Implementation of learning by doing methods in the graphical engineering field

Regarding the different options to approaches with excessively theoretical contents that are applied in teaching, there are several innovative learning strategies for active students’ involvement. According to (1) most of the business look for professional profiles in which applicants not only have an academic background but also good personal skills, such as initiative, undertaking, communication skills, commercial vision, and so on. This paper presents the experiments that aim to achieve the objectives and catching skills by the Learning by doing technique (2), through a contextualization of the subject “Container and Packaging” in the Industrial Design Degree. Moreover, a close relation between university and business is achieved. In this way students acquire the requirements demanded by the company. A particularization of an industrial design methodology proposed by the Technological Institute of Packaging, Transport and Logistics (ITENE, Valencia) has been implemented for the design of packaging and packaging (4). Besides using this method, students take on a project-based learning (PBL) work under the role of company. Then, they realize the redesign of the container of a manufactured product close to his residence province, i.e. Ron Montero Winery, Granada. This practice will not only look for improving the student's ability to research and solve problems, but also to manage the professional and personal relationships that occur within each work group. These situations are necessary in the training process since they will be to be fought daily in their future professional life.Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tec

Customized WO3 nanoplatelets as visible-light photoelectrocatalyst for the degradation of a recalcitrant model organic compound (methyl orange)

WO3 nanoplatelets have been synthesized by electrochemical anodization in acidic electrolytes containing two different complexing agents: fluorides and hydrogen peroxide. The influence of the morphology and size of these nanoplatelets on their photoelectrocatalytic performance has been studied following the degradation of a model organic recalcitrant compound, such as methyl orange (MO). The effect of several supporting electrolytes on this photodegradation process has also been checked. The best MO decoloration was observed for nanoplatelets fabricated in the presence of low H2O2 concentrations, whose distribution and small size made them expose a very high surface area to the problem solution. With this nanostructure, decoloration efficiencies of ca. 100% were obtained after just 60 min. This result is considerably better than others reported in similar works, indicating the excellent behavior of these WO3 nanoplatelets as photoelectrocatalysts

Are the Cells Stronger than we Think?

This work presents a novel methodology to calculate the traction forces exerted by the cell in a three-dimensional (3D) Traction Force Microscopy (TFM) set-up. This methodology starts from the images taken in the TFM essay. In addition, the finite strains hypothesis is assumed in order to capture the cell behaviour.Este trabajo presenta una nueva metodología para calcular las fuerzas de tracción ejercidas por la célula durante un experimento de microscopía de fuerza de tracción. El método presentado parte de las imágenes captadas durante el ensayo experimental. Además, se trabaja bajo la hipótesis de grandes deformaciones para poder modelar de manera más precisa el comportamiento celular

Percepción del estudiantado activo sobre las causas del abandono escolar en instituciones de secundaria de la Dirección Regional de Enseñanza de Cartago, Costa Rica

Son varios los estudios que se han hecho sobre abandono escolar, debido a sus repercusiones tanto para la persona como para la sociedad. En el ámbito costarricense se han creado programas de ayuda socioeconómica, pedagógica y psicosocial, que buscan mantener al estudiantado en las aulas, pero el fenómeno ha prevalecido en el tiempo. También se han implementado estrategias aisladas que pretenden disminuir los índices de exclusión escolar; pero su impacto no ha sido evaluado apropiadamente y tampoco se han socializado los resultados. Este documento presenta un estudio cuantitativo factorial comparativo que se realizó con 624 estudiantes de 20 colegios entre técnico profesionales y académicos de la Dirección Regional de Enseñanza de Cartago, tanto de modalidad diurna como nocturna, quienes expusieron su percepción sobre las causas del abandono escolar. Se busca proponer criterios técnicos de diagnóstico que sirvan como puntos de partida para implementar estrategias y acciones preventivas del abandono escolar, y que sean útiles como referencia para profesionistas en educación que se preocupan por esta problemática y desean ejecutar acciones de intervención y de prevención, en las cuales se consideren la motivación y el sentido de pertenencia del estudiantado al contexto educativo, como pilares de acciones preventivas y de gestión educativa

LIFE Adaptamed Layman’s Report. Action E13. LIFE14 CCA/ES/000612

Aguas de Font Vella y Lanjaró

INDCOR White Paper 5: Addressing Societal Issues in Interactive Digital Narratives

This white paper introduces Interactive Digital Narratives (IDN) as a powerful tool for tackling the complex challenges we face in today's society. In the scope of the COST Action 18230 - Interactive Narrative Design for Complexity Representation, a group of researchers dedicated to studying media, systematically selected six case studies of IDNs, including educational games, news media, and social media content, that confront and challenge the existing traditional media landscape. These case studies cover a wide range of important societal issues, such as racism, coloniality, feminist social movements, cultural heritage, war, and disinformation. By exploring this broad range of examples, we aim to demonstrate how IDN can effectively address social complexity in an interactive, participatory, and engaging manner. We encourage you to examine these case studies and discover for yourself how IDN can be used as a creative tool to address complex societal issues. This white paper might be inspiring for journalists, digital content creators, game designers, developers, educators using information and communication technologies in the classroom, or anyone interested in learning how to use IDN tools to tackle complex societal issues. In this sense, along with key scientific references, we offer key takeaways at the end of this paper that might be helpful for media practitioners at large, in two main ways: 1) Designing IDNs to address complex societal issues and 2) Using IDNs to engage audiences with complex societal issues

