Immunohistochemical localization of glucagon and pancreatic polypeptide on rat endocrine pancreas: coexistence in rat islet cells

We used immunofluorescence double staining method to investigate the cellular localization of glucagon and pancreatic polypeptide (PP) in rat pancreatic islets. The results showed that both A-cells (glucagon-secreting cells) and PP-cells (PP-secreting cells) were located in the periphery of the islets. However, A-cells and PP-cells had a different regional distribution. Most of A-cells were located in the splenic lobe but a few of them were in the duodenal lobe of the pancreas. In contrast, the majority of PP-cells were found in the duodenal lobe and a few of them were in the splenic lobe of the pancreas. Furthermore, we found that 67.74% A-cells had PP immunoreactivity, 70.92% PP-cells contained glucagon immunoreactivity with immunofluorescence double staining. Our data support the concept of a common precursor stem cell for pancreatic hormone-producing cells

Mechanical Properties of Thermoplastic Variable-Angle Composite Laminations for Conical Shells

Thermoplastic composite automated fiber placement technology, as one of the extreme manufacturing technologies for large or extra large composite components with complex surface shapes, has been widely used in the field of aerospace vehicles. This paper takes 8 lamination groups with different initial placement angles generated by the conical shell variable angle placement algorithm as research objects. Variable angle placement algorithm for conical shell and finite element model establishment method for thermoplastic composite laminations of variable angle with different initial placement angles are presented. Static, modal and buckling analyses are conducted for each group. The results show that stress-strain relation, modal and buckling strength of variable-angle laminations vary regularly with the initial placement angle.Технология автоматической укладки термопластичного композитного волокна, являющаяся одной из радикальных технологий получения больших или очень больших компонентов композитов с комплексными формами поверхности, широко используется в авиационно-космической промышленности. В качестве объектов исследования использовали восемь групп слоистых материалов с различными углами конструктивного размещения, которые были созданы с помощью алгоритма размещения переменного угла конической оболочки. Представлены алгоритм размещения переменного угла для конической оболочки и модель на основе метода конечных элементов для термопластичных слоистых композитов с переменным углом. Для каждой группы материалов проведены статистический анализ, исследование методом разложения по собственным формам и расчет устойчивости. Установлено, что зависимость напряжение–деформация, модальная прочность и прочность при продольном изгибе слоистых материалов с переменным углом периодически изменяются в зависимости от угла конструктивного размещения.Технологія автоматичного укладання термопластичного композитного волокна, що є однією з радикальних технологій отримання великих або дуже великих компонентів композитів із комплексними формами поверхні, широко використовується в авіаційно-космічній промисловості. Об’єктом дослідження слугували вісім груп шаруватих матеріалів із різними кутами конструктивного розміщення, які отримано за допомогою алгоритма розміщення змінного кута конічної оболонки. Представлено алгоритм розміщення змінного кута для конічної оболонки і модель на основі методу скінченних елементів для термопластичних шаруватих композитів зі змінним кутом. Для кожної групи матеріалів проведено статистичний аналіз, дослідження методом розкладання за власними формами і розрахунок стійкості. Установлено, що залежність напруження–деформація, модальна міцність і міцність при поздовжньому згині шаруватих матеріалів зі змінним кутом періодично змінюються в залежності від кута конструктивного розміщення

Reversed Drifting Quasi-periodic Pulsating Structure in an X1.3 Solar Flare on 2005 July 30

Based on the analysis of the microwave observations at frequency of 2.60 -- 3.80 GHz in a solar X1.3 flare event observed at Solar Broadband RadioSpectrometer in Huairou (SBRS/Huairou) on 2005 July 30, an interesting reversed drifting quasi-periodic pulsating structure (R-DPS) is confirmed. The R-DPS is mainly composed of two drifting pulsating components: one is a relatively slow very short-period pulsation (VSP) with period of about 130 -- 170 ms, the other is a relatively fast VSP with period of about 70 -- 80 ms. The R-DPS has a weak left-handed circular polarization. Based on the synthetic investigations of Reuven Ramaty High Energy Solar Spectroscopic Imaging (RHESSI) hard X-ray, Geostationary Operational Environmental Satellite (GOES) soft X-ray observation, and magnetic field extrapolation, we suggest the R-DPS possibly reflects flaring dynamic processes of the emission source regions

