Charmless Bs→PP,PV,VVB_s\to PP, PV, VV Decays Based on the six-quark Effective Hamiltonian with Strong Phase Effects II

We provide a systematic study of charmless $B_s \to PP, PV, VV$ decays ($P$ and $V$ denote pseudoscalar and vector mesons, respectively) based on an approximate six-quark operator effective Hamiltonian from QCD. The calculation of the relevant hard-scattering kernels is carried out, the resulting transition form factors are consistent with the results of QCD sum rule calculations. By taking into account important classes of power corrections involving "chirally-enhanced" terms and the vertex corrections as well as weak annihilation contributions with non-trivial strong phase, we present predictions for the branching ratios and CP asymmetries of $B_s$ decays into PP, PV and VV final states, and also for the corresponding polarization observables in VV final states. It is found that the weak annihilation contributions with non-trivial strong phase have remarkable effects on the observables in the color-suppressed and penguin-dominated decay modes. In addition, we discuss the SU(3) flavor symmetry and show that the symmetry relations are generally respected

Differential gene expression profiles in foetal skin of Rex rabbits with different wool density

[EN] This study investigated the mechanisms controlling hair follicle development in the Rex rabbit. The Agilent rabbit gene expression microarray was used to determine differentially expressed genes in Rex rabbit foetuses with different wool densities. The expression patterns of selected differentially-expressed genes were further investigated by quantitative real-time PCR. Compared to low wool density rabbits, 1342 differentially expressed probes were identified in high wool density rabbits, including 950 upregulated probes and 392 downregulated probes. Gene ontology analysis revealed that the most upregulated differentially expressed probes belonged to receptors and the most downregulated differentially expressed probes belonged to DNA binding molecules. Kyoto Encyclopedia of Genes and Genomes pathway analysis revealed that the differentially expressed probes were mainly involved in the sonic hedgehog (Shh) and Eph signalling pathways. The results also suggest that transforming growth factor-beta 1, growth hormone receptor, and the keratin-associated protein 6.1 genes, as well as the Shh and Eph signalling pathways, may be involved in the regulation of hair follicle developmental in Rex rabbits.The authors thank Ms. Libo Huang for her technical assistance. This study was supported by grants from the Modern Agro-industry Technology Research System (CARS-44-B-1), the Postdoctoral Science Foundation of China (2015M580601) and Agricultural Major Application Technology Innovation Project of Shandong Province (2015-2016),Liu, L.; Li, B.; Zhu, Y.; Wang, C.; Li, F. (2016). Differential gene expression profiles in foetal skin of Rex rabbits with different wool density. World Rabbit Science. 24(3):223-231. https://doi.org/10.4995/wrs.2016.2335SWORD22323124

What can the braking indices tell us about pulsars' nature?

As a result of observational difficulties, braking indices of only six rotation-powered pulsars are obtained with certainty, all of which are remarkably smaller than the value ($n=3$) expected for pure magnetodipole radiation model. This is still a real fundamental question not being well answered after nearly forty years of the discovery of pulsar. The main problem is that we are shamefully not sure about the dominant mechanisms that result in pulsars' spin-down. Based on the previous works, the braking index is re-examined, with a conclusion of suggesting a constant gap potential drop for pulsars with magnetospheric activities. New constrains on model parameters from observed braking indices are presented.Comment: 10 pages, 4 figures, submitted to "Advances in Space Research" (Proceedings of COSPAR 2006

Serum hepatocyte growth factor is associated with small vessel disease in Alzheimer's dementia

