An Animal Model Using Metallic Ions to Produce Autoimmune Nephritis

Autoimmune nephritis triggered by metallic ions was assessed in a Long-Evans rat model. The parameters evaluated included antinuclear autoantibody production, kidney damage mediated by immune complexes detected by immunofluorescence, and renal function tested by retention of nitrogen waste products and proteinuria. To accomplish our goal, the animals were treated with the following ionic metals: HgCl2, CuSO4, AgNO3, and Pb(NO3)2. A group without ionic metals was used as the control. The results of the present investigation demonstrated that metallic ions triggered antinuclear antibody production in 60% of animals, some of them with anti-DNA specificity. Furthermore, all animals treated with heavy metals developed toxic glomerulonephritis with immune complex deposition along the mesangium and membranes. These phenomena were accompanied by proteinuria and increased concentrations of urea. Based on these results, we conclude that metallic ions may induce experimental autoimmune nephritis

Perioperative Factors Associated With Postoperative Delirium in Patients Undergoing Noncardiac Surgery:An Individual Patient Data Meta-Analysis

IMPORTANCE: Postoperative delirium (POD) is a common and serious complication after surgery. Various predisposing factors are associated with POD, but their magnitude and importance using an individual patient data (IPD) meta-analysis have not been assessed.OBJECTIVE: To identify perioperative factors associated with POD and assess their relative prognostic value among adults undergoing noncardiac surgery.DATA SOURCES: MEDLINE, EMBASE, and CINAHL from inception to May 2020.STUDY SELECTION: Studies were included that (1) enrolled adult patients undergoing noncardiac surgery, (2) assessed perioperative risk factors for POD, and (3) measured the incidence of delirium (measured using a validated approach). Data were analyzed in 2020.DATA EXTRACTION AND SYNTHESIS: Individual patient data were pooled from 21 studies and 1-stage meta-analysis was performed using multilevel mixed-effects logistic regression after a multivariable imputation via chained equations model to impute missing data.MAIN OUTCOMES AND MEASURES: The end point of interest was POD diagnosed up to 10 days after a procedure. A wide range of perioperative risk factors was considered as potentially associated with POD.RESULTS: A total of 192 studies met the eligibility criteria, and IPD were acquired from 21 studies that enrolled 8382 patients. Almost 1 in 5 patients developed POD (18%), and an increased risk of POD was associated with American Society of Anesthesiologists (ASA) status 4 (odds ratio [OR], 2.43; 95% CI, 1.42-4.14), older age (OR for 65-85 years, 2.67; 95% CI, 2.16-3.29; OR for &gt;85 years, 6.24; 95% CI, 4.65-8.37), low body mass index (OR for body mass index &lt;18.5, 2.25; 95% CI, 1.64-3.09), history of delirium (OR, 3.9; 95% CI, 2.69-5.66), preoperative cognitive impairment (OR, 3.99; 95% CI, 2.94-5.43), and preoperative C-reactive protein levels (OR for 5-10 mg/dL, 2.35; 95% CI, 1.59-3.50; OR for &gt;10 mg/dL, 3.56; 95% CI, 2.46-5.17). Completing a college degree or higher was associated with a decreased likelihood of developing POD (OR 0.45; 95% CI, 0.28-0.72).CONCLUSIONS AND RELEVANCE: In this systematic review and meta-analysis of individual patient data, several important factors associated with POD were found that may help identify patients at high risk and may have utility in clinical practice to inform patients and caregivers about the expected risk of developing delirium after surgery. Future studies should explore strategies to reduce delirium after surgery.</p

Global urban environmental change drives adaptation in white clover

Urbanization transforms environments in ways that alter biological evolution. We examined whether urban environmental change drives parallel evolution by sampling 110,019 white clover plants from 6169 populations in 160 cities globally. Plants were assayed for a Mendelian antiherbivore defense that also affects tolerance to abiotic stressors. Urban-rural gradients were associated with the evolution of clines in defense in 47% of cities throughout the world. Variation in the strength of clines was explained by environmental changes in drought stress and vegetation cover that varied among cities. Sequencing 2074 genomes from 26 cities revealed that the evolution of urban-rural clines was best explained by adaptive evolution, but the degree of parallel adaptation varied among cities. Our results demonstrate that urbanization leads to adaptation at a global scale

SEVEN IMPLICIT CONSIDERATIONS TO BE EXPLICITLY ADDRESSED IN EMPIRICALLY BASED PSYCHOTHERAPIES

La literatura psicológica sobre procesos implícitos (IP), que abarca los pensamientos, acciones y sentimientosde un individuo que ocurren independientemente de la conciencia, se ha expandido en las últimas dos décadas. Durante este mismo período, la proliferación de psicoterapias con base empírica (PBE), con énfasis en los procesos conscientes, ha cobrado impulsoentre muchos profesionales de la salud mental. Sin embargo, la literatura sobre el papel de los IP en psicoterapias basadas empíricamente (EBP) es escasa. El objetivo principal de este documento es sugerir hallazgos de IP que puedan usarse para mejorar laeficacia y efectividad de EBP. Se destacan siete hallazgos de IP que pueden tener aplicaciones importantes para EBP. Dentro de cada una de estas siete consideraciones, se discute el impacto de los IP en el proceso psicoterapéutico

P03 Race Always Matters: Recommendations to Help Students Successfully Navigate Collaborations Across Racial Lines

