Application of the A∗ algorithm to problems of the Euclidean shortest paths in the plane with polygonal obstacles

The Euclidean shortest path between two points s and t in the plane with the cellular decomposition in the presence of obstacles is considered. The A* algorithm for a visibility graph (VG) is used to avoid widened obstacles. Computational experiments show that the proposed algorithm is often faster and it analyzes fewer nodes than the classical Dijkstra algorithm

Fritz Bauer (1903-1968). Lawyer for the sense of freedom

Este ensayo resume los grandes temas en la vida y obra de Fritz Bauer (1903 -1968), el jurista alemán que además reformó el sistema judicial de su país. En 1933 fue detenido por sus convicciones socialdemócratas y encerrado en un campo de concentración, luego de ser liberado sobrevivió en el exilio. En 1949, Bauer regresó a Alemania. Hizo de la desnazificación su tarea principal, entregó a los israelíes los datos determinantes del escondite de Adolf Eichmann y llevó a juicio a los asesinos de Auschwitz.This essay summarizes the themes in the life and work of the German jurist and legal reformer Fritz Bauer (1903–1968), who was interned in a concentration camp as a Social Democrat by the Nazis in 1933 and survived in exile after being released. In 1949 Bauer returned to Germany, where he worked for denazification, provided the Israelis with key information on Adolf Eichmann’s whereabouts, and initiated the trial of the Auschwitz murderers

Periodic behaviour of coronal mass ejections, eruptive events, and solar activity proxies during solar cycles 23 and 24

We report on the parallel analysis of the periodic behaviour of coronal mass ejections (CMEs) based on 21 years [1996 -- 2016] of observations with the SOHO/LASCO--C2 coronagraph, solar flares, prominences, and several proxies of solar activity. We consider values of the rates globally and whenever possible, distinguish solar hemispheres and solar cycles 23 and 24. Periodicities are investigated using both frequency (periodogram) and time-frequency (wavelet) analysis. We find that these different processes, in addition to following the $\approx$11-year Solar Cycle, exhibit diverse statistically significant oscillations with properties common to all solar, coronal, and heliospheric processes: variable periodicity, intermittence, asymmetric development in the northern and southern solar hemispheres, and largest amplitudes during the maximum phase of solar cycles, being more pronounced during solar cycle 23 than the weaker cycle 24. However, our analysis reveals an extremely complex and diverse situation. For instance, there exists very limited commonality for periods of less than one year. The few exceptions are the periods of 3.1--3.2 months found in the global occurrence rates of CMEs and in the sunspot area (SSA) and those of 5.9--6.1 months found in the northern hemisphere. Mid-range periods of $\approx$1 and $\approx$2 years are more wide spread among the studied processes, but exhibit a very distinct behaviour with the first one being present only in the northern hemisphere and the second one only in the southern hemisphere. These periodic behaviours likely results from the complexity of the underlying physical processes, prominently the emergence of magnetic flux.Comment: 33 pages, 15 figures, 2 table

Housing Designs for Sullivan, IN

The city of Sullivan, IN has a neighborhood revitalization plan and requires new housing that will attract new homeowners to Sullivan. The IAD251 course offers Interior Architecture Design sophomores and juniors the opportunity to design their own unique home, so they were tasked with developing concepts and floor plans for Sullivan’s empty lots. The course developed ten housing designs, and six are represented in this report

Matura Evaluation Experiment Based on Human Evaluation of Machine Translation

Abstract—A Web-based system for human evaluation of machine translation is presented in this paper. The system is based on comprehension tests similar to the ones used in Polish matura (secondary school-leaving) examinations. The results of preliminary experiments for Polish-English and English-Polish machine translation evaluation are presented and discussed. I

In vitro evaluation of poly (L-lactide-co-glycolide) membrane

The aim of this study was to prepare and evaluate the properties of a new membrane dedicated for the treatment of bone defects in periodontology according to guided tissue regeneration (GTR) technique. The first part of this study was to prepare the membrane from resorbable poly(L-lactide-co-glycolide) (PLGA) and verify its microstructure. Biological evaluation was lead using the cells interesting from the point of view of GTR, e.g. human fibroblasts and mesenchymal stem cells (hMSC). It was found that the obtained membrane has asymmetric microstructure and defined pore size. Cell culture experiments show that the membrane is biocompatible with fibroblasts and hMSC. Both types of cell proliferated well on the membrane. HMSC cultured on the membrane exhibited better osteogenic differentiation and higher mineralization as compared to control tissue culture polystyrene

