9 research outputs found
Review Paper: Polyphenolic Antioxidants and Neuronal Regeneration
Many studies indicate that oxidative stress is involved in the pathophysiology of neurodegenerative
diseases. Oxidative stress can induce neuronal damages, modulate intracellular signaling and
ultimately leads to neuronal death by apoptosis or necrosis. To review antioxidants preventive
effects on oxidative stress and neurodegenerative diseases we accumulated data from international
medical journals and academic informations' sites. According to many studies, antioxidants
could reduce toxic neuronal damages and many studies confirmed the efficacy of polyphenol
antioxidants in fruits and vegetables to reduce neuronal death and to diminish oxidative stress.
This systematic review showed the antioxidant activities of phytochemicals which play as natural
neuroprotectives with low adverse effects against some neurodegenerative diseases as Parkinson
or Alzheimer diseases
Utilization of curcumine and nanocurcumine compounds in cancer therapy
Curcumin is a polyphenol extracted from the Curcuma plant. Curcumin has been used widely in ayurvedic medicine for centuries; it has a variety of biological properties including anti-oxidant, analgesic, anti-inflammatory and antiseptic activity. Curcumin has shown anti-cancer activities through variety of biological pathways engaged in mutagenesis, oncogene expression, cell cycle regulation, apoptosis, tumorigenesis and metastasis. Curcumin has proved anti-proliferative effect in many cancers, and is an inhibitor of the transcription factor NF-κB and downstream gene products (including c-myc, Bcl-2, COX-2, NOS, Cyclin D1, TNF-α, interleukins and MMP-9). Furthermore, curcumin affects a variety of growth factor receptors and cell adhesion molecules involved in tumor growth, angiogenesis and metastasis. However, a limiting factor is its extremely low bioavailability which hinders its use as therapeutic agent. Therefore, many technologies have been developed to overcome this limitation. We summarize to develop curcumin delivery aims and increase solubility for improving curcumin bioavailability and anticancer potential for therapy.