Multiple sources of infection and potential endemic characteristics of the large outbreak of dengue in Guangdong in 2014

A large outbreak of dengue, with the most documented cases, occurred in Guangdong China in 2014. Epidemiological studies and phylogenetic analysis of the isolated dengue virus (DENV) showed this outbreak was attributed to multiple sources and caused by at least two genotypes of DENV-1 (Genotypes I and III) and two genotypes of DENV-2 (Cosmopolitan and Asian I Genotypes). A retrospective review and phylogenetic analysis of DENV isolated in Guangdong showed that DENV-1 Genotype I strains were reported continuously during 2004-2014, Genotype III strains were reported during 2009-2014 ; DENV-2 Cosmopolitan and Asian I Genotype strains were reported continuously during 2012-2014. At least 45,171 cases were reported in this outbreak, with 65.9% of the patients in the 21-55-year-old group. A trend toward a decrease in the daily newly emerged cases lagged by approximately 20 days compared with the mosquito density curve. Several epidemiological characteristics of this outbreak and the stably sustained serotypes and genotypes of DENV isolated in Guangdong suggest that Guangdong has been facing a threat of transforming from a dengue epidemic area to an endemic area. The high temperature, drenching rain, rapid urbanization, and pandemic of dengue in Southeast Asia may have contributed to this large outbreak of dengue

Mass measurements of neutron-deficient Y, Zr, and Nb isotopes and their impact on rp and νp nucleosynthesis processes

© 2018 The Authors. Published by Elsevier B.V. This manuscript is made available under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International licence (CC BY-NC-ND 4.0). For further details please see: https://creativecommons.org/licenses/by-nc-nd/4.0/Using isochronous mass spectrometry at the experimental storage ring CSRe in Lanzhou, the masses of 82Zr and 84Nb were measured for the first time with an uncertainty of ∼10 keV, and the masses of 79Y, 81Zr, and 83Nb were re-determined with a higher precision. The latter are significantly less bound than their literature values. Our new and accurate masses remove the irregularities of the mass surface in this region of the nuclear chart. Our results do not support the predicted island of pronounced low α separation energies for neutron-deficient Mo and Tc isotopes, making the formation of Zr–Nb cycle in the rp-process unlikely. The new proton separation energy of 83Nb was determined to be 490(400) keV smaller than that in the Atomic Mass Evaluation 2012. This partly removes the overproduction of the p-nucleus 84Sr relative to the neutron-deficient molybdenum isotopes in the previous νp-process simulations.Peer reviewe

Hadronic B Decays to Charmed Baryons

We study exclusive B decays to final states containing a charmed baryon within the pole model framework. Since the strong coupling for $\Lambda_b\bar B N$ is larger than that for $\Sigma_b \bar BN$, the two-body charmful decay $B^-\to\Sigma_c^0\bar p$ has a rate larger than $\bar B^0\to\Lambda_c^+\bar p$ as the former proceeds via the $\Lambda_b$ pole while the latter via the $\Sigma_b$ pole. By the same token, the three-body decay $\bar B^0\to\Sigma_c^{++}\bar p\pi^-$ receives less baryon-pole contribution than $B^-\to\Lambda_c^+\bar p\pi^-$. However, because the important charmed-meson pole diagrams contribute constructively to the former and destructively to the latter, $\Sigma_c^{++}\bar p\pi^-$ has a rate slightly larger than $\Lambda_c^+\bar p\pi^-$. It is found that one quarter of the $B^-\to \Lambda_c^+\bar p\pi^-$ rate comes from the resonant contributions. We discuss the decays $\bar B^0\to\Sigma_c^0\bar p\pi^+$ and $B^-\to\Sigma_c^0\bar p\pi^0$ and stress that they are not color suppressed even though they can only proceed via an internal W emission.Comment: 25 pages, 6 figure

High-efficiency and low-loss gallium nitride dielectric metasurfaces for nanophotonics at visible wavelengths

