Portrayal of psychiatric genetics in Australian print news media, 1996-2009

Objective: To investigate how Australian print news media portray psychiatric genetics. Design and setting: Content and framing analysis of a structured sample of print news items about psychiatric genetics published in Australian newspapers between 1996 and 2009. Main outcome measures: Identify dominant discourses about aetiology of mental illness, and perceived clinical outcomes and implications of psychiatric genetics research. Results: We analysed 406 eligible items about the genetics of psychiatric disorders. News coverage of psychiatric genetics has steadily increased since 1996. Items attributing the aetiology of psychiatric disorders to gene-environment interactions (51%) outnumbered items attributing only genetic (30%) or only environmental factors (20%). Of items that referred to heritability of mental illness, frames of genetic determinism (78%) occurred more frequently than probabilistic frames (22%). Of frames related to genetic prophesy, genetic optimism frames (78%) were used more frequently than frames of genetic pessimism (22%). Psychosocial and ethical implications of psychiatric genetics received comparatively relatively little coverage (23%). The analysis identified 22 predictions about psychiatric genetic discoveries and the availability of molecular-based interventions in psychiatry, most of which (20/ 22, 91%) failed to manifest by the predicted year. Conclusions: Excessive optimism about the power of genetic technology in psychiatric health care, perceived clinical benefits, and largely unfulfilled predictions about availability of these benefits could encourage unrealistic expectations about future molecular-based treatment options for mental health

The role of fundamental solution in Potential and Regularity Theory for subelliptic PDE

In this survey we consider a general Hormander type operator, represented as a sum of squares of vector fields plus a drift and we outline the central role of the fundamental solution in developing Potential and Regularity Theory for solutions of related PDEs. After recalling the Gaussian behavior at infinity of the kernel, we show some mean value formulas on the level sets of the fundamental solution, which are the starting point to obtain a comprehensive parallel of the classical Potential Theory. Then we show that a precise knowledge of the fundamental solution leads to global regularity results, namely estimates at the boundary or on the whole space. Finally in the problem of regularity of non linear differential equations we need an ad hoc modification of the parametrix method, based on the properties of the fundamental solution of an approximating problem

Approximations of Sobolev norms in Carnot groups

This paper deals with a notion of Sobolev space $W^{1,p}$ introduced by J.Bourgain, H.Brezis and P.Mironescu by means of a seminorm involving local averages of finite differences. This seminorm was subsequently used by A.Ponce to obtain a Poincar\'e-type inequality. The main results that we present are a generalization of these two works to a non-Euclidean setting, namely that of Carnot groups. We show that the seminorm expressd in terms of the intrinsic distance is equivalent to the $L^p$ norm of the intrinsic gradient, and provide a Poincar\'e-type inequality on Carnot groups by means of a constructive approach which relies on one-dimensional estimates. Self-improving properties are also studied for some cases of interest

Shear strengthening masonry panels with sheet glass-fiber reinforced polymer

none4This paper investigates strengthening masonry walls using glass-fiber reinforced polymer (GFRP) sheets. An experimental research program was undertaken. Both clay and concrete brick specimens were tested, with and without GFRP strengthening. Singlesided strengthening was considered, as it is often not practicable to apply the reinforcement to both sides of a wall. Static tests were carried out on six masonry panels, under a combination of vertical preload, and in-plane horizontal shear loading. The mechanisms by which load was carried were observed, varying from the initial, uncracked state, to the final, fully cracked state. The results demonstrate that a significant increase of the in-plane shear capacity of masonry can be achieved by bonding GFRP sheets to the surface of masonry walls. The experimental data were used to assess the effectiveness of the GFRP strengthening, and suggestions are made to allow the test results to be used in the design of sheet GFRP strengthening for masonry structures.noneSTRATFORD T.; PASCALE G.; MANFRONI O.; BONFIGLIOLI B.STRATFORD T.; PASCALE G.; MANFRONI O.; BONFIGLIOLI B

Harnack inequality for fractional sub-Laplacians in Carnot groups

In this paper we prove an invariant Harnack inequality on Carnot-Carath\'eodory balls for fractional powers of sub-Laplacians in Carnot groups. The proof relies on an "abstract" formulation of a technique recently introduced by Caffarelli and Silvestre. In addition, we write explicitly the Poisson kernel for a class of degenerate subelliptic equations in product-type Carnot groups

Musculoskeletal Stress and Adult Age Markers in the Krapina Hominid Collection: the Study of Femora 213 Fe.1 and 214 Fe.2.