Background: While hepatocyte growth factor (HGF) is known to exert cell growth, migration and morphogenic effects in various organs, recent studies suggest that HGF may also play a role in synaptic maintenance and cerebrovascular integrity. Although increased levels of HGF have been reported in brain and cerebrospinal fluid (CSF) samples of patients with Alzheimer's disease (AD), it is unclear whether peripheral HGF may be associated with cerebrovascular disease (CeVD) and dementia. In this study, we examined the association of baseline serum HGF with neuroimaging markers of CeVD in a cohort of pre-dementia (cognitive impaired no dementia, CIND) and AD patients. Methods: Serum samples from aged, Non-cognitively impaired (NCI) controls, CIND and AD subjects were measured for HGF levels. CeVD (cortical infarcts, microinfarcts, lacunes, white matter hyperintensities (WMH) and microbleeds) were assessed by magnetic resonance imaging (MRI). Results: After controlling for covariates, higher levels of HGF were associated with both CIND and AD. Among the different CeVD MRI markers in CIND and AD, only small vessel disease, but not large vessel disease markers were associated with higher HGF levels. Conclusion: Serum HGF may be a useful peripheral biomarker for small vessel disease in subjects with cognitive impairment and AD

Water stress in maize production in the drylands of the Loess Plateau

Water stress during two maize (Zea mays L.) growing seasons (2013 and 2014) was investigated in a semiarid region of northwest China. The HYDRUS-1D model gave good simulation of the soil water content in different layers throughout a 0- to 200-cm depth during the maize growing season, with R-2 values of 70.6 and 77.0% for the calibration and validation periods, respectively. Water stress for maize production was observed in June of 2013 and in July of 2014. The soil water storage (SWS) decreased significantly during the early stage of the maize growing season, especially in 2014. The root depth and crop height were 20 cm deeper and 100 cm higher, respectively, in 2014 than in 2013 at the early stage. These results suggest that in the early stage of the maize growing season, pre-seeding SWS can alleviate crop water stress effectively via deep roots. Model simulation showed that the plow pan layer (at a depth of 20-40 cm), with high soil bulk density and a lower soil water retention curve, significantly reduced infiltration. High evapotranspiration and low precipitation result in a temporary dry layer during the early stage, highlighting the plow pan as the sensitive layer for water stress during the drought period. Effective management practices such as deep plowing, plastic film mulching, or water conservation treatments in the fallow period are needed to avoid the formation of this temporary dry layer during the drought period at the early stage and thus improve maize production in rainfed agriculture on the Loess Plateau of China

Serum IL-8 is a marker of white-matter hyperintensities in patients with Alzheimer's disease

Introduction Neuroinflammation and cerebrovascular disease (CeVD) have been implicated in cognitive impairment and Alzheimer's disease (AD). The present study aimed to examine serum inflammatory markers in preclinical stages of dementia and in AD, as well as to investigate their associations with concomitant CeVD. Methods We performed a cross-sectional case–control study including 96 AD, 140 cognitively impaired no dementia (CIND), and 79 noncognitively impaired participants. All subjects underwent neuropsychological and neuroimaging assessments, as well as collection of blood samples for measurements of serum samples interleukin (IL)-6, IL-8, and tumor necrosis factor α levels. Subjects were classified as CIND or dementia based on clinical criteria. Significant CeVD, including white-matter hyperintensities (WMHs), lacunes, and cortical infarcts, was assessed by magnetic resonance imaging. Results After controlling for covariates, higher concentrations of IL-8, but not the other measured cytokines, were associated with both CIND and AD only in the presence of significant CeVD (CIND with CeVD: odds ratios [ORs] 4.53; 95% confidence interval [CI] 1.5–13.4 and AD with CeVD: OR 7.26; 95% CI 1.2–43.3). Subsequent multivariate analyses showed that among the types of CeVD assessed, only WMH was associated with higher IL-8 levels in CIND and AD (WMH: OR 2.81; 95% CI 1.4–5.6). Discussion Serum IL-8 may have clinical utility as a biomarker for WMH in AD. Longitudinal follow-up studies would help validate these findings

Measurement of the Intrinsic Radiopurity of Cs-137/U-235/U-238/Th-232 in CsI(Tl) Crystal Scintillators

