The Impact of the International Convention on the Rights of Persons with Disabilities on Qatari Domestic Legislation

The entry into force of the International Convention on the Rights of Persons with Disabilities means that State Parties shall adapt their legislation and regulation to the social model designed in the international text. The present work aims to identify the general challenges faced by Qatar in that task. After presenting the keys to understanding the requirements of the Convention, the paper underlines the necessity of a cultural change in addition to a legal one. In this way, Qatar shares with other State Parties theoretical, legal, social and economic problems. Specifically, the current medical model in Qatar policies should be replaced with the conventional social model. This implies the elimination of discrimination based on disability, the universal accessibility, the legal capacity for persons with disabilities and their right to live independently. A priority is to generate an associative movement around disability

Interdependence, indivisibility and the social rights of persons with disabilities in the law of Qatar

Based on the description of the situation of some social rights of persons with disability in Qatar, this article is aimed to highlight the need to address the protection of human rights from interdependence and indivisibility. The analysis of Qatar Law reveals that social protection alone is not sufficient guarantee of dignity, as would not be a system based exclusively on freedom as not interference. Although providing noteworthy resources for persons with disabilities along with a good level of social protection and health care, Qatar does not base its system on autonomy and inclusion and this is a shortcoming to move towards a human rights-based approach

Qatar before the Committee on the Rights of Persons with Disabilities

Background: The Convention on the Rights of Persons with Disabilities (the CRPD) is the first human rights treaty of the 21st century and the first binding instrument specifically focused on protecting persons with disabilities within the framework of the UN's universal system of human rights. The CRPD came into force on May 3, 2008, and as of December 3, 2016 it has been ratified by 168 states. The CRPD developed the Committee on the Rights of Persons with Disabilities (Article 34) to monitor compliance with the Convention by States Parties. The main role of the Committee is to review the reports (both the initial and the periodic reports) submitted by States Parties pursuant to Article 35 of the CRPD. In accordance with the CRPD Article 35, States Parties are required to submit to the Committee “a comprehensive report on measures taken to give effect to its obligations [under the CRPD] … and on the progress made in that regard” within two years after the entry into force of the present Convention for the State Party concerned, and subsequently they must submit periodic reports every four years “and further whenever the Committee so requests.” Qatar ratified the UNCRPD in May 2008 and is obliged as a signatory nation to implement a number of social and legal measures to become fully compliant. Aim: The aim of this paper is to identify Qatar»s degree of compliance with the CRPD as per the last available CRPD reports. Subsequently, we list recommended actions toward Qatar's compliance with the Convention. Findings and recommendations: On June 19, 2012 Qatar submitted its report to the Committee on its compliance with the Convention. Following review of the Qatar report, the committee made six concluding observations. The six observations made by the Committee on the Rights of Persons with Disabilities on Qatar's compliance with the Convention: The legislation revolves around a medical (treatment) model of disability, in contrast to the convention's call for a social model and the human rights approach. It is necessary to safeguard non-discrimination, adopting the inclusive social model. Accommodation and accessibility are not in line with the Convention. There is an absence of specific legal and policy frameworks to ensure accessibility for persons with disabilities on an equal basis with others, and reasonable accommodation is not sufficiently guaranteed. Lack of consultation and participation of persons with disabilities in the drafting of regulatory policies that affect them. Lack of systematic information. There is no independent internal mechanism to coordinate policy on the rights of persons with disabilities and monitor the implementation of the Convention. The Committee's six concluding observations on the rights of persons with disabilities indicate that Qatar, similar to many other countries, has a long way to go before reaching compliance with the convention. As a first step towards compliance with the Convention, Qatar action regarding the six issues highlighted here is key, and can be as follows: Adopt a social model whereby the state moves beyond the assistance-based approach to the development of actual individual rights enforceable in a court of law, considers disability rights as validity standards, and regards the field of conflict of rights as other rights or fundamental legal interests. Prevent discrimination by adopting an inclusive social model, as well as via adapting both the situation strategy (equality focused on the situation) and the identity strategy (acknowledging the rights of specific persons or groups). Provide accessibility through universal design and reasonable accommodation. Consult and include persons with disabilities in the drafting of regulatory policies that affect them. Collect systematic (research and statistical) data on persons with disability for use in the development and implementation of policies. Put in place an independent internal mechanism to coordinate policy on the rights of persons with disabilities and monitor the implementation of the Convention. Acknowledgement: This presentation was made possible by the support of the NPRP grant 7 - 380 - 5 - 051 from the Qatar National Research Fund. The statements made herein are solely the responsibility of the authors.Qscienc

