Modelo experimental de artropatia degenerativa en raton transgenico

Centro de Informacion y Documentacion Cientifica (CINDOC). C/Joaquin Costa, 22. 28002 Madrid. SPAIN / CINDOC - Centro de Informaciòn y Documentaciòn CientìficaSIGLEESSpai

Lava flow modelling at El Hierro (Canary Islands): the case of Montaña Aguarijo volcano

EGU General Assembly 2021, vEGU21: Gather Online | 19-30 April 2021Lava flow simulations are valuable tools for forecasting and assessing the areas that may be potentially affected by new eruptions, but also for interpreting past volcanic events and understanding the controls on lava flow behaviour. The plugin Q-LavHA v3.0 (Mossoux et al., 2016), integrated into QGIS, allows simulating the inundation probability of an a¿a lava flow from one or more eruptive vents spatially distributed in a Digital Elevation Model (DEM). Q-LavHA allows running probabilistic and deterministic methods to calculate the spatial propagation and the maximum length of lava flows, considering a number of morphometric and/or thermo-rheological parameters. El Hierro is the smallest and westernmost island of the Canary Archipelago where basaltic lava flows infer the major volcanic hazard. However, no lava flow emplacement modelling has been carried out yet on the island. Here we present Montaña Aguarijo's lava flow simulation, a monogenetic volcano located on the NW rift of El Hierro. Detailed geological fieldwork and current topographic-bathymetric data were used to reconstruct the pre-eruption (before the eruption modifies the relief) and post-eruption (at the end of the eruption, prior to erosive processes) DEMs. The obtained morphometric parameters of the lava flow (2,268m long; 5m medium thickness; 422,560m3) were used to run probabilistic (Maximum Length) and deterministic (FLOWGO) models. The latter also considers a set of thermo-rheological properties of the lava flow such as initial viscosity, phenocryst content, or vesicle proportion. Results obtained show a high degree of overlap between the real and simulated lava flows. Therefore, the thermo-rheological parameters considered in the deterministic approach are close to the real ones that constrained Montaña Aguarijo lava flow propagation. Moreover, this work evidence the effectiveness of Q-LavHA plugin when simulating complex lava flows such as Montaña Aguarijo¿s lava which runs through a coastal platform, a typical morphology of oceanic volcanic islands.Financial support was provided by Project LAJIAL (ref. PGC2018-101027-B-I00, MCIU/AEI/FEDER, EU). This study was carried out in the framework of the Research Consolidated Groups GEOVOL (Canary Islands Government, ULPGC) and GEOPAM (Generalitat de Catalunya, 2017 SGR 1494)

Volcanes en movimiento: El Hierro y La Palma

Paneles expositivos para la divulgación del volcanismo en las islas de El Hiero y La Palma en colaboración con la Asociación Española para la Enseñanza de las Ciencias de la Tierra (AEPECT)[EN] We explain the geological history of the island of El Hierro and the 2021 eruption in the island of La Palma through a collection of ten panels. How the Canary Islands were formed and evolved is contextualized, and we introduce the birth of El Hierro. Next, we observe the landscapes of El Hierro as a response to macro-scale, such as giant landslides and rifts, and micro-scale phenomena (cones, lavas, and shore platforms). The last eruption of the island that gave rise to the Tagoro submarine volcano is also exposed. In addition, we present how the Herreños have adapted to the territory, knowing how to take advantage of its scarce water resources and adapt their way of life to the volcanic landscape, achieving that the entire island was declared in 2000 a UNESCO World Biosphere Reserve and Geopark in 2015. Finally, we expose the 2021 eruption of La Palma island.[ES] A través de una colección de diez paneles se explica la historia geológica de la isla de El Hierro y la erupción de 2021 en la isla de La Palma. Se contextualiza cómo se formaron y evolucionaron las Islas Canarias y se introduce el nacimiento de El Hierro. A continuación, se observan los paisajes herreños como respuesta a fenómenos de macroescala, como los deslizamientos gigantes y las dorsales (rifts), y microescala (conos, lavas e islas bajas). Se expone la última erupción de la isla que dio lugar al volcán submarino Tagoro. Se presenta cómo los herreños se han adaptado al territorio, sabiendo aprovechar sus escasos recursos hídricos y adaptando su modo de vida al paisaje volcánico que le rodea, consiguiendo que la isla al completo haya sido declarada por la UNESCO Reserva Mundial de la Biosfera en el año 2000 y Geoparque en el año 2015. Finalmente, se expone la erupción de 2021 en la vecina isla de La Palma.Project LAJIAL (ref. PGC2018-101027-B-I00, MCIU/AEI/FEDER, EU). Research Consolidated Groups GEOVOL (Canary Islands Government, ULPGC) and GEOPAM (Generalitat de Catalunya, 2017 SGR 1494).dc.description.tableofcontents: Filename 01: Panel01-VolcanesMovimiento-AEPECT.pdf; Filename 02: Panel02-VolcanesMovimiento-AEPECT.pdf; Filename 03: Panel03-VolcanesMovimiento-AEPECT.pdf; Filename 04: Panel04-VolcanesMovimiento-AEPECT,pdf; Filename 05: Panel05-VolcanesMovimiento-AEPECT.pdf; Filename 06: Panel06-VolcanesMovimiento-AEPECT.pdf; Filename 07: Panel07-VolcanesMovimiento-AEPECT.pdf; Filename 08: Panel08-VolcanesMovimiento-AEPECT.pdf; Filename 09: Panel09-VolcanesMovimiento-AEPECT.pdf; Filename 10: Panel10-VolcanesMovimiento-AEPECT.pdfN

