1,176 research outputs found
Visible light emission from reverse-biased silicon nanometer-scale diode-antifuses
Silicon nanometer-scale diodes have been fabricated to emit light in the visible range at low power consumption. Such structures are candidates for emitter elements in Si-based optical interconnect schemes. Spectral measurements of Electroluminescence (EL) on the reverse-biased nanometer-scale diodes brought into breakdown have been carried out over the photon energy range of 1.4-2.8 eV. Previously proposed mechanisms for avalanche emission from conventional silicon p-n junctions are discussed in order to understand the origin of the emission. Also the stability of the diodes has been tested. Results indicate that our nanometer-scale diodes are basically high quality devices. Furthermore due to the nanometer-scale dimensions, very high electrical fields and current densities are possible at low power consumption. This makes these diodes an excellent candidate to be utilized as a light source in Si-based sensors and actuator application
Exponential dichotomies of evolution operators in Banach spaces
This paper considers three dichotomy concepts (exponential dichotomy, uniform
exponential dichotomy and strong exponential dichotomy) in the general context
of non-invertible evolution operators in Banach spaces. Connections between
these concepts are illustrated. Using the notion of Green function, we give
necessary conditions and sufficient ones for strong exponential dichotomy. Some
illustrative examples are presented to prove that the converse of some
implication type theorems are not valid
Spin-orbit interaction in a dual gated InAs/GaSb quantum well
Spin-orbit interaction is investigated in a dual gated InAs/GaSb quantum
well. Using an electric field the quantum well can be tuned between a single
carrier regime with exclusively electrons as carriers and a two-carriers regime
where electrons and holes coexist. Spin-orbit interaction in both regimes
manifests itself as a beating in the Shubnikov-de Haas oscillations. In the
single carrier regime the linear Dresselhaus strength is characterized by
28.5 meV and the Rashba coefficient is tuned from 75 to
53 meV by changing the electric field. In the two-carriers regime the spin
splitting shows a nonmonotonic behavior with gate voltage, which is consistent
with our band structure calculations
No Evidence for Evolution in the Far-Infrared-Radio Correlation out to z ~ 2 in the eCDFS
We investigate the 70 um Far-Infrared Radio Correlation (FRC) of star-forming
galaxies in the Extended Chandra Deep Field South (ECDFS) out to z > 2. We use
70 um data from the Far-Infrared Deep Extragalactic Legacy Survey (FIDEL),
which comprises the most sensitive (~0.8 mJy rms) and extensive far-infrared
deep field observations using MIPS on the Spitzer Space Telescope, and 1.4 GHz
radio data (~8 uJy/beam rms) from the VLA. In order to quantify the evolution
of the FRC we use both survival analysis and stacking techniques which we find
give similar results. We also calculate the FRC using total infrared luminosity
and rest-frame radio luminosity, qTIR, and find that qTIR is constant (within
0.22) over the redshift range 0 - 2. We see no evidence for evolution in the
FRC at 70 um which is surprising given the many factors that are expected to
change this ratio at high redshifts.Comment: 18 pages, 13 figures. Accepted for publication in Ap
Retrieval of material properties of monolayer transition-metal dichalcogenides from magnetoexciton energy spectra
Reduced exciton mass, polarizability, and dielectric constant of the
surrounding medium are essential properties for semiconduction materials, and
they can be extracted recently from the magnetoexciton energies. However, the
acceptable accuracy of the previously suggested method requires very high
magnetic intensity. Therefore, in the present paper, we propose an alternative
method of extracting these material properties from recently available
experimental magnetoexciton s-state energies in monolayer transition-metal
dichalcogenides (TMDCs). The method is based on the high sensitivity of exciton
energies to the material parameters in the Rytova-Keldysh model. It allows us
to vary the considered material parameters to get the best fit of the
theoretical calculation to the experimental exciton energies for the ,
, and states. This procedure gives values of the exciton reduced mass
and 2D polarizability. Then, the experimental magnetoexciton spectra compared
to the theoretical calculation gives also the average dielectric constant.
Concrete applications are presented only for monolayers WSe and WS from
the recently available experimental data. However, the presented approach is
universal and can be applied to other monolayer TMDCs. The mentioned fitting
procedure requires a fast and effective method of solving the Schr\"{o}dinger
of an exciton in monolayer TMDCs with a magnetic field. Therefore, we also
develop such a method in this study for highly accurate magnetoexciton
energies.Comment: 8 pages, 4 figures, 4 table
The CIPAZ study protocol: an open label randomised controlled trial of azithromycin versus ciprofloxacin for the treatment of children hospitalised with dysentery in Ho Chi Minh City, Vietnam
Background: Diarrhoeal disease remains a common cause of illness and death in children <5 years of age. Faecal-oral infection by Shigella spp. causing bacillary dysentery is a leading cause of moderate-to-severe diarrhoea, particularly in low and middle-income countries. In Southeast Asia, S. sonnei predominates and infections are frequently resistant to first-line treatment with the fluoroquinolone, ciprofloxacin. While resistance to all antimicrobials is increasing, there may be theoretical and clinical benefits to prioritizing treatment of bacillary dysentery with the azalide, azithromycin. In this study we aim to measure the efficacy of treatment with azithromycin compared with ciprofloxacin, the current standard of care, for the treatment of children with bacillary dysentery.