Psychological impact on care professionals due to the SARS-Cov-2 virus in Spain

Objective:To analyze the psychological impact of the SARS-Cov-2 pandemic on nursesin Spain in three different dimensions: exposure to stressors, perceived emotions, andstress coping. Background: On March 11, 2019, the World Health Organization recognized a globalpandemic caused by a SARS-Cov-2 virus, COVID-19, which rapidly spread across theplanet, involving a community health emergency of international scope.Introduction:The pandemic situation in health centers has led to significant changesin the work environment, compromising care professionals’ physical and psychologicalhealth and resulting in strong physical and mental exhaustion.Methods: An observational, descriptive, cross-sectional study was carried out, betweenFebruary and April 2021, in a large sample of 1360 participants. The researchers con-ducted the dissemination of a validated questionnaire to working nurses in Spain.Results:The sex variable in relation to the study dimensions (stressors, perceived emo-tions, and coping strategies) showed a mean for stressors of 62.2±10.5 in women and59.8±12.5 in men (p=0.010), showing statistically significant differences. Age was aprotective factor for all dimensions (p<0.001). Time of experience showed statisticallysignificant differences for stressors and coping strategies in professionals with more than15 years of experience. Discussion: Female nurses who are younger, have less work experience, have not builta family of their own, and live in smaller or indoor flats may be more vulnerable to theeffects of the COVID-19 pandemic on their mental health. Other national and inter-national studies, in this line, have shown an important psychological impact on theseprofessionals.Conclusion:It is necessary to design and adopt effective strategies and measures for theprotection of nurses’ mental health, as well as for the prevention and early diagnosis ofpossible mental health problems

Brain dynamics of mild cognitive impairment during face encoding

Brain oscillations are closely correlated with human information processing and fundamental aspects of cognition. Previous literature shows that due to the relation between brain oscillations and memory processes, spectral dynamics during such tasks are good candidates to study and characterize memory related pathologies. Mild cognitive impairment (MCI), defined as a clinical condition characterized by memory impairment and/ or deterioration of additional cognitive domains, is considered a preliminary stage in the dementia process. In consequence, the study of its brain patterns could help to achieve an early diagnosis of Alzheimer Disease

An auxin-regulable oscillatory circuit drives the root clock in Arabidopsis

CSIC - Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (INIA)In Arabidopsis, the root clock regulates the spacing of lateral organs along the primary root through oscillating gene expression. The core molecular mechanism that drives the root clock periodicity and how it is modified by exogenous cues such as auxin and gravity remain unknown. We identified the key elements of the oscillator (AUXIN RESPONSE FACTOR 7, its auxin-sensitive inhibitor IAA18/POTENT, and auxin) that form a negative regulatory loop circuit in the oscillation zone. Through multilevel computer modeling fitted to experimental data, we explain how gene expression oscillations coordinate with cell division and growth to create the periodic pattern of organ spacing. Furthermore, gravistimulation experiments based on the model predictions show that external auxin stimuli can lead to entrainment of the root clock. Our work demonstrates the mechanism underlying a robust biological clock and how it can respond to external stimuli.This work was funded by the Ministerio de Economía y Competitividad of Spain (MINECO) and/or the ERDF (BFU2016-80315-P to M.A.M.-R., BIO2017-82209-R to J.C.d.P., and TIN2016-81079-R to A.R.-P.), the Comunidad de Madrid and/or ERDF and ESF (2017-T1/BIO-5654 to K.W. and S2017/BMD-3691 to A.R.-P.), the Howard Hughes Medical Institute and the NIH (R35-GM131725 to P.N.B.), the Fonds Wetenschappelijk Onderzoek (FWO Flanders) (G022516N, G020918N, and G024118N to T.B.), and the “Severo Ochoa Program for Centres of Excellence in R&D” from the Agencia Estatal de Investigacion of Spain [SEV-2016-0672 (2017–2021)] to K.W., P.P.-G., and M.A.M.-R. through CBGP. M.M. was supported by a postdoctoral contract associated to SEV-2016-0672, E.B.-A. by Ayudante de Investigacion contract PEJ-2017-AI/BIO-7360 from the Comunidad de Madrid, A.S.-C. and L.S.-R. by FPI contracts from MINECO (BES-2014-068852 and BES-2017-080155, respectively), J.C. by a Juan de la Cierva contract from MINECO (FJCI-2016-28607), P.P.-G. by a Juan de la Cierva contract from MINECO (FJCI-2015-24905) and Programa Atraccion Talento from Comunidad Madrid (2017-T2/BIO-3453), A.S. by a Torres Quevedo contract from MINECO (PTQ-15-07915), and K.W. by program PGC2018-093387-A-I00 from the Ministerio de Ciencia e Innovacion (MICIU)Peer reviewe

