Assignment of PCR markers to river buffalo chromosomes

International audienc

A comparison of tracheal scaffold strategies for pediatric transplantation in a rabbit model

Objectives/Hypothesis: Despite surgical advances, childhood tracheal stenosis is associated with high morbidity and mortality. Various tracheal scaffold strategies have been developed as the basis for bioengineered substitutes, but there is no consensus on which may be superior in vivo. We hypothesized that there would be no difference in morbidity and mortality between three competing scaffold strategies in rabbits. Study Design Pilot preclinical study. Methods: Tracheal scaffolds were prepared by three methods that have been applied clinically and reported: preserved cadaveric (“Herberhold”) allografts, detergent-enzymatically decellularized allografts, and synthetic scaffolds (nanocomposite polymer [polyhedral oligomeric silsesquioxane poly(carbonate-urea) urethane (POSS-PCU)]). Scaffolds were implanted into cervical trachea of New Zealand White rabbits (n = 4 per group) without cell seeding. Control animals (n = 4) received autotransplanted tracheal segments using the same technique. Animals underwent bronchoscopic monitoring of the grafts for 30 days. Macroscopic evaluation of tissue integration, graft stenosis, and collapsibility and histological examinations were performed on explants at termination. Results: All surgical controls survived to termination without airway compromise. Mild to moderate anastomotic stenosis from granulation tissue was detected, but there was evidence suggestive of vascular reconnection with minimal fibrous encapsulation. In contrast, three of the four animals in the Herberhold and POSS-PCU groups, and all animals receiving decellularized allografts, required early termination due to respiratory distress. Herberhold grafts showed intense inflammatory reactions, anastomotic stenoses, and mucus plugging. Synthetic graft integration and vascularization were poor, whereas decellularized grafts demonstrated malacia and collapse but had features suggestive of vascular connection or revascularization. Conclusions: There are mirror-image benefits and drawbacks to nonrecellularized, decellularized, and synthetic grafts, such that none emerged as the preferred option. Results from prevascularized and/or cell-seeded grafts (as applied clinically) may elucidate clearer advantages of one scaffold type over another

Search for direct pair production of scalar top quarks in the single- and dilepton channels in proton-proton collisions at √s= 8 TeV

Results: are reported from a search for the top squark t ˜ 1, the lighter of the two supersymmetric partners of the top quark. The data sample corresponds to 19.7 fb−1 of proton-proton collisions at s=8 TeV collected with the CMS detector at the LHC. The search targets t˜1→bχ˜1± and t˜1→t(∗)χ˜10 decay modes, where χ˜1± and χ˜10 are the lightest chargino and neutralino, respectively. The reconstructed final state consists of jets, b jets, missing transverse energy, and either one or two leptons. Leading backgrounds are determined from data. No significant excess in data is observed above the expectation from standard model processes. The results exclude a region of the two-dimensional plane of possible t ˜ 1 and χ˜10 masses. The highest excluded t ˜ 1 and χ˜10 masses are about 700 GeV and 250 GeV, respectively.[Figure not available: see fulltext.

Forward–backward asymmetry of Drell–Yan lepton pairs in pp collisions at √s = 8 TeV

© 2016, CERN for the benefit of the CMS collaboration.A measurement of the forward–backward asymmetry AFB of oppositely charged lepton pairs (μμ and ee) produced via Z / γ∗ boson exchange in pp collisions at √s = 8 TeV is presented. The data sample corresponds to an integrated luminosity of 19.7 fb-1 collected with the CMS detector at the LHC. The measurement of AFB is performed for dilepton masses between 40 GeV and 2TeV and for dilepton rapidity up to 5. The AFB measurements as a function of dilepton mass and rapidity are compared with the standard model predictions

Search for lepton flavour violating decays of heavy resonances and quantum black holes to an eμ pair in proton–proton collisions at √s = 8 TeV

