Genomic Relationships, Novel Loci, and Pleiotropic Mechanisms across Eight Psychiatric Disorders

Genetic influences on psychiatric disorders transcend diagnostic boundaries, suggesting substantial pleiotropy of contributing loci. However, the nature and mechanisms of these pleiotropic effects remain unclear. We performed analyses of 232,964 cases and 494,162 controls from genome-wide studies of anorexia nervosa, attention-deficit/hyper-activity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, and Tourette syndrome. Genetic correlation analyses revealed a meaningful structure within the eight disorders, identifying three groups of inter-related disorders. Meta-analysis across these eight disorders detected 109 loci associated with at least two psychiatric disorders, including 23 loci with pleiotropic effects on four or more disorders and 11 loci with antagonistic effects on multiple disorders. The pleiotropic loci are located within genes that show heightened expression in the brain throughout the lifespan, beginning prenatally in the second trimester, and play prominent roles in neurodevelopmental processes. These findings have important implications for psychiatric nosology, drug development, and risk prediction.Peer reviewe

Computing QoE-Relevant Adaptive Video Streaming Metrics Using Discrete-Time Analysis

HTTP Adaptive Streaming (HAS) is the de-facto standard for video delivery over the Internet. Splitting the video clip into small segments and providing multiple quality levels per segment allows the client to dynamically adapt the quality to current network conditions. The performance of HAS, and as a consequence the user Quality of Experience (QoE), is influenced by a multitude of parameters. This includes adjustable settings like quality switching thresholds, the initial buffer level, or the maximum buffer, as well as video characteristics like segment duration or the variation of segment sizes along the video. Finding an appropriate tuning of those parameters still remains a challenge, which is mainly tackled by performing testbed measurements or simulative analysis. Due to the large problem space and the complex interactions of the involved influence factors, a holistic comparison of a multitude of parameter settings is extremely time intensive. To address this problem, we propose to enhance a GI/GI/1 system with pq-policy, which models video buffer behavior, with the capability to switch between different quality levels. This allows to investigate all relevant QoE influence factors for HAS-based video delivery. In a first evaluation, we illustrate the impact of different quality switching thresholds on the QoE influence factors for varying network conditions

KOMon—Kernel-based Online Monitoring of VNF Packet Processing Times

The ongoing softwarization of networks comes with several advantages like cost efficiency, increased scalability, and better flexibility by migrating functionality from static, application specific hardware appliances to flexible, lightweight software solutions running on COTS hardware. In order to maximize the performance gains promised by the NFV paradigm, several challenges remain to be solved. In this work, we address the accurate acquisition of key performance indicators, specifically the packet processing time, of softwarized network functions. To this end, we present KOMon, a Kernel-based online monitoring tool to reliably measure the packet processing times of network functions through lightweight in-stack monitoring. We show that KOMon reports highly accurate values in different scenarios and discuss the applicability of the proposed mechanism for different use cases

Highlighting the Gap Between Expected and Actual Behavior in P4-enabled Networks

Modern networks increasingly rely on Software-defined Networking (SDN) and Network Function Virtualization (NFV) to augment their flexibility in high load scenarios. To further enhance the performance, a part of the functionality is often offloaded to forwarding devices, which are used as hardware accelerators and are configured by high level programming languages such as P4. However, hardware vendors use sophisticated technologies to implement these standards, which need to be understood by the programmer to avoid unintended behavior. In this demonstration we highlight the severe consequences of only relying on the network programming language when ignoring the device-specific limitations. We show this by the example of a Denial of Service attack against a P4-enabled SmartNIC. Finally, we discuss possible mitigations to this attack and stress the importance of an overall understanding of the entire system

Discrete-Time Modeling of NFV Accelerators that Exploit Batched Processing

Network Functions Virtualization (NFV) is among the latest network revolutions, bringing flexibility and avoiding network ossification. At the same time, all-software NFV implementations on commodity hardware raise performance issues with respect to ASIC solutions. To address these issues, numerous software acceleration frameworks for packet processing have appeared in the last few years. Common among these frameworks is the use of batching techniques. In this context, packets are processed in groups as opposed to individually, which is required at high-speed to minimize the framework overhead, reduce interrupt pressure, and leverage instruction-level cache hits. Whereas several system implementations have been proposed and experimentally benchmarked, the scientific community has so far only to a limited extent attempted to model the system dynamics of modern NFV routers exploiting batching acceleration. In this paper, we fill this gap by proposing a simple generic model for such batching-based mechanisms, which allows a very detailed prediction of highly relevant performance indicators. These include the distribution of the processed batch size as well as queue size, which can be used to identify loss-less operational regimes or quantify the packet loss probability in high-load scenarios. We contrast the model prediction with experimental results gathered in a high-speed testbed including an NFV router, showing that the model not only correctly captures system performance under simple conditions, but also in more realistic scenarios in which traffic is processed by a mixture of functions