Alzheimer’s Disease Computer-Aided Diagnosis on Positron Emission Tomography Brain Images Using Image Processing Techniques

Positron emission tomography (PET) is a molecular medical imaging modality which is commonly used for neurodegenerative disease diagnosis. Computer-aided diagnosis (CAD), based on medical image analysis, could help with the quantitative evaluation of brain diseases such as Alzheimer’s disease (AD). Ranking the effectiveness of brain volume of interest (VOI) to separate healthy or normal control (HC or NC) from AD brain PET images is presented in this book chapter. Brain images are first mapped into anatomical VOIs using an atlas. Different features including statistical, graph, or connectivity-based features are then computed on these VOIs. Top-ranked VOIs are then input into a support vector machine (SVM) classifier. The developed methods are evaluated on a local database image as well as on Alzheimer’s Disease Neuroimaging Initiative (ADNI) public database and then compared to known selection feature methods. These new approaches outperformed classification results in the case of a two-group separation

Stimulated Raman histology: one to one comparison with standard hematoxylin and eosin staining

International audienceWe present for the first time one-to-one correspondence between standard hema-toxylin/eosin (H&E) stained tissue sections and stimulated Raman histology (SRH)-a label-free technique in which stimulated Raman scattering (SRS) and second harmonic generation (SHG) are combined to generate virtual H&E images. Experiments were performed on both human thin cryogenic slides from the gastrointestinal tract (GI) and thick freshly excised biopsies from endoscopic surgery. Results on cryogenic slides evidenced an excellent agreement between SRH and H&E images while the ones on biopsies established the relevance of SRH for rapid intraoperative histology to assist in surgical decision making

Altered resting-state functional connectivity in patients with chronic bilateral vestibular failure

AbstractPatients with bilateral vestibular failure (BVF) suffer from gait unsteadiness, oscillopsia and impaired spatial orientation. Brain imaging studies applying caloric irrigation to patients with BVF have shown altered neural activity of cortical visual–vestibular interaction: decreased bilateral neural activity in the posterior insula and parietal operculum and decreased deactivations in the visual cortex. It is unknown how this affects functional connectivity in the resting brain and how changes in connectivity are related to vestibular impairment.We applied a novel data driven approach based on graph theory to investigate altered whole-brain resting-state functional connectivity in BVF patients (n= 22) compared to age- and gender-matched healthy controls (n= 25) using resting-state fMRI. Changes in functional connectivity were related to subjective (vestibular scores) and objective functional parameters of vestibular impairment, specifically, the adaptive changes during active (self-guided) and passive (investigator driven) head impulse test (HIT) which reflects the integrity of the vestibulo-ocular reflex (VOR).BVF patients showed lower bilateral connectivity in the posterior insula and parietal operculum but higher connectivity in the posterior cerebellum compared to controls. Seed-based analysis revealed stronger connectivity from the right posterior insula to the precuneus, anterior insula, anterior cingulate cortex and the middle frontal gyrus. Excitingly, functional connectivity in the supramarginal gyrus (SMG) of the inferior parietal lobe and posterior cerebellum correlated with the increase of VOR gain during active as compared to passive HIT, i.e., the larger the adaptive VOR changes the larger was the increase in regional functional connectivity.Using whole brain resting-state connectivity analysis in BVF patients we show that enduring bilateral deficient or missing vestibular input leads to changes in resting-state connectivity of the brain. These changes in the resting brain are robust and task-independent as they were found in the absence of sensory stimulation and without a region-related a priori hypothesis. Therefore they may indicate a fundamental disease-related change in the resting brain. They may account for the patients' persistent deficits in visuo-spatial attention, spatial orientation and unsteadiness. The relation of increasing connectivity in the inferior parietal lobe, specifically SMG, to improvement of VOR during active head movements reflects cortical plasticity in BVF and may play a clinical role in vestibular rehabilitation