Candida meningitis in an immunocompetent patient detected through (1→3)-beta-d-glucan

SummaryA 44-year-old female presented with a 3-month history of headache, dizziness, nausea, and vomiting. Her past medical history was significant for long-standing intravenous drug abuse. Shortly after admission, the patient became hypertensive and febrile, with fever as high as 38.8°C. The lumbar puncture profile supported an infectious process; however multiple cultures of blood and cerebrospinal fluid (CSF) did not initially show growth of organisms. Finally after 9 days of incubation, a CSF culture showed evidence of a few colonies of Candida albicans. To confirm the diagnosis, preserved CSF from that sample was tested for (1→3)-β-d-glucan, showing levels >500pg/ml. This report illustrates a rare complication of intravenous drug use in an immunocompetent patient and demonstrates the utility of (1→3)-β-d-glucan testing in possible Candida meningitis

Status of the European Green Crab, Carcinus maenas, in Oregon and Washington coastal Estuaries in 2018

The European green crab (Carcinus maenas) has persisted in Oregon and Washington coastal estuaries since the late 1990s. After the arrival of a strong year class in 1998, significant recruitment to the populations occurred only in 2003, 2005, 2006, 2010, 2015, 2016, 2017 and 2018. Warm winter water temperatures, high Pacific Decadal Oscillation (PDO) and Multivariate ENSO (El Niño Southern Oscillation) Indices, and a high abundance of southern copepods are all correlated with strong year classes and vice versa (Behrens Yamada Peterson and Kosro 2015). Prior to 2015, green crabs were too rare to exert measurable effects on the native benthic community and on shellfish culture in Oregon and Washington. Following the recent strong El Niño, however, we documented the arrival of four strong year classes in 2015, 2016, 2017 and 2018. Average catch rates over the last four years steadily increased from 0.5 to 0.8 to 2.2 and to 3.2 crabs per trap. The catches in the last 2 years are much higher than in any of the previous years, including 1998. Since green crabs live for 6 years, these four consecutive year classes will produce larvae until 2024. A switch to cooler ocean conditions in the coming years will result in poor recruitment, but a return to high PDO and strong El Niño patterns would signal good recruitment and higher green crab densities. For example, green crabs were first documented in New England in 1817, but it took warm ocean conditions during the 1950’s for their numbers to build to a level at which they decimated the soft-shelled clam industry in Maine. With the recent warm trend on the East Coast, green crabs are again abundant. Not only are they preying on shellfish, they are also damaging valuable eelgrass habitat by ripping up the plants in search of food (Neckles 2015). Even though green crab abundance in Oregon and Washington is still low when compared to Europe, eastern North America, Tasmania, California and the west coast of Vancouver Island, it is imperative to continue monitoring efforts for two reasons:1) to elucidate the process of range expansion and population persistence of this model non-indigenous marine species with planktonic larvae, and 2) to predict the arrival of strong year classes from ocean conditions and alert managers and shellfish growers of possible increases in predation pressure from this invader

Climate drives the geography of marine consumption by changing predator communities

Este artículo contiene 7 páginas, 3 figuras, 1 tabla.The global distribution of primary production and consumption by humans (fisheries) is well-documented, but we have no map linking the central ecological process of consumption within food webs to temperature and other ecological drivers. Using standardized assays that span 105° of latitude on four continents, we show that rates of bait consumption by generalist predators in shallow marine ecosystems are tightly linked to both temperature and the composition of consumer assemblages. Unexpectedly, rates of consumption peaked at midlatitudes (25 to 35°) in both Northern and Southern Hemispheres across both seagrass and unvegetated sediment habitats. This pattern contrasts with terrestrial systems, where biotic interactions reportedly weaken away from the equator, but it parallels an emerging pattern of a subtropical peak in marine biodiversity. The higher consumption at midlatitudes was closely related to the type of consumers present, which explained rates of consumption better than consumer density, biomass, species diversity, or habitat. Indeed, the apparent effect of temperature on consumption was mostly driven by temperature-associated turnover in consumer community composition. Our findings reinforce the key influence of climate warming on altered species composition and highlight its implications for the functioning of Earth’s ecosystems.We acknowledge funding from the Smithsonian Institution and the Tula Foundation.Peer reviewe

Dataset for Status of the European Green Crab, Carcinus maenas, in Oregon and Washington coastal Estuaries in 2017

Data on green crabs collected and trapped from Makah Bay to Coos Bay in 2017. Data included: Estuary, site, date, sex, carapace width, weight, molt state, estimated year class, missing limbs, collection method and collector

Dataset for Status of the European Green Crab, Carcinus maenas, in Oregon and Washington coastal Estuaries in 2018

Data on green crabs collected and trapped from Makah Bay to Coos Bay in 2018. Data included: Estuary, site, date, sex, carapace width, weight, molt state, estimated year class, missing limbs, collection method, collector and pheromone treatment

Tetraspanins CD81 and CD82 Facilitate α4β1-Mediated Adhesion of Human Erythroblasts to Vascular Cell Adhesion Molecule-1

The proliferation and terminal differentiation of erythroid progenitors occurs in human bone marrow within erythroblastic islands, specialised structures consisting of a central macrophage surrounded by developing erythroid cells. Many cell-cell and cell-matrix adhesive interactions maintain and regulate the co-ordinated daily production of reticulocytes. Erythroid cells express only one integrin, a4b1, throughout differentiation, and its interactions with both macrophage Vascular Cell Adhesion Molecule-1 and with extracellular matrix fibronectin are critical for erythropoiesis. We observed that proerythroblasts expressed a broad tetraspanin phenotype, and investigated whether any tetraspanin could modulate integrin function. A specific association between a4b1 and CD81, CD82 and CD151 was demonstrated by confocal microscopy and co-immune precipitation. We observed that antibodies to CD81 and CD82 augmented adhesion of proerythroblasts to Vascular Cell Adhesion Molecule-1 but not to the fibronectin spliceoforms FnIII12-IIICS-15 and FnIII12–15. In contrast, different anti-CD151 antibodies augmented or inhibited adhesion of proerythroblasts to Vascular Cell Adhesion Molecule-1 and the fibronectin spliceoform FnIII12-IIICS-15 but not to FnIII12–15. These results strongly suggest that tetraspanins have a functional role in terminal erythropoiesis by modulating interactions of erythroblast a4b1 with both macrophages and extracellular matrix

Climate drives the geography of marine consumption by changing predator communities

The global distribution of primary production and consumption by humans (fisheries) is well-documented, but we have no map linking the central ecological process of consumption within food webs to temperature and other ecological drivers. Using standardized assays that span 105° of latitude on four continents, we show that rates of bait consumption by generalist predators in shallow marine ecosystems are tightly linked to both temperature and the composition of consumer assemblages. Unexpectedly, rates of consumption peaked at midlatitudes (25 to 35°) in both Northern and Southern Hemispheres across both seagrass and unvegetated sediment habitats. This pattern contrasts with terrestrial systems, where biotic interactions reportedly weaken away from the equator, but it parallels an emerging pattern of a subtropical peak in marine biodiversity. The higher consumption at midlatitudes was closely related to the type of consumers present, which explained rates of consumption better than consumer density, biomass, species diversity, or habitat. Indeed, the apparent effect of temperature on consumption was mostly driven by temperature-associated turnover in consumer community composition. Our findings reinforce the key influence of climate warming on altered species composition and highlight its implications for the functioning of Earth's ecosystems