OEGMerge: un modelo de mezcla de ontologías basado en casuísticas

Desde hace tiempo la mezcla de ontologías es una actividad necesaria, sin embargo, los actuales métodos de mezcla de ontologías no tienen una casuística detallada ni una formalización precisa. Para la validación de estos métodos, es conveniente disponer de una casuística lo más completa posible. Por ello, en este artículo se presenta el modelo OEGMerge, desarrollado a partir de la experiencia del Grupo de Ingeniería Ontológica (OEG) de la UPM, en el que se describe detallada y formalmente la casuística de mezcla y las acciones a realizar en cada caso. En esta primera aproximación sólo se abarca taxonomía de conceptos, atributos y relacione

Filter-induced bias in Lyα emitter surveys: a comparison between standard and tunable filters. gran telescopio Canarias preliminary results

Lyα emitter (LAE) surveys have successfully used the excess in a narrowband filter compared to a nearby broadband image to find candidates. However, the odd spectral energy distribution (SED) of LAEs combined with the instrumental profile has important effects on the properties of the candidate samples extracted from these surveys. We investigate the effect of the bandpass width and the transmission profile of the narrowband filters used for extracting LAE candidates at redshifts z sime 6.5 through Monte Carlo simulations, and we present pilot observations to test the performance of tunable filters to find LAEs and other emission-line candidates. We compare the samples obtained using a narrow ideal rectangular filter, the Subaru NB921 narrowband filter, and sweeping across a wavelength range using the ultra-narrow-band tunable filters of the instrument OSIRIS, installed at the 10.4 m Gran Telescopio Canarias. We use this instrument for extracting LAE candidates from a small set of real observations. Broadband data from the Subaru, Hubble Space Telescope, and Spitzer databases were used for fitting SEDs to calculate photometric redshifts and to identify interlopers. Narrowband surveys are very efficient in finding LAEs in large sky areas, but the samples obtained are not evenly distributed in redshift along the filter bandpass, and the number of LAEs with equivalent widths <60 Å can be underestimated. These biased results do not appear in samples obtained using ultra-narrow-band tunable filters. However, the field size of tunable filters is restricted because of the variation of the effective wavelength across the image. Thus, narrowband and ultra-narrow-band surveys are complementary strategies to investigate high-redshift LAEs.This research has been partially funded by the UNAMDGAPA-PAPIIT IN110013 Program. J.A.D. and M.A.D. are grateful for support from CONACyT grant CB-128556. J.A.D. is grateful for support from grant SAB2010-0011 awarded by the Spanish MIED through the “Programa Nacional de Movilidad de Recursos Humanos” included in the Plan Nacional de I-D+i 2008-2011. T.V. acknowledges support from CONACYT grant 165365 through the program “Estancias posdoctorales y sabáticas al extranjero para la consolidación de grupos de investigación.” This work has been partially funded by the Spanish Ministry of Science and Innovation (MICINN) under the Consolider-Ingenio 2010 Program grant CSD2006-00070: First Science with the GTC (http://www.iac.es/consolider-ingenio-gtc), AYA2011-29517-C03-01, and AYA2011-29517-C03-02. Observations presented in this paper were made with the Gran Telescopio Canarias (GTC), installed in the Spanish Observatorio del Roque de los Muchachos of the Instituto de Astrofísica de Canarias, on the island of La Palma. The authors are thankful to the anonymous referee for the critical and constructive suggestion

Exploring host genetic polymorphisms involved in SARS-CoV infection autcomes: implications for personalized medicine in COVID-19

Objective. To systematically explore genetic polymorphisms associated with the clinical outcomes in SARS-CoV infection in humans. Methods. This comprehensive literature search comprised available English papers published in PubMed/Medline and SCOPUS databases following the PRISMA-P guidelines and PICO/AXIS criteria. Results. Twenty-nine polymorphisms located in 21 genes were identified as associated with SARS-CoV susceptibility/resistance, disease severity, and clinical outcomes predominantly in Asian populations. Thus, genes implicated in key pathophysiological processes such as the mechanisms related to the entry of the virus into the cell and the antiviral immune/inflammatory responses were identified. Conclusions. Although caution must be taken, the results of this systematic review suggest that multiple genetic polymorphisms are associated with SARS-CoV infection features by affecting virus pathogenesis and host immune response, which could have important applications for the study and understanding of genetics in SARS-CoV-2/COVID-19 and for personalized translational clinical practice depending on the population studied and associated environments

Development of a learning-oriented computer assisted Instruction designed to improve skills in the clinical assessment of the nutritional status: a pilot evaluation

