Primera cita de cocodrilos zifodontos en el Cenozoico de Asturias: Royo Gómez y los supuestos dientes de dinosaurio del Eoceno de Llamaquique

In 1928, José Royo Gómez mentioned the find of “two teeth similar to those of theropod dinosaurs from the Secondary” in the Eocene of Llamaquique (Oviedo Basin, Asturias). Royo Gómez was aware of the interest of the discovery, “because they would be the youngest remains found of these gigantic reptiles”. According to the hitherto unpublished documents preserved in the Archives of the Museo Nacional de Ciencias Naturales in Madrid, Royo Gómez photographed five teeth from Llamaquique in April 1932, which he regarded as belonging to theropods. The whereabouts of this material is currently unknown. However, the revision of the Llamaquique collection in the above mentioned museum has allowed to recover one labiolingually compressed and serrated tooth (ziphodont condition). We reject here that the tooth belongs to a theropod, and we assign it to a Mesoeucrocodylia indet. This is the first mention of the discovery of ziphodont crocodyliforms in the Paleogene of Asturias.En 1928, José Royo Gómez informó del hallazgo de “dos dientes idénticos a los de los Dinosaurios terópodos del Secundario” en el Eoceno de Llamaquique (Cuenca de Oviedo, Asturias). Royo Gómez era consciente del interés de este descubrimiento, “pues serían los restos más modernos que se conocerían de estos gigantescos reptiles”. Según la documentación conservada en el Archivo del Museo Nacional de Ciencias Naturales en Madrid, hasta ahora inédita, Royo Gómez fotografió en abril de 1932 cinco dientes de Llamaquique que él consideraba pertenecientes a terópodos. Este material se encuentra actualmente en paradero desconocido. No obstante, la revisión de la colección paleontológica de Llamaquique en el mencionado museo ha permitido recuperar un diente comprimido lateralmente y provisto de carenas denticuladas (condición zifodonta). Se descarta que el diente pertenezca a un terópodo, asignándose a un Mesoeucrocodylia indeterminado. Se trata de la primera mención del hallazgo de cocodrilos zifodontos en el Paleógeno de Asturias

A xandarellid artiopodan from Morocco – a middle Cambrian link between soft-bodied euarthropod communities in North Africa and South China

NB. A corrigendum [correction] for this article was published online on 09 May 2017; this has been attached to this article as an additional file. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ © The Author(s) 2017. The attached file is the published version of the article

In-flight Diagnostics in LISA Pathfinder

LISA PathFinder (LPF) will be flown with the objective to test in space key technologies for LISA. However its sensitivity goals are, for good reason, one order of magnitude less than those which LISA will have to meet, both in drag-free and optical metrology requirements, and in the observation frequency band. While the expected success of LPF will of course be of itself a major step forward to LISA, one might not forget that a further improvement by an order of magnitude in performance will still be needed. Clues for the last leap are to be derived from proper disentanglement of the various sources of noise which contribute to the total noise, as measured in flight during the PathFinder mission. This paper describes the principles, workings and requirements of one of the key tools to serve the above objective: the diagnostics subsystem. This consists in sets of temperature, magnetic field, and particle counter sensors, together with generators of controlled thermal and magnetic perturbations. At least during the commissioning phase, the latter will be used to identify feed-through coefficients between diagnostics sensor readings and associated actual noise contributions. A brief progress report of the current state of development of the diagnostics subsystem will be given as well.Peer Reviewe

Learning to live together: a challenge for schools located in contexts of social vulnerability

Currently, there are many educational centres that demonstrate the need to promote initiatives to improve coexistence at school at the international level, especially in those located in contexts of social vulnerability. A socio-educational programme has been developed, applied and evaluated at a Singular Education Action Centre (Centro de Acción Educativa Singular - C.A.E.S) in the city of Valencia (Spain). To ascertain the programme's impact and possible generalization to other contexts, a quasi-experimental pretest-posttest design with a control group was used. Information was collected from 297 students and 54 teachers based on questionnaires assessing coexistence at school. The results obtained demonstrate the satisfactory functioning of the programme. The faculty and students from the experimental group affirm the importance of continuing to work in this direction to invest in creating a democratic school that firmly believes in coexistence and participation. Areas for improvement include the need to incorporate actions to increase family participation and develop strategies to facilitate the implementation of a more comprehensive programme

