The X-ray light curve of Gamma-ray bursts: clues to the central engine

We present the analysis of a large sample of gamma-ray burst (GRB) X-ray light curves in the rest frame to characterise their intrinsic properties in the context of different theoretical scenarios. We determine the morphology, time scales, and energetics of 64 long GRBs observed by \emph{Swift}/XRT \emph{without} flaring activity. We furthermore provide a one-to-one comparison to the properties of GRBs \emph{with} X-ray flares. We find that the steep decay morphology and its connection with X-ray flares favour a scenario in which a central engine origin. We show that this scenario can also account for the shallow decay phase, provided that the GRB progenitor star has a self-similar structure with a constant envelope-to-core mass ratio $\sim 0.02-0.03$. However, difficulties arise for very long duration ($t_p\gtrsim10^4$ s) shallow phases. Alternatively, a spinning-down magnetar whose emitted power refreshes the forward shock can quantitatively account for the shallow decay properties. In particular we demonstrate that this model can account for the plateau luminosity vs. end time anticorrelation.Comment: 12 pages, 8 figures, accepted for publication in A&

Tracing dark energy history with gamma ray bursts

Observations of gamma-ray bursts up to $z\sim 9$ are best suited to study the possible evolution of the Universe equation of state at intermediate redshifts. We apply the Combo-relation to a sample of 174 gamma ray bursts to investigate possible evidence of evolving dark energy parameter $w(z)$. We first build a gamma ray burst Hubble's diagram and then we estimate the set ($\Omega_m$, $\Omega_{\Lambda}$) in the framework of flat and non-flat $\Lambda$CDM paradigm. We then get bounds over the $w$CDM model, where $w$ is thought to evolve with redshift, adopting two priors over the Hubble constant in tension at $4.4$-$\sigma$, i.e. $H_0=(67.4\pm0.5)$ km/s/Mpc and $H_0=(74.03\pm1.42)$ km/s/Mpc. We show our new sample provides tighter constraints on $\Omega_m$ since at $z\leq1.2$ we see that $w(z)$ agrees within 1$\sigma$ with the standard value $w=-1$. The situation is the opposite at larger $z$, where gamma ray bursts better fix $w(z)$ that seems to deviate from $w=-1$ at $2$-$\sigma$ and $4$-$\sigma$ level, depending on the redshift bins. In particular, we investigate the $w(z)$ evolution through a piecewise formulation over seven redshift intervals. From our fitting procedure we show that at $z\geq 1.2$ the case $w<-1$ cannot be fully excluded, indicating that dark energy's influence is not negligible at larger $z$. We confirm the Combo relation as a powerful tool to investigate cosmological evolution of dark energy. Future space missions will significantly enrich the gamma ray burst database even at smaller redshifts, improving de facto the results discussed in this paper.Comment: 10 pages, 7 figures, ApJ submitte

Hereditary Xerocytosis due to Mutations in PIEZO1 Gene Associated with Heterozygous Pyruvate Kinase Deficiency and Beta-Thalassemia Trait in Two Unrelated Families

Hereditary xerocytosis (HX) is a rare disorder caused by defects of RBC permeability, associated with haemolytic anaemia of variable degree and iron overload. It is sometimes misdiagnosed as hereditary spherocytosis or other congenital haemolytic anaemia. Splenectomy is contraindicated due to increased risk of thromboembolic complications. We report the clinical, haematological, and molecular characteristics of four patients from two unrelated Italian families affected by HX, associated with beta-thalassemia trait and heterozygous pyruvate kinase deficiency, respectively. Two patients had been splenectomised and displayed thrombotic episodes. All patients had iron overload in the absence of transfusion, two of them requiring iron chelation. The diagnosis of HX was confirmed by LoRRca Osmoscan analysis showing a left-shifted curve. PIEZO1 gene sequencing revealed the presence of mutation p.E2496ELE, showing that this is one of the most frequent mutations in this disease. The concomitant defects did not aggravate the clinical phenotype; however, in one patient, the initial diagnosis of pyruvate kinase deficiency delayed the correct diagnosis of HX for many years and resulted in splenectomy followed by thrombotic complications. The study underlines the importance of a precise diagnosis in HX, particularly in view of splenectomy, and the need of a molecular confirmation of suspected RBC enzymopathy

X-ray flare candidates in short gamma-ray bursts

We present the first systematic study of X-ray flare candidates in short gamma-ray bursts (SGRBs) exploiting the large 6-year Swift database with the aim to constrain the physical nature of such fluctuations. We find that flare candidates appear in different types of SGRB host galaxy environments and show no clear correlation with the X-ray afterglow lifetime; flare candidates are detected both in SGRBs with a bright extended emission in the soft γ-rays and in SGRBs which do not show such component. We furthermore show that SGRB X-ray flare candidates only partially share the set of observational properties of long GRB (LGRB) flares. In particular, the main parameter driving the duration evolution of X-ray variability episodes in both classes is found to be the elapsed time from the explosion, with very limited dependence on the different progenitors, environments, central engine life-times, prompt variability time-scales and energy budgets. On the contrary, SGRB flare candidates significantly differ from LGRB flares in terms of peak luminosity, isotropic energy, flare-to-prompt luminosity ratio and relative variability flux. However, these differences disappear when the central engine time-scales and energy budget are accounted for, suggesting that (i) flare candidates and prompt pulses in SGRBs likely have a common origin; (ii) similar dissipation and/or emission mechanisms are responsible for the prompt and flare emission in long and short GRBs, with SGRBs being less energetic albeit faster evolving versions of the long class. Finally, we show that in strict analogy to the SGRB prompt emission, flares candidates fall off the lag-luminosity relation defined by LGRBs, thus strengthening the SGRB flare-prompt pulse connection.Astronom

