Synthesis of 3,4-Dihydro-2H-Pyrroles from Ketones, Aldehydes, and Nitro Alkanes via Hydrogenative Cyclization

Syntheses of N-heterocyclic compounds that permit a flexible introduction of various substitution patterns by using inexpensive and diversely available starting materials are highly desirable. Easy to handle and reusable catalysts based on earth-abundant metals are especially attractive for these syntheses. We report here on the synthesis of 3,4-dihydro-2H-pyrroles via the hydrogenation and cyclization of nitro ketones. The latter are easily accessible from three components: a ketone, an aldehyde and a nitroalkane. Our reaction has a broad scope and 23 of the 33 products synthesized are compounds which have not yet been reported. The key to the general hydrogenation/cyclization reaction is a highly active, selective and reusable nickel catalyst, which was identified from a library of 24 earth-abundant metal catalysts

Putting the public back in behavioral public policy

Behavioral public policies are aimed at influencing the behavior of the public in a way that is advantageous for the public itself and within the law. Sanders, Snijders and Hallsworth (2018 , this issue) summarize the state of the art of this new field of study and introduce a number of challenges and opportunities for the time to come. We address an additional challenge that is present and central in all attempts to influence behavior, namely the public – the people that are the target of behavioral public policies. We review evidence revealing that people do not passively accept those influence attempts, but often show reactant responses. We propose that the Persuasion Knowledge Model provides a framework both to understand the reactions of the public and to facilitate communication between academic researchers and practitioners

Synthesis of 3,4-Dihydro-2H-Pyrroles from Ketones, Aldehydes, and Nitro Alkanes via Hydrogenative Cyclization

Syntheses of N‐heterocyclic compounds that permit a flexible introduction of various substitution patterns by using inexpensive and diversely available starting materials are highly desirable. Easy to handle and reusable catalysts based on earth‐abundant metals are especially attractive for these syntheses. We report here on the synthesis of 3,4‐dihydro‐2H‐pyrroles via the hydrogenation and cyclization of nitro ketones. The latter are easily accessible from three components: a ketone, an aldehyde and a nitroalkane. Our reaction has a broad scope and 23 of the 33 products synthesized are compounds which have not yet been reported. The key to the general hydrogenation/cyclization reaction is a highly active, selective and reusable nickel catalyst, which was identified from a library of 24 earth‐abundant metal catalysts

Key Parameters for the Synthesis of Active and Selective Nanostructured 3d Metal Catalysts Starting from Coordination Compounds – Case Study: Nickel Mediated Reductive Amination

The design of nanostructured catalysts based on earth-abundant metals that mediate important reactions efficiently, selectively and with a broad scope is highly desirable. Unfortunately, the synthesis of such catalysts is poorly understood. We report here on highly active Ni catalysts for the reductive amination of ketones by ammonia employing hydrogen as a reducing agent. The key functions of the Ni-salen precursor complex during catalyst synthesis have been identified: (1) Ni-salen complexes sublime during catalyst synthesis, which allows molecular dispersion of the metal precursor on the support material. (2) The salen ligand forms a nitrogen-doped carbon shell by decomposition, which embeds and stabilizes the Ni nanoparticles on the γ-Al2O3 support. (3) Parameters, such as flow rate of the pyrolysis gas, determine the carbon supply for the embedding process of Ni nanoparticles

Key Parameters for the Synthesis of Active and Selective Nanostructured 3d Metal Catalysts Starting from Coordination Compounds – Case Study: Nickel Mediated Reductive Amination

The design of nanostructured catalysts based on earth-abundant metals that mediate important reactions efficiently, selectively and with a broad scope is highly desirable. Unfortunately, the synthesis of such catalysts is poorly understood. We report here on highly active Ni catalysts for the reductive amination of ketones by ammonia employing hydrogen as a reducing agent. The key functions of the Ni-salen precursor complex during catalyst synthesis have been identified: (1) Ni-salen complexes sublime during catalyst synthesis, which allows molecular dispersion of the metal precursor on the support material. (2) The salen ligand forms a nitrogen-doped carbon shell by decomposition, which embeds and stabilizes the Ni nanoparticles on the γ-Al2O3 support. (3) Parameters, such as flow rate of the pyrolysis gas, determine the carbon supply for the embedding process of Ni nanoparticles