Methods and analysis: We will perform a multicentre, open-label, randomized controlled trial of two therapeutic options for the antimicrobial treatment of children hospitalised with dysentery. Children (6â60 months of age) presenting with symptoms and signs of dysentery at Childrenâs Hospital 2 in Ho Chi Minh City will be randomised (1:1) to treatment with either oral ciprofloxacin (15mg/kg/twice daily for 3 days, standard-of-care) or oral azithromycin (10mg/kg/daily for 3 days). The primary endpoint will be the proportion of treatment failure (defined by clinical and microbiological parameters) by day 28 (+3 days) and will be compared between study arms by logistic regression modelling using treatment allocation as the main variable.
Ethics and dissemination: The study protocol (version 1.2 dated 27th December 2018) has been approved by the Oxford Tropical Research Ethics Committee (47â18) and the ethical review boards of Children's Hospital 2 (1341/NÄ2-CÄT). The study has also been approved by the Vietnamese Ministry of Health (5044/QÄ-BYT).
Trial registration: Clinicaltrials.gov: NCT03854929 (February 26th 2019)
Spectral functions in itinerant electron systems with geometrical frustration
The Hubbard model with geometrical frustration is investigated in a metallic
phase close to half-filling. We calculate the single particle spectral function
for the triangular lattice within dynamical cluster approximation, which is
further combined with non-crossing approximation and fluctuation exchange
approximation to treat the resulting cluster Anderson model. It is shown that
frustration due to non-local correlations suppresses short-range
antiferromagnetic fluctuations and thereby assists the formation of heavy
quasi-particles near half-filling.Comment: 4 pages, 5 eps figure
Pichia pastoris versus Saccharomyces cerevisiae:a case study on the recombinant production of human granulocyte-macrophage colony-stimulating factor
BACKGROUND: Recombinant human granulocyte-macrophage colony-stimulating factor (rhGM-CSF) is a glycoprotein that has been approved by the FDA for the treatment of neutropenia and leukemia in combination with chemotherapies. Recombinant hGM-CSF is produced industrially using the baker's yeast, Saccharomyces cerevisiae, by large-scale fermentation. The methylotrophic yeast, Pichia pastoris, has emerged as an alternative host cell system due to its shorter and less immunogenic glycosylation pattern together with higher cell density growth and higher secreted protein yield than S. cerevisiae. In this study, we compared the pipeline from gene to recombinant protein in these two yeasts. RESULTS: Codon optimization in silico for both yeast species showed no difference in frequent codon usage. However, rhGM-CSF expressed from S. cerevisiae BY4742 showed a significant discrepancy in molecular weight from those of P. pastoris X33. Analysis showed purified rhGM-CSF species with molecular weights ranging from 30 to more than 60 kDa. Fed-batch fermentation over 72 h showed that rhGM-CSF was more highly secreted from P. pastoris than S. cerevisiae (285 and 64 mg total secreted protein/L, respectively). Ion exchange chromatography gave higher purity and recovery than hydrophobic interaction chromatography. Purified rhGM-CSF from P. pastoris was 327 times more potent than rhGM-CSF from S. cerevisiae in terms of proliferative stimulating capacity on the hGM-CSF-dependent cell line, TF-1. CONCLUSION: Our data support a view that the methylotrophic yeast P. pastoris is an effective recombinant host for heterologous rhGM-CSF production
Herschel-HIFI detections of hydrides towards AFGL 2591 (Envelope emission versus tenuous cloud absorption)
The Heterodyne Instrument for the Far Infrared (HIFI) onboard the Herschel
Space Observatory allows the first observations of light diatomic molecules at
high spectral resolution and in multiple transitions. Here, we report deep
integrations using HIFI in different lines of hydrides towards the high-mass
star forming region AFGL 2591. Detected are CH, CH+, NH, OH+, H2O+, while NH+
and SH+ have not been detected. All molecules except for CH and CH+ are seen in
absorption with low excitation temperatures and at velocities different from
the systemic velocity of the protostellar envelope. Surprisingly, the CH(JF,P =
3/2_2,- - 1/2_1,+) and CH+(J = 1 - 0, J = 2 - 1) lines are detected in emission
at the systemic velocity. We can assign the absorption features to a foreground
cloud and an outflow lobe, while the CH and CH+ emission stems from the
envelope. The observed abundance and excitation of CH and CH+ can be explained
in the scenario of FUV irradiated outflow walls, where a cavity etched out by
the outflow allows protostellar FUV photons to irradiate and heat the envelope
at larger distances driving the chemical reactions that produce these
molecules.Comment: Accepted for publication in Astronomy and Astrophysics (HIFI first
results issue
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