Damped and sub-damped Lyman-α absorbers in z > 4 QSOs

We present the results of a survey of damped (DLA, log N(H I) > 20.3) and sub-damped Lyman-α systems (19.5 2.55 along the lines-of-sight to 77 quasars with emission redshifts in the range 4 19.5 were detected of which 40 systems are damped Lyman-α systems for an absorption length of ΔX = 378. About half of the lines of sight of this homogeneous survey have never been investigated for DLAs. We study the evolution with redshift of the cosmological density of the neutral gas and find, consistent with previous studies at similar resolution, that Ω_(DLA,HI) decreases at z > 3.5. The overall cosmological evolution of Ω_(HI) shows a peak around this redshift. The H I column density distribution for log N(H I) ≥ 20.3 is fitted, consistent with previous surveys, with a single power-law of index α ~ −1.8 ± 0.25. This power-law overpredicts data at the high-end and a second, much steeper, power-law (or a gamma function) is needed. There is a flattening of the function at lower H I column densities with an index of α ~ −1.4 for the column density range log N(H I) = 19.5−21. The fraction of H I mass in sub-DLAs is of the order of 30%. The H I column density distribution does not evolve strongly from z ~ 2.5 to z ~ 4.5

ESPAÇO NATUREZA: uma proposta para diálogo do museu e a escola

O Observatório Astronômico Antares & Museu Antares de Ciências e Tecnologia(OAA/MACT) é um espaço que utiliza experimentos, filmes, jogos e exposições parapopularização do conhecimento científico através de projetos como, por exemplo, as Férias Divertidas, produzida pelo mesmo

Damped and sub-damped Lyman-? absorbers in z > 4 QSOs

We present the results of a survey for damped (DLA, log N(H I) > 20.3) and sub-damped Lyman-? systems (19.5 2.55 along the lines-of-sight to 77 quasars with emission redshifts in the range 4 < zem < 6.3. Intermediate resolution (R ? 4300) spectra have been obtained with the Echellette Spectrograph and Imager (ESI) mounted on the Keck telescope. A total of 100 systems with log N(H I) > 19.5 are detected of which 40 systems are damped Lyman-? systems for an absorption length of ?X = 378. About half of the lines of sight of this homogeneous survey have never been investigated for DLAs. We study the evolution with redshift of the cosmological density of the neutral gas and find, consis- tently with previous studies at similar resolution, that ?DLA,H I decreases at z > 3.5. The overall cosmological evolution of ?HI shows a peak around this redshift. The H I column density distribution for log N(H I) ? 20.3 is ?tted, consistently with previous surveys, with a single power-law of index ? ? -1.8$\pm$0.25. This power-law overpredicts data at the high-end and a second, much steeper, power-law (or a gamma function) is needed. There is a flattening of the function at lower H I column densities with an index of ? ? ?1.4 for the column density range log N(H I) = 19.5?21. The fraction of H I mass in sub-DLAs is of the order of 30%. The H column density distribution does not evolve strongly from z ? 2.5 to z ? 4.5

Ethnic Minority–Majority Unions in Estonia

Ethnic minority–majority unions—also referred to as mixed ethnic unions—are often seen as the ultimate evidence of the integration of ethnic minorities into their host societies. We investigated minority–majority unions in Estonia, where ethnic minorities account for one-third of the total population (Russians 26%, followed by Ukrainians, Byelorussians, Finns and other smaller groups). Using data from the 2000 Estonian census and regression models, we found that Slavic women are less likely to be in minority–majority unions than are members of other minority groups, with Russians being the least likely. Finns, who are culturally most similar to the Estonian majority population, are the most likely to form a union with an Estonian. For ethnic minority women, the likelihood of being in minority–majority unions is highest in rural areas and increases over generations, with third-generation immigrants being the most likely. Estonian women are most likely to have a minority partner when they or their parents were born abroad and when they live in urban areas. Our findings suggest that both the opportunity to meet potential partners and openness to other ethnic groups are important factors for understanding the dynamics of minority–majority unions

Dust mass distribution around comet 67P/Churyumov-Gerasimenko determined via parallax measurements using Rosetta's OSIRIS cameras

The OSIRIS (optical, spectroscopic and infrared remote imaging system) instrument on board the ESA Rosetta spacecraft collected data of 67P/Churyumov-Gerasimenko for over 2 yr. OSIRIS consists of two cameras, a Narrow Angle Camera and a Wide Angle Camera. For specific imaging sequences related to the observation of dust aggregates in 67P's coma, the two cameras were operating simultaneously. The two cameras are mounted 0.7 m apart from each other, as a result this baseline yields a parallax shift of the apparent particle trails on the analysed images directly proportional to their distance. Thanks to such shifts, the distance between observed dust aggregates and the spacecraft was determined. This method works for particles closer than 6000 m to the spacecraft and requires very few assumptions. We found over 250 particles in a suitable distance range with sizes of some centimetres, masses in the range of 10-6-102 kg and a mean velocity of about 2.4 m s-1 relative to the nucleus. Furthermore, the spectral slope was analysed showing a decrease in the median spectral slope of the particles with time. The further a particle is from the spacecraft the fainter is its signal. For this reason, this was counterbalanced by a debiasing. Moreover, the dust mass-loss rate of the nucleus could be computed as well as the Af ρ of the comet around perihelion. The summed-up dust mass-loss rate for the mass bins 10-4-102 kg is almost 8300 kg s-1

Search for eta_b in two-photon collisions at LEP II with the DELPHI detector

The pseudoscalar meson eta_b has been searched for in two-photon interactions at LEP II. The data sample corresponds to a total integrated luminosity of 617 pb^{-1} at centre-of-mass energies ranging from 161 to 209 GeV. Upper limits at a confidence level of 95% on the product Gamma_{\gamma\gamma}(eta_b) x BR(eta_b) are 190, 470 and 660 eV/c^2 for the eta_b decaying into 4, 6 and 8 charged particles, respectively.Comment: 11 pages, 3 figures, Accepted by Phys. Lett.