In-flight Diagnostics in LISA Pathfinder

LISA PathFinder (LPF) will be flown with the objective to test in space key technologies for LISA. However its sensitivity goals are, for good reason, one order of magnitude less than those which LISA will have to meet, both in drag-free and optical metrology requirements, and in the observation frequency band. While the expected success of LPF will of course be of itself a major step forward to LISA, one might not forget that a further improvement by an order of magnitude in performance will still be needed. Clues for the last leap are to be derived from proper disentanglement of the various sources of noise which contribute to the total noise, as measured in flight during the PathFinder mission. This paper describes the principles, workings and requirements of one of the key tools to serve the above objective: the diagnostics subsystem. This consists in sets of temperature, magnetic field, and particle counter sensors, together with generators of controlled thermal and magnetic perturbations. At least during the commissioning phase, the latter will be used to identify feed-through coefficients between diagnostics sensor readings and associated actual noise contributions. A brief progress report of the current state of development of the diagnostics subsystem will be given as well.Peer Reviewe

Recent advances in Pichia pastoris as host for heterologous expression system for lipases : a review

The production of heterologous lipases is one of the most promising strategies to increase the productivity of the bioprocesses and to reduce costs, with the final objective that more industrial lipase applications could be implemented. In this chapter, an overview of the new success in synthetic biology, with traditional molecular genetic techniques and bioprocess engineering in the last 5 years in the cell factory Pichia pastoris, the most promising host system for heterologous lipase production, is presented. The goals get on heterologous Candida antarctica, Rhizopus oryzae, and Candida rugosa lipases, three of the most common lipases used in biocatalysis, are showed. Finally, new cell factories producing heterologous lipases are presented

Late Cretaceous continental and marine vertebrate assemblages of the Laño Quarry (Basque-Cantabrian Region, Iberian Peninsula): an update

The vertebrate-bearing beds of the Laño quarry (Condado de Treviño) are among the most relevant sites from the Late Cretaceous of Europe. Geologically, Laño and the adjacent region are set on the southern limb of the South-Cantabrian Synclinorium (SE Basque-Cantabrian Region, northern Iberian Peninsula). The Laño sites were discovered in 1984; thousands of bones and teeth, including microfossils, have been collected during the prospection in the field and excavation campaigns. The vertebrate remains occur at two different stratigraphic horizons within a continental to shallow marine succession of Late Campanian-Maastrichtian age. The lower horizon contains the Laño 1 and Laño 2 sites, whereas the upper horizon contains the Albaina site. In the Laño sites, three fossiliferous beds (called L1A, L1B and L2) are known within an alluvial system composed mainly of fluvial sands and silts. The sedimentary structures are consistent with channel areas within an extensive braided river system. Based mainly on stratigraphic correlations, the fluvial beds of Laño are regarded as Late Campanian to Early Maastrichtian in age. These deposits have yielded a very diverse vertebrate assemblage, which consists of nearly 40 species, including actinopterygians, lissamphibians, lepidosaurs, turtles, crocodyliforms, dinosaurs, pterosaurs, and mammals. Seven genera and ten species have been erected to date in Laño. With reference to the marine vertebrate association of Albaina, it consists of at least 37 species, including sharks and rays, actinopterygians, mosasaurids, and plesiosaurs. Two genera and species of rhinobatoids (family indet.) and two new species of rhinobatids have been erected in Albaina. The fossil association indicates a Late (but not latest) Maastrichtian age. Recently, isolated turtle and dinosaur fossils have been discovered in the sublittoral beds of Albaina. The Laño quarry is one of the most noteworthy Campanian-Maastrichtian vertebrate localities of Europe by its taxonomic diversity, and provides useful information about the composition and affinities of both continental and marine vertebrate faunas from the latest Cretaceous of southwestern Europe.Los niveles con fósiles de vertebrados de la cantera de Laño (Condado de Treviño) se cuentan entre los más importantes del Cretácico Superior de Europa. Desde un punto de vista geológico, Laño y la región adyacente forman parte del flanco sur del Sinclinorio Subcantábrico (SE de la Región Vasco-Cantábrica). El descubrimiento de los niveles fosilíferos remonta a 1984; las prospecciones de campo y las campañas de excavación han proporcionado miles de huesos y dientes, incluyendo microfósiles. Los restos de vertebrados aparecen en dos horizontes estratigráficos diferentes formando parte de una sucesión continental a marina litoral de edad Campaniense superior a Maastrichtiense. El horizonte inferior contiene los yacimientos de Laño 1 y Laño 2, mientras que el superior contiene solo uno: Albaina. En los yacimientos de Laño, se reconocen tres niveles fosilíferos (llamados L1A, L1B y L2) formados en el seno de un sistema aluvial compuesto por arenas y limos fluviales. Las estructuras sedimentarias indican áreas de canal dentro de un sistema trenzado muy extendido. Según las correlaciones estratigráficas, los depósitos fluviales de Laño son de edad Campaniense superior a Maastrichtiense inferior. Estos depósitos han proporcionado una asociación muy diversa de vertebrados, que consiste en cerca de 40 especies, incluyendo actinopterigios, lisanfibios, lepidosaurios, tortugas, cocodrilos, dinosaurios, pterosaurios y mamíferos. En Laño se han definido hasta el momento siete géneros y diez especies. Por lo que respecta a la asociación de vertebrados marinos de Albaina, se han reconocido al menos 37 especies, que incluyen tiburones y rayas, actinopterigios, mosasaurios y plesiosaurios. Hasta la fecha se han definido en Albaina cuatro nuevos rinobatoideos: dos especies de rinobátidos y dos géneros y especies cuya familia es indeterminada. La asociación fósil es de edad Maastrichtiense superior no terminal. Recientemente se ha descrito el hallazgo de restos fósiles aislados de tortugas y dinosaurios en los niveles marinos de Albaina. La cantera de Laño es una de las localidades de vertebrados más destacadas del Campaniense-Maastrichtiense por su diversidad taxonómica, y proporciona información relevante sobre la composición y afinidades de las faunas de vertebrados continentales y marinos del Cretácico final del suroeste de Europa

