Effects of a sweptback hydrofoil on the force and longitudinal stability characteristics of a typical high-speed airplane

An investigation was conducted in the Langley 8-foot high-speed tunnel to determine the effects of a sweptback hydrofoil on the force and longitudinal stability characteristics of a typical high-speed airplane. The Mach number range for this investigation was from 0.60 to 0.95 and at M = 1.20. The effects of the hydrofoil on the lift, drag, and pitching-moment characteristics are presented

Could we identify hot Ocean-Planets with CoRoT, Kepler and Doppler velocimetry?

Planets less massive than about 10 MEarth are expected to have no massive H-He atmosphere and a cometary composition (50% rocks, 50% water, by mass) provided they formed beyond the snowline of protoplanetary disks. Due to inward migration, such planets could be found at any distance between their formation site and the star. If migration stops within the habitable zone, this will produce a new kind of planets, called Ocean-Planets. Ocean-planets typically consist in a silicate core, surrounded by a thick ice mantle, itself covered by a 100 km deep ocean. The existence of ocean-planets raises important astrobiological questions: Can life originate on such body, in the absence of continent and ocean-silicate interfaces? What would be the nature of the atmosphere and the geochemical cycles ? In this work, we address the fate of Hot Ocean-Planets produced when migration ends at a closer distance. In this case the liquid/gas interface can disappear, and the hot H2O envelope is made of a supercritical fluid. Although we do not expect these bodies to harbor life, their detection and identification as water-rich planets would give us insight as to the abundance of hot and, by extrapolation, cool Ocean-Planets.Comment: 47 pages, 6 Fugures, regular paper. Submitted to Icaru

A Chandra and Spitzer census of the young star cluster in the reflection nebula NGC 7129

The reflection nebula NGC 7129 has long been known to be a site of recent star formation as evidenced, e.g., by the presence of deeply embedded protostars and HH objects. However, studies of the stellar population produced in the star formation process have remained rudimentary. At a presumed age of ~3 Myr, NGC7129 is in the critical range where disks around young stars disappear. We make use of Chandra X-ray and Spitzer and 2MASS IR imaging observations to identify the pre-main sequence stars in NGC7129. We define a sample of Young Stellar Objects based on color-color diagrams composed from IR photometry between 1.6 and 8 mu, from 2MASS and Spitzer, and based on X-ray detected sources from a Chandra observation. This sample is composed of 26 Class II and 25 Class III candidates. The sample is estimated to be complete down to ~ 0.5 solar masses. The most restricted and least biased sub-sample of pre-main sequence stars is composed of lightly absorbed (A_V < 5 mag) stars in the cluster core. This sample comprises 7 Class II and 14 Class III sources, it has a disk fraction of 33^{+24}_{-19} %, and a median X-ray luminosity of log (L_x) [erg/s] = 30.3. Despite the various uncertainties related to the sample selection, absorption, mass distribution, distance and, consequently, the computation of disk fraction and X-ray luminosities, the data yield consistent results. In particular, we confirm the age of ~3 Myr for the NGC7129 cluster. The derived disk fraction is similar to that of sigma Orionis, smaller than that of Cha I (~2 Myr), and larger than that of Upper Sco (5 Myr). The X-ray luminosity function is similar to that of NGC 2264 (2 Myr) but fainter than that of the Orion Nebula Cluster (1 Myr).Comment: accepted for publication in Astronomy & Astrophysic

Pathogenic Intronic Splice-Affecting Variants in MYBPC3 in Three Patients with Hypertrophic Cardiomyopathy

From MDPI via Jisc Publications RouterHistory: accepted 2021-05-25, pub-electronic 2021-06-02Publication status: PublishedFunder: Medical Research Council; Grant(s): 1916606, IS-BRC-1215-20007, BB/N000258/1Genetic variants in MYBPC3 are one of the most common causes of hypertrophic cardiomyopathy (HCM). While variants in MYBPC3 affecting canonical splice site dinucleotides are a well-characterised cause of HCM, only recently has work begun to investigate the pathogenicity of more deeply intronic variants. Here, we present three patients with HCM and intronic splice-affecting MYBPC3 variants and analyse the impact of variants on splicing using in vitro minigene assays. We show that the three variants, a novel c.927-8G>A variant and the previously reported c.1624+4A>T and c.3815-10T>G variants, result in MYBPC3 splicing errors. Analysis of blood-derived patient RNA for the c.3815-10T>G variant revealed only wild type spliced product, indicating that mis-spliced transcripts from the mutant allele are degraded. These data indicate that the c.927-8G>A variant of uncertain significance and likely benign c.3815-10T>G should be reclassified as likely pathogenic. Furthermore, we find shortcomings in commonly applied bioinformatics strategies to prioritise variants impacting MYBPC3 splicing and re-emphasise the need for functional assessment of variants of uncertain significance in diagnostic testing

Understanding COVID-19 Dynamics and the Effects of Interventions in the Philippines: A Mathematical Modelling Study

Background COVID-19 initially caused less severe outbreaks in many low- and middle-income countries (LMIC) compared with many high-income countries; possibly because of differing demographics; socioeconomics; surveillance; and policy responses. Here; we investigate the role of multiple factors on COVID-19 dynamics in the Philippines; a LMIC that has had a relatively severe COVID-19 outbreak. Methods We applied an age-structured compartmental model that incorporated time-varying mobility; testing; and personal protective behaviors (through a “Minimum Health Standards” policy; MHS) to represent the first wave of the Philippines COVID-19 epidemic nationally and for three highly affected regions (Calabarzon; Central Visayas; and the National Capital Region). We estimated effects of control measures; key epidemiological parameters; and interventions. Findings Population age structure; contact rates; mobility; testing; and MHS were sufficient to explain the Philippines epidemic based on the good fit between modelled and reported cases; hospitalisations; and deaths. The model indicated that MHS reduced the probability of transmission per contact by 13-27%. The February 2021 case detection rate was estimated at ~8%; population recovered at ~9%; and scenario projections indicated high sensitivity to MHS adherence. Interpretation COVID-19 dynamics in the Philippines are driven by age; contact structure; mobility; and MHS adherence. Continued compliance with low-cost MHS should help the Philippines control the epidemic until vaccines are widely distributed; but disease resurgence may be occurring due to a combination of low population immunity and detection rates and new variants of concern