Results from a randomized, controlled trial on efficacy and tolerability of a 5% Lidocaine-Medicated Plaster vs. Pregabalin in patients with Post-Herpetic Neuralgia (PHN) and Painful Diabetic Polyneuropathy (DPN) [poster]

No abstract available

Results from a randomized, controlled trial on efficacy and tolerability of a 5% Lidocaine-Medicated Plaster vs. Pregabalin in patients with Post-Herpetic Neuralgia (PHN) and Painful Diabetic Polyneuropathy (DPN) [poster]

No abstract available

Lasers that operate independently of temperature.

Apparatus, methods, systems and devices for providing a temperature independent laser by determining a temperature dependence of a lasing wavelength, selecting the lasing wavelength having minimal temperature dependence and constraining the lasing wavelength of the laser device to the selected lasing wavelength. In an embodiment, a volumetric Bragg grating in photo-thermal refractive glass is used as a laser cavity mirror for constraining the laser emission at the selected wavelength. The laser device may be a broad spectrum laser such as an Er.sup.3+ doped glass broad spectrum laser. In an embodiment, the lasers are operated where the temperature dependence of the stimulated emission cross section is used to compensate for temperature dependent changes of other laser components

More Than One Way to Float Your Boat : Product Use and Sustainability Impacts

Peer reviewe

Self-reported sensory descriptors are associated with quantitative sensory testing parameters in patients with cervical radiculopathy, but not in patients with fibromyalgia

Background: The painDETECT questionnaire (PD-Q) has been used as a tool to characterize sensory abnormalities in patients with persistent pain. This study investigated whether the self-reported sensory descriptors of patients with painful cervical radiculopathy (CxRAD) and patients with fibromyalgia (FM), as characterized by responses to verbal sensory descriptors from PD-Q (sensitivity to light touch, cold, heat, slight pressure, feeling of numbness in the main area of pain), were associated with the corresponding sensory parameters as demonstrated by quantitative sensory testing (QST). Methods: Twenty-three patients with CxRAD (eight women, 46.3 ± 9.6 years) and 22 patients with FM (20 women, 46.1 ± 11.5 years) completed the PD-Q. Standardized QST of dynamic mechanical allodynia, cold and heat pain thresholds, pressure pain thresholds, mechanical and vibration detection thresholds, was recorded from the maximal pain area. Comparative QST data from 31 age-matched healthy controls (HCs; 15 women) were obtained. Results: Patients with CxRAD demonstrated a match between their self-reported descriptors and QST parameters for all sensory parameters except for sensitivity to light touch, and these matches were statistically significant compared with HC data (p ≤ 0.006). The FM group demonstrated discrepancies between the PD-Q and QST sensory phenotypes for all sensory descriptors, indicating that the self-reported sensory descriptors did not consistently match the QST parameters (p = ≤0.017). Conclusion: Clinicians and researchers should be cautious about relying on PD-Q as a stand-alone screening tool to determine sensory abnormalities in patients with FM

Fibromyalgia and neuropathic pain - differences and similarities. A comparison of 3057 patients with diabetic painful neuropathy and fibromyalgia

<p>Abstract</p> <p>Background</p> <p>Patients with diabetic neuropathy (DPN) and fibromyalgia differ substantially in pathogenetic factors and the spatial distribution of the perceived pain. We questioned whether, despite these obvious differences, similar abnormal sensory complaints and pain qualities exist in both entities. We hypothesized that similar sensory symptoms might be associated with similar mechanisms of pain generation. The aims were (1) to compare epidemiological features and co-morbidities and (2) to identify similarities and differences of sensory symptoms in both entities.</p> <p>Methods</p> <p>The present multi-center study compares epidemiological data and sensory symptoms of a large cohort of 1434 fibromyalgia patients and 1623 patients with painful diabetic neuropathy. Data acquisition included standard demographic questions and self-report questionnaires (MOS sleep scale, PHQ-9, Pain<it>DETECT</it>). To identify subgroups of patients with characteristic combinations of symptoms (sensory profiles) a cluster analysis was performed using all patients in both cohorts.</p> <p>Results</p> <p>Significant differences in co-morbidities (depression, sleep disturbance) were found between both disorders. Patients of both aetiologies chose very similar descriptors to characterize their sensory perceptions. Burning pain, prickling and touch-evoked allodynia were present in the same frequency. Five subgroups with distinct symptom profiles could be detected. Two of the subgroups were characteristic for fibromyalgia whereas one profile occurred predominantly in DPN patients. Two profiles were found frequently in patients of both entities (20-35%).</p> <p>Conclusions</p> <p>DPN and fibromyalgia patients experience very similar sensory phenomena. The combination of sensory symptoms - the sensory profile - is in most cases distinct and almost unique for each one of the two entities indicating aetiology-specific mechanisms of symptom generation. Beside the unique aetiology-specific sensory profiles an overlap of sensory profiles can be found in 20-35% of patients of both aetiologies.</p