The dielectric nanophotonics research community is currently exploring transparent material platforms (e.g., TiO2, Si3N4, and GaP) to realize compact high efficiency optical devices at visible wavelengths. Efficient visible-light operation is key to integrating atomic quantum systems for future quantum computing. Gallium nitride (GaN), a III-V semiconductor which is highly transparent at visible wavelengths, is a promising material choice for active, nonlinear, and quantum nanophotonic applications. Here, we present the design and experimental realization of high efficiency beam deflecting and polarization beam splitting metasurfaces consisting of GaN nanostructures etched on the GaN epitaxial substrate itself. We demonstrate a polarization insensitive beam deflecting metasurface with 64% and 90% absolute and relative efficiencies. Further, a polarization beam splitter with an extinction ratio of 8.6/1 (6.2/1) and a transmission of 73% (67%) for p-polarization (s-polarization) is implemented to demonstrate the broad functionality that can be realized on this platform. The metasurfaces in our work exhibit a broadband response in the blue wavelength range of 430-470 nm. This nanophotonic platform of GaN shows the way to off- and on-chip nonlinear and quantum photonic devices working efficiently at blue emission wavelengths common to many atomic quantum emitters such as Ca+ and Sr+ ions. © 2017 Author(s)

Charmless Exclusive Baryonic B Decays

We present a systematical study of two-body and three-body charmless baryonic B decays. Branching ratios for two-body modes are in general very small, typically less than $10^{-6}$, except that \B(B^-\to p \bar\Delta^{--})\sim 1\times 10^{-6}. In general, $\bar B\to N\bar\Delta>\bar B\to N\bar N$ due to the large coupling constant for $\Sigma_b\to B\Delta$. For three-body modes we focus on octet baryon final states. The leading three-dominated modes are $\bar B^0\to p\bar n\pi^-(\rho^-), n\bar p\pi^+(\rho^+)$ with a branching ratio of order $3\times 10^{-6}$ for $\bar B^0\to p\bar n\pi^-$ and $8\times 10^{-6}$ for $\bar B^0\to p\bar n\rho^-$. The penguin-dominated decays with strangeness in the meson, e.g., $B^-\to p\bar p K^{-(*)}$ and $\bar B^0\to p\bar n K^{-(*)}, n\bar n \bar K^{0(*)}$, have appreciable rates and the $N\bar N$ mass spectrum peaks at low mass. The penguin-dominated modes containing a strange baryon, e.g., $\bar B^0\to \Sigma^0\bar p\pi^+, \Sigma^-\bar n\pi^+$, have branching ratios of order $(1\sim 4)\times 10^{-6}$. In contrast, the decay rate of $\bar B^0\to\Lambda\bar p\pi^+$ is smaller. We explain why some of charmless three-body final states in which baryon-antibaryon pair production is accompanied by a meson have a larger rate than their two-body counterparts: either the pole diagrams for the former have an anti-triplet bottom baryon intermediate state, which has a large coupling to the $B$ meson and the nucleon, or they are dominated by the factorizable external $W$-emission process.Comment: 46 pages and 3 figures, to appear in Phys. Rev. D. Major changes are: (i) Calculations of two-body baryonic B decays involving a Delta resonance are modified, and (ii) Penguin-dominated modes B-> Sigma+N(bar)+p are discusse

Matching the phenology of net ecosystem exchange and vegetation indices estimated with MODIS and FLUXNET in-situ observations

Shifts in ecosystem phenology play an important role in the definition of inter-annual variability of net ecosystem carbon uptake. A good estimate at the global scale of ecosystem phenology, mainly that of photosynthesis or gross primary productivity (GPP), may be provided by vegetation indices derived from MODIS satellite image data. However, the relationship between the start date of a growing (or greening) season (SGS) when derived from different vegetation indices (VI's), and the starting day of carbon uptake is not well elucidated. Additionally, the validation of existing phenology data with in-situ measurements is largely missing. We have investigated the possibility to use different VI's to predict the starting day of the growing season for 28 FLUXNET sites as well as MODIS data. This analysis included main plant functional types (PFT's). Of all VI's taken into account in this paper, the NDVI (Normalized Difference Vegetation Index) shows the highest correlation coefficient for the relationship between the starting day of the growing season as observed with MODIS and in-situ observations. However, MODIS observations elicit a 20-21 days earlier SGS date compared to in-situ observations. The prediction for the NEE start of the growing season diverges when using different VI's, and seems to depend on the amplitude for carbon and VI and on PFT. The optimal VI for estimation of a SGS date was PFT-specific - for example the WRDVI for cropland, but the MODIS NDVI performed best when applied as an estimator for Net Ecosystem Exchange and when considering all PFT's pooled