Comparison of seven prognostic tools to identify low-risk pulmonary embolism in patients aged <50 years

In young patients with acute pulmonary embolism (PE), the predictive value of currently available prognostic tools has not been evaluated. Our objective was to compare prognostic value of 7 available tools (GPS, PESI, sPESI, Prognostic Algorithm, PREP, shock index and RIETE) in patients aged &lt;50 years. We used the RIETE database, including PE patients from 2001 to 2017. The major outcome was 30-day all-cause mortality. Of 34,651 patients with acute PE, 5,822 (17%) were aged &lt;50 years. Of these, 83 (1.4%) died during the first 30 days. Number of patients deemed low risk with tools was: PREP (95.9%), GPS (89.6%), PESI (87.2%), Shock index (70.9%), sPESI (59.4%), Prognostic algorithm (58%) and RIETE score (48.6%). The tools with a highest sensitivity were: Prognostic Algorithm (91.6%; 95% CI: 85.6\u201397.5), RIETE score (90.4%; 95%CI: 84.0\u201396.7) and sPESI (88%; 95% CI: 81\u201395). The RIETE, Prognostic Algorithm and sPESI scores obtained the highest overall sensitivity estimates for also predicting 7- and 90-day all-cause mortality, 30-day PE-related mortality, 30-day major bleeding and 30-day VTE recurrences. The proportion of low-risk patients who died within the first 30 days was lowest using the Prognostic Algorithm (0.2%), RIETE (0.3%) or sPESI (0.3%) scores. In PE patients less 50 years, 30-day mortality was low. Although sPESI, RIETE and Prognostic Algorithm scores were the most sensitive tools to identify patients at low risk to die, other tools should be evaluated in this population to obtain more efficient results

Impact of sex, age, and risk factors for venous thromboembolism on the initial presentation of first isolated symptomatic acute deep vein thrombosis

BACKGROUND AND AIMS: Sex-specific differences exist for the initial presentation of acute venous thromboembolism (VTE): men are more likely to present with proximal deep vein thrombosis (DVT) in the lower limbs (versus pulmonary embolism [PE] or isolated distal DVT [IDDVT]) than women. We studied in detail the influence of sex, age, and VTE risk factors on the initial presentation of IDDVT versus proximal DVT. METHODS: A total of 24,911 patients with a first episode of objectively diagnosed acute symptomatic lower-limb DVT (without symptomatic PE) were enrolled in RIETE (years 2000-2017) and included in the present analysis. RESULTS: A total of 4266 (17.1%) patients had IDDVT. No trend for more IDDVT diagnoses was observed over time. Women aged 40-69 had a higher proportion of IDDVT, especially between 40 and 49 years (+6.7%; 95CI +3.7%; +9.9%), whereas men had more often proximal DVT. The presenting location of first acute DVT depended on sex, age, and the prevalence and type of VTE risk factors. Recent surgery was independently associated with a diagnosis of IDDVT in both women and men, whereas active cancer and pregnancy were associated with proximal DVT. CONCLUSIONS: The interaction between age and VTE risk factors influences the presenting location (distal versus proximal) of the first acute lower-limb DVT observed in women and men. Our observations extend to IDDVT the concept that different clinical manifestations of acute VTE may not fully share the same pathophysiological mechanisms: this contributes to explain sex-specific prognostic differences.status: publishe

Liver status and outcomes in patients without previous known liver disease receiving anticoagulant therapy for venous thromboembolism

The association between elevated liver enzymes or FIB-4 (fibrosis index 4) and outcome in patients with venous thromboembolism (VTE) has not been evaluated. Data from patients in RIETE (Registro Informatizado Enfermedad TromboEmbólica) were used to assess the association between elevated liver enzymes or FIB-4 levels and the rates of major bleeding or death in apparent liver disease-free patients with acute VTE under anticoagulation therapy. A total of 6206 patients with acute VTE and without liver disease were included. Of them, 92 patients had major bleeding and 168 died under anticoagulation therapy. On multivariable analysis, patients with elevated liver enzymes were at increased mortality risk (HR: 1.58; 95% CI: 1.10–2.28), while those with FIB-4 levels > 2.67 points were at increased risk for major bleeding (HR: 1.69; 95% CI: 1.04–2.74). Evaluation of liver enzymes and FIB-4 index at baseline in liver disease-free patients with VTE may provide additional information on the risk for major bleeding or death during anticoagulation