Computer assisted instruction (CAI) is an effective tool for evaluating and training students and professionals. In this article we will present a learning-oriented CAI, which has been developed for students and health professionals to acquire and retain new knowledge through the practice. A two-phase pilot evaluation was conducted, involving 8 nutrition experts and 30 postgraduate students, respectively. In each training session, the software developed guides users in the integral evaluation of a patient’s nutritional status and helps them to implement actions. The program includes into the format clinical tools, which can be used to recognize possible patient’s needs, to improve the clinical reasoning and to develop professional skills. Among them are assessment questionnaires and evaluation criteria, cardiovascular risk charts, clinical guidelines and photographs of various diseases. This CAI is a complete software package easy to use and versatile, aimed at clinical specialists, medical staff, scientists, educators and clinical students, which can be used as a learning tool. This application constitutes an advanced method for students and health professionals to accomplish nutritional assessments combining theoretical and empirical issues, which can be implemented in their academic curriculum

Small-Packet Flows in Software Defined Networks: Traffic Profile Optimization

This paper proposes a method for optimizing bandwidth usage in Software Defined Networks (SDNs) based on OpenFlow. Flows of small packets presenting a high overhead, as the ones generated by emerging services, can be identified by the SDN controller, in order to remove header fields that are common to any packet in the flow, only during their way through the SDN. At the same time, several packets can be multiplexed together in the same frame, thus reducing the overall number of frames. The method can be useful for providing QoS while the packets are traversing the SDN. Four kinds of small-packet traffic flows are considered (VoIP, UDP and TCP-based online games, and ACKs from TCP flows). Both IPv4 and IPv6 are studied, and significant bandwidth savings (up to 68 % for IPv4 and 78 % for IPv6) can be obtained for the considered kinds of traffic. The optimization method is also applied to different public Internet traffic traces, and significant reductions in terms of packets per second are achieved. Results show that bandwidth consumption is also reduced, especially in those traces where the percentage of small packets is high. Regarding the effect on QoS, the additional delay can be kept very low (below 1 millisecond) when the throughput is high, but it may become significant for low- throughput scenarios. Thus, a trade-off between bandwidth saving and additional delay appears in those cases

Macroporous thin membranes for cell transplant in regenerative medicine

The aim of this paper is to present a method to produce macroporous thin membranes made of poly (ethyl acrylate-co-hydroxyethyl acrylate) copolymer network with varying cross-linking density for cell transplantation and prosthesis fabrication. The manufacture process is based on template techniques and anisotropic pore collapse. Pore collapse was produced by swelling the membrane in acetone and subsequently drying and changing the solvent by water to produce 100 microns thick porous membranes. These very thin membranes are porous enough to hold cells to be transplanted to the organism or to be colonized by ingrowth from neighboring tissues in the organism, and they present sufficient tearing stress to be sutured with surgical thread. The obtained pore morphology was observed by Scanning Electron Microscope, and confocal laser microscopy. Mechanical properties were characterized by stress-strain experiments in tension and tearing strength measurements. Morphology and mechanical properties were related to the different initial thickness of the scaffold and the cross-linking density of the polymer network. Seeding efficiency and proliferation of mesenchymal stem cells inside the pore structure were determined at 2 hours, 1, 7, 14 and 21 days from seeding.This work was funded by the Spanish Ministry of Economy and Competitiveness (MINECO) through the project MAT2013-46467-C4-1-R (including the FEDER financial support). J.R.R. acknowledges funding of his PhD by the Generalitat Valenciana through VALi+d grant (ACIF/2010/238). CIBER-BBN is an initiative funded by the VI National R&D&i Plan 2008-2011, Iniciativa Ingenio 2010, Consolider Program, CIBER Actions and financed by the Instituto de Salud Carlos III with assistance from the European Regional Development Fund. The authors acknowledge too the advice of Dr. Daniel Kelly, Dr. Conor Buckley and Dr. Yurong Liu about the isolation and expansion of porcine MSCs. The authors acknowledge the assistance and advice of Electron Microscopy Service of the UPV.Antolinos Turpín, CM.; Morales Román, RM.; Ródenas Rochina, J.; Gómez Ribelles, JL.; Gómez-Tejedor, JA. (2015). Macroporous thin membranes for cell transplant in regenerative medicine. Biomaterials. 67:254-263. https://doi.org/10.1016/j.biomaterials.2015.07.032S2542636

