Open-label, randomized study of Amoxicillin, Azithromycin, and Cefprozil in Childhood Sinusitis

Aim: There are many antibiotics used in acute sinusitis in paediatric practice. We planned this study to contribute rational antibacterial treatment considering the clinical efficiency, side effects and cost of the treatment. Materials and methods: Our study was a prospective, randomized and open label study in children. Patients diagnosed as having acute sinusitis based on the major and minor clinical diagnostic criteria were randomized to receive 14 days of amoxicillin (40 mg/kg/day, in 3 doses), 5 days of azithromycin (10 mg/kg/day, single dose for first 3 days and 5 mg/kg/day-single dose for 2 days) and 14 days of cefprozil (30 mg/kg/day, 2 doses). Results: Of a total of 151 patients who were between the ages of5 and 14 years (mean: 8.33±2.82 standard error), 50 patients received amoxicillin, 52 azitromycin and 49 cefprozil. At the end of the treatment improvement rates were 72 %,80.7 %, and 69.3 % respectively (p>0.05). The occurrence rates of adverse effects were 8 %, 7 %, and 10 % in these groups respectively (p > 0.05). Conclusion: We emphasize that clinicians should prefer appropriate antibiotics for acute sinusitis in children, in regard to the parameters of low cost, high compliance and minimum adverse effects.peer-reviewe

Subjectivity construction at multinationals: Turkish female brand managers' case

With the advent of capitalism, consumption has emerged as a core activity of companies next to production, increasing the importance of marketing and advertising departments. In this context, brand managers of transnational capitalist class occupy a professional position in the midway between production and consumption. Being consumers themselves they produce the consumption alternatives of people. This thesis aims to explore subjectivity construction processes of young women managers working in the marketing departments of multinational corporations in Istanbul, Turkey. I analyze the ways in which disciplinary processes, ways in which distinctions are made and maintained and the mechanisms that are developed to cope with the daily life are narrated. In this, I analyze the parallels and distances they build between themselves and other members of their groups as well as the consumers. My discussion aims to move away from the reductionist approach that sees the people as passive victims and capitalism as a structure that imposes itself regardless of context or agency

The influence of plant addition to some physicochemical, textural, microstructural, melting ability and sensory properties of Mozzarella cheese

Mozzarella je sir koji se proizvodi gnječenjem sirnog tijesta u vrućoj vodi. Samo tijesto je karakteristične filamentozne strukture te ima dobru sposobnost topljenja i rastezanja. Cilj ovog rada bio je istražiti utjecaj dodatka odabranog začinskog bilja na određena svojstva Mozzarella sira. Ružmarin (Rosmarinus officinalis L.), bosiljak (Ocimum basilicum L.), paprena metvica (Mentha piperita L.) i turski origano (Origanum onites L.) dodani su Mozzarella siru u fazi gnječenja, dok su fizikalno-kemijska, teksturalna, mikrostrukturna i senzorska svojstva te sposobnost topljenja određivani tijekom perioda skladištenja. Kontrolni uzorak sira proizveden je bez dodatka začinskog bilja. Prethodno spomenuti dodaci utjecali su na neka svojstva Mozzarella sira kao što su pH, kiselost, slobodne masne kiseline, tekstura i mikrostrukturna svojstva. Nadalje, uočena je i promjena senzorskih svojstava, pri čemu je pogotovo dodatak turskog origana i paprene metvice uzrokovao bolju prihvatljivost te bolji okus i aromu. Dok su niža pH vrijednost i titracijska kiselost utvrđeni kod sireva s dodatkom ružmarina, najniži udio slobodnih masnih kiselina (ADV) utvrđen je kod sireva s dodatkom paprene metvice. Sirevi s dodatkom ružmarina bili su tvrđi i jednoličnije mikrostrukture, dok su najbolja senzorska svojstva imali sirevi s dodatkom turskog origana i paprene metvice. Zaključno, rezultati ovog istraživanja pokazali su kako se trajnost Mozzarella sira može produljiti dodatkom različitog začinskog bilja zbog povoljnog utjecaja na pH, kiselost i slobodne masne kiseline.Mozzarella cheese is produced by kneading the curd, which has a fibrous structure with melting and elongation properties, in hot water. The present study aimed to investigate the impact of the addition of some plants on certain properties of Mozzarella cheese. Rosemary (Rosmarinus officinalis L.), basil (Ocimum basilicum L.), mint (Mentha piperita L.) and Turkish Oregano (Origanum onites L.) were added to Mozzarella cheese at the curd kneading stage, and physicochemical, textural, microstructural, meltability and sensory properties were investigated during the storage period. No plants were added to the control group cheese. Plant addition to Mozzarella cheese affected some physicochemical properties such as pH, acidity, free fatty acids, as well as textural and microstructural properties. Furthermore, it affected sensory properties, especially Turkish Oregano and mint addition provided high general acceptability and taste-aroma scores. While higher pH and lower titration acidity were determined in rosemary-added cheese samples, the lowest free fatty acid (ADV) levels were determined in the mint-added cheese sample. Rosemary-added cheeses had higher hardness and a more even microstructure, while the highest sensory scores were obstained for cheeses that included Turkish Oregano and mint. In conclusion, the present study findings demonstrated that the short shelf life of Mozzarella cheese could be extended with the addition of various plants due to their effects on pH, acidity and free fatty acids