Music Learning with Massive Open Online Courses

Steels, Luc et al.-- Editors: Luc SteelsMassive Open Online Courses, known as MOOCs, have arisen as the logical consequence of marrying long-distance education with the web and social media. MOOCs were confidently predicted by advanced thinkers decades ago. They are undoubtedly here to stay, and provide a valuable resource for learners and teachers alike. This book focuses on music as a domain of knowledge, and has three objectives: to introduce the phenomenon of MOOCs; to present ongoing research into making MOOCs more effective and better adapted to the needs of teachers and learners; and finally to present the first steps towards 'social MOOCs’, which support the creation of learning communities in which interactions between learners go beyond correcting each other's assignments. Social MOOCs try to mimic settings for humanistic learning, such as workshops, small choirs, or groups participating in a Hackathon, in which students aided by somebody acting as a tutor learn by solving problems and helping each other. The papers in this book all discuss steps towards social MOOCs; their foundational pedagogy, platforms to create learning communities, methods for assessment and social feedback and concrete experiments. These papers are organized into five sections: background; the role of feedback; platforms for learning communities; experiences with social MOOCs; and looking backwards and looking forward. Technology is not a panacea for the enormous challenges facing today's educators and learners, but this book will be of interest to all those striving to find more effective and humane learning opportunities for a larger group of students.Funded by the European Commission's OpenAIRE2020 project.Peer reviewe

Collaborative Peer Assessment using PeerLearn

In this chapter we introduce the PeerLearn methodology and its associated tools. We base the design of pedagogical workflows for students on the definition of rubrics (using PeerAssess) as the starting element that drives the creation of lesson plans (using LessonEditor). These plans run over our web platform (Peer-Flow). Students can evaluate one another following given rubrics and teachers can accept (or not) marks produced by a collaborative assessment tool (COMAS). Experimental results show that PeerLearn provide students with a highly satisfying new pedagogical experience and increased learning outcomes. © 2015 The authors and IOS Press.Peer reviewe

Variations in childbirth interventions in high-income countries: protocol for a multinational cross-sectional study

Introduction There are growing concerns about the increase in rates of commonly used childbirth interventions. When indicated, childbirth interventions are crucial for preventing maternal and perinatal morbidity and mortality, but their routine use in healthy women and children leads to avoidable maternal and neonatal harm. Establishing ideal rates of interventions can be challenging. This study aims to describe the range of variations in the use of commonly used childbirth interventions in high-income countries around the world, and in outcomes in nulliparous and multiparous women. Methods and analysis This multinational cross-sectional study will use data from births in 2013 with national population data or representative samples of the population of pregnant women in high-income countries. Data from women who gave birth to a single child from 37 weeks gestation onwards will be included and the results will be presented for nulliparous and multiparous women separately. Anonymised individual level data will be analysed. Primary outcomes are rates of commonly used childbirth interventions, including induction and/or augmentation of labour, intrapartum antibiotics, epidural and pharmacological pain relief, episiotomy in vaginal births, instrument-assisted birth (vacuum or forceps), caesarean section and use of oxytocin postpartum. Secondary outcomes are maternal and perinatal mortality, Apgar score below 7 at 5 min, postpartum haemorrhage and obstetric anal sphincter injury. Univariable and multivariable logistic regression analyses will be conducted to investigate variations among countries, adjusted for maternal age, body mass index, gestational weight gain, ethnic background, socioeconomic status and infant birth weight. The overall mean rates will be considered as a reference category, weighted for the size of the study population per country. Ethics and dissemination The Medical Ethics Review Committee of VU University Medical Center Amsterdam confirmed that an official approval of this study was not required. Results will be disseminated at national and international conferences and published in peer-reviewed journals.The study was developed during a meeting with COST-members (European Cooperation in Science and Technology). These meetings are funded by the COST Action IS1405 ‘BIRTH’ (European Cooperation in Science and Technology). There is no other external funding for this study.Peer Reviewe

Correction : variations in childbirth interventions in high-income countries : protocol for a multinational cross-sectional study

Original article can be fount at: https://www.um.edu.mt/library/oar/handle/123456789/58714Correction issued for the article Variations in childbirth interventions in highincome countries: protocol for a multinational cross-sectional study (10.1136/bmjopen-2017-017993)peer-reviewe