43 research outputs found

    STRIDER (Sildenafil TheRapy in dismal prognosis early onset fetal growth restriction): An international consortium of randomised placebo-controlled trials

    Get PDF
    Background: Severe, early-onset fetal growth restriction due to placental insufficiency is associated with a high risk of perinatal mortality and morbidity with long-lasting sequelae. Placental insufficiency is the result of abnormal formation and function of the placenta with inadequate remodelling of the maternal spiral arteries. There is currently no effective therapy available. Some evidence suggests sildenafil citrate may improve uteroplacental blood flow, fetal growth, and meaningful infant outcomes. The objective of the Sildenafil TheRapy In Dismal prognosis Early onset fetal growth Restriction (STRIDER) collaboration is to evaluate the effectiveness of sildenafil versus placebo in achieving healthy perinatal survival through the conduct of randomised clinical trials and systematic review including individual patient data meta-analysis.Ā  Methods: Five national/bi-national multicentre randomised placebo-controlled trials have been launched. Women with a singleton pregnancy between 18 and 30 weeks with severe fetal growth restriction of likely placental origin, and where the likelihood of perinatal death/severe morbidity is estimated to be significant are included. Participants will receive either sildenafil 25 mg or matching placebo tablets orally three times daily from recruitment to 32 weeks gestation.Ā  Discussion: The STRIDER trials were conceived and designed through international collaboration. Although the individual trials have different primary outcomes for reasons of sample size and feasibility, all trials will collect a standard set of outcomes including survival without severe neonatal morbidity at time of hospital discharge. This is a summary of all the STRIDER trial protocols and provides an example of a prospectively planned international clinical research collaboration. All five individual trials will contribute to a pre-planned systematic review of the topic including individual patient data meta-analysis

    Social status and the academic achievement gap: A social dominance perspective

    No full text
    In this paper we sketch several mechanisms by which low social status is transformed into low academic performance. Using the perspective of social dominance theory, we review three processes by which this transformation takes place. These processes include: (a) the effects of lower economic, cultural, and social capital; (b) the effects of personal and institutional discrimination; and (c) reactions to low social status by members of low status groups. It is argued that members of low status groups engage in various protective mechanisms in response to their low social status. Although these mechanisms have the benefit of protecting self-esteem, this benefit is purchased at a potential cost. This cost includes reduced motivation to succeed which results in lower academic achievement and subsequent reinforcement of the status hierarchy. We argue that future research needs to place substantially more effort into precisely understanding the numerous, and often subtle, mediating mechanisms transforming low social status into low academic achievement.status: publishe

    The effects of ingroup and outgroup friendships on ethnic attitudes in college: A longitudinal study

    Get PDF
    Data for this longitudinal study were collected from over 2000 White, Asian, Latino, and African American college students. Results indicated that students who exhibited more ingroup bias and intergroup anxiety at the end of their first year of college had fewer outgroup friends and more ingroup friends during their second and third years of college, controlling for pre-college friendships and other background variables. In addition, beyond these effects of prior ethnic attitudes and orientations on friendship choices, those with more outgroup friendships and fewer ingroup friendships during their second and third years of college showed less ingroup bias and intergroup anxiety at the end of college, controlling for the prior attitudes, pre-college friendships, and background variables. Results are discussed in terms of the contact hypothesis.status: publishe

    Ethnic-related curricula and intergroup attitudes in college: Movement toward and away from the in-group

    Get PDF
    Using a 5-year longitudinal study, we investigated the long-term effects of courses with ethnic studies content and courses with Latino or Black professors on university students' intergroup attitudes. We found that these curricular variables significantly affected the intergroup attitudes of students beyond pre-existing differences in attitudes and beyond other curriculum variables. As expected, we found differences between ethnic groups: White students showed movement toward other groups as a result of these curricular factors, whereas Latino and African American students showed both increased tolerance toward other groups and movement toward the in-group. The results are discussed in terms of group status differences between the dominant White majority and the stigmatized Latino and Black minority groups.status: publishe

    Ethnic and university identities across the college years: A common in-group identity perspective

    Get PDF
    The common in-group identity model advocates the creation of a superordinate group identity in order to reduce conflict between members of different ethnic subgroups. This study demonstrates that a university identity can serve as an effective common in-group identity for students from different ethnic groups. Longitudinal data were collected from an ethnically diverse sample of university students at the end of each year of college. Although ethnic identification tended to be correlated with status-legitimizing orientations and ideologies in a way that reinforces ethnic-status differences (i.e., these variables tended to be positively related for Whites but less so for ethnic minorities), the status-legitimizing variables were largely unrelated to university identification during each year in college. The longitudinal data also allowed us to examine these relationships over time. The relationships between ethnic and university identification and status-legitimizing orientations and ideologies did not change. Ethnic and university identities are discussed in terms of the common in-group identity model.status: publishe

    Ethnic enclaves and the dynamics of social identity on the college campus: The good, the bad and the ugly

    Get PDF
    The effects of membership in ethnic organizations and fraternities and sororities on intergroup attitudes were examined using a 5-wave panel study at a major, multiethnic university. The results showed that these effects were similar for both minority and White students. Membership in ethnic student organizations for minorities and Greek organizations for Whites was anteceded by the degree of oneā€™s ethnic identity, and the effects of membership in these groups were similar, although not identical, for both White and minority students. These effects included an increased sense of ethnic victimization and a decreased sense of common identity and social inclusiveness. Consistent with social identity theory, at least a portion of these effects were mediated by social identity among both White and minority students.status: publishe

    Mother Teresa meets Genghis Khan: The dialectics of hierarchy enhancing and hierarchy attenuating career choices

    No full text
    We replicated and extended earlier work showing the connection between social dominance orientation and the perceived attractiveness of hierarchy-enhancing and hierarchy-attenuating careers using data from two large and independent samples of UCLA students. Consistent with expectations, the data from both studies showed that the greater the students' level of social dominance orientation, the more attractive hierarchy-enhancing careers such as criminal prosecutor, police officer, and FBI agent were perceived to be. Similarly, the greater the students' social dominance orientation, the less attractive they found hierarchy-attenuating careers such as public defender, civil rights lawyer, and human rights advocate. These conclusions held even after controlling for the effects of socioeconomic status and political conservatism. Canonical correlation analysis disclosed that the attractiveness of these career paths within the general domain of law made only one, bipolar and unidimensional projection within social dominance space. The nature of this bipolar dimension reproduced the hypothesized distinction between hierarchy-enhancing and hierarchy-attenuating social roles. Theoretical implications of the results are discussed.status: publishe
    corecore