LISA and LISA PathFinder, the endeavour to detect low frequency GWs

This is a review about LISA and its technology demonstrator, LISA PathFinder. We first describe the conceptual problems which need to be overcome in order to set up a working interferometric detector of low frequency Gravitational Waves (GW), then summarise the solutions to them as currently conceived by the LISA mission team. This will show that some of these solutions require new technological abilities which are still under development, and which need proper test before being fully implemented. LISA PathFinder (LPF) is the the testbed for such technologies. The final part of the paper will address the ideas and concepts behind the PathFinder as well as their impact on LISA.Comment: 25 pages, 21 figures, presented at the Spanish Relativity Meeting, Mallorca September 2006. Will be published in Journal of Physics: Conference Series, IOP. To be published in Journal of Physics: Conference Series, IO

Prospective associations between a priori dietary patterns adherence and kidney function in an elderly Mediterranean population at high cardiovascular risk.

PURPOSE: To assess the association between three different a priori dietary patterns adherence (17-item energy reduced-Mediterranean Diet (MedDiet), Trichopoulou-MedDiet and Dietary Approach to Stop Hypertension (DASH)), as well as the Protein Diet Score and kidney function decline after one year of follow-up in elderly individuals with overweight/obesity and metabolic syndrome (MetS). METHODS: We prospectively analyzed 5675 participants (55-75 years) from the PREDIMED-Plus study. At baseline and at one year, we evaluated the creatinine-based estimated glomerular filtration rate (eGFR) and food-frequency questionnaires-derived dietary scores. Associations between four categories (decrease/maintenance and tertiles of increase) of each dietary pattern and changes in eGFR (ml/min/1.73m2) or ≥ 10% eGFR decline were assessed by fitting multivariable linear or logistic regression models, as appropriate. RESULTS: Participants in the highest tertile of increase in 17-item erMedDiet Score showed higher upward changes in eGFR (β: 1.87 ml/min/1.73m2; 95% CI: 1.00-2.73) and had lower odds of ≥ 10% eGFR decline (OR: 0.62; 95% CI: 0.47-0.82) compared to individuals in the decrease/maintenance category, while Trichopoulou-MedDiet and DASH Scores were not associated with any renal outcomes. Those in the highest tertile of increase in Protein Diet Score had greater downward changes in eGFR (β: - 0.87 ml/min/1.73m2; 95% CI: - 1.73 to - 0.01) and 32% higher odds of eGFR decline (OR: 1.32; 95% CI: 1.00-1.75). CONCLUSIONS: Among elderly individuals with overweight/obesity and MetS, only higher upward change in the 17-item erMedDiet score adherence was associated with better kidney function after one year. However, increasing Protein Diet Score appeared to have an adverse impact on kidney health. TRIAL REGISTRATION NUMBER: ISRCTN89898870 (Data of registration: 2014)

Late cretaceous continental and marine vertebrate assemblages of the Laño Quarry (Basque-Cantabrian Region, Iberian Peninsula): An update

