Moderate Range Static Magnetic Field Promoted Variation of Blood Parameters: An In vitro Study

This study was undertaken to investigate the influence of a homogenous and uniform static magnetic field (SMF) on the main blood cell counts in vitro experiment. Fresh blood samples were collected from albino rats and exposed to SMF (2.4, 6, 25, 50, 75, and 100 mT) versus 15–60 min. Results showed a significant change of blood counts under the low field effects. A 2.4 mT was a trend of white blood cells (WBCs) count increase non-linearly. However, a 6 mT exposure reduced WBCs with about 39%. Other variations fluctuated within 30%. The 25 mT decreased red blood cells (RBCs), hemoglobin, and hematocrit levels with 13% similarly. The lower exposure field, (2.4 and 6) mT, and effects on RBCs were 6% fluctuation. The 6 mT reduced platelet counts with half in comparison to control blood samples. About 20% increase obtained due to 50 mT exposure during all period. None of 75 and 100 mT exposures dominated blood counts alterations. The quiet magnetic field exposure for a certain time can be interesting to control blood cell count-related diseases

Effect of Static Magnetic Field on Bone Marrow Cellular Density

This study was undertaken to investigate the influence of static magnetic field (SMF) on bone marrow cellular density (BMCD) variation proportionally to bone trabeculae. Female albino Wistar rats exposed with 2.4 ± 0.2 millitesla for 1–4weeks duration continuously versus 1h, 2h, 6h, and 8h/day. Trephine biopsy of femurs bone was examined under optical microscope. Data analyzed with ImageJ software. Results showed that short time exposure per day did not enhance the BMCD compare to high exposure period/day. Six hours/day exposure during 1week increased the marrow cellular density (hypercellularity) significantly (P ≤ 0.05) compares to bone trabeculae. Contrarily, 8h/day exposure reduced the BMCD slightly and significantly (hypocellularity, about 50% reduction) due to 1week and 4weeks exposure duration, respectively. The SMF has associated bone marrow cellularity tendency of rat’s femur

Automatic sound synthesis using the fly algorithm

Our study is demonstrated a new type of evolutionary sound synthesis method. This work based on the fly algorithm, a cooperative co-evolution algorithm; it is derived from the Parisian evolution approach. The algorithm has relatively amended the position of individuals (the Flies) represented by 3-D points. The fly algorithm has successfully investigated in different applications, starting with a real-time stereo vision for robotics. Also, the algorithm shows promising results in tomography to reconstruct 3-D images. The final application of the fly algorithm was generating artistic images, such as digital mosaics. In all these applications, the flies’representation started for simple, 3-D points, to complex one, the structure of 9-elements. Our method follows evolutionary digital art with the fly algorithm in representing the pattern of the flies. They represented in a way of having their structure. This structure includes position, colour, rotation angle, and size. Our algorithm has the benefit of graphics processing units (GPUs) to generate the sound waveform using the modern OpenGL shading language

On finite products of groups and supersolubility

Two subgroups X and Y of a group G are said to be conditionally permutable in G if X permutes with Y(g) for some element g E G. i.e., XY(g) is a subgroup of G. Using this permutability property new criteria for the product of finite supersoluble groups to be supersoluble are obtained and previous results are recovered. Also the behaviour of the supersoluble residual in products of finite groups is studied.Research supported by Proyecto MTM2007-68010-C03-03, Ministerio de Educacion y Ciencia and FEDER, Spain.Arroyo Jordá, M.; Arroyo Jordá, P.; Martínez Pastor, A.; Perez-Ramos, M. (2010). On finite products of groups and supersolubility. Journal of Algebra. 323(10):2922-2934. https://doi.org/10.1016/j.jalgebra.2010.01.001S292229343231

Scalable Test Generators for High-Speed Datapath Circuits

This paper explores the design of efficient test sets and test-pattern generators for on-line BIST. The target applications are high-performance, scalable datapath circuits for which fast and complete fault coverage is required. Because of the presence of carry-lookahead, most existing BIST methods are unsuitable for these applications. High-level models are used to identify potential test sets for a small version of the circuit to be tested. Then a regular test set is extracted and a test generator TG is designed to meet the following goals: scalability, small test set size, full fault coverage, and very low hardware overhead. TG takes the form of a twisted ring counter with a small decoder array. We apply our technique to various datapath circuits including a carry-lookahead adder, an arithmetic-logic unit, and a multiplier-adder.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/43010/1/10836_2004_Article_154697.pd

Methods for the Study of Marine Biodiversity

Recognition of the threats to biodiversity and its importance to society has led to calls for globally coordinated sampling of trends in marine ecosystems. As a step to defining such efforts, we review current methods of collecting and managing marine biodiversity data. A fundamental component of marine biodiversity is knowing what, where, and when species are present. However, monitoring methods are invariably biased in what taxa, ecological guilds, and body sizes they collect. In addition, the data need to be placed, and/or mapped, into an environmental context. Thus a suite of methods will be needed to encompass representative components of biodiversity in an ecosystem. Some sampling methods can damage habitat and kill species, including unnecessary bycatch. Less destructive alternatives are preferable, especially in conservation areas, such as photography, hydrophones, tagging, acoustics, artificial substrata, light-traps, hook and line, and live-traps. Here we highlight examples of operational international sampling programmes and data management infrastructures, notably the Continuous Plankton Recorder, Reef Life Survey, and detection of Harmful Algal Blooms and MarineGEO. Data management infrastructures include the World Register of Marine Species for species nomenclature and attributes, the Ocean Biogeographic Information System for distribution data, Marine Regions for maps, and Global Marine Environmental Datasets for global environmental data. Existing national sampling programmes, such as fishery trawl surveys and intertidal surveys, may provide a global perspective if their data can be integrated to provide useful information. Less utilised and emerging sampling methods, such as artificial substrata, light-traps, microfossils and eDNA also hold promise for sampling the less studied components of biodiversity. All of these initiatives need to develop international standards and protocols, and long-term plans for their governance and support.published_or_final_versio