Clinical and Laboratory Characteristics of Hyperprolactinemia in Children and Adolescents: National Survey

Conclusion: We present the largest cohort of children and adolescents with hyperprolactinemia in the literature to date. Hyperprolactinemia is more common in females and cabergoline is highly effective and practical to use in adolescents, due to its biweekly dosing. Indications for surgery in pediatric cases need to be revised

Sex difference and intra-operative tidal volume: Insights from the LAS VEGAS study

BACKGROUND: One key element of lung-protective ventilation is the use of a low tidal volume (VT). A sex difference in use of low tidal volume ventilation (LTVV) has been described in critically ill ICU patients.OBJECTIVES: The aim of this study was to determine whether a sex difference in use of LTVV also exists in operating room patients, and if present what factors drive this difference.DESIGN, PATIENTS AND SETTING: This is a posthoc analysis of LAS VEGAS, a 1-week worldwide observational study in adults requiring intra-operative ventilation during general anaesthesia for surgery in 146 hospitals in 29 countries.MAIN OUTCOME MEASURES: Women and men were compared with respect to use of LTVV, defined as VT of 8 ml kg-1 or less predicted bodyweight (PBW). A VT was deemed 'default' if the set VT was a round number. A mediation analysis assessed which factors may explain the sex difference in use of LTVV during intra-operative ventilation.RESULTS: This analysis includes 9864 patients, of whom 5425 (55%) were women. A default VT was often set, both in women and men; mode VT was 500 ml. Median [IQR] VT was higher in women than in men (8.6 [7.7 to 9.6] vs. 7.6 [6.8 to 8.4] ml kg-1 PBW, P < 0.001). Compared with men, women were twice as likely not to receive LTVV [68.8 vs. 36.0%; relative risk ratio 2.1 (95% CI 1.9 to 2.1), P < 0.001]. In the mediation analysis, patients' height and actual body weight (ABW) explained 81 and 18% of the sex difference in use of LTVV, respectively; it was not explained by the use of a default VT.CONCLUSION: In this worldwide cohort of patients receiving intra-operative ventilation during general anaesthesia for surgery, women received a higher VT than men during intra-operative ventilation. The risk for a female not to receive LTVV during surgery was double that of males. Height and ABW were the two mediators of the sex difference in use of LTVV.TRIAL REGISTRATION: The study was registered at Clinicaltrials.gov, NCT01601223

Prevalence, associated factors and outcomes of pressure injuries in adult intensive care unit patients: the DecubICUs study

Funder: European Society of Intensive Care Medicine; doi: http://dx.doi.org/10.13039/501100013347Funder: Flemish Society for Critical Care NursesAbstract: Purpose: Intensive care unit (ICU) patients are particularly susceptible to developing pressure injuries. Epidemiologic data is however unavailable. We aimed to provide an international picture of the extent of pressure injuries and factors associated with ICU-acquired pressure injuries in adult ICU patients. Methods: International 1-day point-prevalence study; follow-up for outcome assessment until hospital discharge (maximum 12 weeks). Factors associated with ICU-acquired pressure injury and hospital mortality were assessed by generalised linear mixed-effects regression analysis. Results: Data from 13,254 patients in 1117 ICUs (90 countries) revealed 6747 pressure injuries; 3997 (59.2%) were ICU-acquired. Overall prevalence was 26.6% (95% confidence interval [CI] 25.9–27.3). ICU-acquired prevalence was 16.2% (95% CI 15.6–16.8). Sacrum (37%) and heels (19.5%) were most affected. Factors independently associated with ICU-acquired pressure injuries were older age, male sex, being underweight, emergency surgery, higher Simplified Acute Physiology Score II, Braden score 3 days, comorbidities (chronic obstructive pulmonary disease, immunodeficiency), organ support (renal replacement, mechanical ventilation on ICU admission), and being in a low or lower-middle income-economy. Gradually increasing associations with mortality were identified for increasing severity of pressure injury: stage I (odds ratio [OR] 1.5; 95% CI 1.2–1.8), stage II (OR 1.6; 95% CI 1.4–1.9), and stage III or worse (OR 2.8; 95% CI 2.3–3.3). Conclusion: Pressure injuries are common in adult ICU patients. ICU-acquired pressure injuries are associated with mainly intrinsic factors and mortality. Optimal care standards, increased awareness, appropriate resource allocation, and further research into optimal prevention are pivotal to tackle this important patient safety threat

Correction to: Prevalence, associated factors and outcomes of pressure injuries in adult intensive care unit patients: the DecubICUs study

