Pennsylvania Folklife Vol. 23, No. 3

• Victorian Wall Mottoes • Pennsylvania German Astronomy and Astrology VIII: David Rittenhouse • Sociological Aspects of Quilting in Three Brethren Churches of Southeastern Pennsylvania • Nicknaming in an Amish-Mennonite Community • Fruit Harvesting and Preservation in Early Pennsylvania • Folklore in the Library: Old Schuylkill Tales • Mills and Milling in Pennsylvania: Folk-Cultural Questionnaire No. 33https://digitalcommons.ursinus.edu/pafolklifemag/1057/thumbnail.jp

Pennsylvania Folklife Vol. 21, No. 1

• The Fraktur of Monroe County • Minutes of the West Grove Housekeepers Association as Source Material for Folklife Studies • The Searight Tavern on the National Road: An Archaeological Study • The Brown Sugar Game in Western Pennsylvania • Bread Baking in Mifflin County, Pennsylvania: Commentary for the Documentary Film in the Encyclopaedia Cinematographica • Notes and Documents: Literature for the Allegheny Frontier: The Huntingdon Literary Museum and Monthly Miscellany (1810) • Hunting and Food-Gathering: Folk-Cultural Questionnaire No. 21https://digitalcommons.ursinus.edu/pafolklifemag/1045/thumbnail.jp

Selective Cholinergic Depletion in Medial Septum Leads to Impaired Long Term Potentiation and Glutamatergic Synaptic Currents in the Hippocampus

Cholinergic depletion in the medial septum (MS) is associated with impaired hippocampal-dependent learning and memory. Here we investigated whether long term potentiation (LTP) and synaptic currents, mediated by alpha-amino-3-hydroxy-5-methyl-isoxazole-4-propionate (AMPA) and N-methyl-D-aspartate (NMDA) receptors in the CA1 hippocampal region, are affected following cholinergic lesions of the MS. Stereotaxic intra-medioseptal infusions of a selective immunotoxin, 192-saporin, against cholinergic neurons or sterile saline were made in adult rats. Four days after infusions, hippocampal slices were made and LTP, whole cell, and single channel (AMPA or NMDA receptor) currents were recorded. Results demonstrated impairment in the induction and expression of LTP in lesioned rats. Lesioned rats also showed decreases in synaptic currents from CA1 pyramidal cells and synaptosomal single channels of AMPA and NMDA receptors. Our results suggest that MS cholinergic afferents modulate LTP and glutamatergic currents in the CA1 region of the hippocampus, providing a potential synaptic mechanism for the learning and memory deficits observed in the rodent model of selective MS cholinergic lesioning