Novel anti-invasive properties of a Fascin1 inhibitor on colorectal cancer cells

Tumor invasion and metastasis involve processes in which actin cytoskeleton rearrangement induced by Fascin1 plays a crucial role. Indeed, Fascin1 has been found overexpressed in tumors with worse prognosis. Migrastatin and its analogues target Fascin1 and inhibit its activity. However, there is need for novel and smaller Fascin1 inhibitors. The aim of this study was to assess the effect of compound G2 in colorectal cancer cell lines and compare it to migrastatin in in vitro and in vivo assays. Molecular modeling, actin-bundling, cell viability, inmunofluorescence, migration, and invasion assays were carried out in order to test anti-migratory and anti-invasive properties of compound G2. In addition, the in vivo effect of compound G2 was evaluated in a zebrafish model of invasion. HCT-116 cells exhibited the highest Fascin1 expression from eight tested colorectal cancer cell lines. Compound G2 showed important inhibitory effects on actin bundling, filopodia formation, migration, and invasion in different cell lines. Moreover, compound G2 treatment resulted in significant reduction of invasion of DLD-1 overexpressing Fascin1 and HCT-116 in zebrafish larvae xenografts; this effect being less evident in Fascin1 known-down HCT-116 cells. This study proves, for the first time, the in vitro and in vivo anti-tumoral activity of compound G2 on colorectal cancer cells and guides to design improved compound G2-based Fascin1 inhibitors. Key messages center dot Fascin is crucial for tumor invasion and metastasis and is overexpressed in bad prognostic tumors. center dot Several adverse tumors overexpress Fascin1 and lack targeted therapy. center dot Anti-fascin G2 is for the first time evaluated in colorectal carcinoma and compared with migrastatin. center dot Filopodia formation, migration activity, and invasion in vitro and in vivo assays were performed. center dot G2 blocks actin structures, migration, and invasion of colorectal cancer cells as fascin-dependent.Peer reviewe

New role of the antidepressant imipramine as a Fascin1 inhibitor in colorectal cancer cells

Colorectal cancer: Antitumor antidepressant The antidepressant drug imipramine can block the activity of a protein that contributes to the progression of certain aggressive tumors. Serrated adenocarcinoma (SAC) is a form of colorectal cancer with a poor prognosis. A key factor in SAC development is the overexpression of the protein fascin1, which promotes the formation of structures that help cancer cells move around, thereby leading to metastasis. Pablo Conesa-Zamora at Santa Lucia University Hospital in Cartagena, Horacio Perez-Sanchez at the Universidad Catolica de Murcia in Guadalupe, Spain, and coworkers demonstrated that imipramine shows promise in binding to fascin1 and blocking its activity. The team analyzed over 9500 compounds as potential fascin1 blockers, identifying imipramine as a possible option. In tests on human tissues and in vivo studies using zebrafish, the drug reduced cancer invasion and metastasis. Serrated adenocarcinoma (SAC) is more invasive, has worse outcomes than conventional colorectal carcinoma (CRC), and is characterized by frequent resistance to anti-epidermal growth factor receptor (EGFR) and overexpression of fascin1, a key protein in actin bundling that plays a causative role in tumor invasion and is overexpressed in different cancer types with poor prognosis. In silico screening of 9591 compounds, including 2037 approved by the Food and Drug Administration (FDA), was performed, and selected compounds were analyzed for their fascin1 binding affinity by differential scanning fluorescence. The results were compared with migrastatin as a typical fascin1 inhibitor. In silico screening and differential scanning fluorescence yielded the FDA-approved antidepressant imipramine as the most evident potential fascin1 blocker. Biophysical and different in vitro actin-bundling assays confirm this activity. Subsequent assays investigating lamellipodia formation and migration and invasion of colorectal cancer cells in vitro using 3D human tissue demonstrated anti-fascin1 and anti-invasive activities of imipramine. Furthermore, expression profiling suggests the activity of imipramine on the actin cytoskeleton. Moreover, in vivo studies using a zebrafish invasion model showed that imipramine is tolerated, its anti-invasive and antimetastatic activities are dose-dependent, and it is associated with both constitutive and induced fascin1 expression. This is the first study that demonstrates an antitumoral role of imipramine as a fascin1 inhibitor and constitutes a foundation for a molecular targeted therapy for SAC and other fascin1-overexpressing tumors.Peer reviewe

Machine Learning-Based Analysis in the Management of Iatrogenic Bile Duct Injury During Cholecystectomy: a Nationwide Multicenter Study

Background Iatrogenic bile duct injury (IBDI) is a challenging surgical complication. IBDI management can be guided by artificial intelligence models. Our study identified the factors associated with successful initial repair of IBDI and predicted the success of definitive repair based on patient risk levels. Methods This is a retrospective multi-institution cohort of patients with IBDI after cholecystectomy conducted between 1990 and 2020. We implemented a decision tree analysis to determine the factors that contribute to successful initial repair and developed a risk-scoring model based on the Comprehensive Complication Index. Results We analyzed 748 patients across 22 hospitals. Our decision tree model was 82.8% accurate in predicting the success of the initial repair. Non-type E (p < 0.01), treatment in specialized centers (p < 0.01), and surgical repair (p < 0.001) were associated with better prognosis. The risk-scoring model was 82.3% (79.0-85.3%, 95% confidence interval [CI]) and 71.7% (63.8-78.7%, 95% CI) accurate in predicting success in the development and validation cohorts, respectively. Surgical repair, successful initial repair, and repair between 2 and 6 weeks were associated with better outcomes. Discussion Machine learning algorithms for IBDI are a novel tool may help to improve the decision-making process and guide management of these patients