Demand management for telecommunications services

Accepted versio

Reconfigurable Component-based Middleware for Networked Embedded Systems

Next generation embedded systems will be composed of large numbers of heterogeneous devices. These will typically be resource-constrained (such as sensor motes), will use different operating systems, and will be connected through different types of network interfaces. Additionally, they may be mobile and/or form ad-hoc networks with their peers, and will need to be adaptive to changing conditions based on context-awareness. Our focus in this paper is on the provision of a middleware framework for such system environments. Our approach is based on a small and efficient `middleware kernel' which supports highly modularised and customisable component-based middleware services that can be tailored for specific embedded environments, and are runtime reconfigurable to support adaptivity. These services are primarily communications-related but also address a range of other concerns including service discovery and logical mobility. In the paper we provide an overview of our approach, focusing in detail on both the middleware kernel and the services. We also discuss an application scenario in which we are currently applying and evaluating our middleware approach

Income maximisation using prices and QoS for multi-class telecommunication system

Accepted versio

DNA methylation-based subtype prediction for pediatric acute lymphoblastic leukemia.

To access publisher's full text version of this article, please click on the hyperlink in Additional Links field or click on the hyperlink at the top of the page marked Files. This article is open access.We present a method that utilizes DNA methylation profiling for prediction of the cytogenetic subtypes of acute lymphoblastic leukemia (ALL) cells from pediatric ALL patients. The primary aim of our study was to improve risk stratification of ALL patients into treatment groups using DNA methylation as a complement to current diagnostic methods. A secondary aim was to gain insight into the functional role of DNA methylation in ALL.We used the methylation status of ~450,000 CpG sites in 546 well-characterized patients with T-ALL or seven recurrent B-cell precursor ALL subtypes to design and validate sensitive and accurate DNA methylation classifiers. After repeated cross-validation, a final classifier was derived that consisted of only 246 CpG sites. The mean sensitivity and specificity of the classifier across the known subtypes was 0.90 and 0.99, respectively. We then used DNA methylation classification to screen for subtype membership of 210 patients with undefined karyotype (normal or no result) or non-recurrent cytogenetic aberrations ('other' subtype). Nearly half (n = 106) of the patients lacking cytogenetic subgrouping displayed highly similar methylation profiles as the patients in the known recurrent groups. We verified the subtype of 20% of the newly classified patients by examination of diagnostic karyotypes, array-based copy number analysis, and detection of fusion genes by quantitative polymerase chain reaction (PCR) and RNA-sequencing (RNA-seq). Using RNA-seq data from ALL patients where cytogenetic subtype and DNA methylation classification did not agree, we discovered several novel fusion genes involving ETV6, RUNX1, and PAX5.Our findings indicate that DNA methylation profiling contributes to the clarification of the heterogeneity in cytogenetically undefined ALL patient groups and could be implemented as a complementary method for diagnosis of ALL. The results of our study provide clues to the origin and development of leukemic transformation. The methylation status of the CpG sites constituting the classifiers also highlight relevant biological characteristics in otherwise unclassified ALL patients.Swedish Foundation for Strategic Research RBc08-008 Swedish Cancer Society CAN2010/592 Swedish Childhood Cancer Foundation 11098 Swedish Research Council for Science and Technology 90559401 Swedish Research Council FORTE Swedish Research Council FORMAS Swedish Research Council VINNOVA Swedish Research Council VR 259-2012-2

DNA methylation-based subtype prediction for pediatric acute lymphoblastic leukemia

Peer reviewe

Multi-element analysis based on an automated on-line microcolumn separation/preconcentration system using a novel sol-gel thiocyanatopropyl-functionalized silica sorbent prior to ICP-AES for environmental water samples