The original version of this article unfortunately contained a mistake

Prevalence, associated factors and outcomes of pressure injuries in adult intensive care unit patients: the DecubICUs study

Funder: European Society of Intensive Care Medicine; doi: http://dx.doi.org/10.13039/501100013347Funder: Flemish Society for Critical Care NursesAbstract: Purpose: Intensive care unit (ICU) patients are particularly susceptible to developing pressure injuries. Epidemiologic data is however unavailable. We aimed to provide an international picture of the extent of pressure injuries and factors associated with ICU-acquired pressure injuries in adult ICU patients. Methods: International 1-day point-prevalence study; follow-up for outcome assessment until hospital discharge (maximum 12 weeks). Factors associated with ICU-acquired pressure injury and hospital mortality were assessed by generalised linear mixed-effects regression analysis. Results: Data from 13,254 patients in 1117 ICUs (90 countries) revealed 6747 pressure injuries; 3997 (59.2%) were ICU-acquired. Overall prevalence was 26.6% (95% confidence interval [CI] 25.9–27.3). ICU-acquired prevalence was 16.2% (95% CI 15.6–16.8). Sacrum (37%) and heels (19.5%) were most affected. Factors independently associated with ICU-acquired pressure injuries were older age, male sex, being underweight, emergency surgery, higher Simplified Acute Physiology Score II, Braden score 3 days, comorbidities (chronic obstructive pulmonary disease, immunodeficiency), organ support (renal replacement, mechanical ventilation on ICU admission), and being in a low or lower-middle income-economy. Gradually increasing associations with mortality were identified for increasing severity of pressure injury: stage I (odds ratio [OR] 1.5; 95% CI 1.2–1.8), stage II (OR 1.6; 95% CI 1.4–1.9), and stage III or worse (OR 2.8; 95% CI 2.3–3.3). Conclusion: Pressure injuries are common in adult ICU patients. ICU-acquired pressure injuries are associated with mainly intrinsic factors and mortality. Optimal care standards, increased awareness, appropriate resource allocation, and further research into optimal prevention are pivotal to tackle this important patient safety threat

Fatty acids, phenolic compounds and antioxidant capacity of the seeds from nine grape cultivars (

Seeds are one of the main parts of the grapes, and they contain important constituents such as polyphenols, lipids, proteins and carbohydrates. In this study, oil contents, fatty acid composition, total phenolic content, total flavonoid content, monomeric flavan-3-ols and antioxidant capacities of nine grape seeds from nine cultivars were investigated. The correlations between the analyzed parameters were also examined. The oil contents of seeds ranged from 4.96 to 13.35%. Linoleic acid was the predominant fatty acid in the seeds, and it was followed by oleic acid, palmitic acid, stearic acid, linolenic acid, 11-eicosenoic acid and arachidic acid. Total phenolic and total flavonoid contents were 646.50-1120.78 mg GAE/g and 336.69-589.85 mg CE/g, respectively. ‘Italia’ seeds had the highest antioxidant capacity for DPPH and CUPRAC assays while ‘Cabernet Sauvignon’ seeds had the lowest one. The (-)-epigallocatechin, (+)-catechin, (-)-epigallocatechin gallate, (-)-epicatechin and (-)-epicatechin gallate contents in the seeds varied from 1.23 to 6.53 mg/g, 11.61 to 80.20 mg/g, 0.21 to 0.51 mg/g, 2.78 to 48.26 mg/g and 0.08 to 1.50 mg/g, respectively. The (+)-catechin and (-)-epicatechin were the major flavan-3-ol compounds in the grape seeds. Significant correlations were found between total phenolic content, total flavonoid, RSA (DPPH Radical scavenging activity), CUPRAC (Cupric reducing antioxidant capacity) and flavan-3-ols. Consequently, the current study findings support previous information that grape seeds are an important source of antioxidants as well as unsaturated fatty acids, which have positive effects on human health

Evaluation Of Secondary Malignancy Risk Due To The Whole Body Computerized Tomography Simulation In Radiotherapy Facilities

Nowadays, the use of computed tomography (CT) simulation is getting widespread with the use of new treatment modalities like three dimensional conformal radiotherapy (3D-CRT), intensity modulated radiotherapy (IMRT), adaptive radiotherapy (ART) and stereotactic radiosurgery (SRS) in radiotherapy facilities. The main purpose of these new treatment modalities are to increase the survival and increase the quality of life by reducing the side effects. However, radiation induced secondary malignancy risk is getting important after radiotherapy with the increase in survival. Especially, CT scanning was performed from head to sacral region for 3D-CRT craniospinal treatments techniques in children or young patients and several precautions should be taken to reduce the radiation dose due to the CT simulation. In this study, we measured organ equivalent dose in Alderson Rando phantom and we estimate radiation-induced cancer risk due to CT scanning for different conditions. According to our measurement, secondary malignancy risk was found to be between 0.10% - 0.22% for different conditions in craniospinal CT simulation.WoSScopu