honest protocol. Our construction also allows for different parameter regimes that enable trade-offs between communication and computation

Winners and losers over 35 years of dragonfly and damselfly distributional change in Germany

Aim: Recent studies suggest insect declines in parts of Europe; however, the generality of these trends across different taxa and regions remains unclear. Standardized data are not available to assess large-scale, long-term changes for most insect groups but opportunistic citizen science data are widespread for some. Here, we took advantage of citizen science data to investigate distributional changes of Odonata. Location: Germany. Methods: We compiled over 1 million occurrence records from different regional databases. We used occupancy-detection models to account for imperfect detection and estimate annual distributions for each species during 1980–2016 within 5 × 5 km quadrants. We also compiled data on species attributes that were hypothesized to affect species’ sensitivity to different drivers and related them to the changes in species’ distributions. We further developed a novel approach to cluster groups of species with similar patterns of distributional change to represent multispecies indicators. Results: More species increased (45%) than decreased (29%) or remained stable (26%) in their distribution (i.e. number of occupied quadrants). Species showing increases were generally warm-adapted species and/or running water species, while species showing decreases were cold-adapted species using standing water habitats such as bogs. Time series clustering defined five main patterns of change—each associated with a specific combination of species attributes, and confirming the key roles of species’ temperature and habitat preferences. Overall, our analysis predicted that mean quadrant-level species richness has increased over most of the time period. Main conclusions: Trends in Odonata provide mixed news—improved water quality, coupled with positive impacts of climate change, could explain the positive trends of many species. At the same time, declining species point to conservation challenges associated with habitat loss and degradation. Our study demonstrates the great value of citizen science and the work of natural history societies for assessing large-scale distributional change

Preservation of organic matter in sediments promoted by iron

The biogeochemical cycles of iron and organic carbon are strongly interlinked. In oceanic waters, organic ligands have been shown to control the concentration of dissolved iron. In soils, solid iron phases shelter and preserve organic carbon, but the role of iron in the preservation of organic matter in sediments has not been clearly established. Here we use an iron reduction method previously applied to soils to determine the amount of organic carbon associated with reactive iron phases in sediments of various mineralogies collected from a wide range of depositional environments. Our findings suggest that 21.5 ± 8.6 per cent of the organic carbon in sediments is directly bound to reactive iron phases. We further estimate that a global mass of (19–45) × 1015 grams of organic carbon is preserved in surface marine sediments as a result of its association with iron. We propose that these associations between organic carbon and iron, which are formed primarily through co-precipitation and/or direct chelation, promote the preservation of organic carbon in sediments. Because reactive iron phases are metastable over geological timescales, we suggest that they serve as an efficient ‘rusty sink’ for organic carbon, acting as a key factor in the long-term storage of organic carbon and thus contributing to the global cycles of carbon, oxygen and sulphur