The Power of Composition: Abstracting a Multi-Device SDN Data Path Through a Single API

Software Defined Networking aims to separate network control and data plane by moving the control logic from network elements into a logically-centralized controller. Using a well-defined, unified control-channel protocol, such as OpenFlow, the controller is able to configure the forwarding behavior of data plane devices. Here, the OpenFlow protocol is translated to vendor-and device-specific instructions that, for instance, manipulate the flow table entries of a switch. In practice, SDN-enabled switches often feature different hardware capabilities and configurations with respect to the number of flow tables, their implementation, and which kind of data plane features they support. This leads to device heterogeneity within the SDN landscape, thereby obstructing the increased scalability and flexibility promised by the SDN paradigm. To overcome this challenge we propose TableVisor, a transparent proxy-layer for the SDN control channel that enables the flexible abstraction of heterogeneous data plane devices into a single emulated data plane switch. In this paper, we extend our previous work by introducing features to integrate modern P4 devices into an existing SDN environment and perform a detailed performance evaluation to quantify the overhead induced by our approach

Estimating Video Streaming QoE in the 5G Architecture Using Machine Learning

Compared to earlier mobile network generations, the 5G system architecture has been significantly enhanced by the introduction of network analytics functionalities and ex- tended capabilities of interacting with third party Application Functions (AFs). Combining these capabilities, new features for Quality of Experience (QoE) estimation can be designed and introduced in next generation networks. It is, however, unclear how 5G networks can collect monitoring data and application metrics, how they correlate to each other, and which techniques can be used in 5G systems for QoE estimation. This paper studies the feasibility of Machine Learning (ML) techniques for QoE estimation and evaluates their performance for a mobile video streaming use-case. A simulator has been implemented with OMNeT++ for generating traces to (i) examine the relevance of features generated from 5G monitoring data and (ii) to study the QoE estimation accuracy (iii) for a variable number of used features

Towards Consistent SDNS: A Case for Network State Fuzzing

The conventional wisdom is that a software-defined network (SDN) operates under the premise that the logically centralized control plane has an accurate representation of the actual data plane state. Unfortunately, bugs, misconfigurations, faults or attacks can introduce inconsistencies that undermine correct operation. Previous work in this area, however, lacks a holistic methodology to tackle this problem and thus, addresses only certain parts of the problem. Yet, the consistency of the overall system is only as good as its least consistent part. Motivated by an analogy of network consistency checking with program testing, we propose to add active probe-based network state fuzzing to our consistency check repertoire. Hereby, our system, PAZZ, combines production traffic with active probes to periodically test if the actual forwarding path and decision elements (on the data plane) correspond to the expected ones (on the control plane). Our insight is that active traffic covers the inconsistency cases beyond the ones identified by passive traffic. PAZZ prototype was built and evaluated on topologies of varying scale and complexity. Our results show that PAZZ requires minimal network resources to detect persistent data plane faults through fuzzing and localize them quickly while outperforming baseline approaches

Survey of Performance Acceleration Techniques for Network Function Virtualization

The ongoing network softwarization trend holds the promise to revolutionize network infrastructures by making them more flexible, reconfigurable, portable, and more adaptive than ever. Still, the migration from hard-coded/hard-wired network functions toward their software-programmable counterparts comes along with the need for tailored optimizations and acceleration techniques so as to avoid or at least mitigate the throughput/latency performance degradation with respect to fixed function network elements. The contribution of this paper is twofold. First, we provide a comprehensive overview of the host-based network function virtualization (NFV) ecosystem, covering a broad range of techniques, from low-level hardware acceleration and bump-in-the-wire offloading approaches to high-level software acceleration solutions, including the virtualization technique itself. Second, we derive guidelines regarding the design, development, and operation of NFV-based deployments that meet the flexibility and scalability requirements of modern communication networks