Paroxysmal Nocturnal Hemoglobinuria (Pnh) : Brain Mri Ischemic Lesions in Neurologically Asymtomatic Patients

This study investigated for the first time brain ischemic involvement in 19 consecutive neurologically asymptomatic PNH patients by non-enhanced cerebral MRI, and by intracranial arterial and venous angio-MRI. Eleven cases (58%, 7 aged 5 mm, and 5 cases a score >4 by the age-related white matter changes (ARWMC) scale. Compared with age and sex-matched controls (1:2 ratio), patients showed an increased frequency of periventricular WM vascular degeneration (32% versus 5.2%, p = 0.04) and of severe lesions (ARWMC scale score >4) (26% versus 2.6%, p = 0.05), and a higher overall ARWMC scale score (3.5 \uc2\ub1 1.07 versus 2.0 \uc2\ub1 0.8, mean \uc2\ub1 SD, p < 0.0001). Notably, vascular abnormalities suspected for prior partial venous thrombosis, were observed in PNH cases only. MRI lesions were not related to blood counts, hemolytic markers, clone size, disease duration, and therapy with eculizumab. Neurological examination was unremarkable in all patients but one (Parkinson disease). Psychiatric assessment revealed a case of generalized anxiety disorder, 1 bipolar disorder type 2, and 1 adjustment disorder. In conclusion, brain MRI may be useful at diagnosis and during the course of the disease to explore subclinical neurological involvement

Colour variations in the GRB 120327A afterglow

Aims. We present a comprehensive temporal and spectral analysis of the long Swift GRB 120327A afterglow data to investigate possible causes of the observed early-time colour variations. Methods. We collected data from various instruments and telescopes in X-ray, ultraviolet, optical, and near-infrared bands, and determined the shapes of the afterglow early-time light curves. We studied the overall temporal behaviour and the spectral energy distributions from early to late times. Results. The ultraviolet, optical, and near-infrared light curves can be modelled with a single power-law component between 200 and 2 × 10 4 s after the burst event. The X-ray light curve shows a canonical steep-shallow-steep behaviour that is typical of long gamma-ray bursts. At early times a colour variation is observed in the ultraviolet/optical bands, while at very late times a hint of a re-brightening is visible. The observed early-time colour change can be explained as a variation in the intrinsic optical spectral index, rather than an evolution of the optical extinction. © 2017 ESO

A new class of glycomimetic drugs to prevent free fatty acid-induced endothelial dysfunction

Background: Carbohydrates play a major role in cell signaling in many biological processes. We have developed a set of glycomimetic drugs that mimic the structure of carbohydrates and represent a novel source of therapeutics for endothelial dysfunction, a key initiating factor in cardiovascular complications. Purpose: Our objective was to determine the protective effects of small molecule glycomimetics against free fatty acid­induced endothelial dysfunction, focusing on nitric oxide (NO) and oxidative stress pathways. Methods: Four glycomimetics were synthesized by the stepwise transformation of 2,5­dihydroxybenzoic acid to a range of 2,5­substituted benzoic acid derivatives, incorporating the key sulfate groups to mimic the interactions of heparan sulfate. Endothelial function was assessed using acetylcholine­induced, endotheliumdependent relaxation in mouse thoracic aortic rings using wire myography. Human umbilical vein endothelial cell (HUVEC) behavior was evaluated in the presence or absence of the free fatty acid, palmitate, with or without glycomimetics (1µM). DAF­2 and H2DCF­DA assays were used to determine nitric oxide (NO) and reactive oxygen species (ROS) production, respectively. Lipid peroxidation colorimetric and antioxidant enzyme activity assays were also carried out. RT­PCR and western blotting were utilized to measure Akt, eNOS, Nrf­2, NQO­1 and HO­1 expression. Results: Ex vivo endothelium­dependent relaxation was significantly improved by the glycomimetics under palmitate­induced oxidative stress. In vitro studies showed that the glycomimetics protected HUVECs against the palmitate­induced oxidative stress and enhanced NO production. We demonstrate that the protective effects of pre­incubation with glycomimetics occurred via upregulation of Akt/eNOS signaling, activation of the Nrf2/ARE pathway, and suppression of ROS­induced lipid peroxidation. Conclusion: We have developed a novel set of small molecule glycomimetics that protect against free fatty acidinduced endothelial dysfunction and thus, represent a new category of therapeutic drugs to target endothelial damage, the first line of defense against cardiovascular disease