The vertebrate-bearing beds of the Laño quarry (Condado de Treviño) are among the most relevant sites from the Late Cretaceous of Europe. Geologically, Laño and the adjacent region are set on the southern limb of the South-Cantabrian Synclinorium (SE Basque-Cantabrian Region, northern Iberian Peninsula). The Laño sites were discovered in 1984; thousands of bones and teeth, including microfossils, have been collected during the prospection in the field and excavation campaigns. The vertebrate remains occur at two different stratigraphic horizons within a continental to shallow marine succession of Late Campanian-Maastrichtian age. The lower horizon contains the Laño 1 and Laño 2 sites, whereas the upper horizon contains the Albaina site. In the Laño sites, three fossiliferous beds (called L1A, L1B and L2) are known within an alluvial system composed mainly of fluvial sands and silts. The sedimentary structures are consistent with channel areas within an extensive braided river system. Based mainly on stratigraphic correlations, the fluvial beds of Laño are regarded as Late Campanian to Early Maastrichtian in age. These deposits have yielded a very diverse vertebrate assemblage, which consists of nearly 40 species, including actinopterygians, lissamphibians, lepidosaurs, turtles, crocodyliforms, dinosaurs, pterosaurs, and mammals. Seven genera and ten species have been erected to date in Laño. With reference to the marine vertebrate association of Albaina, it consists of at least 37 species, including sharks and rays, actinopterygians, mosasaurids, and plesiosaurs. Two genera and species of rhinobatoids (family indet.) and two new species of rhinobatids have been erected in Albaina. The fossil association indicates a Late (but not latest) Maastrichtian age. Recently, isolated turtle and dinosaur fossils have been discovered in the sublittoral beds of Albaina. The Laño quarry is one of the most noteworthy Campanian-Maastrichtian vertebrate localities of Europe by its taxonomic diversity, and provides useful information about the composition and affinities of both continental and marine vertebrate faunas from the latest Cretaceous of southwestern EuropeLos niveles con fósiles de vertebrados de la cantera de Laño (Condado de Treviño) se cuentan entre los más importantes del Cretácico Superior de Europa. Desde un punto de vista geológico, Laño y la región adyacente forman parte del flanco sur del Sinclinorio Subcantábrico (SE de la Región Vasco-Cantábrica). El descubrimiento de los niveles fosilíferos remonta a 1984; las prospecciones de campo y las campañas de excavación han proporcionado miles de huesos y dientes, incluyendo microfósiles. Los restos de vertebrados aparecen en dos horizontes estratigráficos diferentes formando parte de una sucesión continental a marina litoral de edad Campaniense superior a Maastrichtiense. El horizonte inferior contiene los yacimientos de Laño 1 y Laño 2, mientras que el superior contiene solo uno: Albaina. En los yacimientos de Laño, se reconocen tres niveles fosilíferos (llamados L1A, L1B y L2) formados en el seno de un sistema aluvial compuesto por arenas y limos fluviales. Las estructuras sedimentarias indican áreas de canal dentro de un sistema trenzado muy extendido. Según las correlaciones estratigráficas, los depósitos fluviales de Laño son de edad Campaniense superior a Maastrichtiense inferior. Estos depósitos han proporcionado una asociación muy diversa de vertebrados, que consiste en cerca de 40 especies, incluyendo actinopterigios, lisanfibios, lepidosaurios, tortugas, cocodrilos, dinosaurios, pterosaurios y mamíferos. En Laño se han definido hasta el momento siete géneros y diez especies. Por lo que respecta a la asociación de vertebrados marinos de Albaina, se han reconocido al menos 37 especies, que incluyen tiburones y rayas, actinopterigios, mosasaurios y plesiosaurios. Hasta la fecha se han definido en Albaina cuatro nuevos rinobatoideos: dos especies de rinobátidos y dos géneros y especies cuya familia es indeterminada. La asociación fósil es de edad Maastrichtiense superior no terminal. Recientemente se ha descrito el hallazgo de restos fósiles aislados de tortugas y dinosaurios en los niveles marinos de Albaina. La cantera de Laño es una de las localidades de vertebrados más destacadas del Campaniense-Maastrichtiense por su diversidad taxonómica, y proporciona información relevante sobre la composición y afinidades de las faunas de vertebrados continentales y marinos del Cretácico final del suroeste de EuropaField research in the Laño quarry has been supported by financial aids of the Ministerio de Economía y Competitividad (MINECO projects CGL2010-18851/BTE and CGL2013-47521-P), Ministerio de Ciencia e Innovación (CGL2007-64061/BTE), Ministerio de Ciencia y Tecnología (CGL2004-02338/BTE, BTE2001-0185-C02-01, BOS2000-1369), Ministerio de Educación y Ciencia (Acción Integrada hispano-francesa 201-B), Diputación Foral de Álava/Arabako Foru Aldundia (93/23, 95/A23), Gobierno Vasco/Eusko Jaurlaritza (IT834-13, IT-320-10, IT-361-07, GV121.310-4/87), Universidad del País Vasco/Euskal Herriko Unibertsitatea (9/ UPV00121.310-15303/2003), Centre National de la Recherche Scientifique (CNRS, France), Institut National des Sciences de l’Univers (INSU), The Dinosaur Society (research grant 1997) and the National Geographic Research (grant #6597-99). This work is part of a palaeontological collaboration (Convenio específico de colaboración) between the Universidad del País Vasco/EHU, the Centre National de la Recherche Scientifique (CNRS, France) and the Muséum National d’Histoire Naturelle (MNHN, Paris). Contribution ISEM n° 2015-04