A sol-gel thiocyanatopropyl-functionalized silica sorbent was synthesized and employed for an automated on-line microcolumn preconcentration platform as a front-end to inductively coupled plasma atomic emission spectroscopy (ICP-AES) for the simultaneous determination of Cd(II), Pb(II), Cu(II), Cr(III), Co(II), Ni(II), Zn(II), Mn(II), Hg(II), and V(II). The developed system is based on an easy-to-repack microcolumn construction integrated into a flow injection manifold coupled directly to ICP-AES’s nebulizer. After on-line extraction/preconcentration of the target analyte onto the surface of the sorbent, successive elution with 1.0 mol L−1 HNO3 was performed. All main chemical and hydrodynamic factors affecting the effectiveness of the system were thoroughly investigated and optimized. Under optimized experimental conditions, for 60 s preconcentration time, the enhancement factor achieved for the target analytes was between 31 to 53. The limits of detection varied in the range of 0.05 to 0.24 μg L−1, while the limits of quantification ranged from 0.17 to 0.79 μg L−1. The precision of the method was expressed in terms of relative standard deviation (RSD%) and was less than 7.9%. Furthermore, good method accuracy was observed by analyzing three certified reference materials. The proposed method was also successfully employed for the analysis of environmental water samples

On The Relationship Between Magnetic Cancellation and UV Burst Formation

Burst-like events with signatures in the UV are often observed co-spatial to strong line-of-sight photospheric magnetic fields. Several authors, for example, have noted the spatial relationship between Ellerman bombs (EBs) and Moving Magnetic Features (MMFs), regions of flux which disconnect from a sunspot or pore before propagating away in the moat flow and often displaying evidence of cancellation. In this article, data collected by the Solar Dynamics Observatory's Helioseismic and Magnetic Imager and Atmospheric Imaging Assembly are analysed in an attempt to understand the potential links between such cancellation and UV burst formation. Two MMFs from AR 11579, three bi-poles from AR 11765, and six bi-poles (four of which were co-spatial to IRIS bursts) in AR 11850 were identified for analysis. All of these cancellation features were found to have lifetimes of the order hours and cancellation rates of the order 10^14-10^15 Mx s^-1. H-alpha line wing data from the Dunn Solar Telescope's Interferometric BIdimensional Spectrometer were also available for AR 11579 facilitating a discussion of links between MMFs and EBs. Using an algebraic model of photospheric magnetic reconnection, the measured cancellation rates are then used to ascertain estimates of certain quantities (such as up-flow speeds, jet extents, and potential energy releases) which compared reasonably to the properties of EBs reported within the literature. Our results suggest that cancellation rates of the order measured here are capable of supplying enough energy to drive certain UV bursts (including EBs), however, they are not a guaranteeing condition for burst formation

Research on information systems failures and successes: Status update and future directions

The final publication is available at Springer via http://dx.doi.org/10.1007/s10796-014-9500-yInformation systems success and failure are among the most prominent streams in IS research. Explanations of why some IS fulfill their expectations, whereas others fail, are complex and multi-factorial. Despite the efforts to understand the underlying factors, the IS failure rate remains stubbornly high. A Panel session was held at the IFIP Working Group 8.6 conference in Bangalore in 2013 which forms the subject of this Special Issue. Its aim was to reflect on the need for new perspectives and research directions, to provide insights and further guidance for managers on factors enabling IS success and avoiding IS failure. Several key issues emerged, such as the need to study problems from multiple perspectives, to move beyond narrow considerations of the IT artifact, and to venture into underexplored organizational contexts, such as the public sector. © 2014 Springer Science+Business Media New York

Financial fragmentation and SMEs’ access to finance

This paper focuses on the impact of financial fragmentation on small and medium enterprises (SMEs)’ access to finance. We combine country-level data on financial fragmentation and the ECB’s SAFE (Survey on the Access to Finance of Enterprises) data for 12 European Union (EU) countries over 2009-2016. Our findings indicate that an increase in financial fragmentation not only raises the probability of all firms to be rationed but also to be charged higher loan rates; in addition, it increases the likelihood of borrower discouragement and it impairs firms’ perceptions of the future availability of bank funds. Less creditworthy firms are even more likely to become credit rationed, suggesting a flight to quality effect in lending. However, our study also documents a potential adverse effect of increasing bank market power resulting from greater integration. This suggests that financial integration could impair firms’ financing, if not accompanied by policy initiatives aimed at maintaining an optimal level of competition in the banking sector