The United States (U.S.) has experienced an unprecedented shift in its demographic makeup, with People of Color significantly contributing to what the literature refers to as the “Browning of America” (Nasser, 2004; White & Henderson, 2008). As the nation becomes more multiracial and multicultural, there is an increased likelihood of cross-racial academic collaborations between individuals from diverse backgrounds. Scholars have begun to look at how racial identity and relational power dynamics influence cross-racial interactions among professionals and professionals-in-training, including psychotherapists, supervisors, and supervisees (Helms & Cook, 1999; Jernigan, Green, Helms, Perez-Gualdron & Henze, 2010); however, little attention has been given to cross-racial relationships formed between students working together on academic projects (e.g., research teams, class group projects). Given the increased likelihood of cross-racial research collaborations, students would benefit from being informed about the implications and dynamics of working within a racially diverse team. For instance, cross-racial alliances have the potential of re-enacting the U.S. racial hierarchy, where People of Color are often silenced and their opinions and contributions are disregarded and/or minimized (Helms & Cook, 1999). Hence, perpetuating the systemic racism in the U.S. Being aware of these re-enactments is vital to forming racially conscious teams where all constituents are equally valued. This socially responsive practice will decrease the likelihood of Students of Color feeling marginalized, silenced, or having to compromise what they can bring to the team. The objectives of the proposed poster presentation are threefold: one, discuss the implications of cross-racial academic collaborations, including the potential effect they could have on Students of Color; two, outline recommendations for how to mobilize academic resources that will help mitigate potential challenges when forming cross-racial alliances; three, provide recommendations for ways Students of Color can maintain a strong racial identity and self-concept while engaged in cross-racial alliances. Working with a racially diverse group of students can result in benefits for all members of the team, by accurately representing the needs and voices of all individuals. Overall, it is essential that both Students of Color and white students learn how to engage in mutually respectful, egalitarian, and collaborative relationships that break the cycle of racial socialization

Multicultural Initiatives Across Educational Contexts in Psychology: Becoming Diverse in Our Approach

Educational context plays a role in promoting and maintaining multicultural competence. Whereas in the past decade psychology has considered the impact of multiculturalism in educational training; however, less attention has been paid to the institutional contexts that house these efforts. In this paper, four professional psychologists with expertise in multicultural education enumerate the barriers they encountered as they attempted to establish culture-centered educational contexts. Focusing on three specific educational contexts (a psychology department, a training clinic, and a medical setting), they provide insightful and compelling narratives that educators can relate to and apply to their own institutions. The article concludes with recommendations

Integration of Latino/a Cultural Values Into Palliative Health Care: A Culture Centered Model

Objective: Culture helps us grapple with, understand, and navigate the dying process. Although often overlooked, cultural values play a critical and influential role in palliative care. The purpose of the present study was two-fold: one, to review whether Latino/a cultural values have been integrated into the palliative care literature for Latinos/as; two, identify publications that provide recommendations on how palliative care providers can integrate Latino/a cultural values into the end-of-life care. Method: A comprehensive systematic review on the area of Latino/a cultural values in palliative care was conducted via an electronic literature search of publications between 1930-2013. Five articles were identified for reviewing, discussing, or mentioning Latino/a cultural values and palliative care. Results: Only one article specifically addressed Latino/a cultural values in palliative care. The four remaining articles discuss or mention cultural values; however, the cultural values were not the main focus of each article\u27s thesis. Significance of results: The results of the current study highlight the lack of literature specifically addressing the importance of integrating Latino/a cultural values into the delivery of palliative care. As a result, this article introduces the Culture-Centered Palliative Care Model (CCPC). The article defines five key traditional Latino/a cultural values (i.e., familismo, personalismo, respeto, confianza, and dignidad), discusses the influence of each value on palliative health care, and ends with practical recommendations for service providers. Special attention is given to the stages of acculturation and ethnic identity

Radical Hope in Revolting Times: Proposing a Culturally Relevant Psychological Framework

Growing research supports the link between individual expressions of hope and psychological well‐being. In this paper, we draw on psychological theories of hope, racial and ethnic studies, and the literature on radical healing to propose a framework of radical hope. Although the proposed multidimensional framework integrates cultural practices of People of Color in the United States, it is flexible enough to be adapted to other contexts. The paper begins by providing a brief review of the literature that conceptualizes the concept of hope in the field of psychology as a prelude to comparing the concept to the interdisciplinary notion of radical hope. Based on this body of work, we then introduce a culturally relevant psychological framework of radical hope, which includes the components of collective memory as well as faith and agency. Both components require an orientation to one of four directions including individual orientation, collective orientation, past orientation, and future orientation. The framework also consists of pathways individuals can follow to experience radical hope including (a) understanding the history of oppression along with the actions of resistance taken to transform these conditions, (b) embracing ancestral pride, (c) envisioning equitable possibilities, and (d) creating meaning and purpose in life by adopting an orientation to social justice. We conclude with a proposed research agenda for radical hope

Toward a Psychological Framework of Radical Healing in Communities of Color

Advancing beyond individual-level approaches to coping with racial trauma, we introduce a new psychological framework of radical healing for People of Color and Indigenous individuals (POCI) in the United States. We begin by providing a context of race and racism in the United States and its consequences for the overall well-being of POCI. We build on existing frameworks rooted in social justice education and activism and describe a form of healing and transformation that integrates elements of liberation psychology, Black psychology, ethnopolitical psychology, and intersectionality theory. We briefly review these conceptual foundations as a prelude to introducing a psychological framework of radical healing and its components grounded in five anchors including: (a) collectivism, (b) critical consciousness, (c) radical hope, (d) strength and resistance, and (e) cultural authenticity and self-knowledge. We conclude with a discussion of the applications of radical healing to clinical practice, research, training, and social justice advocacy