A search for narrow resonances decaying to an electron and a muon is presented. The eμ mass spectrum is also investigated for non-resonant contributions from the production of quantum black holes (QBHs). The analysis is performed using data corresponding to an integrated luminosity of 19.7 fb-1 collected in proton-proton collisions at a centre-of-mass energy of 8 TeV with the CMS detector at the LHC. With no evidence for physics beyond the standard model in the invariant mass spectrum of selected eμ pairs, upper limits are set at 95 % confidence level on the product of cross section and branching fraction for signals arising in theories with charged lepton flavour violation. In the search for narrow resonances, the resonant production of τ sneutrino in R-parity violating supersymmetry is considered. The τ sneutrino is excluded for masses below 1.28 TeV for couplings λ132= λ231= λ311′= 0.01 , and below 2.30 TeV for λ132= λ231= 0.07 and λ311′= 0.11. These are the most stringent limits to date from direct searches at high-energy colliders. In addition, the resonance searches are interpreted in terms of a model with heavy partners of the Z boson and the photon. In a framework of TeV-scale quantum gravity based on a renormalization of Newton’s constant, the search for non-resonant contributions to the eμ mass spectrum excludes QBH production below a threshold mass Mth of 1.99 TeV. In models that invoke extra dimensions, the bounds range from 2.36 TeV for one extra dimension to 3.63 TeV for six extra dimensions. This is the first search for QBHs decaying into the eμ final state.We acknowledge the enduring support for the construction and operation of the LHC and the CMS detector provided by the following funding agencies: BMWFWand FWF (Austria); FNRS and FWO (Belgium); CNPq, CAPES, FAPERJ, and FAPESP (Brazil);MES (Bulgaria);CERN; CAS, MoST, and NSFC (China); COLCIENCIAS (Colombia); MSES and CSF (Croatia); RPF (Cyprus); MoER, ERC IUT and ERDF (Estonia); Academy of Finland, MEC, and HIP (Finland); CEA and CNRS/IN2P3 (France); BMBF, DFG, and HGF (Germany); GSRT (Greece); OTKA and NIH (Hungary); DAE and DST (India); IPM (Iran); SFI (Ireland); INFN (Italy);MSIP and NRF (Republic of Korea); LAS (Lithuania); MOE and UM (Malaysia); CINVESTAV, CONACYT, SEP, and UASLP-FAI (Mexico);MBIE(NewZealand); PAEC(Pakistan);MSHE and NSC (Poland); FCT (Portugal); JINR (Dubna); MON, RosAtom, RAS and RFBR (Russia);MESTD (Serbia); SEIDI and CPAN (Spain); Swiss Funding Agencies (Switzerland); MST (Taipei); ThEPCenter, IPST, STAR and NSTDA (Thailand); TUBITAK and TAEK (Turkey); NASU and SFFR (Ukraine); STFC (United Kingdom); DOE and NSF (USA). Individuals have received support from the Marie-Curie programme and the European Research Council and EPLANET (European Union); the Leventis Foundation; the A. P. Sloan Foundation; the Alexander von Humboldt Foundation; the Belgian Federal Science Policy Office; the Fonds pour la Formation à la Recherche dans l’Industrie et dans l’Agriculture (FRIA-Belgium); the Agentschap voor Innovatie doorWetenschap en Technologie (IWT-Belgium); the Ministry of Education, Youth and Sports (MEYS) of the Czech Republic; the Council of Science and Industrial Research, India; the HOMING PLUS programme of the Foundation for Polish Science, cofinanced from European Union, RegionalDevelopment Fund; the Mobility Plus programme of the Ministry of Science and Higher Education (Poland); the OPUS programme of the National Science Center (Poland); MIUR project 20108T4XTM (Italy); the Thalis and Aristeia programmes cofinanced by EU-ESF and the Greek NSRF; the National Priorities Research Program by QatarNationalResearch Fund; theRachadapisek Sompot Fund for Postdoctoral Fellowship, Chulalongkorn University (Thailand); the Chulalongkorn Academic into Its 2nd Century Project Advancement Project (Thailand); and the Welch Foundation, contract C-1845

Measurement of the t t ¯ production cross section using events in the e μ final state in pp collisions at √s=13 TeV

© 2017, CERN for the benefit of the CMS collaboration.The cross section of top quark–antiquark pair production in proton–proton collisions at s=13TeV is measured by the CMS experiment at the LHC, using data corresponding to an integrated luminosity of 2.2fb-1. The measurement is performed by analyzing events in which the final state includes one electron, one muon, and two or more jets, at least one of which is identified as originating from hadronization of a b quark. The measured cross section is 815±9(stat)±38(syst)±19(lumi) pb, in agreement with the expectation from the standard model

Measurement of the W+W- cross section in pp collisions at √s= 8 TeVand limits on anomalous gauge couplings

A measurement of the W boson pair production cross section in proton-proton collisions at √s = 8 TeV is presented. The data collected with the CMS detector at the LHC correspond to an integrated luminosity of 19.4fb-1. The W +W - candidates are selected from events with two charged leptons, electrons or muons, and large missing transverse energy. The measured W +W - cross section is 60.1 ± 0.9 (stat) ± 3.2 (exp) ± 3.1 (theo) ± 1.6 (lumi) pb = 60.1±4.8 pb, consistent with the standard model prediction. The W +W - cross sections are also measured in two different fiducial phase space regions. The normalized differential cross section is measured as a function of kinematic variables of the final-state charged leptons and compared with several perturbative QCD predictions. Limits on anomalous gauge couplings associated with dimension-six operators are also given in the framework of an effective field theory. The corresponding 95 % confidence level intervals are -5.7<cWWW/Λ2<5.9TeV-2, -11.4<cW/Λ2<5.4TeV-2, -29.2<cB/Λ2<23.9TeV-2, in the HISZ basis

Observation of the diphoton decay of the Higgs boson and measurement of its properties

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