The inorganic crystal scintillator CsI(Tl) has been used for low energy neutrino and Dark Matter experiments, where the intrinsic radiopurity is an issue of major importance. Low-background data were taken with a CsI(Tl) crystal array at the Kuo-Sheng Reactor Neutrino Laboratory. The pulse shape discrimination capabilities of the crystal, as well as the temporal and spatial correlations of the events, provide powerful means of measuring the intrinsic radiopurity of Cs-137 as well as the U-235, U-238 and Th-232 series. The event selection algorithms are described, with which the decay half-lives of Po-218, Po-214, Rn-220, Po-216 and Po-212 were derived. The measurements of the contamination levels, their concentration gradients with the crystal growth axis, and the uniformity among different crystal samples, are reported. The radiopurity in the U-238 and Th-232 series are comparable to those of the best reported in other crystal scintillators. Significant improvements in measurement sensitivities were achieved, similar to those from dedicated massive liquid scintillator detector. This analysis also provides in situ measurements of the detector performance parameters, such as spatial resolution, quenching factors, and data acquisition dead time.Comment: 28 pages, 12 figure

Mapping of periodically poled crystals via spontaneous parametric down-conversion

A new method for characterization of periodically poled crystals is developed based on spontaneous parametric down-conversion. The method is demonstrated on crystals of Y:LiNbO3, Mg:Y:LiNbO3 with non-uniform periodically poled structures, obtained directly under Czochralski growth procedure and designed for application of OPO in the mid infrared range. Infrared dispersion of refractive index, effective working periods and wavelengths of OPO were determined by special treatment of frequency-angular spectra of spontaneous parametric down-conversion in the visible range. Two-dimensional mapping via spontaneous parametric down-conversion is proposed for characterizing spatial distribution of bulk quasi-phase matching efficiency across the input window of a periodically poled sample.Comment: 19 pages, 6 figure

Selective deletion of PPARβ/δ in fibroblasts causes dermal fibrosis by attenuated LRG1 expression.

Connective tissue diseases of the skin are characterized by excessive collagen deposition in the skin and internal organs. Fibroblasts play a pivotal role in the clinical presentation of these conditions. Nuclear receptor peroxisome-proliferator activated receptors (PPARs) are therapeutic targets for dermal fibrosis, but the contribution of the different PPAR subtypes are poorly understood. Particularly, the role of fibroblast PPARβ/δ in dermal fibrosis has not been elucidated. Thus, we generated a mouse strain with selective deletion of PPARβ/δ in the fibroblast (FSPCre- <i>Pparb/d</i> <sup>-/-</sup> ) and interrogated its epidermal and dermal transcriptome profiles. We uncovered a downregulated gene, leucine-rich alpha-2-glycoprotein-1 ( <i>Lrg1</i> ), of previously unknown function in skin development and architecture. Our findings suggest that the regulation of <i>Lrg1</i> by PPARβ/δ in fibroblasts is an important signaling conduit integrating PPARβ/δ and TGFβ1-signaling networks in skin health and disease. Thus, the FSPCre- <i>Pparb/d</i> <sup>-/-</sup> mouse model could serve as a novel tool in the current gunnery of animal models to better understand dermal fibrosis

Tightly Coupled Array Antennas for Ultra-Wideband Wireless Systems

Tightly coupled array (TCA) antenna has become a hot topic of research recently, due to its potential of enabling one single antenna array to operate over an extremely wide frequency range. Such an array antenna is promising for applications in numerous wideband/multi-band and multi-function wireless systems such as wideband high-resolution radars, 5G mobile communications, satellite communications, global navigation satellite systems, sensors, wireless power transmission, internet of things and so on. Many papers on this topic have been published by researchers internationally. This paper provides a detailed review of the recent development on TCA that utilizes the capacitive coupling. The basic principles and the historical evolution of the TCAs are introduced firstly. Then, recent development in the analysis and design of TCAs, such as equivalent circuit analysis, bandwidth limitation analysis, array elements, feed structures, substrates/superstrates loading, etc., are explained and discussed. The performances of the state-of-the-art TCAs are presented and a comparison amongst some TCAs reported recently is summarized and discussed. To illustrate the practical designs of TCA, one case study is provided, and the detailed design procedures of the TCA are explained so as to demonstrate the TCA design methodology. Simulated results including the VSWR at different angles of scanning, patterns and antenna gain are shown and discussed. A conclusion and future work are given in the end