Transcutaneous electrical nerve stimulation (TENS) for fibromyalgia in adults (Review)

Background: Fibromyalgia is a long-term medical condition that is characterised by long-lasting widespread pain throughout the body. TENS is a treatment that involves putting pulsed electrical currents across the surface of the skin using two or four electrodes. It is used to manage painful conditions. TENS is inexpensive, can be self-administered by people with fibromyalgia, and is not associated with any particular side effects. TENS reduces pain during movement so it may be useful in addition to other treatments to help people carry on their normal lives. Study characteristics: In January 2017, we found eight clinical studies that examined 315 people. We included TENS administered to produce a non-painful 'tingling' sensation at the site of pain either as a treatment alone or combined with exercise treatment. All studies used TENS in comparison with 'fake' (called placebo or sham) TENS, no treatment, or other treatments such as medicine or hydrotherapy (treatment in water). Key results: We did not find enough high-quality studies to allow us to come to any conclusions about the effectiveness of TENS for fibromyalgia pain. Even though seven studies concluded that TENS relieved pain associated with fibromyalgia, the studies were low quality and the findings for measures of pain were inconsistently reported. Studies did not measure most of our outcomes and it was not always clear what aspects of pain were being reported (e.g. present pain, remembered pain, pain severity, etc.). Only one small pilot study found that one 30-minute treatment of TENS reduced pain on movement during and immediately after treatment; however, there were too few participants observed and it is unknown whether this effect would be maintained over a longer course of TENS treatments. Overall, it is not possible to judge whether TENS reduces pain associated with fibromyalgia. There were no serious side events reported in any of the studies. Quality of the evidence: We rated the quality of the evidence from studies using four levels: very low, low, moderate, or high. Very low-quality evidence means that we are very uncertain about the results. High-quality evidence means that we are very confident in the results. The quality of the evidence was very low overall because of a lack of data

Transcutaneous Electrical Nerve Stimulation (TENS) for fibromyalgia in adults

This is the protocol for a review and there is no abstract. The objectives are as follows: To assess the analgesic efficacy and adverse events of TENS for fibromyalgia in adults. We will assess TENS on its own or added to usual care in comparisons with placebo (sham) TENS, usual care, or no treatment

Antifouling in the Baltic Sea

This thesis explores how to (re-)configure environmentally unsustainable practices into more sustainable forms in the empirical context of leisure boat antifouling. Current antifouling practices predominantly involve the use of biocide-based paint to avoid the adherence of marine organisms to boats. However, antifouling paints are harmful to marine life, and therefore policy makers and businesses seek options to replace the toxic paint through more environmental alternatives. This thesis uses a practice theoretical-perspective to study the reconfiguration of environmentally unsustainable practices. Practices can be understood as routinized human activity, consisting of various interconnected practice elements. Previous research explains that the reconfiguration process is initiated by breaking or loosening the linkages between practice elements, but in practice, various aspects keep practice elements glued together. To learn more about the persistence of unsustainable practices and how we can reconfigure them, for example through exchanging an unsustainable material element with an environmentally friendly one, it is vital to elucidate the linkages between practice elements sustaining the eco-unfriendly practice. A multi-method approach consisting of observations, interviews, visual and textual materials has been used to explore these linkages. The collective findings and analysis reveal several ‘configurators’ that impact and sustain the linkages between practice elements of unsustainable practices and ‘re-configurators’ that can loosen these linkages. This study suggests a framework that facilitates the reconfiguration of environmentally unsustainable practices, based on four ‘re-configurators’: eco-innovation, regulation, marketing practices and infrastructures. This thesis contributes to the field of researching sustainable consumption by proposing a combinational approach of several ‘re-configurators’ to facilitate more sustainable practices. Additionally, this study contributes to practice theory by expanding the knowledge on the under-theorized concept of linkages. With regard to marketing, this thesis has implications for the adoption of new products in practices and how sustainable products should be marketed