The superstring Hagedorn temperature in a pp-wave background

The thermodynamics of type IIB superstring theory in the maximally supersymmetric plane wave background is studied. We compute the thermodynamic partition function for non-interacting strings exactly and the result differs slightly from previous computations. We clarify some of the issues related to the Hagedorn temperature in the limits of small and large constant RR 5-form. We study the thermodynamic behavior of strings in the case of $AdS_3 \times S^3 \times T^4$ geometries in the presence of NS-NS and RR 3-form backgrounds. We also comment on the relationship of string thermodynamics and the thermodynamic behavior of the sector of Yang-Mills theory which is the holographic dual of the string theory.Comment: 22 pages, JHEP style, minor misprints corrected, some comments adde

QUIJOTE scientific results - VIII. Diffuse polarized foregrounds from component separation with QUIJOTE-MFI

We derive linearly polarized astrophysical component maps in the Northern Sky from the QUIJOTE-MFI data at 11 and 13?GHz in combination with the Wilkinson Microwave Anisotropy Probe K and Ka bands (23 and 33?GHz) and all Planck polarized channels (30-353-GHz), using the parametric component separation method B-SeCRET. The addition of QUIJOTE-MFI data significantly improves the parameter estimation of the low-frequency foregrounds, especially the estimation of the synchrotron spectral index, [beta]s. We present the first detailed ?s map of the Northern Celestial Hemisphere at a smoothing scale of 2°. We find statistically significant spatial variability across the sky. We obtain an average value of ?3.08 and a dispersion of 0.13, considering only pixels with reliable goodness of fit. The power-law model of the synchrotron emission provides a good fit to the data outside the Galactic plane but fails to track the complexity within this region. Moreover, when we assume a synchrotron model with uniform curvature, cs, we find a value of cs = ?0.0797 ± 0.0012. However, there is insufficient statistical significance to determine which model is favoured, either the power law or the power law with uniform curvature. Furthermore, we estimate the thermal dust spectral parameters in polarization. Our cosmic microwave background, synchrotron, and thermal dust maps are highly correlated with the corresponding products of the PR4 Planck release, although some large-scale differences are observed in the synchrotron emission. Finally, we find that the ?s estimation in the high signal-to-noise synchrotron emission areas is prior-independent, while, outside these regions, the prior governs the [beta]s estimation.We thank the staff of the Teide Observatory for invaluable assistance in the commissioning and operation of QUIJOTE. The QUIJOTE experiment is being developed by the Instituto de Astrofisica de Canarias (IAC), the Instituto de Fisica de Cantabria (IFCA), and the Universities of Cantabria, Manchester, and Cambridge. Partial financial support was provided by the Spanish Ministry of Science and Innovation under the projects AYA2007-68058-C03-01, AYA2007- 68058-C03-02, AYA2010-21766-C03-01, AYA2010-21766-C03-02, AYA2014-60438-P, ESP2015-70646-C2-1-R, AYA2017-84185-P, ESP2017-83921-C2-1-R, AYA2017-90675-REDC (co-funded with EU FEDER funds), PGC2018-101814-B-I00, PID2019-110610RBC21, PID2020-120514GB-I00, IACA13-3E-2336, IACA15-BE3707, EQC2018-004918-P, the Severo Ochoa Programs SEV-2015- 0548 and CEX2019-000920-S, the Maria de Maeztu Program MDM2017-0765, and by the Consolider-Ingenio project CSD2010-00064 (EPI: Exploring the Physics of Inflation). We acknowledge support from the ACIISI, Consejeria de Economia, Conocimiento y Empleo del Gobierno de Canarias, and the European Regional Development Fund (ERDF) under grant with reference ProID2020010108. This project has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement number 687312 (RADIOFOREGROUNDS). EdlH acknowledges financial support from the Concepcion´ Arenal Programme of the Universidad de Cantabria. DT acknowledges the support from the Chinese Academy of Sciences (CAS) President’s International Fellowship Initiative (PIFI) with grant no. 2020PM0042. FP acknowledges support from the Spanish State Research Agency (AEI) under grant number PID2019-105552RB-C43. The authors acknowledge the computer resources, technical expertise, and assistance provided by the Spanish Supercomputing Network (RES) node at Universidad de Cantabria. Some of the presented results are based on observations obtained with Planck (http://www.esa.int/Planck), an ESA science mission with instruments and contributions directly funded by ESA Member States, NASA, and Canada. We acknowledge the use of the Legacy Archive for Microwave Background Data Analysis (LAMBDA) and the Planck Legacy Archive (PLA). Support for LAMBDA is provided by the NASA Office of Space Science. Some of the results in this paper have been derived using the HEALPIX package (Gorski ´ et al. 2005), and the HEALPY (Zonca et al. 2019), NUMPY (Harris et al. 2020), EMCEE (ForemanMackey et al. 2013), and MATPLOTLIB (Hunter 2007) PYTHON packages