The purpose of this study was to examine morphological markers of activity and age on femora 213 Fe.1 and 214 Fe.2 of the Krapina hominid collection. This study is part of a large research on the Krapina collection aimed at studying morphological markers of activity (entheses, enthesopathies, articular modifications) and age, as well as dento-alveolar alterations and pathologies. For this purpose, we apply scoring methods that we have devised and standardized on modern Italian skeletal collections with known age, sex, activity during life, cause of death, etc.. This approach has been used to study other human skeletal series and it allows us to obtain homogeneous data that can be more easily compared and interpreted. On the basis of our recent investigations of Upper Palaeolithic skeletal remains of Taforalt (Morocco, 12000–11000), we also intend to re-examine the cutmarks on bones of the Krapina hominid collection to provide further knowledge about possible funerary practices of these Neandertalians. The study of markers of activity and age on femora 213 Fe.1 and 214 Fe.2 revealed strong robusticity and a postero-lateral position of the m. gluteus maximus enthesis, indicating morphological and size differences with respect to modern humans. The strong mechanical stress on the lateral parts of the proximal end of the femur seems to be confirmed by the partial dislocation of the hip joint suggested by the articular features observed on two coxal bones. Finally, we used our results to re-assess the attribution of age to the individuals represented by these two specimens

Potential theory results for a class of PDOs admitting a global fundamental solution

We outline several results of Potential Theory for a class of linear par-tial differential operators L of the second order in divergence form. Under essentially the sole assumption of hypoellipticity, we present a non-invariant homogeneous Harnack inequality for L; under different geometrical assumptions on L (mainly, under global doubling/Poincar\ue9 assumptions), it is described how to obtainan invariant, non-homogeneous Harnack inequality. When L is equipped with a global fundamental solution \u393, further Potential Theory results are available (such as the Strong Maximum Principle). We present some assumptions on L ensuring that such a \u393 exists

On the Hausdorff volume in sub-Riemannian geometry

For a regular sub-Riemannian manifold we study the Radon-Nikodym derivative of the spherical Hausdorff measure with respect to a smooth volume. We prove that this is the volume of the unit ball in the nilpotent approximation and it is always a continuous function. We then prove that up to dimension 4 it is smooth, while starting from dimension 5, in corank 1 case, it is C^3 (and C^4 on every smooth curve) but in general not C^5. These results answer to a question addressed by Montgomery about the relation between two intrinsic volumes that can be defined in a sub-Riemannian manifold, namely the Popp and the Hausdorff volume. If the nilpotent approximation depends on the point (that may happen starting from dimension 5), then they are not proportional, in general.Comment: Accepted on Calculus and Variations and PD

Language and memory for object location

In three experiments, we investigated the influence of two types of language on memory for object location: demonstratives (this, that) and possessives (my, your). Participants first read instructions containing demonstratives/possessives to place objects at different locations, and then had to recall those object locations (following object removal). Experiments 1 and 2 tested contrasting predictions of two possible accounts of language on object location memory: the Expectation Model (Coventry, Griffiths, & Hamilton, 2014) and the congruence account (Bonfiglioli, Finocchiaro, Gesierich, Rositani, & Vescovi, 2009). In Experiment 3, the role of attention allocation as a possible mechanism was investigated. Results across all three experiments show striking effects of language on object location memory, with the pattern of data supporting the Expectation Model. In this model, the expected location cued by language and the actual location are concatenated leading to (mis)memory for object location, consistent with models of predictive coding (Bar, 2009; Friston, 2003)