Comparison of seven prognostic tools to identify low-risk pulmonary embolism in patients aged <50 years

publishersversionPeer reviewe

The evolution of the ventilatory ratio is a prognostic factor in mechanically ventilated COVID-19 ARDS patients

Background: Mortality due to COVID-19 is high, especially in patients requiring mechanical ventilation. The purpose of the study is to investigate associations between mortality and variables measured during the first three days of mechanical ventilation in patients with COVID-19 intubated at ICU admission. Methods: Multicenter, observational, cohort study includes consecutive patients with COVID-19 admitted to 44 Spanish ICUs between February 25 and July 31, 2020, who required intubation at ICU admission and mechanical ventilation for more than three days. We collected demographic and clinical data prior to admission; information about clinical evolution at days 1 and 3 of mechanical ventilation; and outcomes. Results: Of the 2,095 patients with COVID-19 admitted to the ICU, 1,118 (53.3%) were intubated at day 1 and remained under mechanical ventilation at day three. From days 1 to 3, PaO2/FiO2 increased from 115.6 [80.0-171.2] to 180.0 [135.4-227.9] mmHg and the ventilatory ratio from 1.73 [1.33-2.25] to 1.96 [1.61-2.40]. In-hospital mortality was 38.7%. A higher increase between ICU admission and day 3 in the ventilatory ratio (OR 1.04 [CI 1.01-1.07], p = 0.030) and creatinine levels (OR 1.05 [CI 1.01-1.09], p = 0.005) and a lower increase in platelet counts (OR 0.96 [CI 0.93-1.00], p = 0.037) were independently associated with a higher risk of death. No association between mortality and the PaO2/FiO2 variation was observed (OR 0.99 [CI 0.95 to 1.02], p = 0.47). Conclusions: Higher ventilatory ratio and its increase at day 3 is associated with mortality in patients with COVID-19 receiving mechanical ventilation at ICU admission. No association was found in the PaO2/FiO2 variation

CIBERER : Spanish national network for research on rare diseases: A highly productive collaborative initiative

Altres ajuts: Instituto de Salud Carlos III (ISCIII); Ministerio de Ciencia e Innovación.CIBER (Center for Biomedical Network Research; Centro de Investigación Biomédica En Red) is a public national consortium created in 2006 under the umbrella of the Spanish National Institute of Health Carlos III (ISCIII). This innovative research structure comprises 11 different specific areas dedicated to the main public health priorities in the National Health System. CIBERER, the thematic area of CIBER focused on rare diseases (RDs) currently consists of 75 research groups belonging to universities, research centers, and hospitals of the entire country. CIBERER's mission is to be a center prioritizing and favoring collaboration and cooperation between biomedical and clinical research groups, with special emphasis on the aspects of genetic, molecular, biochemical, and cellular research of RDs. This research is the basis for providing new tools for the diagnosis and therapy of low-prevalence diseases, in line with the International Rare Diseases Research Consortium (IRDiRC) objectives, thus favoring translational research between the scientific environment of the laboratory and the clinical setting of health centers. In this article, we intend to review CIBERER's 15-year journey and summarize the main results obtained in terms of internationalization, scientific production, contributions toward the discovery of new therapies and novel genes associated to diseases, cooperation with patients' associations and many other topics related to RD research

Spread of a SARS-CoV-2 variant through Europe in the summer of 2020.

Following its emergence in late 2019, the spread of SARS-CoV-21,2 has been tracked by phylogenetic analysis of viral genome sequences in unprecedented detail3–5. Although the virus spread globally in early 2020 before borders closed, intercontinental travel has since been greatly reduced. However, travel within Europe resumed in the summer of 2020. Here we report on a SARS-CoV-2 variant, 20E (EU1), that was identified in Spain in early summer 2020 and subsequently spread across Europe. We find no evidence that this variant has increased transmissibility, but instead demonstrate how rising incidence in Spain, resumption of travel, and lack of effective screening and containment may explain the variant’s success. Despite travel restrictions, we estimate that 20E (EU1) was introduced hundreds of times to European countries by summertime travellers, which is likely to have undermined local efforts to minimize infection with SARS-CoV-2. Our results illustrate how a variant can rapidly become dominant even in the absence of a substantial transmission advantage in favourable epidemiological settings. Genomic surveillance is critical for understanding how travel can affect transmission of SARS-CoV-2, and thus for informing future containment strategies as travel resumes. © 2021, The Author(s), under exclusive licence to Springer Nature Limited