Cancer Surveillance Guideline for individuals with PTEN hamartoma tumour syndrome

Abstract: PTEN hamartoma tumour syndrome is a diverse multi-system disorder predisposing to the development of hamartomatous growths, increasing risk of breast, thyroid, renal cancer, and possibly increasing risk of endometrial cancer, colorectal cancer and melanoma. There is no international consensus on cancer surveillance in PHTS and all current guidelines are based on expert opinion. A comprehensive literature review was undertaken and guidelines were developed by clinicians with expertise from clinical genetics, gynaecology, endocrinology, dermatology, radiology, gastroenterology and general surgery, together with affected individuals and their representatives. Recommendations were put forward for surveillance for breast, thyroid and renal cancers. Limited recommendations were developed for other sites including endometrial, colon and skin. The proposed cancer surveillance recommendations for PHTS require a coordinated multidisciplinary approach and significant patient commitment. The evidence base for cancer surveillance in this guideline are limited, emphasising the need for prospective evaluation of the effectiveness of surveillance in the PHTS population

Revised diagnostic criteria for neurofibromatosis type 1 and Legius syndrome: an international consensus recommendation

Abstract Purpose By incorporating major developments in genetics, ophthalmology, dermatology, and neuroimaging, to revise the diagnostic criteria for neurofibromatosis type 1 (NF1) and to establish diagnostic criteria for Legius syndrome (LGSS). Methods We used a multistep process, beginning with a Delphi method involving global experts and subsequently involving non-NF experts, patients, and foundations/patient advocacy groups. Results We reached consensus on the minimal clinical and genetic criteria for diagnosing and differentiating NF1 and LGSS, which have phenotypic overlap in young patients with pigmentary findings. Criteria for the mosaic forms of these conditions are also recommended. Conclusion The revised criteria for NF1 incorporate new clinical features and genetic testing, whereas the criteria for LGSS were created to differentiate the two conditions. It is likely that continued refinement of these new criteria will be necessary as investigators (1) study the diagnostic properties of the revised criteria, (2) reconsider criteria not included in this process, and (3) identify new clinical and other features of these conditions. For this reason, we propose an initiative to update periodically the diagnostic criteria for NF1 and LGSS. </jats:sec

World Health Organization cardiovascular disease risk charts: revised models to estimate risk in 21 global regions

BACKGROUND: To help adapt cardiovascular disease risk prediction approaches to low-income and middle-income countries, WHO has convened an effort to develop, evaluate, and illustrate revised risk models. Here, we report the derivation, validation, and illustration of the revised WHO cardiovascular disease risk prediction charts that have been adapted to the circumstances of 21 global regions. METHODS: In this model revision initiative, we derived 10-year risk prediction models for fatal and non-fatal cardiovascular disease (ie, myocardial infarction and stroke) using individual participant data from the Emerging Risk Factors Collaboration. Models included information on age, smoking status, systolic blood pressure, history of diabetes, and total cholesterol. For derivation, we included participants aged 40-80 years without a known baseline history of cardiovascular disease, who were followed up until the first myocardial infarction, fatal coronary heart disease, or stroke event. We recalibrated models using age-specific and sex-specific incidences and risk factor values available from 21 global regions. For external validation, we analysed individual participant data from studies distinct from those used in model derivation. We illustrated models by analysing data on a further 123 743 individuals from surveys in 79 countries collected with the WHO STEPwise Approach to Surveillance. FINDINGS: Our risk model derivation involved 376 177 individuals from 85 cohorts, and 19 333 incident cardiovascular events recorded during 10 years of follow-up. The derived risk prediction models discriminated well in external validation cohorts (19 cohorts, 1 096 061 individuals, 25 950 cardiovascular disease events), with Harrell's C indices ranging from 0·685 (95% CI 0·629-0·741) to 0·833 (0·783-0·882). For a given risk factor profile, we found substantial variation across global regions in the estimated 10-year predicted risk. For example, estimated cardiovascular disease risk for a 60-year-old male smoker without diabetes and with systolic blood pressure of 140 mm Hg and total cholesterol of 5 mmol/L ranged from 11% in Andean Latin America to 30% in central Asia. When applied to data from 79 countries (mostly low-income and middle-income countries), the proportion of individuals aged 40-64 years estimated to be at greater than 20% risk ranged from less than 1% in Uganda to more than 16% in Egypt. INTERPRETATION: We have derived, calibrated, and validated new WHO risk prediction models to estimate cardiovascular disease risk in 21 Global Burden of Disease regions. The widespread use of these models could enhance the accuracy, practicability, and sustainability of efforts to reduce the burden of cardiovascular disease worldwide. FUNDING: World Health Organization, British Heart Foundation (BHF), BHF Cambridge Centre for Research Excellence, UK Medical Research Council, and National Institute for Health Research