Z-permutable subgroups of finite groups

Let ℨ be a complete set of Sylow subgroups of a finite group G, that is, a set composed of a Sylow p-subgroup of G for each p dividing the order of G. A subgroup H of G is called ℨ-permutable if H permutes with all members of ℨ. The main goal of this paper is to study the embedding of the ℨ-permutable subgroups and the influence of ℨ-permutability on the group structure

Efficacy of checkpoint inhibition after CAR-T failure in aggressive B-cell lymphomas: outcomes from 15 US institutions

Checkpoint inhibitor (CPI) therapy with anti-PD-1 antibodies has been associated with mixed outcomes in small cohorts of patients with relapsed aggressive B-cell lymphomas after CAR-T failure. To define CPI therapy efficacy more definitively in this population, we retrospectively evaluated clinical outcomes in a large cohort of 96 patients with aggressive B-cell lymphomas receiving CPI therapy after CAR-T failure across 15 US academic centers. Most patients (53%) had diffuse large B-cell lymphoma, were treated with axicabtagene ciloleucel (53%), relapsed early (≤180 days) after CAR-T (83%), and received pembrolizumab (49%) or nivolumab (43%). CPI therapy was associated with an overall response rate of 19% and a complete response rate of 10%. Median duration of response was 221 days. Median progression-free survival (PFS) and overall survival (OS) were 54 and 159 days, respectively. Outcomes to CPI therapy were significantly improved in patients with primary mediastinal B-cell lymphoma. PFS (128 vs 51 days) and OS (387 vs 131 days) were significantly longer in patients with late (>180 days) vs early (≤180 days) relapse after CAR-T. Grade ≥3 adverse events occurred in 19% of patients treated with CPI. Most patients (83%) died, commonly because of progressive disease. Only 5% had durable responses to CPI therapy. In the largest cohort of patients with aggressive B-cell lymphoma treated with CPI therapy after CAR-T relapse, our results reveal poor outcomes, particularly among those relapsing early after CAR-T. In conclusion, CPI therapy is not an effective salvage strategy for most patients after CAR-T, where alternative approaches are needed to improve post-CAR-T outcomes

Spatiotemporal neural characterization of prediction error valence and surprise during reward learning in humans

Reward learning depends on accurate reward associations with potential choices. These associations can be attained with reinforcement learning mechanisms using a reward prediction error (RPE) signal (the difference between actual and expected rewards) for updating future reward expectations. Despite an extensive body of literature on the influence of RPE on learning, little has been done to investigate the potentially separate contributions of RPE valence (positive or negative) and surprise (absolute degree of deviation from expectations). Here, we coupled single-trial electroencephalography with simultaneously acquired fMRI, during a probabilistic reversal-learning task, to offer evidence of temporally overlapping but largely distinct spatial representations of RPE valence and surprise. Electrophysiological variability in RPE valence correlated with activity in regions of the human reward network promoting approach or avoidance learning. Electrophysiological variability in RPE surprise correlated primarily with activity in regions of the human attentional network controlling the speed of learning. Crucially, despite the largely separate spatial extend of these representations our EEG-informed fMRI approach uniquely revealed a linear superposition of the two RPE components in a smaller network encompassing visuo mnemonic and reward areas. Activity in this network was further predictive of stimulus value updating indicating a comparable contribution of both signals to reward learning

Craniectomy for Malignant Cerebral Infarction: Prevalence and Outcomes in US Hospitals

Randomized trials have demonstrated the efficacy of craniectomy for the treatment of malignant cerebral edema following ischemic stroke. We sought to determine the prevalence and outcomes related to this by using a national database.Patient discharges with ischemic stroke as the primary diagnosis undergoing craniectomy were queried from the US Nationwide Inpatient Sample from 1999 to 2008. A subpopulation of patients was identified that underwent thrombolysis. Two primary end points were examined: in-hospital mortality and discharge to home/routine care. To facilitate interpretations, adjusted prevalence was calculated from the overall prevalence and two age-specific logistic regression models. The predictive margin was then generated using a multivariate logistic regression model to estimate the probability of in-hospital mortality after adjustment for admission type, admission source, length of stay, total hospital charges, chronic comorbidities, and medical complications.After excluding 71,996 patients with the diagnosis of intracranial hemorrhage and posterior intracranial circulation occlusion, we identified 4,248,955 adult hospitalizations with ischemic stroke as a primary diagnosis. The estimated rates of hospitalizations in craniectomy per 10,000 hospitalizations with ischemic stroke increased from 3.9 in 1999-2000 to 14.46 in 2007-2008 (p for linear trend<0.001). Patients 60+ years of age had in-hospital mortality of 44% while the 18-59 year old group was found to be 24% (p = 0.14). Outcomes were comparable if recombinant tissue plasminogen activator had been administered.Craniectomy is being increasingly performed for malignant cerebral edema following large territory cerebral ischemia. We suspect that the increase in the annual incidence of DC for malignant cerebral edema is directly related to the expanding collection of evidence in randomized trials that the operation is efficacious when performed in the correct patient population. In hospital mortality is high for all patients undergoing this procedure